LOCUS AF326736 21501 bp DNA linear HUM 28-FEB-2001
DEFINITION Homo sapiens sclerostin gene, complete cds.
ACCESSION AF326736
VERSION AF326736.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 21501)
AUTHORS Brunkow,M.E., Gardner,J.C., Van Ness,J., Paeper,B.W.,
Kovacevich,B.R., Proll,S., Skonier,J.E., Zhao,L., Sabo,P.J.,
Fu,Y.H., Alisch,R.S., Gillett,L., Colbert,T., Tacconi,P., Galas,D.,
Hamersma,H., Beighton,P. and Mulligan,J.T.
TITLE Bone dysplasia sclerosteosis results from loss of the SOST gene
product, a novel cystine knot-containing protein
JOURNAL Am. J. Hum. Genet. 68 (3), 577-589 (2001)
PUBMED 11179006
REFERENCE 2 (bases 1 to 21501)
AUTHORS Brunkow,M.E., Gardner,J.C., Van Ness,J., Paeper,B.W.,
Kovacevich,B.R., Proll,S., Skonier,J.E., Zhao,L., Sabo,P.J.,
Fu,Y.H., Alisch,R.S., Gillett,L., Colbert,T., Tacconi,P., Galas,D.,
Hamersma,H., Beighton,P. and Mulligan,J.T.
TITLE Direct Submission
JOURNAL Submitted (07-DEC-2000) Genomics, Celltech Chiroscience Inc., 1631
220th St. SE, Bothell, WA 98021, USA
FEATURES Location/Qualifiers
source 1..21501
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q21"
mRNA join(<11961..12180,14939..>15360)
/product="sclerostin"
CDS join(11961..12180,14939..15360)
/codon_start=1
/product="sclerostin"
/protein_id="AAK13451.1"
/translation="MQLPLALCLVCLLVHTAFRVVEGQGWQAFKNDATEIIPELGEYP
EPPPELENNKTMNRAENGGRPPHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTE
LVCSGQCGPARLLPNAIGRGKWWRPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVR
LVASCKCKRLTRFHNQSELKDFGTEAARPQKGRKPRPRARSAKANQAELENAY"
BASE COUNT 5546 a 5259 c 5419 g 5277 t
ORIGIN
1 acccccatcc ccagctccca gggcctctgc cacgcgggct tctttttttt tttgagacag
61 agtctcgctc tgtcacccag gctggagcac aatctcagca caatctcacc tcaccgcaac
121 ctctgcctcc tgggttcaag caattctctg gcctcagcct cctgagtagc tgggattata
181 ggctcgcgcc accacaccca gctatttttt tgtatcttta gtaaagacgg gatttcacta
241 tgttggccag tctggtctcg aactcctgac cttgtgatcc agttgccttg gcctcccaaa
301 gtgctgggat tacaggcgtg agccactgtg cccagcccct tgcaggcttc tgacagcaca
361 gatggttttg cccgctttcc tactctgtgg gctcatccac ctcatatgtg tgtgctgcct
421 ccgtgttgct tctgctaagt ggcagtctgg tcattctttg tatttgtcct ttctactgtg
481 gatgggcctt tgggggtttc taactgtggg ccatgatgtg cagtgttgcc tgtgaacatt
541 ctggcccatg ttcgtgaatg tgaatgcgta tctctattgg acctgggcct gggagtggga
601 ttgctgggcc agaggggatg cacgtgttca gcttgaggag ataccgccgt gccgcacagc
661 tttccaaagt ggttgtgcca attcacgcct cacctccccc agccacgcag aagagttcca
721 gttgccccat atcttcacca gcactttggg ttttccatcc ttttcatttt agccattctg
781 acaggcacac agtggcgtga cattgtgctt ttaagtggca cttcacggaa gagtcttgac
841 caacgccatg gtgtgatggg acgcccccag ctcaccacgt ctcccctgtt tcttacaggc
901 cgggtgctcg tccactgccg ggaaggttat agccgctccc caacgctagt tatcgcctac
961 ctcatgatgc ggcagaagat ggacgtcaag tctgccctga gcatcgtgag gcagaaccgt
1021 gagatcggcc ccaacgatgg cttcctggcc cagctctgcc agctcaatga cagactagcc
1081 aaggagggga agttgaaacc ctagggcacc cccaccgcct ctgctcgaga ggtccgtggg
1141 ggaggccgtg ggcaaaggtg tcccgagctg ccatgtttag gaaacacact gtaccctgct
1201 cccagcatca caaggcactt gtctacaagt gtgtcccaac acagtcctgg gccactttcc
1261 ccaccctggg gagcacataa agaagcttgc caaggggggc gtccttgctc cccagttgtc
1321 ctgtttctgt aacttatgat gtcttttccc tgagatgggg gctcagaggg ggaaggcctg
1381 tggcctgcat gcttcccgat ggcccacggc aggaggtgtg tggaagtgta aggcctaaga
1441 tgctcacaga ggtccctcat gacctccctt ccccaactcc cgaatcctct cttgagtgtg
1501 gacctcaaca ccttgagccc tagtaaagga actatgcaaa tgcaggccac tctccccacc
