LOCUS AF290004 1625 bp mRNA linear HUM 27-FEB-2001
DEFINITION Homo sapiens acidic mammalian chitinase precursor, mRNA, complete
cds.
ACCESSION AF290004
VERSION AF290004.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1625)
AUTHORS Boot,R.G., Blommaart,E.F., Swart,E., Ghauharali-van der Vlugt,K.,
Bijl,N., Moe,C., Place,A. and Aerts,J.M.
TITLE Identification of a novel acidic mammalian chitinase distinct from
chitotriosidase
JOURNAL J. Biol. Chem. 276 (9), 6770-6778 (2001)
PUBMED 11085997
REFERENCE 2 (bases 1 to 1625)
AUTHORS Boot,R.G., Verhoek,M., Swart,E. and Aerts,J.M.
TITLE Direct Submission
JOURNAL Submitted (26-JUL-2000) Dept. of Biochemistry, Academic Medical
Center, University of Amsterdam, Meibergdreef 15, Amsterdam 1105
AZ, The Netherlands
FEATURES Location/Qualifiers
source 1..1625
/db_xref="H-InvDB:HIT000076447"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="stomach; lung"
CDS 104..1534
/EC_number="3.2.1.14"
/note="chitinase precursor; AMCase; chitinase activity
demonstrated by expression in COS cells; similar to
sequences presented in GenBank Accession Numbers AB025008
and AB025009"
/codon_start=1
/product="acidic mammalian chitinase precursor"
/protein_id="AAG60019.1"
/translation="MTKLILLTGLVLILNLQLGSAYQLTCYFTNWAQYRPGLGRFMPD
NIDPCLCTHLIYAFAGRQNNEITTIEWNDVTLYQAFNGLKNKNSQLKTLLAIGGWNFG
TAPFTAMVSTPENRQTFITSVIKFLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQ
EMREAFEQEAKQINKPRLMVTAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSW
EGYTGENSPLYKYPTDTGSNAYLNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNP
SNTGIGAPTSGAGPAGPYAKESGIWAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWV
GYDNIKSFDIKAQWLKHNKFGGAMVWAIDLDDFTGTFCNQGKFPLISTLKKALGLQSA
SCTAPAQPIEPITAAPSGSGNGSGSSSSGGSSGGSGFCAVRANGLYPVANNRNAFWHC
VNGVTYQQNCQAGLVFDTSCDCCNWA"
sig_peptide 104..166
BASE COUNT 387 a 468 c 399 g 371 t
ORIGIN
1 gctttccagt ctggtggtga atcctccata gtctgaagcc tttgtgataa ccacagaatc
61 agaacatata aaaagctctg cgggactggt gctgactgca accatgacaa agcttattct
121 cctcacaggt cttgtcctta tactgaattt gcagctcggc tctgcctacc agctgacatg
181 ctacttcacc aactgggccc agtaccggcc aggcctgggg cgcttcatgc ctgacaacat
241 cgacccctgc ctctgtaccc acctgatcta cgcctttgct gggaggcaga acaacgagat
301 caccaccatc gaatggaacg atgtgactct ctaccaagct ttcaatggcc tgaaaaataa
361 gaacagccag ctgaaaactc tcctggccat tggaggctgg aacttcggga ctgccccttt
421 cactgccatg gtttctactc ctgagaaccg ccagactttc atcacctcag tcatcaaatt
481 cctgcgccag tatgagtttg acgggctgga ctttgactgg gagtaccctg gctctcgtgg
541 gagccctcct caggacaagc atctcttcac tgtcctggtg caggaaatgc gtgaagcttt
601 tgagcaggag gccaagcaga tcaacaagcc caggctgatg gtcactgctg cagtagctgc
661 tggcatctcc aatatccagt ctggctatga gatcccccaa ctgtcacagt acctggacta
721 catccatgtc atgacctacg acctccatgg ctcctgggag ggctacactg gagagaacag
781 ccccctctac aaatacccga ctgacaccgg cagcaacgcc tacctcaatg tggattatgt
841 catgaactac tggaaggaca atggagcacc agctgagaag ctcatcgttg gattccctac
901 ctatggacac aacttcatcc tgagcaaccc ctccaacact ggaattggtg cccccacctc
961 tggtgctggt cctgctgggc cctatgccaa ggagtctggg atctgggctt actacgagat
1021 ctgtaccttc ctgaaaaatg gagccactca gggatgggat gcccctcagg aagtgcctta
1081 tgcctatcag ggcaatgtgt gggttggcta tgacaacatc aagagcttcg atattaaggc
1141 tcaatggctt aagcacaaca aatttggagg cgccatggtc tgggccattg atctggatga
1201 cttcactggc actttctgca accagggcaa gtttccccta atctccaccc tgaagaaggc
1261 cctcggcctg cagagtgcaa gttgcacggc tccagctcag cccattgagc caataactgc
1321 tgctcccagt ggcagcggga acgggagcgg gagtagcagc tctggaggca gctcgggagg
1381 cagtggattc tgtgctgtca gagccaacgg cctctacccc gtggcaaata acagaaatgc
1441 cttctggcac tgcgtgaatg gagtcacgta ccagcagaac tgccaggccg ggcttgtctt
1501 cgacaccagc tgtgattgct gcaactgggc ataaacctga cctggtctat attccctaga
1561 gttccagtct cttttgctta ggacatgttg cccctaccta aagtcctgca ataaaatcag
1621 cagtc
//