LOCUS AF289220 9700 bp DNA linear HUM 10-APR-2001
DEFINITION Homo sapiens Bcl-2 related proline-rich protein (BCL2L12) gene,
complete cds, alternatively spliced.
ACCESSION AF289220
VERSION AF289220.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 9700)
AUTHORS Scorilas,A., Kyriakopoulou,L., Yousef,G.M., Ashworth,L.K.,
Kwamie,A. and Diamandis,E.P.
TITLE Molecular cloning, physical mapping, and expression analysis of a
novel gene, BCL2L12, encoding a proline-rich protein with a highly
conserved BH2 domain of the Bcl-2 family
JOURNAL Genomics 72 (2), 217-221 (2001)
PUBMED 11401436
REFERENCE 2 (bases 1 to 9700)
AUTHORS Scorilas,A. and Diamandis,E.P.
TITLE Direct Submission
JOURNAL Submitted (24-JUL-2000) Pathology and Laboratory Medicine, Mount
Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada
FEATURES Location/Qualifiers
source 1..9700
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19q13.3"
gene 256..>8992
/gene="BCL2L12"
/gene_synonym="BPR"
/note="BCL2-like 12 (proline rich)"
mRNA join(256..1181,1799..1913,2133..2275,3965..4051,
4138..4229,5330..5602,8812..8862,8987..>8992)
/gene="BCL2L12"
/gene_synonym="BPR"
mRNA join(256..1181,1799..1913,3965..4051,4138..4229,
5330..5602,8812..8862,8987..>8992)
/gene="BCL2L12"
/gene_synonym="BPR"
CDS join(938..1181,1799..1913,2133..2275,3965..4051,
4138..4229,5330..5602,8812..8862)
/gene="BCL2L12"
/gene_synonym="BPR"
/note="contains BH2 domain of Bcl-2 family"
/codon_start=1
/product="Bcl-2 related proline-rich protein"
/protein_id="AAG29495.1"
/translation="MGRPAGLFPPLCPFLGFRPEACWERHMQIERAPSVPPFLRWAGY
RPGPVRRRGKVELIKFVRVQWRRPQVEWRRRRWGPGPGASMAGSEELGLREDTLRVLA
AFLRRGEAAGSPVPTPPRSPAQEEPTDFLSRLRRCLPCSLGRGAAPSESPRPCSLPIR
PCYGLEPGPATPDFYALVAQRLEQLVQEQLKSPPSPELQGPPSTEKEAILRRLVALLE
EEAEVINQKLASDPALRSKLVRLSSDSFARLVELFCSRDDSSRPSRACPGPPPPSPEP
LARLALAMELSRRVAGLGGTLAGLSVEHVHSFTPWIQAHGGWEGILAVSPVDLNLPLD
"
CDS join(938..1181,1799..1913,3965..4051,4138..4222)
/gene="BCL2L12"
/gene_synonym="BPR"
/note="BPR-variant 1; alternatively spliced"
/codon_start=1
/product="Bcl-2 related proline-rich protein"
/protein_id="AAG29496.1"
/translation="MGRPAGLFPPLCPFLGFRPEACWERHMQIERAPSVPPFLRWAGY
RPGPVRRRGKVELIKFVRVQWRRPQVEWRRRRWGPGPGASMAGSEELGLREDTLRVLA
AFLRRGEAAGSPVPTPPRPSYSRLLCFGGPAAGTAGPRAAEISAQPRITGSPIDREGS
HTAEAGGPAGGGGRSH"
regulatory 8987..8992
/regulatory_class="polyA_signal_sequence"
/gene="BCL2L12"
/gene_synonym="BPR"
BASE COUNT 2074 a 2622 c 2586 g 2418 t
ORIGIN
1 ccggacccac ctggcctgga gtttccgcac ccagacctcc ttctcacggg ccacggcaca
61 ggtccttcac ccatattttc gggggtacaa acaggaaacc tcctcttccc atcctcccat
121 cctcccgaga ggctctctaa tcagctaggg ttccttccca tatccatggc acatccttcc
181 ccagcgtctt cagtgcagac cctccactcc ctcaattccg ccagtataga cctcctccct
241 cccccacatc atcgaaagta agtatcccca ctttcagggt agcatcctct ttccctagtt
301 atttcagtgc agaatcgatt cacgtgtaag cctctacctc ctgcacttac cccaatgtag
361 acccccttcc acagtccccc tacagaagat ctcccaaaac atttccaaca cagaacttcc
