LOCUS AF304370 2908 bp mRNA linear HUM 23-FEB-2001
DEFINITION Homo sapiens putative prostate cancer susceptibility protein
HPC2/ELAC2 mRNA, complete cds.
ACCESSION AF304370
VERSION AF304370.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2908)
AUTHORS Tavtigian,S.V., Simard,J., Teng,D.H.F., Abtin,V., Baumgard,M.,
Beck,A., Camp,N.J., Carillo,A.R., Chen,Y., Dayananth,P.,
Desrochers,M., Dumont,M., Farnham,J.M., Frank,D., Frye,C.,
Ghaffari,S., Gupte,J.S., Hu,R., Iliev,D., Janecki,T., Kort,E.N.,
Laity,K.E., Leavitt,A., Leblanc,G., McArthur-Morrison,J.,
Pederson,A., Penn,B., Peterson,K.T., Reid,J.E., Richards,S.,
Schroeder,M., Smith,R., Snyder,S.C., Swedlund,B., Swensen,J.,
Thomas,A., Tranchant,M., Woodland,A.M., Labrie,F., Skolnick,M.H.,
Neuhausen,S., Rommens,J. and Cannon-Albright,L.A.
TITLE A candidate prostate cancer susceptibility gene at chromosome 17p
JOURNAL Nat. Genet. 27 (2), 172-180 (2001)
PUBMED 11175785
REFERENCE 2 (bases 1 to 2908)
AUTHORS Tavtigian,S.V., Simard,J., Teng,D.H.F., Baumgard,M., Beck,A.,
Camp,N.J., Carillo,A.R., Chen,Y., Dayananth,P., Desrochers,M.,
Dumont,M., Farnham,J.M., Frank,D., Frye,C., Ghaffari,S.,
Gupte,J.S., Hu,R., Iliev,D., Janecki,T., Kort,E.N., Laity,K.E.,
Leavitt,A., Leblanc,G., McArthur-Morrison,J., Pederson,A., Penn,B.,
Peterson,K.T., Reid,J.E., Richards,S., Schroeder,M., Smith,R.,
Snyder,S.C., Swedlund,B., Swensen,J., Thomas,A., Tranchant,M.,
Woodland,A.-M., Labrie,F., Skolnick,M.H., Neuhausen,S., Rommens,J.
and Cannon-Albright,L.A.
TITLE Direct Submission
JOURNAL Submitted (12-SEP-2000) Myriad Genetics, Inc., 320 Wakara Way, Salt
Lake City, UT 84108, USA
FEATURES Location/Qualifiers
source 1..2908
/db_xref="H-InvDB:HIT000076727"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17p"
CDS 1..2481
/codon_start=1
/product="putative prostate cancer susceptibility protein
HPC2/ELAC2"
/protein_id="AAG24441.1"
/translation="MWALCSLLRSAAGRTMSQGRTISQAPARRERPRKDPLRHLRTRE
KRGPSGCSGGPNTVYLQVVAAGSRDSGAALYVFSEFNRYLFNCGEGVQRLMQEHKLKV
ARLDNIFLTRMHWSNVGGLSGMILTLKETGLPKCVLSGPPQLEKYLEAIKIFSGPLKG
IELAVRPHSAPEYEDETMTVYQIPIHSEQRRGKHQPWQSPERPLSRLSPERSSDSESN
ENEPHLPHGVSQRRGVRDSSLVVAFICKLHLKRGNFLVLKAKEMGLPVGTAAIAPIIA
AVKDGKSITHEGREILAEELCTPPDPGAAFVVVECPDESFIQPICENATFQRYQGKAD
APVALVVHMAPASVLVDSRYQQWMERFGPDTQHLVLNENCASVHNLRSHKIQTQLNLI
HPDIFPLLTSFRCKKEGPTLSVPMVQGECLLKYQLRPRREWQRDAIITCNPEEFIVEA
LQLPNFQQSVQEYRRSAQDGPAPAEKRSQYPEIIFLGTGSAIPMKIRNVSATLVNISP
DTSLLLDCGEGTFGQLCRHYGDQVDRVLGTLAAVFVSHLHADHHTGLPSILLQRERAL
ASLGKPLHPLLVVAPNQLKAWLQQYHNQCQEVLHHISMIPAKCLQEGAEISSPAVERL
ISSLLRTCDLEEFQTCLVRHCKHAFGCALVHTSGWKVVYSGDTMPCEALVRMGKDATL
LIHEATLEDGLEEEAVEKTHSTTSQAISVGMRMNAEFIMLNHFSQRYAKVPLFSPNFS
EKVGVAFDHMKVCFGDFPTMPKLIPPLKALFAGDIEEMEERREKRELRQVRAALLSRE
LAGGLEDGEPQQKRAHTEEPQAKKVRAQ"
BASE COUNT 702 a 793 c 826 g 587 t
ORIGIN
1 atgtgggcgc tttgctcgct gctgcggtcc gcggccggac gcaccatgtc gcagggacgc
61 accatatcgc aggcacccgc ccgccgcgag cggccgcgca aggacccgct gcggcacctg
121 cgcacgcgag agaagcgcgg accgtcgggg tgctccggcg gcccaaacac cgtgtacctg
181 caggtggtgg cagcgggtag ccgggactcg ggcgccgcgc tctacgtctt ctccgagttc
241 aaccggtatc tcttcaactg tggagaaggc gttcagagac tcatgcagga gcacaagtta
