LOCUS AF327441 7224 bp mRNA linear HUM 02-FEB-2004
DEFINITION Homo sapiens beta-spectrin 2 isoform 2 mRNA, complete cds.
ACCESSION AF327441
VERSION AF327441.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7224)
AUTHORS Chen,Y., Yu,P., Lu,D., Tagle,D.A. and Cai,T.
TITLE A novel isoform of beta-spectrin II localizes to cerebellar
Purkinje-cell bodies and interacts with neurofibromatosis type 2
gene product schwannomin
JOURNAL J. Mol. Neurosci. 17 (1), 59-70 (2001)
PUBMED 11665863
REFERENCE 2 (bases 1 to 7224)
AUTHORS Chen,Y. and Yu,P.
TITLE Direct Submission
JOURNAL Submitted (10-DEC-2000) Potobio USA Inc., 8809 Post Oak Road,
Potomac, MD 20854, USA
FEATURES Location/Qualifiers
source 1..7224
/db_xref="H-InvDB:HIT000077544"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2p21-p13; between D2S2251 and D2S357"
CDS 386..6853
/note="SPNB2; cytoskeleton protein"
/codon_start=1
/product="beta-spectrin 2 isoform 2"
/protein_id="AAO15362.1"
/translation="MELQRTSSISGPLSPAYTGQVPYNYNQLEGRFKQLQDEREAVQK
KTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLEN
VDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKK
SAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAH
YNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKR
IGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTY
RTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHE
RELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKK
HEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARR
QRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGI
QAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEES
RRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFE
QAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADA
DDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALP
QEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKE
QWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIK
AQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLG
NDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDV
WEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLL
TQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWE
NRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTT
MDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNR
DLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKI
EKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCAD
LDKWLHGLESQIQSDDYGKHLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQE
GKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPL
ATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQ
RLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKD
EQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYA
GLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQER
FREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTR
TQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQA
LGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDK
FRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCI
ELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVA
EAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEV
RRQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRVSYRS
QTYQNYKNFNSRRTASDQPWSGL"
BASE COUNT 2020 a 1770 c 2055 g 1379 t
ORIGIN
1 ggtgtgcgcg ctgcgcccgc gagctcccgg gctcggcaac cgtggcatgc ttaggattgg
61 ccatatttaa aagttctgaa gtagaacctg cgcctcctct ctgcttctcc ctcctcctca
121 gtaatttatt tcgagcttcc aggcaagggc cacggaagaa gggaaagcaa gaaactagat
181 gcctgtgtgg taactcctcg cggagctaag gtggactctc ttgcagccaa cttcccatca
241 gatcaccttg ctggacttgc agaccggaat ggggctcgcc taaggagccg agcgctgcgg
301 aggctgctgc gtgttggatg ggagtgggag ggggctggag cgagatttcc agggcgcagt
361 cctccggggc gttacgccgg gcataatgga attgcagagg acgtctagta tctccgggcc
421 gctgtcgccg gcgtacacgg ggcaggtgcc ttacaactac aaccagctgg aaggcagatt
481 caagcagctg caagatgagc gtgaagccgt gcagaagaag accttcacca agtgggtcaa
541 ttcccacctt gcccgtgtgt cctgccggat cacagacctg tacactgacc ttcgagatgg
601 acggatgctc atcaagctgc tggaggtcct ctctggagag aggctgccta aacccaccaa
661 gggacgaatg cgcatccact gcttagagaa tgtggacaag gcccttcagt tcctgaagga
721 gcagagagtc catcttgaga acatggggtc ccatgacatc gtggatggaa accaccggct
781 gacccttggc ctcatctgga ccatcatcct gcgcttccag atccaggata tcagtgtgga
841 aactgaagac aacaaagaga agaaatctgc caaggatgca ttgctgttgt ggtgccagat
901 gaagacagct gggtacccca atgtcaacat tcacaatttc accactagct ggagggacgg
961 catggccttc aatgcactga tacacaaaca ccggcctgac ctgatagatt ttgacaaact
1021 aaagaaatct aacgcacact acaacctgca gaatgcattt aatctggcag aacagcacct
1081 cggcctcact aaactgttgg accccgaaga catcagcgtg gaccatcctg atgagaagtc
1141 cataatcact tatgtggtga cttattacca ctacttctct aagatgaagg ccttagctgt
1201 tgaaggaaaa cgaattggaa aggtgcttga caatgctatt gaaacagaaa aaatgattga
1261 aaagtatgaa tcacttgcct ctgaccttct ggaatggatt gaacaaacca tcatcattct
1321 gaacaatcgc aaatttgcca attcactggt cggggttcaa cagcagcttc aggcattcaa
1381 cacttaccgc actgtggaga aaccacccaa atttactgag aaggggaact tggaagtgct
1441 gctcttcacc attcagagca agatgagggc caacaaccag aaggtctaca tgccccggga
1501 ggggaagctc atctctgaca tcaacaaggc ctgggaaaga ctggaaaaag cggaacacga
1561 aagagaactg gctttgcgga atgagctcat aagacaggag aaactggaac agctcgcccg
1621 cagatttgat cgcaaggcag ctatgaggga gacttggctg agcgaaaacc agcgtctggt
1681 gtctcaggac aactttgggt ttgaccttcc tgcagttgag gccgccacaa aaaagcacga
1741 ggccattgag acagacattg ccgcatacga ggagcgtgtg caggctgtgg tagccgtggc
1801 cagggagctc gaggccgaga attaccacga catcaagcgc atcacagcga ggaaggacaa
1861 tgtcatccgg ctctgggaat acctactgga actgctcagg gcccggagac agcggctcga
1921 gatgaacctg gggctgcaga agatattcca ggaaatgctc tacattatgg actggatgga
1981 tgaaatgaag gtgctagtat tgtctcaaga ctatggcaaa cacttacttg gtgtggaaga
2041 cctgttacag aagcacaccc tggttgaagc agacattggc atccaggcag agcgggtgag
2101 aggtgtcaat gcctccgccc agaagttcgc aacagacggg gaaggttaca agccctgtga
2161 cccccaggtg atccgagacc gcgtggccca catggagttc tgttatcaag agctttgcca
2221 gctggcggct gagcgcaggg cccgtctgga agagtcccgc cgcctctgga agttcttctg
