LOCUS AF318574 5195 bp mRNA linear HUM 31-JAN-2001
DEFINITION Homo sapiens UPF2 (UPF2) mRNA, complete cds.
ACCESSION AF318574
VERSION AF318574.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5195)
AUTHORS Serin,G., Gersappe,A., Black,J.D., Aronoff,R. and Maquat,L.E.
TITLE Identification and characterization of human orthologues to
Saccharomyces cerevisiae Upf2 protein and Upf3 protein
(Caenorhabditis elegans SMG-4)
JOURNAL Mol. Cell. Biol. 21 (1), 209-223 (2001)
PUBMED 11113196
REFERENCE 2 (bases 1 to 5195)
AUTHORS Serin,G., Gersappe,A., Black,J.D., Aronoff,R. and Maquat,L.E.
TITLE Direct Submission
JOURNAL Submitted (02-NOV-2000) Department of Biochemistry and Biophysics,
School of Medicine and Dentistry, Rochester, NY 14642, USA
FEATURES Location/Qualifiers
source 1..5195
/db_xref="H-InvDB:HIT000077310"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..5195
/gene="UPF2"
CDS 76..3894
/gene="UPF2"
/note="involved in NMD pathway; interacts with UPF1, UPF3,
and UPF3X; similar to Saccharomyces cerevisiae Upf2 and
Caenorhabditis elegans SMG-3"
/codon_start=1
/product="UPF2"
/protein_id="AAG60689.1"
/translation="MPAERKKPASMEEKDSLPNNKEKDCSERRTVSSKERPKDDIKLT
AKKEVSKAPEDKKKRLEDDKRKKEDKERKKKDEEKVKAEEESKKKEEEEKKKHQEEER
KKQEEQAKRQQEEEAAAQMKEKEESIQLHQEAWERHHLRKELRSKNQNAPDSRPEENF
FSRLDSSLKKNTAFVKKLKTITEQQRDSLSHDFNGLNLSKYIAEAVASIVEAKLKISD
VNCAVHLCSLFHQRYADFAPSLLQVWKKHFEARKEEKTPNITKLRTDLRFIAELTIVG
IFTDKEGLSLIYEQLKNIINADRESHTHVSVVISFCRHCGDDIAGLVPRKVKSAAEKF
NLSFPPSEIISPEKQQPFQNLLKEYFTSLTKHLKRDHRELQNTERQNRRILHSKGELS
EDRHKQYEEFAMSYQKLLANSQSLADLLDENMPDLPQDKPTPEEHGPGIDIFTPGKPG
EYDLEGGIWEDEDARNFYENLIDLKAFVPAILFKDNEKSCQNKESNKDDTKEAKESKE
NKEVSSPDDLELELENLEINDDTLELEGGDEAEDLTKKLLDEQEQEDEEASTGSHLKL
IVDAFLQQLPNCVNRDLIDKAAMDFCMNMNTKANRKKLVRALFIVPRQRLDLLPFYAR
LVATLHPCMSDVAEDLCSMLRGDFRFHVRKKDQINIETKNKTVRFIGELTKFKMFTKN
DTLHCLKMLLSDFSHHHIEMACTLLETCGRFLFRSPESHLRTSVLLEQMMRKKQAMHL
DARYVTMVENAYYYCNPPPAEKTVKKKRPPLQEYVRKLLYKDLSKVTTEKVLRQMRKL
PWQDQEVKDYVICCMINIWNVKYNSIHCVANLLAGLVLYQEDVGIHVVDGVLEDIRLG
MEVNQPKFNQRRISSAKFLGELYNYRMVESAVIFRTLYSFTSFGVNPDGSPSSLDPPE
HLFRIRLVCTILDTCGQYFDRGSSKRKLDCFLVYFQRYVWWKKSLEVWTKDHPFPIDI
DYMISDTLELLRPKIKLCNSLEESIRQVQDLEREFLIKLGLVNDKDSKDSMTEGENLE
EDEEEEEGGAETEEQSGNESEVNEPEEEEGSDNDDDEGEEEEEENTDYLTDSNKENET
DEENTEVMIKGGGLKHVPCVEDEDFIQALDKMMLENLQQRSGESVKVHQLDVAIPLHL
KSQLRKGPPLGGGEGEAESADTMPFVMLTRKGNKQQFKILNVPMSSQLAANHWNQQQA
EQEERMRMKKLTLDINERQEQEDYQEMLQSLAQRPAPANTNRERRPRYQHPKGAPNAD
LIFKTGGRRR"
BASE COUNT 1764 a 925 c 1161 g 1254 t
ORIGIN
1 ccgagcgctg gagttggtgc tgggaaaccc ggggctaatg ttgacaacag gctcgagatt
61 gtcctgggtc acataatgcc agctgagcgt aaaaagccag caagtatgga agaaaaagac
121 tctttaccaa acaacaagga aaaagactgc agtgaaaggc ggacagtgag cagcaaggag
181 aggccaaaag acgatatcaa gctcactgcc aagaaggagg tcagcaaggc ccctgaagac
241 aagaagaaga gactggaaga tgataagaga aaaaaggaag acaaggaacg caagaaaaaa
301 gacgaagaaa aggtgaaggc agaggaagaa tcaaagaaaa aagaagagga agaaaaaaag
