LOCUS AF320223 4515 bp mRNA linear HUM 11-JUN-2002
DEFINITION Homo sapiens WD40 repeat domain 11 protein (WDR11) mRNA, complete
cds.
ACCESSION AF320223
VERSION AF320223.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4515)
AUTHORS Chernova,O.B., Hunyadi,A., Malaj,E., Pan,H., Crooks,C., Roe,B. and
Cowell,J.K.
TITLE A novel member of the WD-repeat gene family, WDR11, maps to the
10q26 region and is disrupted by a chromosome translocation in
human glioblastoma cells
JOURNAL Oncogene 20 (38), 5378-5392 (2001)
PUBMED 11536051
REFERENCE 2 (bases 1 to 4515)
AUTHORS Chernova,O.B. and Cowell,J.K.
TITLE Direct Submission
JOURNAL Submitted (08-NOV-2000) Molecular Genetics, Cleveland Clinic
Foundation, 9500 Euclid Ave., Cleveland, OH 44195, USA
FEATURES Location/Qualifiers
source 1..4515
/db_xref="H-InvDB:HIT000077350"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q26; SHGC-36479"
gene 1..4515
/gene="WDR11"
CDS 34..3708
/gene="WDR11"
/note="contains six WD40 repeats; disrupted by
translocation rearrangement; similar to unnamed
hypothetical proteins encoded by GenBank Accession Numbers
AB037772, AL137699, and AK001368; belongs to WD40 gene
family"
/codon_start=1
/product="WD40 repeat domain 11 protein"
/protein_id="AAK08064.1"
/translation="MLPYTVNFKVSARTLTGALNAHNKAAVDWGWQGLIAYGCHSLVV
VIDSITAQTLQVLEKHKADVVKVKWARENYHHNIGSPYCLRLASADVNGKIIVWDVAA
GVAQCEIQEHAKPIQDVQWLWNQDASRDLLLAIHPPNYIVLWNADTGTKLWKKSYADN
ILSFSFDPFDPSHLTLLTSEGIVFISDFSPSKPPSGPGKKVYISSPHSSPAHNKLATA
TGAKKALNKVKILITQEKPSAEFITLNDCLQLAYLPSKRNHMLLLYPREILILDLEVN
QTVGVIAIERTGVPFLQVIPCFQRDGLFCLHENGCITLRVRRSYNNIFTTSNEEPDPD
PVQELTYDLRSQCDAIRVTKTVRPFSMVCCPVNENAAALVVSDGRVMIWELKSAVCNR
NSRNSSSGVSPLYSPVSFCGIPVGVLQNKLPDLSLDNMIGQSAIAGEEHPRGSILREV
HLKFLLTGLLSGLPAPQFAIRMCPPLTTKNIKMYQPLLAVGTSNGSVLVYHLTSGLLH
KELSIHSCEVKGIEWTSLTSFLSFATSTPNNMGLVRNELQLVDLPTGRSIAFRGERGN
DESAIEMIKVSHLKQYLAVVFRDKPLELWDVRTCTLLREMSKNFPTITALEWSPSHNL
KSLRKKQLATREAMARQTVVSDTELSIVESSVISLLQEAESKSELSQNISAREHFVFT
DIDGQVYHLTVEGNSVKDSARIPPDGSMGSITCIAWKGDTLVLGDMDGNLNFWDLKGR
VSRGIPTHRSWVRKIRFAPGKGNQKLIAMYNDGAEVWDTKEVQMVSSLRSGRNVTFRI
LDVDWCTSDKVILASDDGCIRVLEMSMKSACFRMDEQELTEPVWCPYLLVPRASLALK
AFLLHQPWNGQYSLDISHVDYPENEEIKNLLQEQLNSLSNDIKKLLLDPEFTLLQRCL
LVSRLYGDESELHFWTVAAHYLHSLSQEKSASTTAPKEAAPRDKLSNPLDICYDVLCE
NAYFQKFQLERVNLQEVKRSTYDHTRKCTDQLLLLGQTDRAVQLLLETSADNQHYYCD
SLKACLVTTVTSSGPSQSTIKLVATNMIANGKLAEGVQLLCLIDKAADACRYLQTYGE
WNRAAWLAKVRLNPEECADVLRRWVDHLCSPQVNQKSKALLVLLSLGCFFSVAETLHS
MRYFDRAALFVEACLKYGAFEVTEDTEKLITAIYADYARSLKNLGFKQGAVLFASKAG
AAGKDLLNELESPKEEPIEE"
BASE COUNT 1274 a 928 c 1035 g 1278 t
ORIGIN
1 ggtcagcgcc caggtcctgg gctggccgcc gggatgttgc cctacacagt gaacttcaag