2281 ggagatggca gaagaggaag gctggatacg ggagaaggag aagatcctgt cctcggacga
2341 ttacgggaaa gacctgacca gcgtcatgcg cctgctcagc aagcaccggg cgttcgagga
2401 cgagatgagc ggccgcagtg gccactttga gcaggccatc aaggaaggcg aagacatgat
2461 cgcggaggag cacttcgggt cggagaagat ccgtgagagg atcatttaca tccgggagca
2521 gtgggccaac ctagagcagc tctcggccat tcggaagaag cgcctggagg aggcctccct
2581 gctgcaccag ttccaggcag atgctgatga cattgatgcc tggatgctgg acatcctcaa
2641 gattgtctcc agcagcgacg tgggccacga tgagtattcc acacagtctc tggtcaagaa
2701 acacaaggac gtggcggaag agatcgccaa ttacaggccc acccttgaca cgctgcacga
2761 acaagccagc gccctccccc aggagcatgc cgagtctcca gacgtgaggg gcaggctgtc
2821 gggcatcgag gagcggtata aggaggtggc agagctgacg cggctgcgga agcaggcact
2881 ccaggacact ctggccctgt acaagatgtt cagcgaggct gatgcctgtg agctctggat
2941 cgacgagaag gagcagtggc tcaacaacat gcagatccca gagaagctgg aggatctgga
3001 ggtcatccag cacagatttg agagcctaga accagaaatg aacaaccagg cttcccgggt
3061 tgcagtggtg aaccagattg cacgccagct gatgcacagc ggccacccaa gtgagaagga
3121 aatcaaagcc cagcaggaca aactcaacac aaggtggagc cagttcagag aactggttga
3181 caggaagaag gatgccctcc tgtctgccct gagcatccag aactaccacc tcgagtgcaa
3241 tgaaaccaaa tcctggattc gggaaaagac caaggtcatc gagtccaccc aggacctggg
3301 caatgacctg gctggcgtca tggccctgca gcgcaagctg accggcatgg agcgggactt
3361 ggtggccatt gaggcaaagc tgagtgacct gcagaaggag gcggagaagc tggagtccga
3421 gcaccccgac caggcccagg ccatcctgtc tcggctggcc gagatcagcg acgtgtggga
3481 ggagatgaag accaccctga aaaaccgaga ggcctccctg ggagaggcca gcaagctgca
3541 gcagttccta cgggacttgg acgacttcca gtcctggctc tctaggaccc agacagcgat
3601 cgcctcggag gacatgccaa acaccctgac cgaggctgag aagctgctca cgcagcacga
3661 gaacatcaag aatgagatcg acaactacga ggaggactac cagaagatga gggacatggg
3721 cgagatggtc acccaggggc agaccgatgc ccagtacatg tttctgcggc agcggctgca
3781 ggccctggac actggatgga acgagctcca caagatgtgg gagaacagac aaaatctcct
3841 atcccagtca catgcctacc agcagttcct cagagacacg aagcaagccg aagcctttct
3901 taacaaccag gagtatgttc tggctcacac tgaaatgcct accaccttgg aaggagctga
3961 agcagcaatt aaaaagcaag aggacttcat gaccaccatg gacgccaatg aggagaagat
4021 caatgctgtg gtggagactg gccggaggct ggtgagcgat gggaacatca actcagatcg
4081 catccaggag aaggtggact ctattgatga cagacatagg aagaatcgtg agacagccag
4141 tgaacttttg atgaggttga aggacaacag ggatctacag aaattcctgc aagattgtca
4201 agagctgtct ctctggatca atgagaagat gctcacagcc caggacatgt cttacgatga
4261 agccagaaat ctgcacagta aatggttgaa gcatcaagca tttatggcag aacttgcatc
4321 caacaaagaa tggcttgaca aaatcgagaa ggaaggaatg cagctcattt cagaaaagcc
4381 tgagacggaa gctgtggtga aggagaaact cactggttta cataaaatgt gggaagtcct
4441 tgaatccact acccagacaa aggcccagcg gctctttgat gcaaacaagg ccgaactttt
4501 cacccagagc tgtgcagatc tagacaaatg gctgcacggc ctggagagtc agattcagtc
4561 tgatgactat ggcaaacacc tgaccagtgt caatatcctg ctgaaaaagc aacagatgct
4621 ggagaatcag atggaagtgc ggaagaagga gatcgaagag ctccaaagcc aagcccaggc
4681 cctgagtcag gaagggaaga gcaccgacga ggtagacagc aagcgcctca ccgtgcagac