1561 acgtctgtgc cccgcactgt ccccacagcc ttccacaccc tgtgcatagg cagccctctc
1621 acgtcttgag gtccgaagct ggggtggggg tgtccgtcag ttattagtgg atggagattc
1681 ccacagcaag gctgcatttg aatgatttcc ttaggatgaa tggtccctac acaaagaggc
1741 cttgtgggca aacctggaga accctcctaa atccatagag ttttcaaaat gtgaatcttt
1801 ggaagccttg agttcagaat ctgctgctct ggaatatttc ccttcgatct tatctcagtc
1861 acttcgtttt tgagaagagt gatgccttgg gcatgctttt ttttttttct tttttagaaa
1921 acagggagtt gaagtccaac ctatttaaaa accccaccat ttggagaatt acaagggttt
1981 tgtcctgaat tgtagtgttg gcaagcccaa gccactcgtg ctaactgctt tttgtctcgg
2041 ttgctattcc aagaacagaa ggaggaagtt ggccaattac agcgtgtgtg catggatgtg
2101 tgtggggggc gtgcctctca gaaacgcggc cagaagacaa gcagggaagt gaaaggtccc
2161 aggcacacac cctgcccatt gcaggtggct cttacagctc tctggtgcca gcacgggatc
2221 cctgaagtga ctcagccagg cagacatgag acatggcgga gtgtccaaat ggatccttta
2281 ttggtggtag agcaaaaaaa cccaaacacg ataaaccttt caaaagactt tctaaggatg
2341 atattggaat gcaccagccc tcacatgtgt atgcacattt gccagaatat aagagttttg
2401 ttttaaatac agtcttgtta ggattttacg ttattgttat tatggaaagt gattgtgatg
2461 ctatttatct tcagggtcac tctgggcaaa gagaaggtcc tcagccatgc ccccagcacc
2521 ttgcacatag gtgtctgata aaagtttaag aaattaaaca ctttttgagc accaaatata
2581 tatagggcat tgttctggtg ggtgtgtcac gctcccagaa gactgaattt atggtaggat
2641 cactcgcaag gccttgtgaa ggagtcttac ctaaaacaaa agaaatatca gggacttttg
2701 ttgactattt acaactcagt tttacattta aattcaggca gtgttaatat gccaaggtag
2761 ggaatgtgcc tttttcagag ttggccagga gctcctggct gggacacgga gaggcaggtg
2821 tggcgtaagg cctcactccc ggctgtgaag gtctctgatc acacagaagc agccctgccc
2881 agcctggtca tttgctgtcc gcttttctct gtgaccacag cagccctgaa caaccagtat
2941 gtgtcttctt ctccagatag tgaaaaaggt gtccagataa acccacctaa gtgaaatggc
3001 catcctctaa actgggtacc tcactgcaca gcttctaggt agccttccaa cttaatctaa
3061 cttgagcctc acagtaaccc tgtaaagtta gtagagcttg ttcttgtatt gtgacctttt
3121 ttaaaaaaaa ggaactgagg ttcagaatga ttaagggcct ggcccccagg gttgtccagc
3181 tccataaggt ggagctgggc aagattttgg gtttgctgct ccctgaagct ggattctttc
3241 atacgatact ctttctcaag aagggggctc cctgggatct ccaggtgtac tgcacttacc
3301 ctcaatccag ccccggagaa gcaagtgaaa agggtgggtc cctcataggc tagaatgtgc
3361 agctctttct ccaggtggga tgtagcaccc caaagtagag ctttctgctc tgctcctgga
3421 aaaggctagg gagctggggc tggggctccc ctcccatgac caggcagtgg tcaccccatg
3481 ggacaggcac agctacttac gcgaacacag caggttggtg tggctggcta actaggacct
3541 ctcgaaagtc tctgtggggg catgagggag aaaaggccat tgggagaatt actgccttta
3601 ctttgggact acttttatgc tgataacttg ggatttcttg atagtccttc acccctgaaa
3661 ccccgtattt acttaacaag atttagctct tagttcttca agtaaaatta aagtctcttg
3721 tgtaagagcc aacacatgcc cagctgcgga tgggagctgt tcctggacag ccttctactg
3781 cctgggaagt gatggaacag gaactcaggg tgcccttacc ccctccccag acctgttccc
3841 tttctttgac tgacagagca ccatccaggc aaaattagag cgccaaatgg ttttcttctc
3901 aatcttaaag cagtatacct ttccacaggc tcgtctgtgt ccctgccact ctgagttatc
3961 cagaaaccac cacctacaaa tgaggggact catctagaag acctctaagg tccccttttg
4021 gctctgaggg gtctctaata atccccactt ggaattcagc accgcaagga aattatgggt
4081 atgtgagcca taatatgatg gccagcaggt ggcgctgcct tccacccatg gtgatggatg
4141 gtttggaaag ggaatgttgg tgccttttgt gccacaagtt aagatgctac tgttttaaag
4201 gaaaaaaaaa aaaaaaagta ctgatcttca atatgaagac atgagctttt ctcgcaggaa
4261 attttctttt tcacagaact ggtgtcagga atcactgaag ggctaaccgt gatagtcctt
4321 gcaagtaagt caaggtttta tcctgattgg aaatagaaga catttccggt tgagagaaca
4381 gattcgttgg aagcttaact tttgttgcct cttaacgcca ccaaatttta gggtaatttg
