LOCUS AF298117 10728 bp DNA linear HUM 26-SEP-2000
DEFINITION Homo sapiens homeobox protein OTX2 gene, complete cds.
ACCESSION AF298117
VERSION AF298117.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 10728)
AUTHORS Perrault,I., Rozet,J.-M., Gerber,S., Munnich,A. and Kaplan,J.
TITLE Direct Submission
JOURNAL Submitted (22-AUG-2000) Inserm U393, Hopital Necker Enfants
Malades, 149 rue De Sevres, Paris 75743 CEDEX 15, France
FEATURES Location/Qualifiers
source 1..10728
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/chromosome="14"
/map="14q21-q22"
mRNA join(<1427..1523,2520..2695,4528..>5148)
/product="homeobox protein OTX2"
CDS join(1427..1523,2520..2695,4528..5148)
/note="similar to Homo sapiens homeobox protein OTX2 in
Accession Number AB037505"
/codon_start=1
/product="homeobox protein OTX2"
/protein_id="AAG16243.1"
/translation="MMSYLKQPPYAVNGLSLTTSGMDLLHPSVGYPGPWASCPAATPR
KQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCR
QQQQQQQNGGQNKVRPAKKKTSPAREVSSESGTSGQFTPPSSTSVPTIASSSAPVSIW
SPASISPLSDPLSTSSSCMQRSYPMTYTQASGYSQGYAGSTSYFGGMDCGSYLTPMHH
QLPGPGATLSPMGTNAVTSHLNQSPASLSTQGYGASSLGFNSTTDCLDYKDQTASWKL
NFNADCLDYKDQTSSWKFQVL"
BASE COUNT 2800 a 2486 c 2588 g 2854 t
ORIGIN
1 attttaggaa aataaaggcc agacttgcaa actgccagtc tatattaaca tctactttga
61 atctctttgc tggggtggag gcggggagct cagctgaaga aagtaaataa cttttctttt
121 tcttcctttc ttttccccct tgagctcttt ttcttatagg attgtaggaa acttgaaagg
181 tagggagaaa ttctactagt ttcacaactt tgggtgtttg tgtatctact ttcttcaaaa
241 ctaaaatgtg caaaaggcag ttagagttaa caggaaactc tgctgcagct gccgaggacc
301 caaatgtctg aaaatttgcc tcccgcagga tctgcagcct ccacacatca aaatcaacat
361 ggaagcagct tgcactacaa atgtggggtc ccgtcattat ctgattggtg ggattctaac
421 tttacttcac aatttctggc aagccctgtg ccaatcttga agactttttt ggaatatgct
481 taaatatttg atgggtgtct attaaaagtt aaatacttgt ttgtttagct ttcgttcctt
541 agacacatat aatcaagatt ctccaaaacc ctaataaatc tgttacttac ctcgaaatct
601 aattacccag actactaatt aggtgaaaat gattaccgga aatgacttca aatgtggaat
661 aatagtggtt gagcggtttt tccaagtttg tggtttagtg agttggtatt ttagatgtta
721 aacgcactga cattttaggt tcgcagcagt tgaaagtggt aaaaagctaa gataattaaa
781 atctctgcca tggaaaggca acagtctggg gagaggtaga tttcttgaat tgtttctttg
841 tttctcacca atgggctttg ttatcagcat tatttattta gccaaagagt tctttgtctc
901 tgcaaatggc cccaatcaag ttttgtttga gacaattagc tagtgccagc caatgagtcc
961 tatgcaaatg tagggatagg aatgcaatgt gtgcatttga aggcacgggt ttttgttctt
1021 ggggaaggca gattgtaatt gctttcttcg ggtacttttt tttttttttt aagtttaggg
1081 tgggggtggg gaagacaggt ttatctggtc tccttccatc ccctctagtt ccagagcagc
1141 tgggggtggg ggtggggatg ggggtggggg gagtgtctgc aagtccttta aaagcctctg
1201 cctcgcctag tccgtgctct ttttaagtta gtgctggaac gtggaagagc tgctgcctcc
1261 gaagcagtaa accagcccct ctgtttgttt gtttgctttg cccttagttc cactgctcca
