LOCUS AF311856 2450 bp mRNA linear HUM 26-JUN-2001
DEFINITION Homo sapiens spectrin beta IV (SPTBN3) mRNA, complete cds,
alternatively spliced.
ACCESSION AF311856
VERSION AF311856.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2450)
AUTHORS Tse,W.T., Tang,J., Jin,O., Korsgren,C., John,K.M., Kung,A.L.,
Gwynn,B., Peters,L.L. and Lux,S.E.
TITLE A new spectrin, beta IV, has a major truncated isoform that
associates with promyelocytic leukemia protein nuclear bodies and
the nuclear matrix
JOURNAL J. Biol. Chem. 276 (26), 23974-23985 (2001)
PUBMED 11294830
REFERENCE 2 (bases 1 to 2450)
AUTHORS Tse,W.T., Tang,J., Jin,O., Korsgren,C., John,K.M., Gwynn,B.,
Peters,L.L. and Lux,S.E.
TITLE Direct Submission
JOURNAL Submitted (06-OCT-2000) Division of Hematology/Oncology, Children's
Hospital, 300 Longwood Ave., Boston, MA 02115, USA
FEATURES Location/Qualifiers
source 1..2450
/db_xref="H-InvDB:HIT000077016"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19q13.13-q13.2"
gene 1..2450
/gene="SPTBN3"
exon 1..103
/gene="SPTBN3"
/number=18a
exon 104..250
/gene="SPTBN3"
/number=19
CDS 128..2164
/gene="SPTBN3"
/note="77 kDa isoform"
/codon_start=1
/product="spectrin beta IV"
/protein_id="AAG42474.1"
/translation="MLMARDSTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQ
QLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKL
LHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKE
LVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTE
RGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQ
SAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQ
LLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELG
EERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFAS
ETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAA
SRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQ
VRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFH
SQVRDLLSWMDGIASQIGAADKPRCPSSLLGLPASPWWPTPATPSPLTAPFSME"
misc_feature 149..379
/gene="SPTBN3"
/note="B&C helices; Region: spectrin repeat"
misc_feature 380..694
/gene="SPTBN3"
/note="Region: spectrin repeat"
misc_feature 695..1012
/gene="SPTBN3"
/note="Region: spectrin repeat"
misc_feature 1013..1330
/gene="SPTBN3"
/note="Region: spectrin repeat"
misc_feature 1331..1651
/gene="SPTBN3"
/note="Region: spectrin repeat"
misc_feature 1652..1975
/gene="SPTBN3"
/note="putative ankyrin binding; Region: spectrin repeat"
misc_feature 1976..2071
/gene="SPTBN3"
/note="A helix; Region: spectrin repeat"
misc_feature 2072..2161
/gene="SPTBN3"
/note="Region: proline-rich C-ter domain"
exon 251..514
/gene="SPTBN3"
/number=20
exon 515..739
/gene="SPTBN3"
/number=21
exon 740..829
/gene="SPTBN3"
/number=22
exon 830..1108
/gene="SPTBN3"
/number=23
exon 1109..1239
/gene="SPTBN3"
/number=24
exon 1240..1444
/gene="SPTBN3"
/number=25
exon 1445..1825
/gene="SPTBN3"
/number=26
exon 1826..2070
/gene="SPTBN3"
/number=27
BASE COUNT 509 a 691 c 863 g 387 t
