LOCUS AF314142 3190 bp mRNA linear HUM 19-APR-2002
DEFINITION Homo sapiens apical protein 2 (APXL2) mRNA, complete cds.
ACCESSION AF314142
VERSION AF314142.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3190)
AUTHORS Karlen,S., Staub,O., Rohrbach,B. and Braathen,L.R.
TITLE The cytoplasmic tail of the melanoma cell adhesion molecule MCAM
mediates selective binding of APXL2, a new member of the Apx/Shroom
actin-binding protein family
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 3190)
AUTHORS Karlen,S., Staub,O., Rohrbach,B. and Braathen,L.R.
TITLE Direct Submission
JOURNAL Submitted (16-OCT-2000) Dermatological Clinic, Inselspital,
Freiburgstrasse, Berne 3010, Switzerland
FEATURES Location/Qualifiers
source 1..3190
/db_xref="H-InvDB:HIT000077095"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="brain"
gene 1..3190
/gene="APXL2"
CDS 171..2714
/gene="APXL2"
/note="member of the Apx/Shrm family comprised of Xenopus
laevis Apx, Mus musculus Shrm and Homo sapiens APXL
proteins"
/codon_start=1
/product="apical protein 2"
/protein_id="AAM15526.1"
/translation="MEALGPGGDRASPASSTSSLDLWHLSMRADSAYSSFSAASGGPE
PRTQSPGTDLLPYLDWDYVRVVWGGPGPAPPDAALCTSPRPRPAVAARSGPQPTEVPG
TPGPLNRQATPLLYALAAEAEAAAQAVEPPSPPASRAAYRQRLQGAQRRVLRETSFQR
KELRMSLPARLRPTVPARPPATHPRSASLSHPGGEGEPARSRAPAPGTAGRGPLANQQ
RKWCFSEPGKLDRVGRGGGPARECLGEACSSSGLPGPEPLEFQHPALAKFEDHEVGWL
PETQPQGSMNLDSGSLKLGDAFRPASRSRSASGEVLGSWGGSGGTIPIVQAVPQGAET
PRPLFQTKLSRFLPQKEAAVMYPAELPQSSPADSEQRVSETCIVPAWLPSLPDEVFLE
EAPLVRMRSPPDPHASQGPPASVHASDQPYGTGLGQRTGQVTVPTEYPLHECPGTAGA
DDCWQGVNGSVGISRPTSHTPTGTANDNIPTIDPTGLTTNPPTAAESDLLKPVPADAL
GLSGNDTPGPSHNTALARGTGQPGSRPTWPSQCLEELVQELARLDPSLCDPLASQPSP
EPPLGLLDGLIPLAEVRAAMRPACGEAGEEAASTFEPGSYQFSFTQLLPAPREETRLE
NPATHPVLDQPCGQGLPAPNNSIQGKKVELAARLQKMLQDLHTEQERLQGEAQAWARR
QAALEAAVRQACAPQELERFSRFMADLERVLGLLLLLGSRLARVRRALARAASDSDPD
EQRLRLLQRQEEDAKELKEHVARRERAVREVLVRALPVEELRVYCALLAGKAAVLAQQ
RNLDERIRLLQDQLDAIRDDLGHHAPSPSPARPPGTCPPVQPPFPLLLT"
misc_feature 591..869
/gene="APXL2"
/note="conserved in Apx/Shrm family members; Region: ASD1
domain"
misc_feature 2106..2627
/gene="APXL2"
/note="conserved in Apx/Shrm family members; Region: ASD2
domain"
BASE COUNT 588 a 1067 c 996 g 539 t
ORIGIN
1 agcgcttgtg acggtgtgac cagggagggg aagtgtaagt gtctggccgt ccgtggtggc
61 ggggccagca ggctgtccca gccctcaccc ggagctcctc acccggcacc acatctgtgt
121 tttcccagga cccacgcagc cacccagcct cagcactcat ctgcgcagcc atggaggccc
181 tgggacctgg gggcgaccgc gcctccccgg cctcgtccac tagcagcctg gacctgtggc
241 atctgtccat gcgcgcggac tcggcctaca gctctttctc cgcagcctcc ggcggccccg
301 agccgcgcac gcagtcgccg gggacagacc tccttcctta cctagactgg gactacgtgc
361 gtgtggtttg gggcggcccg ggccccgccc cgcccgacgc tgccctttgc acatccccgc
421 ggccccggcc cgcggttgca gcccgcagtg ggccgcagcc aacagaggtc ccggggaccc
481 cgggaccact gaacaggcag gccaccccgc tgctgtacgc gctggcggcc gaggcggagg
541 ccgcggcgca ggctgtcgag ccgcccagcc cgccggcctc gagggccgcc taccgccagc
601 ggcttcaggg cgcgcagcgg cgagtgctcc gggagacgtc gttccagcgc aaggagctcc
