LOCUS AF316894 1353 bp DNA linear HUM 07-FEB-2001 DEFINITION Homo sapiens alpha 2A adrenergic receptor (ADRA2A) gene, complete cds. ACCESSION AF316894 VERSION AF316894.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1353) AUTHORS Small,K.M., Forbes,S.L., Brown,K.M. and Liggett,S.B. TITLE An asn to lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling JOURNAL J. Biol. Chem. 275 (49), 38518-38523 (2000) PUBMED 10948191 REFERENCE 2 (bases 1 to 1353) AUTHORS Small,K.M., Forbes,S.L., Brown,K.M. and Liggett,S.B. TITLE Direct Submission JOURNAL Submitted (26-OCT-2000) Internal Medicine, University of Cincinnati, 231 Bethesda Ave., Cincinnati, OH 45267, USA FEATURES Location/Qualifiers source 1..1353 /db_xref="H-InvDB:HIT000383906" /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /chromosome="10" gene <1..>1353 /gene="ADRA2A" mRNA <1..>1353 /gene="ADRA2A" /product="alpha 2A adrenergic receptor" CDS 1..1353 /gene="ADRA2A" /note="G-protein coupled receptor" /codon_start=1 /product="alpha 2A adrenergic receptor" /protein_id="AAK01634.1" /translation="MGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLM LLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFG KAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVI SAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVR IYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPKGLGPERSAGPGGAEAEPLPTQLNGA PGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPR RGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFF TYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV " variation 753 /gene="ADRA2A" /note="compared to wild type sequence presented in GenBank Accession Number AF281308; polymorphic sequence encodes Lys at amino acid 251" /frequency="Caucasians 0.004; African-Americans 0.05" /replace="c" BASE COUNT 200 a 489 c 443 g 221 t ORIGIN 1 atgggctccc tgcagccgga cgcgggcaac gcgagctgga acgggaccga ggcgccgggg 61 ggcggcgccc gggccacccc ttactccctg caggtgacgc tgacgctggt gtgcctggcc 121 ggcctgctca tgctgctcac cgtgttcggc aacgtgctcg tcatcatcgc cgtgttcacg 181 agccgcgcgc tcaaggcgcc ccaaaacctc ttcctggtgt ctctggcctc ggccgacatc 241 ctggtggcca cgctcgtcat ccctttctcg ctggccaacg aggtcatggg ctactggtac 301 ttcggcaagg cttggtgcga gatctacctg gcgctcgacg tgctcttctg cacgtcgtcc 361 atcgtgcacc tgtgcgccat cagcctggac cgctactggt ccatcacaca ggccatcgag 421 tacaacctga agcgcacgcc gcgccgcatc aaggccatca tcatcaccgt gtgggtcatc 481 tcggccgtca tctccttccc gccgctcatc tccatcgaga agaagggcgg cggcggcggc 541 ccgcagccgg ccgagccgcg ctgcgagatc aacgaccaga agtggtacgt catctcgtcg 601 tgcatcggct ccttcttcgc tccctgcctc atcatgatcc tggtctacgt gcgcatctac 661 cagatcgcca agcgtcgcac ccgcgtgcca cccagccgcc ggggtccgga cgccgtcgcc 721 gcgccgccgg ggggcaccga gcgcaggccc aagggtctgg gccccgagcg cagcgcgggc 781 ccggggggcg cagaggccga accgctgccc acccagctca acggcgcccc tggcgagccc 841 gcgccggccg ggccgcgcga caccgacgcg ctggacctgg aggagagctc gtcttccgac 901 cacgccgagc ggcctccagg gccccgcaga cccgagcgcg gtccccgggg caaaggcaag 961 gcccgagcga gccaggtgaa gccgggcgac agcctgccgc ggcgcgggcc gggggcgacg 1021 gggatcggga cgccggctgc agggccgggg gaggagcgcg tcggggctgc caaggcgtcg 1081 cgctggcgcg ggcggcagaa ccgcgagaag cgcttcacgt tcgtgctggc cgtggtcatc 1141 ggagtgttcg tggtgtgctg gttccccttc ttcttcacct acacgctcac ggccgtcggg 1201 tgctccgtgc cacgcacgct cttcaaattc ttcttctggt tcggctactg caacagctcg 1261 ttgaacccgg tcatctacac catcttcaac cacgatttcc gccgcgcctt caagaagatc 1321 ctctgtcggg gggacaggaa gcggatcgtg tga //