LOCUS AF301463 2280 bp mRNA linear HUM 21-NOV-2000
DEFINITION Homo sapiens ubiquitin E3 ligase SMURF2 (SMURF2) mRNA, complete
cds.
ACCESSION AF301463
VERSION AF301463.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2280)
AUTHORS Lin,X., Liang,M. and Feng,X.H.
TITLE Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent
degradation of Smad2 in transforming growth factor-beta signaling
JOURNAL J. Biol. Chem. 275 (47), 36818-36822 (2000)
PUBMED 11016919
REFERENCE 2 (bases 1 to 2280)
AUTHORS Lin,X. and Feng,X.-H.
TITLE Direct Submission
JOURNAL Submitted (30-AUG-2000) Departments of Surgery and Molecular &
Cellular Biology, Baylor College of Medicine, One Baylor Plaza,
Houston, TX 77030, USA
FEATURES Location/Qualifiers
source 1..2280
/db_xref="H-InvDB:HIT000076658"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..2280
/gene="SMURF2"
CDS 9..2255
/gene="SMURF2"
/note="HECT-class ubiquitin ligase"
/codon_start=1
/product="ubiquitin E3 ligase SMURF2"
/protein_id="AAG25641.1"
/translation="MSNPGGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGS
GQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSN
AINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLP
DGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGA
TCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGV
STWHDPRVPRDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANL
HLVLNRQNQLKDQQQQQVVSLCPDDTECLTVPRYKRDLVQKLKILRQELSQQQPQAGH
CRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEML
NPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPF
YKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEIIQHELKP
NGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELEL
IICGLGKIDVNDWKVNTRLKHCTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSSRVP
LQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIE
ETCGFAVE"
BASE COUNT 703 a 459 c 534 g 584 t
ORIGIN
1 ccggggacat gtctaacccc ggaggccgga ggaacgggcc cgtcaagctg cgcctgacag
61 tactctgtgc aaaaaacctg gtgaaaaagg attttttccg acttcctgat ccatttgcta
121 aggtggtggt tgatggatct gggcaatgcc attctacaga tactgtgaag aatacgcttg
181 atccaaagtg gaatcagcat tatgacctgt atattggaaa gtctgattca gttacgatca
241 gtgtatggaa tcacaagaag atccataaga aacaaggtgc tggatttctc ggttgtgttc
301 gtcttctttc caatgccatc aaccgcctca aagacactgg ttatcagagg ttggatttat
361 gcaaactcgg gccaaatgac aatgatacag ttagaggaca gatagtagta agtcttcagt
421 ccagagaccg aataggcaca ggaggacaag ttgtggactg cagtcgttta tttgataacg
481 atttaccaga cggctgggaa gaaaggagaa ccgcctctgg aagaatccag tatctaaacc
541 atataacaag aactacgcaa tgggagcgcc caacacgacc ggcatccgaa tattctagcc
601 ctggcagacc tcttagctgc tttgttgatg agaacactcc aattagtgga acaaatggtg
661 caacatgtgg acagtcttca gatcccaggc tggcagagag gagagtcagg tcacaacgac
721 atagaaatta catgagcaga acacatttac atactcctcc agacctacca gaaggctatg
781 aacagaggac aacgcaacaa ggccaggtgt atttcttaca tacacagact ggtgtgagca
841 catggcatga tccaagagtg cccagggatc ttagcaacat caattgtgaa gagcttggtc
901 cgttgcctcc tggatgggag atccgtaata cggcaacagg cagagtttat ttcgttgacc
961 ataacaacag aacaacacaa tttacagatc ctcggctgtc tgctaacttg catttagttt
1021 taaatcggca gaaccaattg aaagaccaac agcaacagca agtggtatcg ttatgtcctg
1081 atgacacaga atgcctgaca gtcccaaggt acaagcgaga cctggttcag aaactaaaaa
1141 ttttgcggca agaactttcc caacaacagc ctcaggcagg tcattgccgc attgaggttt
1201 ccagggaaga gatttttgag gaatcatatc gacaggtcat gaaaatgaga ccaaaagatc
1261 tctggaagcg attaatgata aaatttcgtg gagaagaagg ccttgactat ggaggcgttg
1321 ccagggaatg gttgtatctc ttgtcacatg aaatgttgaa tccatactat ggcctcttcc
1381 agtattcaag agatgatatt tatacattgc agatcaatcc tgattctgca gttaatccgg
1441 aacatttatc ctatttccac tttgttggac gaataatggg aatggctgtg tttcatggac
1501 attatattga tggtggtttc acattgcctt tttataagca attgcttggg aagtcaatta
1561 ccttggatga catggagtta gtagatccgg atcttcacaa cagtttagtg tggatacttg
1621 agaatgatat tacaggtgtt ttggaccata ccttctgtgt tgaacataat gcatatggtg
1681 aaattattca gcatgaactt aaaccaaatg gcaaaagtat ccctgttaat gaagaaaata
1741 aaaaagaata tgtcaggctc tatgtgaact ggagattttt acgaggcatt gaggctcaat
1801 tcttggctct gcagaaagga tttaatgaag taattccaca acatctgctg aagacatttg
1861 atgagaagga gttagagctc attatttgtg gacttggaaa gatagatgtt aatgactgga
1921 aggtaaacac ccggttaaaa cactgtacac cagacagcaa cattgtcaaa tggttctgga
1981 aagctgtgga gttttttgat gaagagcgac gagcaagatt gcttcagttt gtgacaggat
2041 cctctcgagt gcctctgcag ggcttcaaag cattgcaagg tgctgcaggc ccgagactct
2101 ttaccataca ccagattgat gcctgcacta acaacctgcc gaaagcccac acttgcttca
2161 atcgaataga cattccaccc tatgaaagct atgaaaagct atatgaaaag ctgctaacag
2221 ccattgaaga aacatgtgga tttgctgtgg aatgacaagc ttcaaggatt tacccaggac
//