4441 attatgaaag agtgaatttt tctggacaga aaagggagag ctaccaaatt gtttttttct
4501 ttttaaaagg aagtttaatg tccgttgtat cacaaatcag tgttaaaaca ccagaacttt
4561 agccaaaata aatgtcttac attacaaagg tattgttttt ttgtccttct tatcacagtt
4621 ggtattcttt tacgttttta tgcttagctt tttttgtttg ggcttagctt ttatatttgc
4681 gatttctaac tttttaaaaa taatcatcta aaacatagcc gttctgagct agttataggt
4741 tccatgatgg cactgtttat gcagtagata ttgatgaaca cctttccagt accagaaatg
4801 ttctggtagg aatattctta ggtagaatgg ccataatggt cctgaatgaa ggaggtaagg
4861 tttgtgcttc taagaaagca ggggactagg gtgttcatct caaggtagcc tcacgtgatg
4921 actgggtgac attttgagat ttgagtgatc ctgcaaatga acagtcccta aacatatccc
4981 cttcccccag atgccttaaa ttccactatt ggtgctatgt tcctttgaat aaaaaacctt
5041 agagaaagta ggtgcctttt cctcccagac agaagtctgg gcagagaaag cctctcgagg
5101 ttcccattcc ctctatcaca tgaagcaatt ggactcgctt cctatttgtc aagactctga
5161 caatgtaatc tttatggttc tacacaaaat cttaaggcag agcactaaaa tataaaacag
5221 gtaaaagttt ttaagtataa tttttaaaaa atttttcatt aaaaataata ctatatgtac
5281 atagtaatac acttaaacaa tgcaaaaggc ttatacggaa aagtgagtca cttgctcctt
5341 caatctatct ccccataagc gtcatatcct taaaggaaaa tgtcaagcat atataagcac
5401 acatatgtgc atacgtgtgt atatacagag atatctctgc tttgttgttt gttttgctta
5461 gcttatatta tggttattgt ttttattgct ctaccccctt catcttaaca gctacatagc
5521 attccattgt gtatggatgt gtaaataaag acaaggtgat ttggacatcc ctcaatgcag
5581 ggtactgcct aaaagcagaa gtttgccctc ctaatccaga tatttccttt ttaccaccta
5641 caagtgggag caaaatctgt tttaaaatgc agccaataag gagaatcctc agtttccatt
5701 aattagagat aggggcctcc tccagaacca agtagagaat gaaaccggat gacctttgag
5761 agtccttcca gatcaaagat tctatgatcc caaggagtca aaggagcata atatactttc
5821 caaatttggc ctgtcattca aagtctggtc caaatgccac atcttaccat aaggatccca
5881 gatcctcccc aggggaaaga gattgttctc tcctttgaag gcccataaga aaattgtcct
5941 tttgaaaaaa tgcatctggt gaggatgtgg aacaacagga actctttgtt tcagtgggga
6001 atgcaaaatg gtacagccac tttggaggac agtttgcagt ttagtttctt gcaaaactac
6061 acatactttt attgcacaat ccagcagtca tgctccttgg tatttattca aatgatttga
6121 aaacttaacg ttcgtataaa aacctgcaca cagctgggca tggtggctca tgcctgtaat
6181 cccagcactt tgggaggctg aggtgggcag atcacttgag gttaggagtt tgagaccata
6241 ctggccaaca tggggaaacc ccttctctac taaaaataca aaaattagcc aggtgtggtg
6301 gtgctcacct gtaatcccac ctactcggga ggctgagcca ggagaatcac ttgaacccag
6361 gaggcggagg ttgcagtgag ctgagatcac ggcactgcac cccagcctgg gagacagagt
6421 aagactccgt cttaagacaa aacaaaacaa aaaacctgta caaaatgttt ataccacctc
6481 tattaataat tgccagagct tgaaagcaac caagatgtcc ttcagtagat gacagtaggt
6541 gactagataa accgtgatac atcaagacga tggagtatta ctcagtgcta aaaaaaaaaa
6601 taagctgttc atgccatgaa aagacatgga ggaaccccaa atgaatatta ctaactgaaa
6661 gaagccaatc tgaaaagact atgtatgggt atattccaac tctatatgac atcctggaaa
6721 aggcaaaaat aaaggtacag taaaaagatc agtggttgcc aggggttggg gaaagtcggg
6781 gagggatgaa taggcagagc agatagtttt tttggacaat gaaaatactg cccatctgta
6841 tgatactata atggtagatg tatgtcatta tacatttgtc caaagccata ggatgtacaa
6901 cactagtgct gtgatgtaaa ccatggactt caggtgataa tgatgtgtca tgtaggctca
6961 tcaatcatag caaatgcacc actctggtgg cgggatgttg ataacggggg cagctgtaca
7021 tgtgtgggca caggacataa atgagaaatc tctgtaccat ccactcagtt ttgctgtgaa
7081 cctaaaagtg ctccagaaaa aaaataaagt tttttttaga aaaaagcatc tgaacctttt
7141 tttcagtggc attgatcacc ttccatctgg tagtggagtt gtttggatgc ggaaattatt
7201 tcttccatgg tatgcgagct cctggagagg gagtgcgtgt cccccttgct ttattaaacg
7261 tttggcgagt gaacatcaga agaagcaact cgacagaaac aaaagctggt aaataatcac