361 aaacatcaag aggaagagag aaagaagcaa gaagagcagg ccaaacgtca gcaagaagaa
421 gaagcagctg ctcagatgaa agaaaaagaa gaatccattc agcttcatca ggaagcttgg
481 gaacgacatc atttaagaaa ggaacttcgt agcaaaaacc aaaatgctcc ggacagccga
541 ccagaggaaa acttcttcag ccgcctcgac tcaagtttga agaaaaatac tgcttttgtc
601 aagaaactaa aaactattac agaacaacag agagactcct tgtcccatga ttttaatggc
661 ctaaatttaa gcaaatacat tgcagaagct gtagcttcca tcgtggaagc aaaactaaaa
721 atctctgatg tgaactgtgc tgtgcacctc tgctctctct ttcaccagcg ttatgctgac
781 tttgccccat cacttcttca ggtctggaaa aaacattttg aagcaaggaa agaggagaaa
841 acacctaaca tcaccaagtt aagaactgat ttgcgtttta ttgcagaatt gacaatagtt
901 gggattttca ctgacaagga aggtctttcc ttaatctatg aacagctaaa aaatattatt
961 aatgctgatc gggagtccca cactcatgtc tctgtagtga ttagtttctg tcgacattgt
1021 ggagatgata ttgctggact tgtaccaagg aaagtaaaga gtgctgcaga gaagtttaat
1081 ttgagttttc ctcctagtga gataattagt ccagagaaac aacagccctt ccagaatctt
1141 ttaaaagagt actttacgtc tttgaccaaa cacctgaaaa gggaccacag ggagctccag
1201 aatactgaga gacaaaacag gcgcattcta cattctaaag gggagctcag tgaagataga
1261 cataaacagt atgaggaatt tgctatgtct taccagaagc tgctggcaaa ttctcaatcc
1321 ttagcagacc ttttggatga aaatatgcca gatcttcctc aagacaaacc cacaccagaa
1381 gaacatgggc ctggaattga tatattcaca cctggtaaac ctggagaata tgacttggaa
1441 ggtggtatat gggaagatga agatgctcgg aatttttatg agaacctcat tgatttgaag
1501 gcttttgtcc cagccatctt gtttaaagac aatgaaaaaa gttgtcagaa taaagagtcc
1561 aacaaagatg ataccaaaga ggcaaaagaa tctaaggaga ataaggaggt atcaagtccc
1621 gatgatttgg aacttgagtt ggagaatcta gaaattaatg atgacacctt agaattagag
1681 ggtggagatg aagctgaaga tcttacaaag aaacttcttg atgaacaaga acaagaagat
1741 gaggaagcca gcactggatc tcatctcaag ctcatagtag atgctttcct acagcagtta
1801 cccaactgtg tcaaccgaga tctgatagac aaggcagcaa tggatttttg catgaacatg
1861 aacacaaaag caaacaggaa gaagttggta cgggcactct tcatagttcc tagacaaagg
1921 ttggatttgc taccatttta tgcaagattg gttgctacat tgcatccctg catgtctgat
1981 gtagcagagg atctttgttc catgctgagg ggggatttca gatttcatgt acggaaaaag
2041 gaccagatca atattgaaac aaagaataaa actgttcgtt ttataggaga actaactaag
2101 tttaagatgt tcaccaaaaa tgacacactg cattgtttaa agatgcttct gtcagacttc
2161 tctcatcacc atattgaaat ggcatgcacc ctgctggaga catgtggacg gtttcttttc
2221 agatctccag aatctcacct gaggaccagt gtacttttgg agcaaatgat gagaaagaag
2281 caagcaatgc atcttgatgc gagatacgtc acaatggtag agaatgcata ttactactgc
2341 aacccacctc cagctgaaaa aaccgtgaaa aagaaacgtc ctcctctcca ggaatatgtc
2401 cggaaacttt tgtacaaaga tctctctaag gttaccaccg agaaggtttt gagacagatg
2461 cgaaagctgc cctggcagga ccaagaagtg aaagactatg ttatttgttg tatgataaac
2521 atctggaatg tgaaatataa tagtattcat tgtgtagcca acctcttagc aggactagtg
2581 ctctaccaag aggatgttgg gatccacgtt gtggatggag tgttagaaga tattcgatta
2641 ggaatggagg ttaatcaacc taaatttaat cagaggcgca tcagcagtgc caagttctta
2701 ggagaacttt acaattaccg aatggtggaa tcagctgtta ttttcagaac tctgtattct
