LOCUS AF318616 6746 bp mRNA linear HUM 27-DEC-2000
DEFINITION Homo sapiens synaptojanin 2 mRNA, complete cds.
ACCESSION AF318616
VERSION AF318616.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6746)
AUTHORS Malecz,N., McCabe,P.C., Spaargaren,C., Qiu,R., Chuang,Y. and
Symons,M.
TITLE Synaptojanin 2, a novel Rac1 effector that regulates
clathrin-mediated endocytosis
JOURNAL Curr. Biol. 10 (21), 1383-1386 (2000)
PUBMED 11084340
REFERENCE 2 (bases 1 to 6746)
AUTHORS Malecz,N., McCabe,P.C., Spaargaren,C., Qiu,R.-G., Chuang,Y.-y. and
Symons,M.H.
TITLE Direct Submission
JOURNAL Submitted (02-NOV-2000) Molecular Oncology, Picower Institute, 350
Community Drive, Manhasset, NY 11030, USA
FEATURES Location/Qualifiers
source 1..6746
/db_xref="H-InvDB:HIT000077313"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 84..4574
/function="polyphosphoinositide phosphatase"
/codon_start=1
/product="synaptojanin 2"
/protein_id="AAG46036.1"
/translation="MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAP
EEKEVIKGQYGKLTDAYGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITAT
DFYPLQEEAKEEERLIALKKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSF
FWNQLLHVPLRQHQVSCCDWLLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRF
HTRGVNDDGHVSNFVETEQMIYMDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRG
LEANAPAFDRHMVLLKEQYGQQVVVNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMIN
FDFHQFAKGGKLEKLETLLRPQLKLHWEDFDVFTKGENVSPRFQKGTLRMNCLDCLDR
TNTVQSFIALEVLHLQLKTLGLSSKPIVDRFVESFKAMWSLNGHSLSKVFTGSRALEG
KAKVGKLKDGARSMSRTIQSNFFDGVKQEAIKLLLVGDVYGEEVADKGGMLLDSTALL
VTPRILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLS
GATDSQDDSSPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRSHRYILL
TSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFI
CSHLTAGQSQVKERNEDYKEITQKLCFPMGRNVFSHDYVFWCGDFNYRIDLTYEEVFY
FVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDVGSAAYDTSDKCRTP
AWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDHR
PVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPTLEEKNEFPEDLRTE
LMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRAVKIRPKTKDWLK
GLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDDEDYLVDEFNQPG
VSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFR
HRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLP
GAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLE
ASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVH
FTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVP
PPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVF
PQGDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDP
LDSGTRSPKRDPIDPVSAGASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPLA
KT"
BASE COUNT 1761 a 1688 c 1734 g 1563 t
ORIGIN
1 ggcacgaggc ggggagctgt cgcgggcagc gcgccctcgg gaggacgtgg ccccggcccc
61 cgcccgcagt gggcccgacc ctcatggccc tgagcaaagg gctgcggctg ctggggcgcc
121 tgggggccga gggggactgt agcgtgctgc tggaggcgcg cggccgcgac gactgcctgc
181 tgttcgaggc cggcacggtg gccacgctgg ctccagaaga aaaggaagtc attaaaggac
241 agtatggcaa gctcacggac gcgtacggct gcctggggga gctgaggctg aaatctggtg
301 gcacgtctct gagcttcctg gtgttggtga caggctgcac atctgtgggc agaattccag
361 atgctgaaat ctacaaaatc actgccactg acttttaccc tcttcaggaa gaggccaagg
421 aggaggaacg cctcatagct ttgaagaaaa tcctcagctc gggggtgttc tatttctcat
481 ggccaaacga tgggtctcgc tttgacctga ctgtccgcac gcagaagcag ggggatgaca
541 gctctgaatg ggggaactcc ttcttctgga accagctgtt gcacgtgccc ttgaggcagc
601 accaggtgag ctgctgtgac tggctgctga agatcatctg cggggtggtc accatccgca
661 ccgtgtatgc ctcccacaag caggccaagg cctgcctcgt ctctcgcgtt agctgtgagc