7321 atggaaaagc agcttttctg gaaattaagt ttcaactgtt aaattcaatg tttaaaaaaa
7381 tcggctgggt gcggtggctc ccgcctgcaa tcccagcact ttatgggatt gtgggaacac
7441 ctgatgtcag gagttcaaga ccagcctggc cgacatggcg aaaccccatc tctacaaaac
7501 aaacaaaaaa aaatgcaaaa attagctggg tgtggtggcg ggagtctgta gtcctagcta
7561 ctcgggaggc tgaggcagga gaactgcttg aacccaggag gtggaggtta tatgagccaa
7621 gatcacacca ctgcactccc gcctgggtga cagagcgaga ctctgtctca aaaaaaaaaa
7681 aaaaaatcaa catcccaaac ccagtgttga cagtcttatt tatgggttga actgcattcc
7741 tcccaaatgc atatattgaa gtcctaagtc acagtacctg agaatgtgac cttatttgga
7801 aatagggcta ttacagatgt aactcgttaa gatgaggtca ttaggctggg cctaatctaa
7861 tatgcctgac ctccttagaa aaaagggaaa attcgaacac agagagaaca ccatgtgaag
7921 atgaaggcag ggattggggg tgacacttct gcaagccagt gaatgccaca gcttgtcagc
7981 agccagcaga aggcaggtaa aaggccttcc tcactgtcct cgaaggaacc aactctgcca
8041 atgtcttgaa cttgcactcc taacctccag ctctgtgaga cgacttctgt tgtttatgcc
8101 acccaatttg tggtacttag ttacggcagc ctcatcaaag taccacctat gggagcctct
8161 attttgcagg tgagggcggg gactgggctg agttttctgg aaaacagccc tgcaataccc
8221 tcatcagacc accaaactct tcacactccc tcagacacag cattcacttc cagaaataac
8281 tctaaagttt tgttttgttt ttttaaactt tgtggaatac tactcagcca aaaaaaaaaa
8341 aaaagaaaag aaaaaggaac atgttactga tatgtacaac ttggataatg gaaataatgc
8401 tgagtgaaaa aaaaatcccc aaaggctaca tactaattga ttccatttat ataacctttt
8461 tttttttttt ttgagacagt ctcactctgt cacccaggct ggagcacagt ggcgcgatct
8521 cagctcactg caacttccgc ctcctgagtt caagcgattc tcttgcctta gcttcccaag
8581 tagctgggat tacaggtgcg tgccaccatg cccagctaat ttttgtattt ttagtagaga
8641 cagggtttcg ccatgttggc caggctggtc tcgaactcct gacctcaagt gatctgcctg
8701 ccttggcttc ccaaagtgct gggattacat gagtgagcca ccgcacctgg tcgcatttat
8761 gtaacaattt tgaagtgaaa aaaaaaatga cagaaatgga gattagatga gtagttgcca
8821 ggggttagtt gtgggaggga gggaaaagga gggaaggagg tgggcaacag gagaaagact
8881 tgtggtcaca gagctgtgct ttatcttgac tgtggtggat ccccaaattt acccgtgaca
8941 agattgcata gaactaagta tacacacacg tgaatgcgtg tgcacgcaca cagtagaggt
9001 taagccacgg gagatgtggg taagattggt aaattgtgtc aatatcaata tcctagttgt
9061 gatattgtcc tatagtttcg caaggtgtta ttgttgtggg aaactggata aaggatacac
9121 ggagtctgca ttttcttttt tttattttta ttttttgaga cggggtctca ctctgtcaac
9181 caggctggag tgcagtggcc caagtatggc tcactgcagc ctcgacctca acctcaagtg
9241 aacctcccac ctcagcctcc caagtagcta agaccacagg cgtgcgaccc catgcccagc
9301 taatttttaa attttttgta gagactaggc ctcaccatgt tgcccaggct tttatttctt
9361 ataagtatat ttaaatttat aattatatcc acattttaaa attttaattt aaaaaattac
9421 tctgaggccg ggcattgtgg ctcatgcctc taatccccag caccttggga ggccgagttg
9481 ggcagatcac ccgaggtcag aagttcgaga ccagcctgag taacatggag aaacccccgt
9541 ctctactaaa aatacaaaat tggccgggcg tggtggtgca ttcctgtaat cccagctact
9601 cgggaggctg aggcaggaga attgcttgaa cccaggaggt ggaggttgca gtgagccaag
9661 attgtgccac tgcactgcag cctgggccac agagagaatc tgccaaaaaa agaaaaaaaa
9721 aaaaatttca gccgtacaag gatgttcata gcaaccctgc tggaaatagg aaaaaaaatt
9781 ggaaataacc taaactactc acaataggaa tcagctaaaa ccctgggggt ttaattccag
9841 ggaatactgt gaacaatgac aagtttgtgg actgagtaaa aataaacagc tgtcaatgac
9901 ttaacattaa atgaaacagc agaagatgtc acagcaggtt ctcgctgagc cattcagagg
9961 ggtgtggatc atttagaggt tcaagtccac tggattcttc tttttccttt taatattact
10021 tcacttccaa ataaggaaag gaaaggaaag gaaatcacgt ccagtcctga gacttgccat
10081 cctgcagtca cccctccttt tgtctccagc aggtggcaga cgcgttccag ggatgaatcc
10141 cactgcctct gtttaatgca gacggtccag ccgctcccaa cagcaggtgg ggctataagc