421 attcaattcc cctccgactg cccgcctccc tcctccagga cagagcacgc cccaggtttc
481 gagactgaac tacccccatc tacggagtcc acccctccct ctctagaacc ccctcagtgt
541 agacgcctcc tcttttcctc tttcctccct actttttcta gtttttctgc agccgacctc
601 cagcgtcggc cactgtagct ccttccttgc tccactttcc ccagagtaca cagcctgcct
661 ttccactctc cgtgcagacc catcctcttt cccgctcctc gctctcggac gccaccaacg
721 ctctcccggg ctcttccgcg ttacctacga tggaaggtcg gggcgtgcgg gcagctggaa
781 cccacccctg tcttggagct ccgggtagct ctcaaactcg aggctgcgca ccccctttcc
841 cgtcagctga gctctagagc gctggggctt tctttttgat cgacttcttg aaataaaacc
901 aactttatca ttctttgggt aacagaccca aaagccgatg ggacggcccg ctgggctgtt
961 cccgccccta tgcccttttt tgggtttccg gccagaggca tgctgggagc gtcacatgca
1021 aattgagcgt gcacccagcg ttccgccctt tctacgctgg gccggttatc gacccggccc
1081 agtgcgcagg cgcgggaaag ttgaactaat aaagtttgta cgagttcagt ggaggagacc
1141 gcaagttgag tggaggaggc ggcggtgggg ccccggacca ggtcagcggg gtgttgacga
1201 ggggtggggt gaggagggaa gaggaggggg ccgggatcca gtggtgggca ccccagtccc
1261 gcttctctga tatccaaggg tccagggtcc tctagattcc agcaggggtc ggagatttgg
1321 aactacacct cacagcaggc tgcgcggcga agaagcgcgg acctagggga agatttgccc
1381 tgaaacctct tgggattggt agttcccgat gctttaaggg tttcaggagt ttggcatatg
1441 cctcttatag aatccaggag ttggggcgct aagcctcttc ttcctgggag acctaagggt
1501 ctggggctcc agttcctttt tctctaagac tcagaagtcc aggaccccag ctccctcctc
1561 ctttagaccc acgaatctgg gcacccagcc ccaccacctt tccttggatc gaagagtctt
1621 tttcctgatc gctttttcgt ctgaggactc aagagtctag gcccccagac ccacactctc
1681 caaaggaccc aggagtccag gccctcagca ccttccttgg gactcacaag tcctggtccc
1741 caagcctcca cttcttgcta aacccttgga gtccagtccc taaccctctc tctcacaggt
1801 gcctccatgg caggctctga agagctgggg ctccgggaag acacgctgag ggtcctagct
1861 gccttcctta ggcgtggtga ggctgccggg tctcctgttc caactccacc taggtaagag
1921 gagtggccct tctcccccag gggccagcat ttgaggctcc ctcctaactc ttgctcctgg
1981 tctcagtctg tctcctctct ttatatctgg ctctattctc tgtctttggg gttttggaga
2041 gaggtcctca gcgggggagg gagggagttg gggaaagaga ctgcttgcag gggatctctg
2101 gtggggtcag tctctgaagt cctcctctcc agaagccctg cccaagaaga gccaacagac
2161 ttcctgagcc gccttcgaag atgtcttccc tgctccctgg ggcgaggagc agccccctct
2221 gagtcccctc ggccttgctc tctgcccatc cgcccctgct atggtttaga gcctggtaag
2281 agatttccat gatcatctat gaagccggca gaacacggga taaggtgcta gtttaagatc
2341 actcagctag ggggtggctg tgtggagtct ctagcaccag ccttcaggac agaaccgtcc
2401 tgtcctctcc cctccccagt tagatttctg tcaattctgt gggttggctt tcagagagca
2461 tttggtcaat ctggttgttg tctctttcct tccataacta cttccctgcc cctaggactt
2521 ttgtagccag gaatacccct gatagagggg cagaagggct ggttttcaat cacatctccc
2581 tggctgtttt agttgcgtga ctctggggaa aatgctttct cttccctgct cccctgtttt
2641 tccaatagca gagtaggaat tggggaggag gtcactggac ttgatcaagg tgacccacaa
2701 gtttcctcat aggtgtgaac ctggacagac tagtaatggc tgctgggagt gctagcttga
2761 aaaggggttc acagcttggg agaggaagtg ctgtgatcaa ttggtgatgt ctgtagtgag
2821 tgagggaagg ggatactaac agtaatgtct tgtgtttgcc ttccttggat gagatcatct
2881 tcaaggtcta gttgagctct gacagtcttt tggagacaga ttgttgctct gtcacccagg
