LOCUS AF315325 1608 bp mRNA linear HUM 07-FEB-2001
DEFINITION Homo sapiens cytochrome P450 variant 3A7 (CYP3A7) mRNA, complete
cds.
ACCESSION AF315325
VERSION AF315325.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1608)
AUTHORS Finta,C. and Zaphiropoulos,P.G.
TITLE The human cytochrome P450 3A locus. Gene evolution by capture of
downstream exons
JOURNAL Gene 260 (1-2), 13-23 (2000)
PUBMED 11137287
REFERENCE 2 (bases 1 to 1608)
AUTHORS Finta,C. and Zaphiropoulos,P.G.
TITLE Direct Submission
JOURNAL Submitted (23-OCT-2000) Department of Biosciences, Karolinska
Institute, NOVUM, Huddinge 14157, Sweden
FEATURES Location/Qualifiers
source 1..1608
/db_xref="H-InvDB:HIT000077140"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7q21-q22.1"
gene 1..1608
/gene="CYP3A7"
CDS 1..1608
/gene="CYP3A7"
/note="mono-oxygenase"
/codon_start=1
/product="cytochrome P450 variant 3A7"
/protein_id="AAG48618.1"
/translation="MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPL
PFLGNALSFRKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVF
TNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNL
RREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDP
FVLSIKVFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMI
DSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKE
IDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGV
VVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALV
NMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESRDETFVDMEPIHM
DFLRSLAFQGPHLCFFWELLCPTIRSR"
misc_feature 1498..1599
/gene="CYP3A7"
/note="originates from cytochrome P450 3A pseudogene
(CYP3AP1) exon 2"
misc_feature 1600..1608
/gene="CYP3A7"
/note="originates from cytochrome P450 3A pseudogene
(CYP3AP1) exon 13"
BASE COUNT 475 a 361 c 336 g 436 t
ORIGIN
1 atggatctca tcccaaactt ggccgtggaa acctggcttc tcctggctgt cagcctgata
61 ctcctctatc tatatggaac ccgtacacat ggacttttta agaagcttgg aattccaggg
121 cccacacctc tgcctttttt gggaaatgct ttgtccttcc gtaagggcta ttggacgttt
181 gacatggaat gttataaaaa gtatagaaaa gtctggggta tttatgactg tcaacagcct
241 atgctggcta tcacagatcc cgacatgatc aaaacagtgc tagtgaaaga atgttattct
301 gtcttcacaa accggaggcc tttcgggcca gtgggattta tgaaaaatgc catctctata
361 gctgaggatg aagaatggaa gagaatacga tcattgctgt ctccaacatt caccagcgga
421 aaactcaagg agatggtccc tatcattgcc cagtatggag atgtgttggt gagaaatctg
481 aggcgggaag cagagacagg caagcctgtc accttgaaac acgtctttgg ggcctacagc
541 atggatgtga tcactagcac atcatttgga gtgagcatcg actctctcaa caatccacaa
601 gacccctttg tggaaaacac caagaagctt ttaagattta atccattaga tccattcgtt
661 ctctcaataa aagtctttcc attccttacc ccaattcttg aagcattaaa tatcactgtg
721 tttccaagaa aagttataag ttttctaaca aaatctgtaa aacagataaa agaaggtcgc
781 ctcaaagaga cacaaaagca ccgagtggat ttccttcagc tgatgattga ctctcagaat
841 tcaaaagact ctgagaccca caaagctctg tctgatctgg agctcatggc ccaatcaatt
901 atctttattt ttgctggcta tgaaaccacg agcagtgttc tctccttcat tatatatgaa
961 ctggccactc accctgatgt ccagcagaaa gtgcagaagg aaattgatac agttttaccc
1021 aataaggcac cacccaccta tgatactgtg ctacagttgg agtatcttga catggtggtg
1081 aatgaaacac tcagattatt cccagttgct atgagacttg agagggtctg caaaaaagat
1141 gttgaaatca atgggatgtt tattcccaaa ggggtggtgg tgatgattcc aagctatgtt
1201 cttcatcatg acccaaagta ctggacagag cctgagaagt tcctccctga aaggttcagt
1261 aaaaagaaca aggacaacat agatccttac atatacacac cctttggaag tggacccaga
1321 aactgcattg gcatgaggtt tgctctcgtg aacatgaaac ttgctctagt cagagtcctt
1381 cagaacttct ccttcaaacc ttgtaaagaa acacagatcc ccctgaaatt acgctttgga
1441 ggacttcttc taacagaaaa acccattgtt ctaaaggctg agtcaaggga tgagaccttt
1501 gtagatatgg agcccattca catggacttt ttaagaagct tggcattcca gggcccacac
1561 ctctgctttt tttgggaact actttgtcct accatcagat cccgctga
//