10201 atccatccta cctgctcaag gaacccaggc atcagaactg ctctctccca agtccattgc
10261 aagaaggcag tcgtctggtc atgagagggt taacagtcca cattccagag caagggaaaa
10321 ggaggctgga gggtcataga caaggggagg tggtgcggag ggccagcttc tcacaacact
10381 accggctctg ctgggagaga tagatcaccc ccaacaatgg ccacagctgt tttcatctgc
10441 cctgaaggaa actgacttag gaagcaggta tcagagaggg cccttcctga gggggcttct
10501 gtctggcttg taaaactgtc agagcagctg cattcatgtg tcggatgatg gatgatggaa
10561 aggacagtcg gctgcagatg gacacagcga cttgcaagtt gaggcaggtg gcaaaggact
10621 tgcagaggct ctgcaggtgg ggcatgctga ttcattgccc agttaaaata ccagaggatc
10681 tgggcagcct cttcacagga gctgcttgtc ctcaaacaat ctgtcttcaa tgaaagattc
10741 ctctggcctt cctttctctt cttgcacctc aggtgtgaat ccttctcccc cacgcctcta
10801 cctgcgcccc cgccccccgc cccggccctg tgtggctcat tatatgcagg gccaaggcag
10861 cattttctct tagcttcttt gtgaccagtt ggtcctggga tggcttcatg gaacacatcc
10921 tgtggtgtgc accaatgaag ctttccatac aggactcaaa actgtttttg aaaaatgtaa
10981 ccagctggaa gacaagaaaa taaaatgtca gcactaaaaa cgctggctgt ggcttttgct
11041 aaggaaagga atttggtgtt gtcttctcac acacacagac tggttgggga aatgactgtc
11101 ttcagcacat caccctgcga gccacagtga gtgccctggc tcagaagtgc ctgtcacagt
11161 gcacaggatc cctgaggagc atgagctggg atttcctctg tgctgtccat cacaggagcc
11221 tgagtgacca gcgcatcctc gatttgtaac cagaatcctg ccctctctcc caagcgggca
11281 cccttgctct gaccctctag ttctctctct tgccttccag agaataccaa gagaggcttt
11341 cttggttagg acaatgaatg ctgagacttg tggagttggg accaatggga tttctttaaa
11401 agcatctttt tgcctctggc tgggtctatg ggggtcaaac agaaacacct tgggccattt
11461 gttggtgggg tgacaaatga acttggcctg agaaatggaa taggccgggc tcagccccgc
11521 gaagcactca gaactgcaca ttttctttgt tgagcgggtc cacagtttgt tttgagaatg
11581 cccgagggcc cagggagaca gacaattaaa agccggagct cattttgata tctgaaaacc
11641 acagccgcca gcacgtggga ggtgccggag agcaggcttg ggccttgcct cacacgcccc
11701 ctctctctgg gtcacctggg agtgccagca gcaatttgga agtttgctga gctagaggag
11761 aagtctttgg ggagggtttg ctctgagcac acccctttcc ctccctccgg ggctgaggga
11821 aacatgggac cagccctgcc ccagcctgtc ctcattggct ggcatgaagc agagaggggc
11881 tttaaaaagg cgaccgtgtc tcggctggag accagagcct gtgctactgg aaggtggcgt
11941 gccctcctct ggctggtacc atgcagctcc cactggccct gtgtctcgtc tgcctgctgg
12001 tacacacagc cttccgtgta gtggagggcc aggggtggca ggcgttcaag aatgatgcca
12061 cggaaatcat ccccgagctc ggagagtacc ccgagcctcc accggagctg gagaacaaca
12121 agaccatgaa ccgggcggag aacggagggc ggcctcccca ccaccccttt gagaccaaag
12181 gtatggggtg gaggagagaa ttcttagtaa aagatcctgg ggaggtttta gaaacttctc
12241 tttgggaggc ttggaagact ggggtagacc cagtgaagat tgctggcctc tgccagcact
12301 ggtcgaggaa cagtcttgcc tggaggtggg ggaagaatgg ctcgctggtg cagccttcaa
12361 attcaggtgc agaggcatga ggcaacagac gctggtgaga gcccagggca gggaggacgc
12421 tggggtggtg agggtatggc atcagggcat cagaacaggc tcaggggctc agaaaagaaa
12481 aggtttcaaa gaatctcctc ctgggaatat aggagccacg tccagctgct ggtaccactg
12541 ggaagggaac aaggtaaggg agcctcccat ccacagaaca gcacctgtgg ggcaccggac
12601 actctatgct ggtggtggct gtccccacca cacagaccca catcatggaa tccccaggag
12661 gtgaaccccc agctcgaagg ggaagaaaca ggttccaggc actcagtaac ttggtagtga
12721 gaagagctga ggtgtgaacc tggtttgatc caactgcaag atagccctgg tgtgtggggg
12781 ggtgtggggg acagatctcc acaaagcagt ggggaggaag gccagagagg cacccctgca
12841 gtgtgcattg cccatggcct gcccagggag ctggcacttg aaggaatggg agttttcggc
12901 acagttttag cccctgacat gggtgcagct gagtccaggc cctggagggg agagcagcat
12961 cctctgtgca ggagtaggga catctgtcct cagcagccac cccagtccca accttgcctc