1321 aacccaccca ccaaggactc tgaacctgtc caccccgggc gcatcaagat cttccagctg
1381 ggtacccccg atttgggccg actttgcacc tccaaacaac cttagcatga tgtcttatct
1441 taagcaaccg ccttacgcag tcaatgggct gagtctgacc acttcgggta tggacttgct
1501 gcacccctcc gtgggctacc cgggtaagtg agccctgctg cactcccgca cccctcttcc
1561 ccatgcccac cctccgggga tgcaacaccc tgttcccatg gaacacgggg gttggcagtc
1621 acactgtccc cacccagctt caggcttggt ctcctctagg tttgccttct gaggaagcag
1681 tcccagggca tttactgacc aagcagagaa caggggttgg gaaaagtgag taggtgggtc
1741 tgcaaccgtt acaatcacat cactttattc ttaattcgag taaataagga ttggcatcag
1801 agtgggatga ggaatgttac tgtccttgtc atttgggcaa aagaccccta cccatatctc
1861 aatgaccaat tcctcagaag tgtcctcttg gagaagctga gttttccctc cgtaagtcct
1921 tagcactctc gggcttcgca gttgttccct ccatgcccag gccttcccct atgacctcca
1981 gagcctgctt taatcccaag aggcgtgact tcctccaaat gcgggtgctt tcctttccaa
2041 tcagatatgt ttaaaaatcc tcccaggagt atgaactatg tccccatttt aaagatggag
2101 gaacaaaggc ccatggtgtg ctaaaaacca tgggaacagg atccagattt cccccatcaa
2161 ttcgagctgc cagtctgtcc tcggagatcc tttgacttct tggaatagcc tttttgtgtt
2221 gtggtttggg ggttgatctt ggagaacttt tttgtgtgtc ttttaaaaaa tgtttcattt
2281 gttaactttc caagtgatgc tctgattgga gcaatctcaa caccaagaag agtagggaaa
2341 gaagcagcgt gtgtcctggg tccccgggga gcaaggctgg ggagacggtg gggagagcat
2401 tggtaggctc ccggctgaag ggctgtgagg aacgggggac tgctgcgggg tggagggcag
2461 gggcgtcgga gaacccgcgg aaacgcctat gactgagaaa ctgctccccc accctaaagg
2521 gccctgggct tcttgtcccg cagccacccc ccggaaacag cgccgggaga ggacgacgtt
2581 cactcgggcg cagctagatg tgctggaagc actgtttgcc aagacccggt acccagacat
2641 cttcatgcga gaggaggtgg cactgaaaat caacttgccc gagtcgaggg tgcaggtagg
2701 gcagatgcag gcagaaccat ccttcctgat catgccaccc ttcccgagta tgggactgtg
2761 gagagcccca ggtctttcag aggactgaag gaaggcttga aattctcctt cactcactaa
2821 ggggccagga aactattctc cttctgccct tttttgcctg cccgtcacca cttaatcccg
2881 taagcaaggg tcttcaaggc ccgggttgct ggtggagaga gacccatcct tgagcaggtt
2941 tcaagagtag tcacgtggtg ttgtaaccct tcccttcctc tgtatagaaa tcctctccta
3001 ttctcatgga cttgtacgtg tgaaagcagc ttagctcttg gacagtccaa gtatttttac
3061 agatgaaaaa atagagtaaa tgacttgctc aaggtcataa ctaagtttgg tggcagagtc
3121 agggtataga cgcagctggt gcttttacca aataaatcaa cacaaaaaga atgtattttc
3181 cttgacttct tagggattga agagaatttt ctagttctga gccatttaac agataaaata
3241 tctacataat gtctctagtg acacccctct tgttttagtt cccctaaact tgaccttaaa
3301 ctggagaggg aaggtcaact ccagcttgcc ttgtgagtga gccctgtaca gaattctctg
3361 caaagtgttt agcacataaa ccacatacac acctgggcct ctccttcggc tagaatatgt
3421 ttatgaaagc gacagacatc agtgtcagct gcaaattggg aaaggggctt tttcaaagta
3481 ggttagagga agttttagca cttgcaaggc ttgaaccaaa gtcctcacta ggagaaaaca
3541 aatggctcca aatggttggt ggtcttgagc ttggccttgg tggcctcact tttaccacag
3601 ttacggcacc catacagaga gctcattcaa aagttcagct aaggatttgt cctccagaaa
3661 atgccagtag ttcctcttct aagccccctc gtacaccaat catagctcct tcattgcaga
