LOCUS AF310972 2529 bp mRNA linear HUM 23-FEB-2001
DEFINITION Homo sapiens 3-methylcrotonyl-CoA carboxylase alpha subunit (MCCA)
mRNA, complete cds.
ACCESSION AF310972
VERSION AF310972.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2529)
AUTHORS Gallardo,M.E., Desviat,L.R., Rodriguez,J.M., Esparza-Gordillo,J.,
Perez-Cerda,C., Perez,B., Rodriguez-Pombo,P., Criado,O., Sanz,R.,
Morton,D.H., Gibson,K.M., Le,T.P., Ribes,A., Rodriguez de
Cordoba,S., Ugarte,M. and Penalva,M.A.
TITLE The molecular basis of 3-methylcrotonylglycinuria, a disorder of
leucine catabolism
JOURNAL Am. J. Hum. Genet. 68 (2), 334-346 (2001)
PUBMED 11170888
REFERENCE 2 (bases 1 to 2529)
AUTHORS Penalva,M.A., Rodriguez,J.M., Gallardo,M.E., Esparza,J.,
Ruiz-Desviat,L., Perez-Cerda,C., Perez,B., Rodriguez-Pombo,P.,
Ugarte,M. and Rodriguez de Cordoba,S.
TITLE Direct Submission
JOURNAL Submitted (04-OCT-2000) Microbiologia Molecular, Centro de
Investigaciones Biologicas CSIC, Velazquez 144, Madrid 28006, Spain
FEATURES Location/Qualifiers
source 1..2529
/db_xref="H-InvDB:HIT000076996"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3p11.2-p13"
gene 1..2529
/gene="MCCA"
CDS 134..2311
/gene="MCCA"
/EC_number="6.4.1.4"
/note="biotin carboxylase"
/codon_start=1
/product="3-methylcrotonyl-CoA carboxylase alpha subunit"
/protein_id="AAG53095.1"
/translation="MAAASAVSVLLVAAERNRWHRLPSLLLPPRTWVWRQRTMKYTTA
TGRNITKVLIANRGEIACRVMRTAKKLGVQTVAVYSEADRNSMHVDMADEAYSIGPAP
SQQSYLSMEKIIQVAKTSAAQAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIRDM
GIKSTSKSIMAAAGVPVVEGYHGEDQSDQCLKEHARRIGYPVMIKAVRGGGGKGMRIV
RSEQEFQEQLESARREAKKSFNDDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDC
SVQRRHQKIIEEAPAPGIKSEVRKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFM
EMNTRLQVEHPVTEMITGTDLVEWQLRIAAGEKIPLSQEEITLQGHAFEARIYAEDPS
NNFMPVAGPLVHLSTPRADPSTRIETGVRQGDEVSVHYDPMIAKLVVWAADRQAALTK
LRYSLRQYNIVGLHTNIDFLLNLSGHPEFEAGNVHTDFIPQHHKQLLLSRKAAAKESL
CQAALGLILKEKAMTDTFTLQAHDQFSPFSSSSGRRLNISYTRNMTLKDGKNNVAIAV
TYNHDGSYSMQIEDKTFQVLGNLYSEGDCTYLKCSVNGVASKAKLIILENTIYLFSKE
GSIEIDIPVPKYLSSVSSQETQGGPLAPMTGTIEKVFVKAGDKVKAGDSLMVMIAMKM
EHTIKSPKDGTVKKVFYREGAQANRHTPLVEFEEEESDKRESE"
BASE COUNT 733 a 536 c 658 g 602 t
ORIGIN
1 gcccaaaggt aggctcaggc tccgacggtg gccggcgggg gtcacgaggc ttcgtagtgg
61 aggaacgggt ttggcgtgtg ggacgcagct gcctctgtac tggggagtca cggagtggcc
121 gggctccagg gacatggcgg cggcctctgc ggtgtcggtg ctgctggtgg cggcggagag
181 gaaccggtgg catcgtctcc cgagcctgct cctgccgccg aggacatggg tgtggaggca
241 aagaaccatg aagtacacaa cagccacagg aagaaacatt accaaggtcc tcattgcaaa
301 cagaggagaa attgcctgca gggtgatgcg cacagccaaa aaactgggtg tacagactgt