2761 tttacctcat ttggtgttaa tcctgatggc tctccaagtt ccctggaccc acctgagcat
2821 cttttcagaa ttagactcgt atgcactatt ctggacacat gtggccagta ctttgacaga
2881 ggttccagta aacgaaaact tgattgtttc cttgtatatt ttcagcgtta tgtttggtgg
2941 aagaaaagtt tggaggtttg gacaaaagac catccatttc ctattgatat agattacatg
3001 atcagtgata cactagaact gctaagacca aagatcaaac tctgtaattc tctggaagaa
3061 tccatcaggc aggtacaaga cttggaacga gaattcttaa taaaactagg cctagtaaat
3121 gacaaagact caaaagattc tatgacagaa ggagaaaatc ttgaagagga tgaagaagaa
3181 gaagaaggtg gggctgaaac agaagaacaa tctggaaatg aaagtgaagt aaatgagcca
3241 gaagaagagg agggttctga taatgatgat gatgagggag aagaagagga ggaagagaat
3301 acagattacc ttacagattc caataaggaa aatgaaaccg atgaagagaa tactgaggta
3361 atgattaaag gcggtggact taagcatgta ccttgtgtag aagatgagga cttcattcaa
3421 gctctggata aaatgatgct agaaaatcta cagcaacgaa gtggtgaatc tgttaaagtg
3481 caccaactag atgtggccat tcctttgcat ctcaaaagcc agctgaggaa agggccccca
3541 ctgggaggtg gggaaggaga ggctgagtct gcagacacaa tgccgtttgt catgttaaca
3601 agaaaaggca ataaacagca gtttaagatc cttaatgtac ccatgtcctc tcaacttgct
3661 gcaaatcact ggaaccagca acaggcagaa caagaagaga ggatgagaat gaagaagctc
3721 acactagata tcaatgaacg gcaagaacaa gaagattatc aagaaatgtt gcagtctctt
3781 gcacagcgcc cagctccagc aaacaccaat cgtgagaggc ggcctcgcta ccaacatccg
3841 aagggagcac ctaatgcaga tctaatcttt aagactggtg ggaggagacg ttgatccagc
3901 agcacgtgtc atttcattag gtcctgtatc tgatgttgtg gttagtggag tcctccagca
3961 attgaatgag agcagtggac acatctcagc aggtcggtct agagagttgc gaatctaaac
4021 ctgggacagg ctggggccag gaggcagaaa caccagcctc tgccaacacc ggaacaagcc
4081 gacgcttcca gacaaggcgg aaaaggcctt ttgtaatgga aatctcgcga gggttaatct
4141 tctcttgaga atggcagtca agaaatgaga tggttcactt gactactgag cagttacacc
4201 aaggagagcg tgaaggagat gattgagcca gagaagaaac gggttgtgat ggtaatggtg
4261 tgggggaaat gaacttgagc tttaaacttg atttgagttt cagtgtctct gaattgaaca
4321 tcccacgttg gaagaagata catttggggg ctccaggact acagtagaaa agtatagagc
4381 aagcaggaaa atcttctagt aaaacttaca tgcaggacaa caaaatgatg aaagatatcc
4441 aaataccaga taatccacca ggaaggcttt tgtttaggaa tttgtttcaa gaggaacaag
4501 ggatgaggga gaaaaatccg ttttatccat cagagtcagt gctataaaat tgcctattaa
4561 ggtaaaagaa aaatgtggag actattttac tatacagaga gcattaattc agatggctta
4621 gaaaagtgat accagcccaa gaacagggat ctaggtgagc ccattgtaag tatcattgaa
4681 aacaaaacat gcccgtcaac atgtcacaga aaacgaacga aggacaacaa gaagtggatg
4741 agaatatttt gttgaccttc atgggtttac agcctctgtc tctaaacaaa gtatggaaac
4801 aagtagagct tttattttgc ttttgttttt gttttgtttt tttttggttt cccccccnaa
4861 aaaaaaaagg ggggccctna tctgnttttn acnanntgnt aanttnttan ggcnncnnnn
4921 tttngnttnc tttncnnccg gnnttntntn tttnatcngn nancccnntt ntttnccana
4981 acctnnttac nttttttttt ttaaccnttt tgcntttttt tttttaccnn ntttnaattt
5041 ntnccttttn anttaaaaaa aaaannaaac ntnnnaaant nnaanntttn nnnnngnaan
5101 ncnncccnan ttttaccnnc tttaaaaant ttaccnttnc ccanncnncn anaaaangnt
5161 nntnttttaa aaaaaaaaaa aaaaaaaaaa aaaaa
//