301 aaggttgctc gcctggacaa catattcctg acacgaatgc actggtctaa tgttgggggc
361 ttaagtggaa tgattcttac tttaaaggaa accgggcttc caaagtgtgt actttctgga
421 cctccacaac tggaaaaata cctcgaagca atcaaaatat tttctggtcc attgaaagga
481 atagaactgg ctgtgcggcc ccactctgcc ccagaatacg aggatgaaac catgacagtt
541 taccagatcc ccatacacag tgaacagagg aggggaaagc accaaccatg gcagagtcca
601 gaaaggcctc tcagcaggct cagtccagag cgatcttcag actccgagtc gaatgaaaat
661 gagccacacc ttccacatgg tgttagccag agaagagggg tcagggactc ttccctggtc
721 gtagctttca tctgtaagct tcacttaaag agaggaaact tcttggtgct caaagcaaag
781 gagatgggcc tcccagttgg gacagctgcc atcgctccca tcattgctgc tgtcaaggac
841 gggaaaagca tcactcatga aggaagagag attttggctg aagagctgtg tactcctcca
901 gatcctggtg ctgcttttgt ggtggtagaa tgtccagatg aaagcttcat tcaacccatc
961 tgtgagaatg ccacctttca gaggtaccaa ggaaaggcag atgcccccgt ggccttggtg
1021 gttcacatgg ccccagcatc tgtgcttgtg gacagcaggt accagcagtg gatggagagg
1081 tttgggcctg acacccagca cttggtcctg aatgagaact gtgcctcagt tcacaacctt
1141 cgcagccaca agattcaaac ccagctcaac ctcatccacc cggacatctt ccccctgctc
1201 accagtttcc gctgtaagaa ggagggcccc accctcagtg tgcccatggt tcagggtgaa
1261 tgcctcctca agtaccagct ccgtcccagg agggagtggc agagggatgc cattattact
1321 tgcaatcctg aggaattcat agttgaggcg ctgcagcttc ccaacttcca gcagagcgtg
1381 caggagtaca ggaggagtgc gcaggacggc ccagccccag cagagaaaag aagtcagtac
1441 ccagaaatca tcttccttgg aacagggtct gccatcccga tgaagattcg aaatgtcagt
1501 gccacacttg tcaacataag ccccgacacg tctctgctac tggactgtgg tgagggcaca
1561 tttgggcagc tgtgccgtca ttacggagac caggtggaca gggtcctggg caccctggct
1621 gctgtgtttg tgtcccacct gcacgcagat caccacacgg gcttgccaag tatcttgctg
1681 cagagagaac gcgccttggc atctttggga aagccgcttc accctttgct ggtggttgcc
1741 cccaaccagc tcaaagcctg gctccagcag taccacaacc agtgccagga ggtcctgcac
1801 cacatcagta tgattcctgc caaatgcctt caggaagggg ctgagatctc cagtcctgca
1861 gtggaaagat tgatcagttc gctgttgcga acatgtgatt tggaagagtt tcagacctgt
1921 ctggtgcggc actgcaagca tgcgtttggc tgtgcgctgg tgcacacctc tggctggaaa
1981 gtggtctatt ccggggacac catgccctgc gaggctctgg tccggatggg gaaagatgcc
2041 accctcctga tacatgaagc caccctggaa gatggtttgg aagaggaagc agtggaaaag
2101 acacacagca caacgtccca agccatcagc gtggggatgc ggatgaacgc ggagttcatt
2161 atgctgaacc acttcagcca gcgctatgcc aaggtccccc tcttcagccc caacttcagc
2221 gagaaagtgg gagttgcctt tgaccacatg aaggtctgct ttggagactt tccaacaatg
2281 cccaagctga ttcccccact gaaagccctg tttgctggcg acatcgagga gatggaggag
2341 cgcagggaga agcgggagct gcggcaggtg cgggcggccc tcctgtccag ggagctggca
2401 ggcggcctgg aggatgggga gcctcagcag aagcgggccc acacagagga gccacaggcc
2461 aagaaggtca gagcccagtg aagatctggg agaccctgaa ctcagaaggc tgtgtgtctt
2521 ctgccccacg cacgcacccg tatctgccct ccttgctggt agaagctgaa gagcacggtc
2581 ccccaggagg cagctcagga taggtggtat ggagctgtgc cgaggcttgg gctcccacat
2641 aagcactagt ctatagatgc ctcttaggac tggtgcctgg cacagccgcg ggccaggagg
2701 ctgccacacg gaagcaagca gatgaactaa tttcatttca aggcagtttt taaagaagtc
2761 ttggaaacag acggcggcac ctttcctcta atccagcaaa gtgattccct gcacaccaga
2821 gacaagcaga gtaacaggat cagtgggtct aagtgtccga gacttaacga aaatagtatt
2881 tcagctgcaa taaagattga gtttgcaa
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