3721 acatgaacag ggctggtaaa gagaattgtc aagattgcag cagggggttg aagtggtaag
3781 tcagtaaaca cagcacagga gactgagtct atgtgctgag tggcactact ctaacaacac
3841 agactcgagt cccagagact agcaggtctg tgctccagct caaagcagag tgcatgtaag
3901 tcactccttt taccacaaag aagcttttag caaatagtgg ctttcagacc tctttcttca
3961 acaagatcat gtcttcccct tggagctttg ttctgtgagt ctttctaaga gagacagaag
4021 ggtgatggaa ccaaccaacc tctatattag cagttgcttc ctggaagatg aactgtaaat
4081 gaatttaggc tgttcctgtt agcctgtaac aacagaattg ctttctctca cttctcatgt
4141 atttccctcc aaaagacaga gatacattct attcctctgt gagagtgttc caaaatatag
4201 ctgggtctat gtgtatgtgt gtgttagagg cgaaataaga taggaaagtg atgtggagag
4261 tttttagcta tatgatttgg gggattatct taaatgttat tctgggcaag aaataagaca
4321 gtgtcaagtg tttttagaca gagcctcccc aactttctta caagtccagg agtttatatg
4381 agagtaccac ataataggtc ttcagtggca ggggaaattg tgtgtttagc tgatctgccc
4441 atgtaggata gatttataat acgggagcca ttcttgtcct taaggaacta tcaaaaccga
4501 gttaaagaat tttctttccc ttccaaggta tggtttaaga atcgaagagc taagtgccgc
4561 caacaacagc aacaacagca gaatggaggt caaaacaaag tgagacctgc caaaaagaag
4621 acatctccag ctcgggaagt gagttcagag agtggaacaa gtggccaatt cactcccccc
4681 tctagcacct cagtcccgac cattgccagc agcagtgctc ctgtgtctat ctggagccca
4741 gcttccatct ccccactgtc agatcccttg tccacctcct cttcctgcat gcagaggtcc
4801 tatcccatga cctatactca ggcttcaggt tatagtcaag gatatgctgg ctcaacttcc
4861 tactttgggg gcatggactg tggatcatat ttgaccccta tgcatcacca gcttcccgga
4921 ccaggggcca cactcagtcc catgggtacc aatgcagtca ccagccatct caatcagtcc
4981 ccagcttctc tttccaccca gggatatgga gcttcaagct tgggttttaa ctcaaccact
5041 gattgcttgg attataagga ccaaactgcc tcctggaagc ttaacttcaa tgctgactgc
5101 ttggattata aagatcagac atcctcgtgg aaattccagg ttttgtgaag acctgtagaa
5161 cctctttttg tgggtgattt ttaaatatac tgggctggac attccagttt tagccaggca
5221 ttggttaaaa gagttagatg ggatgatgct cagactcatc tgatcaaagt tccgagaggc
5281 atagaaggaa aaacgaaggg ccttagaggg gcctacaaac cagcaacatg aaatggacaa
5341 accaatctgc ttaagatcct gtcatagttt tagatcattg gttatcctga tttgcaaagt
5401 gatcaaaagc attctagcca tgtgcaacca aacaccacca aaaataaaat caaacaaaac
5461 taagttgtga aggaagggag ggaaggtcat agccttctta agcagaggtg ttccattgtt
5521 ttagccaatc cttggttgaa tcttaggaat gaacagtgtc tcaagctcat tcacgtttca
5581 tgaccaactg gtagttggca ctgaaaaaac ttttcagggc tgtgtgaatt gtgtgactga
5641 ttgtcctaga tgcactactt tatttaaaaa ataatgttca taaggagtca atatgtagtt
5701 taagagacaa tcagtgtgtg tcttataaat ggtacatctg tggtttttaa tctgtgctag
5761 acttcaaaac tgtgatctcc tgttattgta tgcaaccttg aactccacct ctgcaggggt
5821 tcttctgtga ttaaataggt tataattata agcaaaattc agagcaactg agtactgatc
5881 taaaaagatt acctttggct ggaggtgagc tgcactgaaa ctttacgaca aaatgtctct
5941 ggacaaagag agtcagagaa gagaagcaaa aggacactaa ttcatctgta atttactgtt
6001 ggtaagccta gcagtaaaga gacattggtc aattgctctg accctgatga attattaaac
