LOCUS AF321876 2200 bp mRNA linear HUM 28-FEB-2001
DEFINITION Homo sapiens candidate tumor suppressor (DPH2L1) mRNA, complete
cds.
ACCESSION AF321876
VERSION AF321876.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2200)
AUTHORS Schultz,D.C., Vanderveer,L., Berman,D.B., Hamilton,T.C., Wong,A.J.
and Godwin,A.K.
TITLE Identification of two candidate tumor suppressor genes on
chromosome 17p13.3
JOURNAL Cancer Res. 56 (9), 1997-2002 (1996)
PUBMED 8616839
REFERENCE 2 (bases 1 to 2200)
AUTHORS Bruening,W., Prowse,A.H., Schultz,D.C., Holgado-Madruga,M., Wong,A.
and Godwin,A.K.
TITLE Expression of OVCA1, a candidate tumor suppressor, is reduced in
tumors and inhibits growth of ovarian cancer cells
JOURNAL Cancer Res. 59 (19), 4973-4983 (1999)
PUBMED 10519411
REFERENCE 3 (bases 1 to 2200)
AUTHORS Godwin,A.K. and Vanderveer,L.A.
TITLE Direct Submission
JOURNAL Submitted (16-NOV-2000) Medical, Oncology, 7701 Burholme Avenue,
Philadelphia, PA 19111, USA
FEATURES Location/Qualifiers
source 1..2200
/db_xref="H-InvDB:HIT000077401"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17p13.3 between D17S28 and D17S5/30"
gene 1..2200
/gene="DPH2L1"
CDS 19..1350
/gene="DPH2L1"
/note="OVCA1/DPH2L; similar to diphthamide biosynthesis
protein 2; ~ubiquitiously expressed in human tissues and
mammalian cell lines to varying degrees; exogenous
expression inhibits tumor cell growth in vivo and in
vitro"
/codon_start=1
/product="candidate tumor suppressor"
/protein_id="AAK13428.1"
/translation="MRRQVMAVLVVSGAAEQGGRDGPGRGRAPRGRVANQIPPEILKN
PQLQAAIRVLPSNYNFEIPKTIWRIQQAQAKKVALQMPEGLLLFACTIVDILERFTEA
EVMVMGDVTYGACCVDDFTARALGADFLVHYGHSCLIPMDTSAQDFRVLYVFVDIRID
TTHLLDSLRLTFPPATALALVSTIQFVSTLQAAAQELKAEYRVSVPQCKPLSPGEILG
CTSPRLSKEVEAVVYLGDGRFHLESVMIANPNVPAYRYDPYSKVLSREHYDHQRMQAA
RQEAIATARSAKSWGLILGTLGRQGSPKILEHLESRLRALGLSFVRLLLSEIFPSKLS
LLPEVDVWVQVACPRLSIDWGTAFPKPLLTPYEAAVALRDISWQQPYPMDFYAGSSLG
PWTVNHGQDRRPHAPGRPARGKVQEGSARPPSAVACEDCSCRDEKVAPLAP"
BASE COUNT 425 a 673 c 634 g 468 t
ORIGIN
1 ctgtcttttt agtaccacat gcgcaggcag gtgatggcgg tgctggtcgt atccggggca
61 gcggagcagg gcggccgaga cggccctggc agaggtcggg cccctcgggg ccgcgtggcc
121 aatcagatcc cccctgagat cctgaagaac cctcagctgc aggcagcaat ccgggtcctg
181 ccttccaact acaactttga gatccccaag accatctgga ggatccaaca agcccaggcc
241 aagaaggtgg ccttgcaaat gccggaaggc ctcctcctct ttgcctgtac cattgtggat
301 atcttggaaa ggttcacgga ggccgaagtg atggtgatgg gtgacgtgac ctacggggct
361 tgctgtgtgg atgacttcac agcgagggcc ctgggagctg acttcttggt gcactacggc
421 cacagttgcc tgattcccat ggacacctcg gcccaagact tccgggtgct gtacgtcttt
481 gtggacatcc ggatagacac tacacacctc ctggactctc tccgcctcac ctttccccca
541 gccactgccc ttgccctggt cagcaccatt cagtttgtgt cgaccttgca ggcagccgcc
601 caggagctga aagccgagta tcgtgtgagt gtcccacagt gcaagcccct gtcccctgga
661 gagatcctgg gctgcacatc cccccgactg tccaaagagg tggaggccgt tgtgtatctt
721 ggagatggcc gcttccatct ggagtctgtc atgattgcca accccaatgt ccccgcttac
781 cggtatgacc catatagcaa agtcctatcc agagaacact atgaccacca gcgcatgcag
841 gctgctcgcc aagaagccat agccactgcc cgctcagcta agtcctgggg ccttattctg
901 ggcactttgg gccgccaggg cagtcctaag atcctggagc acctggaatc tcgactccga
961 gccttgggcc tttcctttgt gaggctgctg ctctctgaga tcttccccag caagcttagc
1021 ctacttcccg aggtggatgt gtgggtgcag gtggcatgtc cacgtctctc cattgactgg
1081 ggcacagcct tccccaagcc gctgctgaca ccctatgagg cggccgtggc tctgagggac
1141 atttcctggc agcagcccta cccgatggac ttctacgctg gcagctcctt ggggccctgg
1201 acggtgaacc acggccagga ccgccgtccc cacgccccgg gccggcccgc gcgggggaag
1261 gtgcaggagg ggtccgcgcg tcccccttcg gccgtggctt gcgaggactg cagctgcagg
1321 gacgagaagg tggcgccgct ggctccttga cgcgctcccg ggcctcaggg tcctgccctc
1381 cggaggagca gcctcgaggc tggtggtttt cagagcagga ggccgacgtt ttctccgcat
1441 tggaagagcc cgccgtctgc aggggcctgg aggaatcact ggggatggtg gcacaggcac
1501 tgaacaggct ggggcctttt gacggccttc ttggtttcag ccaaggggct gcgctagcag
1561 cccttgtgtg tgccctgggc caggcaggcg atccccgctt ccccttgcca cggtttatcc
1621 tcttggtgtc tagtttctgt ccccggggca ttgggttcaa ggaatccatc ctgcaaaggc
1681 ccttgtcatt gccttcgctc catgtttttg gggacactga caaagtcatc ccctctcagg
1741 agagtgtgca actggccagc caatttcccg gagccatcac cctcacccac tctggtggcc
1801 acttcattcc agcagctgca ccccagcgtc aggcctacct caagttcttg gaccagtttg
1861 cagagtgaaa gatcaagaaa tgtctctgct cctacatcca gctcctctag gggcagcctc
1921 cgtcatccat gccctcccag gaccctccac tcactgctgt gagtgcgcct caccagaacc
1981 agttaagaga caactatcaa ttcttgagac ccaaattata agggccctgc cctgtactga
2041 agaaaagggg agcacaaggc cttaatggac attgacttgt gaaaacgcaa acatgaatat
2101 ggttggagag ccctggatta ggagggtgac atggggaagg cagaggctgg cacgatggtg
2161 actgccacat aataaagtgg tgatttggat tttgaaaaaa
//