13021 attccagggg agggagaagg aagaggaacc ctgggttcct ggtcaggcct gcacagagaa
13081 gcccaggtga cagtgtgcat ctggctctat aattggcagg aatcctgagg ccatgggggc
13141 gtctgaaatg acacttcaga ctaagagctt ccctgtcctc tggccattat ccaggtggca
13201 gagaagtcca ctgcccaggc tcctggaccc cagccctccc cgcctcacaa cctgttggga
13261 ctatggggtg ctaaaaaggg caactgcatg ggaggccagc caggaccctc cgtcttcaaa
13321 atggaggaca agggcgcctc cccccacagc tccccttcta ggcaaggtca gctgggctcc
13381 agcgactgcc tgaagggctg taaggaaccc aaacacaaaa tgtccacctt gctggactcc
13441 cacgagaggc cacagcccct gaggaagcca catgctcaaa acaaagtcat gatctgcaga
13501 ggaagtgcct ggcctagggg cgctattctc gaaaagccgc aaaatgcccc cttccctggg
13561 caaatgcccc cctgaccaca cacacattcc agccctgcag aggtgaggat gcaaaccagc
13621 ccacagacca gaaagcagcc ccagacgatg gcagtggcca catctcccct gctgtgcttg
13681 ctcttcagag tgggggtggg gggtggcctt ctctgtcccc tctctggttt ggtcttaaga
13741 ctatttttca ttctttcttg tcacattgga actatcccca tgaaaccttt gggggtggac
13801 tggtactcac acgacgacca gctatttaaa aagctcccac ccatctaagt ccaccatagg
13861 agacatggtc aaggtgtgtg caggggatca ggccaggcct cggagcccaa tctctgcctg
13921 cccagggagt atcaccatga ggcgcccatt cagataacac agaacaagaa atgtgcccag
13981 cagagagcca ggtcaatgtt tgtggcagct gaacctgtag gttttgggtc agagctcagg
14041 gcccctatgg taggaaagta acgacagtaa aaagcagccc tcagctccat cccccagccc
14101 agcctcccat ggatgctcga acgcagagcc tccactcttg ccggagccaa aaggtgctgg
14161 gaccccaggg aagtggagtc cggagatgca gcccagcctt ttgggcaagt tcttttctct
14221 ggctgggcct cagtattctc attgataatg agggggttgg acacactgcc tttgattcct
14281 ttcaagtcta atgaattcct gtcctgatca cctccccttc agtccctcgc ctccacagca
14341 gctgccctga tttattacct tcaattaacc tctactcctt tctccatccc ctgtccaccc
14401 ctcccaagtg gctggaaaag gaatttggga gaagccagag ccaggcagaa ggtgtgctga
14461 gtacttaccc tgcccaggcc agggaccctg cggcacaagt gtggcttaaa tcataagaag
14521 accccagaag agaaatgata ataataatac ataacagccg acgctttcag ctatatgtgc
14581 caaatggtat tttctgcatt gcgtgtgtaa tggattaact cgcaatgctt ggggcggccc
14641 attttgcaga caggaagaag agagaggtta aggaacttgc ccaagatgac acctgcagtg
14701 agcgatggag ccctggtgtt tgaaccccag cagtcatttg gctccgaggg gacagggtgc
14761 gcaggagagc tttccaccag ctctagagca tctgggacct tcctgcaata gatgttcagg
14821 ggcaaaagcc tctggagaca ggcttggcaa aagcagggct ggggtggaga gagacgggcc
14881 ggtccagggc aggggtggcc aggcgggcgg ccaccctcac gcgcgcctct ctccacagac
14941 gtgtccgagt acagctgccg cgagctgcac ttcacccgct acgtgaccga tgggccgtgc
15001 cgcagcgcca agccggtcac cgagctggtg tgctccggcc agtgcggccc ggcgcgcctg
15061 ctgcccaacg ccatcggccg cggcaagtgg tggcgaccta gtgggcccga cttccgctgc
15121 atccccgacc gctaccgcgc gcagcgcgtg cagctgctgt gtcccggtgg tgaggcgccg
15181 cgcgcgcgca aggtgcgcct ggtggcctcg tgcaagtgca agcgcctcac ccgcttccac
15241 aaccagtcgg agctcaagga cttcgggacc gaggccgctc ggccgcagaa gggccggaag
15301 ccgcggcccc gcgcccggag cgccaaagcc aaccaggccg agctggagaa cgcctactag
15361 agcccgcccg cgcccctccc caccggcggg cgccccggcc ctgaacccgc gccccacatt
15421 tctgtcctct gcgcgtggtt tgattgttta tatttcattg taaatgcctg caacccaggg
15481 cagggggctg agaccttcca ggccctgagg aatcccgggc gccggcaagg cccccctcag
15541 cccgccagct gaggggtccc acggggcagg ggagggaatt gagagtcaca gacactgagc
15601 cacgcagccc cgcctctggg gccgcctacc tttgctggtc ccacttcaga ggaggcagaa
15661 atggaagcat tttcaccgcc ctggggtttt aagggagcgg tgtgggagtg ggaaagtcca
15721 gggactggtt aagaaagttg gataagattc ccccttgcac ctcgctgccc atcagaaagc
15781 ctgaggcgtg cccagagcac aagactgggg gcaactgtag atgtggtttc tagtcctggc
15841 tctgccacta acttgctgtg taaccttgaa ctacacaatt ctccttcggg acctcaattt
