LOCUS       AF310971                2170 bp    mRNA    linear   HUM 23-FEB-2001
DEFINITION  Homo sapiens 3-methylcrotonyl-CoA carboxylase beta subunit (MCCB)
            mRNA, complete cds.
ACCESSION   AF310971
VERSION     AF310971.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2170)
  AUTHORS   Gallardo,M.E., Desviat,L.R., Rodriguez,J.M., Esparza-Gordillo,J.,
            Perez-Cerda,C., Perez,B., Rodriguez-Pombo,P., Criado,O., Sanz,R.,
            Morton,D.H., Gibson,K.M., Le,T.P., Ribes,A., Rodriguez de
            Cordoba,S., Ugarte,M. and Penalva,M.A.
  TITLE     The molecular basis of 3-methylcrotonylglycinuria, a disorder of
            leucine catabolism
  JOURNAL   Am. J. Hum. Genet. 68 (2), 334-346 (2001)
   PUBMED   11170888
REFERENCE   2  (bases 1 to 2170)
  AUTHORS   Penalva,M.A., Rodriguez,J.M., Gallardo,M.E., Esparza,J.,
            Ruiz-Desviat,L., Perez-Cerda,C., Perez,B., Rodriguez-Pombo,P.,
            Ugarte,M. and Rodriguez de Cordoba,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2000) Microbiologia Molecular, Centro de
            Investigaciones Biologicas CSIC, Velazquez 144, Madrid 28006, Spain
FEATURES             Location/Qualifiers
     source          1..2170
                     /db_xref="H-InvDB:HIT000076995_03"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q12-q13"
     gene            1..2170
                     /gene="MCCB"
     CDS             121..1812
                     /gene="MCCB"
                     /EC_number="6.4.1.4"
                     /note="biotin carboxylase"
                     /codon_start=1
                     /product="3-methylcrotonyl-CoA carboxylase beta subunit"
                     /protein_id="AAG53094.1"
                     /translation="MWAVLRLALRPCARASPAGPRAYHGDSVASLGTQPDLGSALYQE
                     NYKQMKALVNQLHERVEHIKLGGGEKARALHISRGKLLPRERIDNLIDPGSPFLELSQ
                     FAGYQLYDNEEVPGGGIITGIGRVSGVECMIIANDATVKGGAYYPVTVKKQLRAQEIA
                     MQNRLPCIYLVDSGGAYLPRQADVFPDRDHFGRTFYNQAIMSSKNIAQIAVVMGSCTA
                     GGAYVPAMADENIIVRKQGTIFLAGPPLVKAATGEEVSAEDLGGADLHCRKSGVSDHW
                     ALDDHHALHLTRKVVRNLNYQKKLDVTIEPSEEPLFPADELYGIVGANLKRSFDVREV
                     IARIVDGSRFTEFKAFYGDTLVTGFARIFGYPVGIVGNNGVLFSESAKKGTHFVQLCC
                     QRNIPLLFLQNITGFMVGREYEAEGIAKDGAKMVAAVACAQVPKITLIIGGSYGAGNY
                     GMCGRAYSPRFLYIWPNARISVMGGEQAANVLATITKDQRAREGKQFSSADEAALKEP
                     IIKKFEEEGNPYYSSARVWDDGIIDPADTRLVLGLSFSAALNAPIEKTDFGIFRM"
BASE COUNT          597 a          465 c          545 g          563 t
ORIGIN      
        1 gaagccttct ctggggctgc aaggacctga gctcagcttc cgccccagcc agggaagcgg
       61 caggggaaag caccggctcc aggccagcgt gggccgctct ctcgctcggt gcccgccgcc
      121 atgtgggccg tcctgaggtt agccctgcgg ccgtgtgccc gcgcctctcc cgccgggccg
      181 cgcgcctatc acggggactc ggtggcctcg ctgggcaccc agccggactt gggctctgcc
      241 ctctaccagg agaactacaa gcagatgaaa gcactagtaa atcagctcca tgaacgagtg
      301 gagcatataa aactaggagg tggtgagaaa gcccgagcac ttcacatatc aagaggaaaa
      361 ctattgccca gagaaagaat tgacaatctc atagacccag ggtctccatt tctggaatta
      421 tcccagtttg caggttacca gttatatgac aatgaggagg tgccaggagg tggcattatt
      481 acaggcattg gaagagtatc aggagtagaa tgcatgatta ttgccaatga tgccaccgtc
      541 aaaggaggtg cctactaccc agtgactgtg aaaaaacaat tacgggccca agaaattgcc
      601 atgcaaaaca ggctcccctg catctactta gttgattcgg gaggagcata cttacctcga
      661 caagcagatg tgtttccaga tcgagaccac tttggccgta cattctataa tcaggcaatt
      721 atgtcttcta aaaatattgc acagatcgca gtggtcatgg gctcctgcac cgcaggagga
      781 gcctatgtgc ctgccatggc tgatgaaaac atcattgtac gcaagcaggg taccattttc
      841 ttggcaggac cccccttggt taaagcggca actggggaag aagtatctgc tgaggatctt
      901 ggaggtgctg atcttcattg cagaaagtct ggagtaagtg accactgggc tttggatgat
      961 catcatgccc ttcacttaac taggaaggtt gtgaggaatc taaattatca gaagaaattg
     1021 gatgtcacca ttgaaccttc tgaagagcct ttatttcctg ctgatgaatt gtatggaata
     1081 gttggtgcta accttaagag gagctttgat gtccgagagg tcattgctag aatcgtggat
     1141 ggaagcagat tcactgagtt caaagccttt tatggagaca cattagttac aggatttgct
     1201 cgaatatttg ggtacccagt aggtatcgtt ggaaacaacg gagttctctt ttctgaatct
     1261 gcaaaaaagg gtactcactt tgtccagtta tgctgccaaa gaaatattcc tctgctgttc
     1321 cttcaaaaca ttactggatt tatggttggt agagagtatg aagctgaagg aattgccaag
     1381 gatggtgcca agatggtggc cgctgtggcc tgtgcccaag tgcctaagat aaccctcatc
     1441 attgggggct cctatggagc cggaaactat gggatgtgtg gcagagcgta tagcccaaga
     1501 tttctctaca tttggccaaa tgctcgtatc tcagtgatgg gaggagagca ggcagccaat
     1561 gtgttggcca cgataacaaa ggaccaaaga gcccgggaag gaaagcagtt ctccagtgct
     1621 gatgaagcgg ctttaaaaga gcccatcatt aagaagtttg aagaggaagg aaacccttac
     1681 tattccagcg caagggtatg ggatgatggg atcattgatc cagcagacac cagactggtc
     1741 ttgggtctca gttttagtgc agccctcaac gcaccaatag agaagactga cttcggtatc
     1801 ttcaggatgt aactggaata aaggatgttt tctgttggac atgtactgaa aattaacaca
     1861 tgtagtagcc ttaaaatttt agacttctcg aacatgaggc tgttacagta atttttttaa
     1921 cactgtgcat tgtacttttc taccttaaaa aaatcagtga ggatatttat ttaatgaaca
     1981 tcaattcctt ttaaattttc ttagagaaat ttctctgtgg ctcagtttta ccacccataa
     2041 agcggagaca gtaatttatg gttatccttt ctgacccaca aagtatgaaa agttctgtaa
     2101 tctgtaaact cagttctgta atctgtatta ttgagatgat taatataaag ttgtattttc
     2161 actgaaaatg
//