361 ggcggtttat agtgaggctg acagaaattc catgcatgta gatatggcag atgaagcata
421 ttccatcggc cccgctccct cccagcagag ctacctatct atggagaaaa tcattcaagt
481 ggccaagacc tctgctgcac aggctatcca tccaggatgc ggttttcttt cagaaaacat
541 ggaatttgct gaactttgta agcaagaagg aattattttt ataggccctc ctccatctgc
601 aattagagac atgggtataa agagcacatc caaatccata atggctgctg ctggagtacc
661 tgttgtggag ggttatcatg gtgaggacca atcagaccag tgcctgaagg aacacgccag
721 gagaattggc tatcctgtca tgattaaagc cgtccggggt ggaggaggaa aaggaatgag
781 gattgttaga tcagaacaag aatttcaaga acagttagag tcagcacgga gagaagctaa
841 gaagtctttc aatgatgatg ctatgctgat cgagaagttt gtagacacac cgaggcatgt
901 agaagtccag gtgtttggtg atcaccatgg caatgctgtg tacttgtttg aaagagactg
961 tagtgtgcag aggcgacatc agaagatcat tgaggaggcc ccagcgcctg gtattaaatc
1021 tgaagtaaga aaaaagctgg gagaagctgc agtcagagct gctaaagctg taaattatgt
1081 tggagcaggg actgtggagt ttattatgga ctcaaaacat aatttctgtt tcatggagat
1141 gaatacaagg ctgcaagtgg aacatcctgt tactgagatg atcacaggaa ctgacttggt
1201 ggagtggcag cttagaattg cagcaggaga gaagattcct ttgagccagg aagaaataac
1261 tctgcagggc catgccttcg aagctagaat atatgcagaa gatcctagca ataacttcat
1321 gcctgtggca ggcccattag tgcacctctc tactcctcga gcagaccctt ccaccaggat
1381 tgaaactgga gtacggcaag gagacgaagt ttccgtgcat tatgacccca tgattgcgaa
1441 gctggtcgtg tgggcagcag atcgccaggc ggcattgaca aaactgaggt acagccttcg
1501 tcagtacaat attgttggac tgcacaccaa cattgacttc ttactcaacc tgtctggcca
1561 cccagagttt gaagctggga acgtgcacac tgatttcatc cctcaacacc acaaacagtt
1621 gttgctcagt cggaaggctg cagccaaaga gtctttatgc caggcagccc tgggtctcat
1681 cctcaaggag aaagccatga ccgacacttt cactcttcag gcacatgatc aattctctcc
1741 attttcgtct agcagtggaa gaagactgaa tatctcgtat accagaaaca tgactcttaa
1801 agatggtaaa aacaatgtag ccatagctgt aacgtataac catgatgggt cttatagcat
1861 gcagattgaa gataaaactt tccaagtcct tggtaatctt tacagcgagg gagactgcac
1921 ttacctgaaa tgttctgtta atggagttgc tagtaaagcg aagctgatta tcctggaaaa
1981 cactatttac ctattttcca aggaaggaag tattgagatt gacattccag tccccaaata
2041 cttatcttct gtgagctcac aagaaactca gggcggcccc ttagctccta tgactggaac
2101 cattgaaaag gtgtttgtca aagctggaga caaagtgaaa gcgggagatt ccctcatggt
2161 tatgatcgcc atgaagatgg agcataccat aaagtctcca aaggatggca cagtaaagaa
2221 agtgttctac agagaaggtg ctcaggccaa cagacacact cctttagtcg agtttgagga
2281 ggaagaatca gacaaaaggg aatcggaata aactccagca aggaaatggc cagttaagta
2341 gtgtcttctc tctccaccaa aaagaggaag tgcctccagc ttttctgggg gtctcataaa
2401 gagcagtttt actaaatgat tgtatgctta tgctgaacac ctttcatatt ggagaatcat
2461 gcatttgggt cactaattat ctcaaaatat ttcatactaa taaagttgaa ttatttttta
2521 ttggaagcc
//