6061 tgagatcatt gtcgtttatg cttgcagatg ttaaatggaa aagttatata tgcataaacc
6121 ttttcttcct ggatttggca gatatgtata attatattaa aatggttcta gcacaacatt
6181 gggtccagtt taattttaca ccgctattta tgaataagaa gcctacattc agcctttcct
6241 ccccaaaaca cgtttttctt aggacagaga gtaaattagc aaacttattt ttactttttt
6301 tttttgctaa tctatgcata aaatagatat gaatgacagt ggtaggtaga ctttttgtga
6361 ctttcatcag gattgctctg aaattgagtt tggagagcct aacaacaaga tcttgttttc
6421 cttgcttttc cctccctact tcaaacctga acgatttctt aggcacttta ttagaatgtt
6481 ttaaaatata tcaagttttt aagagggagg aggagaattg gagtatctct gaaaacatga
6541 gaatgacaag aatttcttgt tactattctc ttatttgatt aaggggattt ttttttttta
6601 acttccaaaa actgaggtaa acatgagagg gagtgtaatc agaatctgaa agtaattcag
6661 gcagaaatga ttcctgaaca aaagagtttc agaaaagttt taaaacctat aatttcagta
6721 gttgaacata aggcaccctg gtcagtttgt gtgtatgtgt ttaagaaagt gccgaggggg
6781 aaaaaatggg tcccttttca gttgtacctg cattttgtaa accagtcacc agaaaagaca
6841 aatgggccaa tgatcatggt gctcctcagg taaaagcaat atttaatttc attttaagct
6901 gcttaagctc ttacagctga ccaaaattaa gtgactcttg attgtaacgt tttaaatgaa
6961 ggttagcagt tgcaaccatt ttgttttctg gctatttcat ttttccggtc cctggctgcg
7021 catgctctct tgaactctgt aatttttcct aataagtaaa ttggttcgct ggtaaaggaa
7081 atgcaatagt ttgcaaccaa aatttgaggc caaatttgat ggcaagagtt ttcagcacct
7141 attgataacc ttcaacatac tgtagtttac acgaagttaa attggggcct gaggtttacc
7201 cagattcagt gtcttaatct cccagctttt cttctgcaac agtaatgcag aatcaaaata
7261 accattttct accattgcct tcagttttca ggatgtcccg caaggggcag ggaaagatta
7321 ccccttcttt aaaaacaata atgacgataa acattgggct actcagcaaa taacgcagtt
7381 ggcagtttct ctcctgaaac tttaaaaaaa aggtcagaaa gaagaggcac tgagcaccct
7441 ctgaaactaa tttttccatc acctctgcac aacttctctt aactaagacc acgcagttaa
7501 atccctttga atcaaaggcg aagtagaaat gaattcctct gaccgaaggc aacggaggga
7561 gggaaggagg cggggagcga acactggctt aaagacatcc agagagttcc gatctccact
7621 cctagtcaag accggtttta atgaagttaa taagcccaat aatggtgata cttggtactg
7681 aaatgacgcc gtcctccaaa gaggtcaggg agctacttca gctgcgtatc ggcaattaac
7741 aagaagtgag ccggcagtat aagcttcggt ttggaggtca ggtcctgatg agggtggggg
7801 tagtttgctt tacaaagatc tgttgcccca aatctttatc tttcccacag ggattcttgg
7861 ccctttgtat ttcaccttgg gagtgtttct ttccttccta gataagaaga gaaattcaat
7921 caactcaatt aagttccggc tttggaaacc tccaagtttt agataatggt gggtttcctc
7981 aacccctctc ccacatggtg ctgctaatct cacctttcct gtgggtgacc ccccaggccc
8041 gtactgccgc cgccacaggc gcaagacgct gggaggctgg ggcggaactg ccagaaggaa
8101 cgtggtgccg ggcggcccgc tctccgccgc gccctaggcg ctctggctaa agagctggct
8161 tttctaactc cccagtgccc agtcggagtt acctgggaac agcactcaca tctctgcccc
8221 gagggccccc agctggggca gacgccggac tccccaggtt ggcgctgccc aatgggcccc
8281 actcacagcc tggcgggcca ggcaggggcg agactgaggc tcttgccttg ccgggttttc
8341 ccctttctct ctgggctggc tccatccctg gcccgcacct aggacctctc ttgagcctca