721 gcacaggcac tcgcttccac acccgtggcg tgaacgacga cggccatgtg tccaacttcg
781 tggagacaga gcagatgatt tacatggacg atggagtgtc atcttttgtc cagatcagag
841 gctccgttcc gctgttctgg gaacagccag ggcttcaggt tggctcccat catctgagac
901 tccacagagg cctggaagcc aatgcccctg ctttcgacag gcacatggtg cttctgaagg
961 agcagtacgg gcagcaggtg gtcgtgaacc ttctgggaag cagaggcgga gaggaggtgc
1021 tcaacagagc cttcaagaag ctgctctggg cttcttgcca cgcgggcgac acgcctatga
1081 tcaattttga cttccatcag tttgccaaag gtgggaagct agagaaattg gagaccctct
1141 tgaggccaca gttaaagctg cactgggaag acttcgatgt gttcacaaag ggggagaacg
1201 tcagtccacg ttttcagaaa ggcactttgc ggatgaactg tcttgactgc ctggaccgaa
1261 ccaacactgt gcagagcttc atcgcgctcg aggtcctgca tctgcagctc aagaccctgg
1321 ggctgagttc aaaacccatc gttgaccgct ttgtggagtc cttcaaagcc atgtggtctc
1381 tgaatggcca cagcctgagc aaggtgttca caggcagcag agccctggaa gggaaggcca
1441 aggtggggaa gctgaaggat ggagcccggt ccatgtctcg aaccatccag tccaacttct
1501 tcgacggggt gaagcaggag gccatcaagc tgctgctggt tggggacgtc tacggcgagg
1561 aggtggcaga caaagggggc atgctgctgg acagcacggc gctcctggtg actcccagga
1621 tcctgaaagc tatgactgag cgtcagtccg aattcacaaa tttcaagcgg atccggattg
1681 ctatggggac ctggaacgtg aacggaggaa agcagttccg gagcaacgtg ctcaggacgg
1741 cggagctgac agactggctg ctcgactcgc cccagctctc gggagctacc gactcccagg
1801 atgacagcag cccagctgac atatttgctg tggggtttga agagatggtg gaattgagcg
1861 cagggaatat tgtcaatgcc agtactacca acaagaagat gtggggtgaa cagcttcaga
1921 aagccatctc acgctctcat agatacattc tgttgacttc ggcacagctg gtgggcgtct
1981 gtctttatat ctttgtacgt ccataccatg tcccgttcat cagggacgta gccatcgaca
2041 cagtgaagac gggcatgggg ggcaaggcgg ggaacaaggg cgccgtcggc atccgcttcc
2101 agttccacag caccagcttc tgcttcatat gtagtcacct gacggccggg cagtcccagg
2161 tgaaggagcg gaatgaagac tacaaggaga tcacccagaa actctgcttc ccaatgggga
2221 gaaatgtttt ttctcatgat tatgtatttt ggtgtggcga tttcaactac cgcattgatc
2281 ttacttatga agaagtcttc tattttgtta aacgccaaga ctggaagaaa cttctggaat
2341 ttgatcaact acagctacag aaatcaagtg gaaaaatttt taaggacttt cacgaaggag
2401 ccattaactt tggacccacc tacaagtatg acgttggctc agccgcctac gatacaagcg
2461 acaaatgccg cacccccgcc tggacagaca gggtgctgtg gtggaggaag aaacatccct
2521 ttgataaaac agctggagaa ctcaaccttc tagacagtga tctagatgtt gacaccaaag
2581 tcagacacac ctggtctcct ggtgccctgc agtattatgg tcgtgcggag ctacaagcgt
2641 ctgatcacag acctgtgctg gcgatcgtgg aggtggaagt tcaggaagtc gatgtgggtg
2701 ctcgggagag ggttttccag gaagtgtcct ccttccaggg ccccctggat gccactgttg
2761 tagtaaacct tcaatcaccg accttagaag agaaaaacga gtttccagag gacctgcgta
2821 ctgagctcat gcagaccttg gggagttatg ggacaattgt tcttgtcagg atcaaccaag
2881 ggcagatgct ggtaactttt gcagacagtc actcggctct cagtgtcctg gacgtggacg
2941 gtatgaaggt gaaaggcaga gcagtgaaga ttagaccgaa gaccaaggac tggctgaaag
3001 gtttgcgaga ggagatcatt cggaaacgag acagcatggc ccccgtgtct cccactgcca
3061 actcctgttt gctggaggaa aactttgact tcacaagttt ggactatgag tcagaagggg
3121 atattcttga agacgatgaa gactacttgg tggatgaatt caatcagcct ggagtctcgg
3181 acagtgaact cgggggagac gacctctctg atgtccccgg ccccacagca ctggctcctc
3241 ccagcaagtc acctgctctc accaaaaaga agcagcatcc aacgtacaaa gatgacgcgg
3301 acctggtgga gctcaagcgg gagctggaag ccgtcgggga gttccgccac cgttctccga
3361 gcaggtctct gtcggtcccc aaccggcctc ggccacctca acccccgcag agaccccccc
3421 ctccaaccgg tttaatggtg aaaaagtcgg cttcagatgc gtccatctcc tccggcaccc
3481 atggacagta ttcaattttg cagacggcaa gacttctacc aggagcacct cagcaacctc
3541 ccaaggctcg gactggaata agtaaacctt ataatgtcaa gcagatcaaa accaccaatg
3601 cccaggaggc agaagcagca atccggtgtc tcctggaagc cagaggaggt gcctccgaag
3661 aagccctaag tgccgtggcc ccaagggacc ttgaagcatc ctctgaacca gagcccacac