2941 ctggagtgca ggggtgcaat ctcgactcac tgcaatcccc acctcctggg ttcaagcgat
3001 tctcgtgcct cagcctcccg agtgactggg attacaggtg cacgccagca tactagctga
3061 tttttatact tttagtagac acggggtttc gccacgttgg ccaggctggc ctcaaactcc
3121 tggcctcaag tgaccctccc acgtcggcct cccaaaatgt tgagattgca gacgtgagcc
3181 accgcaccct gtcagctctg acattctttt tttttttttt ttttttgaga cggagtttcg
3241 cccttgttgc ccaggctgga gtgcaatggc ccgatctcgg ctcaccacaa cctctacctc
3301 ccgggttcaa gtaattctcc tgcctcagcc tcccaagtag ctgggattat aggcatgcgc
3361 caccatgccc ggctaatttt ttttgtattt ttagtagaga tggggtttct ccatgttggt
3421 caggctgctc tcgaactccc aacctcaggt gatctgcctg cctcagcctc ccaaagtgat
3481 gggattacag gcgtgagcca ctgcgcctgg ccccagctct gacattctaa gtccagtctg
3541 aggatctcat aaagtgaaaa gtacaagggt tttggcattt ttaaccaagt tttctcactg
3601 ggcctcagtt taccccatta taaaatggga atcatggcca ggcttggttg ctcacgcctg
3661 taatcctagc actttgggag gctgaggtgg gtggattgcc tgaggtcagc ctgggcaaca
3721 cggtgaaacc ccatttctac taaaatacaa aaaattagcc aggtatggcg gcgtgcgcct
3781 gtagtcccag ctactcatga ggctgaggca ggagaattgc gagactccgt ttcccaaaat
3841 caatacataa ataaataata aataaaatgg gaatcattgc cacctgccaa ggtagttggg
3901 ggaaggagag aatccgtaag tttccaatgt cctggaaacc tgtcattaac tcttttcacc
3961 ccaggcccag ctactccaga cttctatgct ttggtggccc agcggctgga acagctggtc
4021 caagagcagc tgaaatctcc gcccagccca ggtgaggcac agaggagccc cagagaagga
4081 tggcggtggg aggatagtca gggttctgcc cccagccaaa ttctcttctg cctccagaat
4141 tacagggtcc cccatcgaca gagaaggaag ccatactgcg gaggctggtg gccctgctgg
4201 aggaggaggc agaagtcatt aaccagaagg tgatgggcat ctgtcccact ccttggcaag
4261 gacaggagtt gcggaatggt ggggcactgg gatcagaagc tggatctgta ttttctttgg
4321 atggtcaggt ggaaagaggc tgggacaagg tttcaatgaa gggttgaggc cgggtgtggt
4381 ggctcacgcc tgtaatccca gcactttggg aggccgagtt gggtggatga cttgaggtca
4441 ggagttcgag accagcctgg ccaacatggt gaaaccccat ctctactaaa aatacaaaaa
4501 tcggacaggt gtggtggtgc gcttctgtaa tcccagctac tcagaaggct gaggcaggag
4561 aatcgcttga gcccaggagg tggaggttgc agtgagccaa gattgcgcca ctgcactcca
4621 gcctgggtga cagagtgaga ctctgtcttt aaaaaaaaaa aaaaaaaaga atagttgaat
4681 gacaggggta tggttagggt agtactgtac cgtaaattag ttgttttaat tgattgttta
4741 gaggggcatg gcctaaatgc agagggtgtg gccatcagaa acattatcca caagagactg
4801 gccaagctgg ggaagtaagt gaatgaatgt gggggtgggg ggagtggcta aaatcttact
4861 gagcatagaa gggacctggc ttagaatgta ggggaaaatg tactaccaga ggaggtgtgg
4921 cttgtggctg tgtcctggaa tctgattggc ttcggagctt ggacaaggta catcgtcctt
4981 taatattaat tgaatggtag agggcaagat tgttgtagac actaggttgg cccctgggaa
5041 aggtcaccag gggcatggct agattaactc agttacagta gagattggcc ctgattggct
5101 gttgaggcaa gggcctggca tggcttaggg actcacgttc caggccacta tcccgggggt
5161 agtttggcag agaccctgga gtctggcttg attggctaat atggatgagg ggtggcctag
5221 aaccttagca tctagaacga tcctgaaccg ggaagccacg cctcccggcc ctctattggc
5281 tggccccggg ggcgctgctg acgcggaccc tgcctcttcc accctacagc tggcctcgga
5341 ccccgccctg cgcagcaagc tggtccgcct gtcctccgac tctttcgccc gcctggtgga