8401 gcccgcgccc cccgggcgta gttctcaggc ctcgggggcg ccggtcccag ggcgctgtgg
8461 gccgcggcaa ggccgaggcc cggtggcgag gcctgtacgc ccgcgggagt gggccgccag
8521 ccagagccga gagagggccc cgcccgagcc ctgcagtcag gcctccaggt cggccgcggg
8581 ccggggcgcc ggtcgctggg aaacctcgcg gcctggcgga gtgcaggggt cgggtcggcc
8641 tcggggattg gagggtgggg tggcccggcc gggaggcgag cgccctgcgc ccgaaggagc
8701 taaaaccgag actgacagac gggacggcga gcggggtcca ctggccgggg agaaggggcc
8761 ggggcggcga aagcaagccc agcagggccc gcggctgctg gttttccagg tctcccggta
8821 ggatgagccg ctgacggctt aggagggggc cgcttctcct ggcctcgaag ggcgaggccg
8881 ccacagcggg ggctcccgcc acggctgagg cctcccgcgt cccgagcaga cggggcccag
8941 ctgggcctgc ctcgggcccc cggggatcct cccaggaaat ccaggtcttc ggccactgga
9001 tttgggggag tctggccctc cgttggggtc tcccccggca ctgagctgag gctttcgggg
9061 gaagcccgag caattcccag tttgccttgg ctcatcccct tttccccagt cctctagatc
9121 tctttttttt aaaactgagt gccttctctt tcttttcgga cctgtcagcg gccctgaagg
9181 ccagaggcag gctctggaat ggggaagcgg tcccttcggc gtcccgggca gggccaactt
9241 gccaggcaac ccattccagt tacctgcaag gcaggggacg cagtcaagtc cccgcgtcca
9301 cttaaccgga agcggccagc cctggcgcgc acaccacatg ttcgaacccg catctcacac
9361 ccagggagaa cttcgctgtt attatacgga caaagctgta acccaaaacc aggcgtgcca
9421 gtgctaggtg atggtttagt gcatatagaa acgtgttttt aatcatgcaa aagaggaaca
9481 caaaagagtc gggcaggaga ccagcgcatc ccacgcaaat gggagcagac gcggtggaaa
9541 acaaccagaa tgagaagatg caggatcaga gtcagccatg acttccgcct gggtttttgc
9601 ctccttcgag acttttaaga tgaacagcag tctctctcct tttcgtgcca cgaaagggtc
9661 caagccccca tcaggcatct gcatgcccag gtttgtgacc aggtgccctg agcacctctg
9721 attttctctt ctaaaccgcc cgagcctgtc agcgcagggt gctctgataa aacctgattc
9781 ccctagtcgc cccgtttccg cccttgggtt ggtgtgacag aaaagactgg gagcccctgg
9841 gactttcccc tggaatgggg agagcaaaac cccaaacaaa acccatcccc atgttttttg
9901 gtattaggct ctgaaactgc acagattata ggatttgtct tggacagaat taacattaca
9961 tgtgaaactg tagtgctctg gtgtattgag acacgttgta taggattgct tggaccatct
10021 ctttcaaact gcctgttaat agtatcatga gaccttcaat gataatgtgt tggggggggg
10081 gttgtttttt acctgatgga aacaaaatct aggcactatt tggaaaaggt agtttttctg
10141 atggcagcag atggaaggaa acggaaccaa atgagaaact agaggaagtt tctgtatact
10201 gaagtggctg taaaggaggg agcagacgtg cgtttgaaag gccttctact aagcagcagt
10261 ccttacaacc aagggaggcc ccccaatgct aaagagaaac agccagactt cctctcttgc
10321 aagcagtgtg ttttatgttt aaaaaccaac ctgctgtcaa ctgcaaacaa acagtaagca
10381 aattcaaata aaggatccct accaagtcca acccatttgg tcaaagataa ctgcaggtgc
10441 cagggaagcc aggctatcac tagggggagg gtcgcttcaa attttgtttt tctcctagag
10501 ggaaagtcaa acagcatgag gtctatgact cacttttatt ccttaatctc cccacccctt
10561 ttcttttaat tcttagtgga aacacggtat tttgaaagaa aaaacaacag caacaacaaa
10621 gaaaacaaaa aagaatccca ctgaaaatat aatggtaagt gggcaaagtt tggattgact
10681 tctgtttcag caccacaagg aaaaaaaggt attcaagaat cagaatcc
//