61 gtgtcggcgc gcaccctcac gggggccctc aacgcccaca acaaggcggc ggtggactgg
121 ggctggcaag gtttaattgc ttatggatgt cattcacttg tggtagtgat tgattccatt
181 actgcccaaa ctcttcaagt tttagaaaag cataaagctg atgttgtaaa ggttaaatgg
241 gccagggaaa actatcacca taacattggc tcaccatatt gcttacggtt agcttctgct
301 gatgtcaatg ggaagatcat cgtctgggat gtagcagcag gagtagctca gtgtgagatc
361 caagagcatg ccaagcctat ccaggatgtt cagtggttgt ggaatcaaga tgcttcccgc
421 gatttactgc ttgctatcca cccgccaaat tacattgtgc tctggaatgc cgacactggc
481 accaaactat ggaagaagag ctatgcagat aacattcttt ctttttcttt tgaccctttt
541 gatccctcac atttaacttt gcttaccagc gagggtattg ttttcatctc agacttctcc
601 ccatccaagc ctccctcagg ccctgggaaa aaagtttaca tatccagccc acactctagc
661 ccagctcata acaagctggc cacagccaca ggtgccaaga aagctctaaa taaagtaaaa
721 attttaatca ctcaagagaa acctagtgct gaattcataa ctctcaatga ttgccttcag
781 ttggcatacc tgccttcaaa aaggaatcac atgttgttgc tctatcctcg agagatttta
841 atccttgacc ttgaggtgaa tcagacggtg ggtgtgattg caatagaacg cacaggagtt
901 ccatttttac aggtaatacc ctgctttcag cgtgatggtt tattttgtct acatgaaaat
961 ggttgtataa ctttacgtgt tcgaagatct tataataaca tttttaccac ttcaaatgag
1021 gaaccagatc cagatccagt tcaggagctt acctatgatt tacgaagcca gtgtgatgca
1081 atcagggtga caaaaaccgt ccgtcccttc agtatggtgt gctgtcctgt caatgagaat
1141 gcagccgccc tcgtagtgag tgatggcagg gtcatgatat gggaactcaa gtctgcagtt
1201 tgtaatcgaa attcacggaa cagtagttct ggtgtgtcac ctttatattc accagtgtct
1261 ttctgtggaa ttcctgtagg agtgctacag aataaactcc cagacctttc cttagataac
1321 atgattgggc aaagtgcaat tgctggggaa gaacatccca gaggttcaat tctgcgggaa
1381 gtgcacctca agttcctgct gacgggactg ctttcaggac tgcccgcacc acagtttgct
1441 attcgtatgt gtccaccgtt gaccacaaaa aacatcaaga tgtatcagcc actgctggct
1501 gttggtacaa gtaatggttc tgtcctggtg taccatctca ccagtggtct gctacacaaa
1561 gagttaagca tccactcatg tgaagtcaag ggtattgaat ggacaagttt gactagtttt
1621 ctttcttttg ctacctcaac accaaacaat atgggattag tgagaaatga acttcaactg
1681 gttgatcttc caacaggtag gagcattgct tttcgtggtg aaagaggcaa tgatgaatct
1741 gccatcgaaa tgattaaagt atctcatttg aagcagtatt tggcagtcgt attcagagat
1801 aaacccctgg agctatggga tgttaggact tgtacccttc ttagagagat gtccaaaaac
1861 ttccctacaa taactgcttt ggagtggtca ccatctcaca acttgaagag cctgagaaag
1921 aagcaacttg ctactcgaga ggccatggcc cgccagaccg tagtctcaga cacagagctg
1981 agtattgttg aatcatctgt gatcagcttg ctgcaggagg cagaaagtaa atctgaactt
2041 agtcagaaca tctctgcccg ggaacatttt gtatttaccg atattgatgg ccaagtgtat
2101 catctcactg ttgaaggaaa ctcagtaaaa gacagtgctc ggattccacc agatggaagt
2161 atgggtagta ttacctgcat cgcttggaaa ggtgatacat tagtgcttgg agatatggat
2221 ggaaatttaa atttctggga cttgaaaggc agagtatcca gaggaatacc cacacaccga