3721 cgggggcagc caaaccagag accccacagg cgcccccact ccttccccgt cggcccccac
3781 ccagagttcc tgccatcaag aagccaacct tgagaaggac aggaaagccc ctgtcaccgg
3841 aagaacagtt tgagcaacag actgtccatt ttacaatcgg gcccccggag acaagcgttg
3901 aggcccctcc tgtcgtgaca gcccctcgag tccctcctgt tcccaaacca agaacatttc
3961 agcctgggaa agctgcagag aggccaagcc acaggaagcc agcatcagac gaagcccctc
4021 ctggggcagg agcctctgtg ccaccacctc tggaggcgcc gcctcttgtg cccaaggtac
4081 ccccgaggag gaagaagtca gcccccgcag ccttccacct gcaggtcctg cagagcaaca
4141 gccagcttct ccagggcctc acttacaata gcagtgacag cccctctggg cacccacctg
4201 ccgcgggcac cgtcttccca caaggggact ttctcagcac ttcatctgct acaagccccg
4261 acagcgatgg caccaaagcg atgaagccag aggcagcccc acttcttggt gattatcagg
4321 accccttctg gaaccttctt caccacccta aactgttgaa taacacttgg ctttctaaga
4381 gctcagaccc tttggactca ggaaccagga gccccaaaag agatcccata gacccagtgt
4441 cagctggcgc ttcagctgcc aaggcagagc tgccaccaga tcatgaacac aaaaccttag
4501 gtcactgggt gacaatcagt gaccaagaaa agaggacagc actgcaggtg tttgacccac
4561 tggcaaaaac atgactgagc agctttgaag gctgcagtcc tatagaatgc ataccttcct
4621 ccctctagac atccctccac cagaagagac atctatttaa aggcacactg gccaaaacgt
4681 ttgtgcatct gtcactctcg tgtagtttac aaaaatcgtg tctcttattc agtaagatgg
4741 ttactcagcc accaaaatat atttcactca aggcttgtac atctgaagtt tgctcttcaa
4801 ggaatgggaa ccttcctgtt aaattcggtg tatggatttt aagaaaggaa tctagccaat
4861 gaggtccaag aagttctcac ccattgaatt tttaaatggc tgttcagttc atgttgtacg
4921 tgatggagat ttgtcttttg ttttatttgc attttacaga tttggtataa cattttgggg
4981 agccacctga aggttgatgt ataaagtaag gattagagaa agaggtcgtt gtgaccatta
5041 atagctgtcc tggcccactt aaacaaggtt acaaaaaatc agagtcggaa gcagccaaat
5101 aggtcaacct aatgactaga ctgtacattc ccatgagcct tcatgtttaa gtgtgtacat
5161 gtgcgttaac cttgatgatg cgtgaatccc gagggagccg gtggcataca ccgttagctt
5221 aaccttagct taaactagct gaaggctcct gtgccatgtc ttagacattg catgccctat
5281 caattactat aatcctgagc catggtgtgc tactgaaacc aatttttatc caccatctag
5341 tccttattaa atgaaacctc acggatcctt tgttccgctt atattccatg cataccacat
5401 aaaagcacac agtgcgaaaa ctcttgctga tacgcgatat tgattctcat tgttagaata
5461 tggagagtgt ttcagcctcg tctgtccggc tggagcttcg ggatggaaag tgctatgtgt
5521 ccctgcatat aagaatcacc aggccagtgt ttctgggttt gcttgtctat atgtttgtct
5581 atattttttg cctatacatt tttcccacgt ttccaacagc acttctcacc tattcaataa
5641 ctgaaaaaga cattaccata gtgctttaca tttttaaagt aatgttacaa ggtctggaat
5701 ccatttggag cagataccgt gttttcgcta tttaataaga agttcagtag tgaaatctta
5761 ctgtaccgcc tgttgtatct gggagcctcg tacagaggct cgcacagcag tgatcaagtg
5821 tcatccctta cgtgactggg ggatgtctgt cctaaaagct gactgctagg atagtaagga
5881 tcatcttgcc tgggctatgc cactgtcttg ttaccaatta gacatctgga atttcataat
5941 tagttttcat tgtcactgtc aagatatatt gcagattact taaatatggc catcaaaaca
6001 aaagttacaa cacgtatctc ttttcatctg aaaactaata cctggaaaag gataaaaaaa
6061 aaaaggaatc cgtgacccac agagctagac agataagatg catagttgac cagtcataaa
6121 aggcggtgtt taagtgatca ggatgccgtt ggtggcattt acgtgcttta tatgattttt
6181 acctctgtaa caaacacaag aaataaacag aatggtcctt aacagagttt gggggagaga
6241 gcaagatggg ttccttggag aagctgattt gccaagatgc acatcgctat taacagccag
6301 agtcataaat gaaatgaaat tgaagaattc attcaaatgc tcttttccct ataacctctt
6361 ttctcaccaa aaaggagata aatttgaaaa cagataaatg taacaaccag tcaaagaagc
6421 aggggaaaag taagctcctc caaagttgct tgcagtgctg gaaatagatc tcatttttag
6481 gttttctctt cgttccagat accaaataaa tgggacagag aataaaattt ttgttaaaat
6541 atgtgctcat ctcctaagta gctcttcaga gtctgaccgt aagtaaaaac acacagaatt
6601 gtgttgactg ggggaggtga atcacaaaaa agttacgagg agtttaagag ttaaatatta
6661 tttgatcgtg gctgtcaaat ttagtgaaca acatagattg gatttggagt tggtagtaag
6721 tatggttctc ataccagaat tctctt
//