15901 ccactttgta aaatgagggt ggaggtggga ataggatctc gaggagacta ttggcatatg
15961 attccaagga ctccagtgcc ttttgaatgg gcagaggtga gagagagaga gagaaagaga
16021 gagaatgaat gcagttgcat tgattcagtg ccaaggtcac ttccagaatt cagagttgtg
16081 atgctctctt ctgacagcca aagatgaaaa acaaacagaa aaaaaaaagt aaagagtcta
16141 tttatggctg acatatttac ggctgacaaa ctcctggaag aagctatgct gcttcccagc
16201 ctggcttccc cggatgtttg gctacctcca cccctccatc tcaaagaaat aacatcatcc
16261 attggggtag aaaaggagag ggtccgaggg tggtgggagg gatagaaatc acatccgccc
16321 caacttccca aagagcagca tccctccccc gacccatagc catgttttaa agtcaccttc
16381 cgaagagaag tgaaaggttc aaggacactg gccttgcagg cccgagggag cagccatcac
16441 aaactcacag accagcacat cccttttgag acaccgcctt ctgcccacca ctcacggaca
16501 catttctgcc tagaaaacag cttcttactg ctcttacatg tgatggcata tcttacacta
16561 aaagaatatt attgggggaa aaactacaag tgctgtacat atgctgagaa actgcagagc
16621 ataatagctg ccacccaaaa atctttttga aaatcatttc cagacaacct cttactttct
16681 gtgtagtttt taattgttaa aaaaaaaaag ttttaaacag aagcacatga catatgaaag
16741 cctgcaggac tggtcgtttt tttggcaatt cttccacgtg ggacttgtcc acaagaatga
16801 aagtagtggt ttttaaagag ttaagttaca tatttatttt ctcacttaag ttatttatgc
16861 aaaagttttt cttgtagaga atgacaatgt taatattgct ttatgaatta acagtctgtt
16921 cttccagagt ccagagacat tgttaataaa gacaatgaat catgaccgaa aggatgtggt
16981 ctcattttgt caaccacaca tgacgtcatt tctgtcaaag ttgacaccct tctcttggtc
17041 actagagctc caaccttgga cacacctttg actgctctct ggtggccctt gtggcaatta
17101 tgtcttcctt tgaaaagtca tgtttatccc ttcctttcca aacccagacc gcatttcttc
17161 acccagggca tggtaataac ctcagccttg tatcctttta gcagcctccc ctccatgctg
17221 gcttccaaaa tgctgttctc attgtatcac tcccctgctc aaaagccttc catagctccc
17281 ccttgcccag gatcaagtgc agtttcccta tctgacatgg gaggccttct ctgcttgact
17341 cccacctccc actccaccaa gcttcctact gactccaaat ggtcatgcag atccctgctt
17401 ccttagtttg ccatccacac ttagcacccc caataactaa tcctctttct ttaggattca
17461 cattacttgt catctcttcc cctaaccttc cagagatgtt ccaatctccc atgatccctc
17521 tctcctctga ggttccagcc ccttttgtct acaccactac tttggttcct aattctgttt
17581 tccatttgac agtcattcat ggaggaccag cctggccaag tcctgcttag tactggcata
17641 gacaacacaa agccaagtac aattcaggac cagctcacag gaaacttcat cttcttcgaa
17701 gtgtggattt gatgcctcct gggtagaaat gtaggatctt caaaagtggg ccagcctcct
17761 gcacttctct caaagtctcg cctccccaag gtgtcttaat agtgctggat gctagctgag
17821 ttagcatctt cagatgaaga gtaaccctaa agttactctt cagttgccct aaggtgggat
17881 ggtcaactgg aaagctttaa attaagtcca gcctaccttg ggggaaccca cccccacaaa
17941 gaaagctgag gtccctcctg atgacttgtc agtttaacta ccaataaccc acttgaatta
18001 atcatcatca tcaagtcttt gataggtgtg agtgggtatc agtggccggt cccttcctgg
18061 ggctccagcc cccgaggagg cctcagtgag cccctgcaga aaatccatgc atcatgagtg
18121 tctcagggcc cagaatatga gagcaggtag gaaacagaga catcttccat ccctgagagg
18181 cagtgcggtc cagtgggtgg ggacacgggc tctgggtcag gtttgtgttg tttgtttgtt
18241 tgttttgaga cagagtctcg ctctattgcc caggctggag tgcagtgtca caatctcggc
18301 ttactgcaac ttctgccttc ccggattcaa gtgattctcc tgcctcagcc tccagagtag
18361 ctgggattac aggtgcgtgc caccacgcct ggctaatttt tgtatttttg atagagacgg
18421 ggtttcacca tgttggccag gctagtctcg aactcttgac ctcaagtgat ctgcctgcct
18481 cggcctccca aagtgctggg attacaggcg tgagccacca cacccagccc caggttggtg
18541 tttgaatctg aggagactga agcaccaagg ggttaaatgt tttgcccaca gccatacttg
18601 ggctcagttc cttgccctac ccctcacttg agctgcttag aacctggtgg gcacatgggc
18661 aataaccagg tcacactgtt ttgtaccaag tgttatggga atccaagata ggagtaattt
