LOCUS       AF304431                2509 bp    mRNA    linear   HUM 29-DEC-2000
DEFINITION  Homo sapiens hypoxia-inducible factor 1 alpha subunit (HIF1A) mRNA,
            complete cds.
ACCESSION   AF304431
VERSION     AF304431.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2509)
  AUTHORS   Sun,B., Zhao,H.R., Yu,R.T. and Ni,M.S.H.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-SEP-2000) Department of Neurosurgery, Affiliated
            Hospital of Xuzhou Medical College, Huaihai West Road, Xuzhou,
            Jiangsu 221002, China
FEATURES             Location/Qualifiers
     source          1..2509
                     /db_xref="H-InvDB:HIT000076731"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q21-q24"
                     /tissue_type="glioma"
     gene            1..2509
                     /gene="HIF1A"
     CDS             1..2481
                     /gene="HIF1A"
                     /codon_start=1
                     /product="hypoxia-inducible factor 1 alpha subunit"
                     /protein_id="AAG43026.1"
                     /translation="MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQL
                     PLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMV
                     LTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKE
                     QNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMT
                     CLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIY
                     EYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQC
                     IVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKK
                     EPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAM
                     SPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQ
                     SSPEPNSPSEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYI
                     PMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDEL
                     KTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEK
                     SHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKRKMEHDGSLFQAVGIGTLLQQ
                     PDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLACRLLGQSMDESGLPQLTSY
                     DCEVNAPIQGSRNLLQGEELLRALDQVN"
BASE COUNT          832 a          517 c          502 g          658 t
ORIGIN      
        1 atggagggcg ccggcggcgc gaacgacaag aaaaagataa gttctgaacg tcgaaaagaa
       61 aagtctcgag atgcagccag atctcggcga agtaaagaat ctgaagtttt ttatgagctt
      121 gctcatcagt tgccacttcc acataatgtg agttcgcatc ttgataaggc ctctgtgatg
      181 aggcttacca tcagctattt gcgtgtgagg aaacttctgg atgctggtga tttggatatt
      241 gaagatgaca tgaaagcaca gatgaattgc ttttatttga aagccttgga tggttttgtt
      301 atggttctca cagatgatgg tgacatgatt tacatttctg ataatgtgaa caaatacatg
      361 ggattaactc agtttgaact aactggacac agtgtgtttg attttactca tccatgtgac
      421 catgaggaaa tgagagaaat gcttacacac agaaatggcc ttgtgaaaaa gggtaaagaa
      481 caaaacacac agcgaagctt ttttctcaga atgaagtgta ccctaactag ccgaggaaga
      541 actatgaaca taaagtctgc aacatggaag gtattgcact gcacaggcca cattcacgta
      601 tatgatacca acagtaacca acctcagtgt gggtataaga aaccacctat gacctgcttg
      661 gtgctgattt gtgaacccat tcctcaccca tcaaatattg aaattccttt agatagcaag
      721 actttcctca gtcgacacag cctggatatg aaattttctt attgtgatga aagaattacc
      781 gaattgatgg gatatgagcc agaagaactt ttaggccgct caatttatga atattatcat
      841 gctttggact ctgatcatct gaccaaaact catcatgata tgtttactaa aggacaagtc
      901 accacaggac agtacaggat gcttgccaaa agaggtggat atgtctgggt tgaaactcaa
      961 gcaactgtca tatataacac caagaattct caaccacagt gcattgtatg tgtgaattac
     1021 gttgtgagtg gtattattca gcacgacttg attttctccc ttcaacaaac agaatgtgtc
     1081 cttaaaccgg ttgaatcttc agatatgaaa atgactcagc tattcaccaa agttgaatca
     1141 gaagatacaa gtagcctctt tgacaaactt aagaaggaac ctgatgcttt aactttgctg
     1201 gccccagccg ctggagacac aatcatatct ttagattttg gcagcaacga cacagaaact
     1261 gatgaccagc aacttgagga agtaccatta tataatgatg taatgctccc ctcacccaac
     1321 gaaaaattac agaatataaa tttggcaatg tctccattac ccaccgctga aacgccaaag
     1381 ccacttcgaa gtagtgctga ccctgcactc aatcaagaag ttgcattaaa attagaacca
     1441 aatccagagt cactggaact ttcttttacc atgccccaga ttcaggatca gacacctagt
     1501 ccttccgatg gaagcactag acaaagttca cctgagccta atagtcccag tgaatattgt
     1561 ttttatgtgg atagtgatat ggtcaatgaa ttcaagttgg aattggtaga aaaacttttt
     1621 gctgaagaca cagaagcaaa gaacccattt tctactcagg acacagattt agacttggag
     1681 atgttagctc cctatatccc aatggatgat gacttccagt tacgttcctt cgatcagttg
     1741 tcaccattag aaagcagttc cgcaagccct gaaagcgcaa gtcctcaaag cacagttaca
     1801 gtattccagc agactcaaat acaagaacct actgctaatg ccaccactac cactgccacc
     1861 actgatgaat taaaaacagt gacaaaagac cgtatggaag acattaaaat attgattgca
     1921 tctccatctc ctacccacat acataaagaa actactagtg ccacatcatc accatataga
     1981 gatactcaaa gtcggacagc ctcaccaaac agagcaggaa aaggagtcat agaacagaca
     2041 gaaaaatctc atccaagaag ccctaacgtg ttatctgtcg ctttgagtca aagaactaca
     2101 gttcctgagg aagaactaaa tccaaagata ctagctttgc agaatgctca gagaaagcga
     2161 aaaatggaac atgatggttc actttttcaa gcagtaggaa ttggaacatt attacagcag
     2221 ccagacgatc atgcagctac tacatcactt tcttggaaac gtgtaaaagg atgcaaatct
     2281 agtgaacaga atggaatgga gcaaaagaca attattttaa taccctctga tttagcatgt
     2341 agactgctgg ggcaatcaat ggatgaaagt ggattaccac agctgaccag ttatgattgt
     2401 gaagttaatg ctcctataca aggcagcaga aacctactgc agggtgaaga attactcaga
     2461 gctttggatc aagttaactg agctttttct taatttcatt ccttttttg
//