2281 agttgggtga ggaagattcg ttttgctcct ggtaaaggaa atcaaaaatt aatagcaatg
2341 tacaatgatg gagctgaagt gtgggatact aaagaggttc agatggtgag cagtttaaga
2401 agtggcagaa atgtgacctt tcgtatattg gatgtggact ggtgtacgtc agataaagtg
2461 atcttggcct cagatgatgg gtgcatcaga gtcctagaga tgtctatgaa gtctgcgtgc
2521 tttagaatgg atgaacaaga gttaaccgag cctgtgtggt gcccctatct ccttgttcca
2581 agggcctctc ttgccttgaa agccttctta ttacaccagc cttggaatgg acagtattct
2641 ttggacattt ctcatgttga ctatccagaa aatgaagaaa taaagaatct cctccaagaa
2701 cagttgaatt cattgtctaa tgacataaag aaactgttgc ttgatccaga attcactctc
2761 ttgcagaggt gcctgcttgt ttcaaggctc tatggtgatg aatcggagct gcacttctgg
2821 actgtcgctg cccactacct gcacagctta tcccaggaaa agtcagccag cacaacagct
2881 cctaaagaag ctgctcctcg agacaaactg agcaacccac tggatatatg ctatgacgtg
2941 ctctgtgaaa atgcctactt tcagaaattt cagctagaaa gggttaatct acaggaagtg
3001 aaacggtcaa cttatgatca tacaaggaaa tgtacagacc agctactgct cttgggtcaa
3061 acagacagag ctgtgcagtt gctgttggaa acaagtgcag ataaccagca ttattactgt
3121 gattcactga aagcctgttt agtcactact gtcacctcgt caggcccctc tcagagcacc
3181 attaagttgg tggcaacgaa tatgattgcc aatggcaaat tggcagaggg cgttcagttg
3241 ctctgcctga tagataaggc tgcagacgcc tgccgctacc tgcagacata cggcgagtgg
3301 aatcgggctg catggctggc aaaagtccgt ttgaatcctg aggagtgtgc cgatgtttta
3361 aggcggtggg ttgaccacct ttgttctcca caagtcaatc agaaatcaaa ggctctcctg
3421 gttctcctct ctctgggctg cttttttagc gtggcagaga cgcttcacag catgagatac
3481 tttgatagag cagccttatt tgtggaagct tgcctcaagt atggagcatt tgaagtcact
3541 gaggacacag agaaactcat cactgctata tatgcagatt atgcccggag tttgaagaac
3601 ctcggtttta agcagggagc agttctcttt gcttcaaaag ccggagcagc tggcaaagac
3661 ttattgaatg agcttgagtc ccccaaggaa gaacccattg aagagtgaca gcttaataaa
3721 tgccagggaa tctgacctgg aaggcagatg ggagggggct ggtctggctg tggccaccgt
3781 cacagtccag gatgaagagg agtacagggt cctgtgagct gtttgaccac tgttctaaga
3841 ctatgtgtgc ccaaaagcac ataagcatct atgttgagag taagtttgta tcctgcgttg
3901 gtctcagaaa gaacgtgaat gcttaagatt ttgaaagtac ataatatttt atactttggg
3961 agagagcttt aagagtccct ggaaatactt tttaattttt ttaacttaaa attcaagaga
4021 ctgaatcact tttctcattg attaaatgta aagattattg agaaacctat agtaaatgaa
4081 atttgtaaga tgttttctca aatatatgct gtgcctgtac ttatatacag tctttcaaga
4141 gagatacaaa caaggcagaa acatttaaac tagtattaaa ggtagtttac caaagcattt
4201 tttgttttct taccttgaaa acacagaacc gttaattcct tggtttaagc agttgctaag
4261 ttttttaatt ttaggctcag aggcccatag gaggttttaa gatttatgtt tagtccgata
4321 ggtgaggtct ttgatatttt gaattttaac tccttttatg atacatcaca gtaacctcat
4381 ttttgaagtc tttctttgta ctttaatgtt ctctctgttc taatagttga agtatgagat
4441 gtaactatta taaactgttg ctgaaaacat aaatgtctgt aacttacaaa catgataaat
4501 aaattaaaaa ttcca
//