18721 gctctgtgga ggggatgagg gatagtggtt agggaaagct tcacaaagtg ggtgttgctt
18781 agagattttc caggtggaga agggggcttc taggcagaag gcatagccca agcaaagact
18841 gcaagtgcat ggctgctcat gggtagaaga gaatccacca ttcctcaaca tgtaccgagt
18901 ccttgccatg tgcaaggcaa catgggggta ccaggaattc caagcaatgt ccaaacctag
18961 ggtctgcttt ctgggacctg aagatacagg atggatcagc ccaggctgca atcccattac
19021 cacgaggggg aaaaaaacct gaaggctaaa ttgtaggtcg ggttagaggt tatttatgga
19081 aagttatatt ctacctacat ggggtctata agcctggcgc caatcagaaa aggaacaaac
19141 aacagaccta gctgggaggg gcagcatttt gttgtagggg gcggggcaca tgttctgggg
19201 gtacagccag actcagggct tgtattaata gtctgagagt aagacagaca gagggataga
19261 aggaaatagg tccctttctc tctctctctc tctctctctc tcactctctc tctctctcac
19321 acacacacac agacacacac acacgctctg taggggtcta cttatgctcc aagtacaaat
19381 caggccacat ttacacaagg aggtaaagga aaagaacgtt ggaggagcca caggacccca
19441 aaattccctg ttttccttga atcaggcagg acttacgcag ctgggagggt ggagagcctg
19501 cagaagccac ctgcgagtaa gccaagttca gagtcacaga caccaaaagc tggtgccatg
19561 tcccacaccc gcccacctcc cacctgctcc ttgacacagc cctgtgctcc acaacccggc
19621 tcccagatca ttgattatag ctctggggcc tgcaccgtcc ttcctgccac atccccaccc
19681 cattcttgga acctgccctc tgtcttctcc cttgtccaag ggcaggcaag ggctcagcta
19741 ttgggcagct ttgaccaaca gctgaggctc cttttgtggc tggagatgca ggaggcaggg
19801 gaatattcct cttagtcaat gcgaccatgt gcctggtttg cccagggtgg tctcgtttac
19861 acctgtaggc caagcgtaat tattaacagc tcccacttct actctaaaaa atgacccaat
19921 ctgggcagta aattatatgg tgcccatgct attaagagct gcaacttgct gggcgtggtg
19981 gctcacacct gtaatcccag tactttggga cgtcaaggcg ggtggatcac ctgaggtcac
20041 gagttagaga ctggcctggc cagcatggca aaaccccatc tttactaaaa atacaaaaat
20101 tagcaaggca tggtggcatg cacctgtaat cccaggtact cgggaggctg agacaggaga
20161 atggcttgaa cccaggaggc agaggttgca gtgagccaag attgtgccac tgccctccag
20221 ccctggcaac agagcaagac ttcatctcaa aagaaaaagg atactgtcaa tcactgcagg
20281 aagaacccag gtaatgaatg aggagaagag aggggctgag tcaccatagt ggcagcaccg
20341 actcctgcag gaaaggcgag acactgggtc atgggtactg aagggtgccc tgaatgacgt
20401 tctgctttag agaccgaacc tgagccctga aagtgcatgc ctgttcatgg gtgagagact
20461 aaattcatca ttccttggca ggtactgaat cctttcttac ggctgccctc caatgcccaa
20521 tttccctaca attgtctggg gtgcctaagc ttctgcccac caagagggcc agagctggca
20581 gcgagcagct gcaggtagga gagataggta cccataaggg aggtgggaaa gagagatgga
20641 aggagagggg tgcagagcac acacctcccc tgcctgacaa cttcctgagg gctggtcatg
20701 ccagcagatt taaggcggag gcaggggaga tggggcggga gaggaagtga aaaaggagag
20761 ggtggggatg gagaggaaga gagggtgatc attcattcat tccattgcta ctgactggat
20821 gccagctgtg agccaggcac caccctagct ctgggcatgt ggttgtaatc ttggagcctc
20881 atggagctca cagggagtgc tggcaaggag atggataatg gacggataac aaataaacat
20941 ttagtacaat gtccgggaat ggaaagttct cgaaagaaaa ataaagctgg tgagcatata
21001 gacagccctg aaggcggcca ggccaggcat ttctgaggag gtggcatttg agctaagacc
21061 aaaatgtggt gggagaggga gccacacaag gatctggggg tgtgtgcact gggaggggga
21121 gcagcaagtg caaagggcct gaaggtatgt agggggtgga gaagggacac cactaattgc
21181 cttgggtgcc tttcaggcgt ctccatgcca aggctctaac ccctgatgtg gaagccaaca
21241 tagtaattat aattatagtg aagaggggtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
21301 tgattgaaag agagagagaa tgagtctctg taccttctct tgggtctgta tgttgaaaac
21361 ctaagtgacc ctaaagaaga atatttgcat attattaatt atgtagctat acatgttttt
21421 tttgagacaa agtcttgctt tgtcacccag actggagtgc agtggcagca atcatggctc
21481 actgcagcct ctgcctccca g
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