661 gcatgagcct gcccgcccgt ctgcggccca ctgtcccagc gcggcccccg gcgactcacc
721 cgcgctccgc ctcgctcagc cacccgggcg gggaggggga gccggcgcgc tcccgggctc
781 ccgcgccagg aactgccggc cggggtcccc tcgccaacca gcagcggaag tggtgcttct
841 cagagccagg aaagctggat cgtgtgggtc ggggcggtgg gccggcgcgg gaatgcctgg
901 gtgaggcctg ctccagctct ggcctccctg ggcccgagcc cttggagttc cagcatccgg
961 cgctggctaa gtttgaagat cacgaggtcg gatggctgcc cgagacgcaa ccccaaggct
1021 ccatgaacct ggactccggg tccttgaagc tcggtgatgc cttcaggccc gccagtcgga
1081 gtcggagcgc ttcaggcgaa gtcttgggtt cctggggagg atcaggaggg accataccca
1141 ttgtccaggc tgttccccaa ggagcagaaa cccccagacc attgtttcag accaaacttt
1201 ccaggttctt gcctcagaaa gaggctgcgg tgatgtatcc tgcagagtta ccccagagca
1261 gccctgctga cagtgaacag agggtctcag agacctgcat tgtgcctgcc tggctcccct
1321 cccttcctga tgaagtgttc ctagaagagg ccccactggt cagaatgaga tcaccaccag
1381 acccccatgc ctcccagggg cccccagcca gtgtccatgc ctctgaccag ccgtatggaa
1441 ctggcttagg ccaaagaact ggccaggtta cagtccccac ggagtacccg ctccatgagt
1501 gtccaggaac tgcaggggca gatgactgct ggcagggggt gaatggttct gtaggtattt
1561 ccaggcccac aagccacacc cccactggga ctgcaaatga taacatccca actattgacc
1621 ccactggact gaccaccaat ccccccacag ctgcagagag tgacctcctc aaacctgtcc
1681 cagctgatgc cttgggactt tcaggcaatg atactccagg tccctctcac aatactgccc
1741 tagccagggg cactggccag cctggttcca ggcccacatg gcctagtcag tgcctcgagg
1801 agctggttca ggagctggcc agattagatc cctctctatg tgaccctctt gcttcccagc
1861 ccagcccaga gccacccctg ggcctgctgg atggactgat tcctttagca gaggtccggg
1921 ctgcaatgcg gcctgcctgt ggggaggctg gagaggaggc tgccagtact tttgagccag
1981 ggtcctatca gttcagcttc acccagctcc tgccggctcc tcgggaggag acaaggcttg
2041 aaaaccctgc cacccaccct gtgcttgacc agccatgtgg gcaggggctc cctgcaccaa
2101 acaacagcat ccagggcaag aaagtggagc tggccgcccg cctccaaaag atgcttcagg
2161 accttcacac ggagcaggag cggctgcagg gggaggcaca agcatgggcc aggcgccaag
2221 cggctctgga ggctgcagtg cgccaggcct gtgcccctca ggagctggag cggttcagcc
2281 ggttcatggc cgacctagag cgcgtgcttg gccttctgct gctgctgggc agtcgcctgg
2341 cgcgcgtgcg ccgcgccctg gcccgggcgg cctcagacag cgaccctgat gagcagcgac
2401 tccggctcct gcagcggcag gaggaggacg ccaaggagct gaaggagcac gtagcgcggc
2461 gcgagcgggc cgtgcgggag gtgctggtgc gagcactacc ggtggaggag ctgcgcgtct
2521 attgcgccct gctggcgggc aaggccgccg tcctggccca gcagcgcaac ctggacgagc
2581 gcatccgcct ccttcaggac caactggacg ccatcaggga cgaccttggc catcatgccc
2641 cgtctcccag cccggcgcgg cccccaggga cctgtcctcc agttcagccg cccttccctc
2701 ttctccttac atagttatag gtggagaggg tggggtgcac cgcccctatc tctcacccac
2761 gtaagtgggg tgatgctgat ttagtctctg cttttccctt gagggattgg ggaggaccca
2821 gtccaggcct ttctaagata ctcctccagc cgggcgcggt ggctcacgcc tgtaatccca
2881 gcactttggg aggccgaggc gggcggatca caaggtcagg agatcgagac catcctggct
2941 aacacggtga aaccccgtct ctactaaaaa tataaaaaat tagccgggcg tggtggcggg
3001 tgcctgtatt gccagctact cggaaggctg aggcaggaga atggcgtgaa cctgggaggt
3061 ggagcttgca gtgagcggac atcgcgccac tgcactccag cctgggcgac agagcaagac
3121 tccgtctcaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaga tacttctcca aagtgttctc
3181 atgtggcctc
//