ORIGIN
1 ggagcctcag ccttcgccgc cgctgccgct gccgtcgcag ttgaggggcg agcacccgcc
61 cgcccgctgc agggacgccc cgccaacgcc actgccactt cagctggatg gctggatcca
121 tgagaagatg ctgatggcgc gggatagcac gcgggaggac aaccacaagc tgcataagag
181 atggctccgg caccaggcat tcatggccga gctggctcag aataaggagt ggctggagaa
241 gatcgagcgg gagggccagc aactgatgca ggagaagccc gaactggcgg cctccgtgcg
301 gaagaagctg ggcgagatcc gccagtgctg ggcggagctg gagagcacca cccaggccaa
361 ggcacggcag ctctttgagg ccagcaaagc agaccagctg gtgcagagct ttgctgagct
421 ggacaagaag ctccttcaca tggagagcca gctgcaagac gtggaccctg gaggagacct
481 ggccactgtc aacagtcagc tcaagaagct gcagtccatg gagtcgcagg tggaggagtg
541 gtaccgcgag gtgggagagc tgcaggcgca gacggcggcg ctgccgctgg agccggcgag
601 caaggagctg gtgggtgagc ggcagaacgc ggtgggcgag cgcctggtgc gcctgctcga
661 gccgttgcag gagcgccgcc gcttgctgct ggcttccaag gagttgcacc aggtggcgca
721 cgacctggac gacgagctgg catgggttca ggagcggctg ccactggcca tgcagacaga
781 gcgaggcaac ggtttgcagg cggtccagca gcacatcaaa aagaaccagg gcctgcggcg
841 ggagatccag gcgcatgggc cgcgcctgga ggaggtgctg gagcgcgcgg gcgcgctggc
901 gtcgctgcgc agcccggagg cagaggcagt gcgccggggc ctggagcagc tgcagagcgc
961 ctgggccgga ctgcgggagg ctgccgagcg acggcagcag gtgctggacg ccgccttcca
1021 ggtggagcag tactacttcg acgtggctga ggtggaggcg tggctgggcg agcaggagct
1081 gctcatgatg agtgaggaca agggcaagga cgaacagagc accctgcagc tgctcaagaa
1141 acacctgcag ctggagcaag gcgtggagaa ctacgaggaa agcatcgcgc agctgtcgcg
1201 ccagtgccgg gcgctgctgg agatggggca cccggacagc gagcagatca gccggcggca
1261 gtctcaggtg gaccgcctgt acgtggcgct caaggagctg ggtgaggagc gccgggtggc
1321 tctggaacag cagtactggc tgtaccagct cagccgccag gtgagcgagc ttgagcactg
1381 gattgccgag aaggaggtgg tggctggctc acccgagctc ggccaggact ttgagcatgt
1441 ctcggtgctg caggagaaat tctcagagtt tgccagcgag acaggtatgg cagggcggga
1501 acggctggca gctgtgaacc agatggtgga tgagctgatc gagtgtggcc atacagcagc
1561 ggccaccatg gccgagtgga aggacggact gaacgaggcc tgggctgagc tgctggagct
1621 catgggcaca cgggcccagc tgctggccgc ctctcgggag cttcataagt tcttcagtga
1681 cgcccgagag cttcagggac agattgagga gaagcggagg cggctgcccc gcctgaccac
1741 cccgcctgag ccgagaccca gtgccagttc catgcagcgg accctgagag cctttgagca
1801 tgacctgcag ctcctcgtgt cccaggtacg gcagctgcag gagggggcgg cccagctgcg
1861 gacggtgtat gcgggtgaac atgccgaggc catcgctagc cgggagcagg aggtgctgca
1921 gggttggaaa gagctgctgt cagcctgtga ggatgcccgc ctgcatgtca gctccacagc
1981 cgacgccctg cgcttccaca gccaagtccg cgacctgctc tcctggatgg atggcatcgc
2041 cagccagatt ggggcagccg acaagcccag gtgcccctca tccctcctcg ggcttcctgc
2101 ctccccctgg tggcctaccc cagccacccc cagcccattg acagccccct tctcaatgga
2161 atgacaacag ccaatatctg tgtggcgcct ctgtgtgcta ggcactgttc taggtgcttc
2221 gtgtgtattc agaccccttt tttaggcctg tcattgggga cttcggtcat ggggcatcct
2281 tctgtccgct gtccttccca gttgcctatt attaccctct ccatgggatg tcacagcatg
2341 aaacaggcta aagacaggat gggcaaggga ggtgtgggac tgtatttgtg agggtgggtg
2401 aagaattcta acaattccaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//