4741 caagttcatg gagttgctgg agcccttgaa cgagaggaag cataacctgc tggcctccaa
4801 agagatccat cagttcaaca gggatgtgga ggacgagatc ttgtgggttg gagagaggat
4861 gcctttggca acttccacgg atcatggcca caacctccag actgtgcagc tgttaataaa
4921 gaaaaatcag accctccaga aagaaatcca ggggcaccag cctcgcattg acgacatctt
4981 tgagaggagc caaaacatcg tcactgacag cagcagcctc agcgctgagg ccatcagaca
5041 gaggcttgcc gacctgaagc agctgtgggg tctcctcatt gaggagacag agaaacgcca
5101 caggcggctg gaggaggcgc acagggccca gcagtactac tttgacgctg ctgaggccga
5161 agcctggatg agcgagcagg agctgtacat gatgtcagag gagaaggcca aggatgagca
5221 gagtgctgtc tccatgttga agaagcacca gatcttagaa caagctgtgg aggactatgc
5281 agagaccgtg catcagctct ccaagaccag ccgggccctg gtggccgaca gccatcctga
5341 aagtgagcgc attagcatgc ggcagtccaa agtggataaa ctgtacgctg gtctgaaaga
5401 ccttgctgaa gagagaagag gcaagctgga tgagagacac aggttattcc agctcaaccg
5461 ggaggtggac gacctggagc agtggatcgc tgagagggag gtggtcgcag ggtcccatga
5521 actgggacag gactatgagc atgtcacgat gttacaagaa cgattccggg agtttgcccg
5581 agacaccggg aacattgggc aggagcgcgt ggacacggtc aatcacctgg cagatgagct
5641 catcaactct ggacattcag atgccgccac catcgctgaa tggaaggatg gcctcaatga
5701 agcctgggcc gacctcctgg agctcattga cacaagaaca cagattcttg ccgcttccta
5761 tgaactgcac aagttttacc acgatgccaa ggagatcttt gggcgtatac aggacaaaca
5821 caagaaactc cctgaggagc ttgggagaga tcagaacaca gtggagacct tacagagaat
5881 gcacactaca tttgagcatg acatccaggc tctgggcaca caggtgaggc agctgcagga
5941 ggatgcagcc cgcctccagg cggcctatgc gggtgacaag gccgacgata tccagaagcg
6001 cgagaacgag gtcctggaag cctggaagtc cctcctggac gcctgtgaga gccgcagggt
6061 gcggctggtg gacacagggg acaagttccg cttcttcagc atggtgcgcg acctcatgct
6121 ctggatggag gatgtcatcc ggcagatcga ggcccaggag aagccaaggg atgtatcatc
6181 tgttgaactc ttaatgaata atcatcaagg catcaaagct gaaattgatg cacgtaatga
6241 cagtttcaca acctgcattg aacttgggaa atccctgttg gcgagaaaac actatgcatc
6301 tgaggagatc aaggaaaaat tactgcagtt gacggaaaag aggaaagaaa tgatcgacaa
6361 gtgggaagac cgatgggaat ggttaagact gattctggag gtccatcagt tctcaagaga
6421 cgccagtgtg gccgaggcct ggctgcttgg acaggagccg tacctatcca gccgagagat
6481 aggccagagc gtggacgagg tggagaagct catcaagcgc cacgaggcat ttgaaaagtc
6541 tgcagcaacc tgggatgaga ggttctctgc cctggaaagg ctgactacat tggagttact
6601 ggaagtgcgc agacagcaag aggaagagga gaggaagagg cggccgcctt ctcccgagcc
6661 gagcacgaag gtttcagagg aagccgagtc ccagcagcag tgggatactt caaaaggaga
6721 acaagtttcc caaaacggtt tgccagctga acagggatct ccacgggtta gttaccgctc
6781 tcaaacctac caaaactaca aaaactttaa tagcagacgg acagccagtg accagccatg
6841 gtctggactg tgaagtttac taccatttgt caagaatcac cctttccaaa tcctctgggt
6901 tttgactttt tggcttccac ttcacccaaa atgttaaaat ttttacttaa ttcatagcct
6961 tccttggttt catatttgtt tgcatttaat tcatgtttga gtctcttaac tgatggatgc
7021 ccacttgcct taaagcagca tacttatttt ttgtttattt attgtgagct ttttacttta
7081 ttaagatttt acagcgaaac ccttacatga gtaattgaaa tgaaattaaa tgagattaca
7141 gcataatgaa gaagacaact agaatctaac aggtatgaca cattcagtta ttctaacagg
7201 gcacagtact gtgctatatg tagc
//