5401 gctgttctgt agccgggatg acagctctcg cccaagccga gcatgccccg ggcccccgcc
5461 tccttccccg gagcccctgg cccgcctggc cctagccatg gagctgagcc ggcgcgtggc
5521 cgggctgggg ggcaccctgg ccggactcag cgtggagcac gtgcacagct tcacgccctg
5581 gatccaggcc cacgggggct gggtgagccg ctgaagcctc tctctccggg cctcacttta
5641 cctaactgtc atgtgataga ggaggggcgg ggacttctta ggttcctctc agacctcagg
5701 tattctccca gctccactgc gttcgttctg ttgagccctt gctgtatgcc aggactgcag
5761 cgatgagtgc agacactatg cctggcgtca acgactgggt acgctaatac tgtgagcgtg
5821 aaaccagtga ctgaggttac tcagggagag gccggacggg gtagctcatg cctgtaatcc
5881 cagcactttt ggaggccaag gcaggagaat tatttgaggc caggagttca agaccagcct
5941 ggacaacata gtaagacccc atctctacaa aaattgaaaa taactagcca gggtcgggtg
6001 cggtggctca cacctgtaat cccagcactt tgggaggccg aggcaggtgg atcacctgag
6061 gtcaggagtt tgagaccagc tggccaacgt ggtgaaaccc tgtgtctact aaaaaaaata
6121 cataaattag ccgggcgcgg tggcaggtgc ctgtaatccc agctaccgag gagactgagg
6181 catgagaatc gcttgaacct gggaggcaga gattgcagtg agctgagatc atgccactgc
6241 actccagcct gggcgacaga gtgagactgt gtctcaacaa aataatataa taaaaacctg
6301 gtgcggtggc tcacacctgt aatcccagca ctttgggaga ctgaggtggg tggatcactt
6361 gaggtcagga gtttgagacc agcctgacca tggtgacatt cagtctctac taaaaataca
6421 aaattagccc ggcatgcctg taatcccagc tagggaggct gaggcaagag aattgcttga
6481 acctgggagg cagaggttgt agtgagccga gattgcacca ctgcactcca gcctgggcaa
6541 caagagcggg gctctgtctc aaaaaataaa taaatacaaa tttttaaaat taataataat
6601 tagcaaagca tggtagctca cacgtttact cccagctact caggaggcag aggagccggg
6661 aggatcactt gagcccagga gttcaaggct gtggtgagct atgattgcgc cactgtactc
6721 cagtgtgggt gacagagtgg gaccctgtct caaaaaataa aatagtgaga gtagtagtgc
6781 tacctcaaag ggtcgctctg agggttaaaa tggggtcaat gtggtaagcc ctctgtgcac
6841 tgcctggcat gcaggcattt tgttggtgag gttatatggc tacctgctgc ctttccaaca
6901 gtgcctgcca ggatgccctc ccggggaacc ccctgcctcc gtcctgctcc ttctggtggg
6961 ctctggtttc acccccaacg aggccttccc aggtccccat tgacaatcac agccacctgc
7021 acaccctccc accgccctcc ttcccccttc ctgctttact tttccttcca tagcactttg
7081 ggccttccaa cagatggtgg aattgacttg ttttacttgt cttctggttt atttttcttt
7141 gttggtgtct cccacctcta acacatcagc ttcaggagac ccagaagtct tcccctctcc
7201 ttttcttact ttatctccag tgccggtttc agagttggat tgggctccag cgtgctggcc
7261 ctgtggcttg gcgactgtcg cagtctccct gagcggcact ctccccactg gtccagtgag
7321 caccgtctca tttacctgcc ttggggggtc gctgtgggta ttcactgaga gagggacaca
7381 agccaggctc tggatggaac cggtttccct ggcaggagct ggtcaagtgt gtttgaggag
7441 cagggaggag gaggccagta gggctacagt agggtgagcg ggcgacagat gagaggagga
7501 gaggcgccgg gccagccagg accctgtggt cacggtgagt gacaactcgg actttgactc
7561 tgggtaagcc aaggtctctg agcagcggag ggacaggcgc tgatttaggc gctaatgggc
7621 gccctctggc ggctgcctgg ggacagactg ctgggggcga gggcagaagt aggggcacag
7681 ggaggaggtg agtggatctc acccaagtcg ggggcggtgg agaatgctgg atttaactta
7741 gcggtgaagc tgacagattt ggctaatggg ccagatgtgg ggacagacta aaggatgctg
7801 gcccgagcag ctgcagggcg acatcttaag ttccccgaga tggggaaggt gtggggatgg
7861 gggcgatggg ggtggggagc aggactggag gtggtccggt ctacagtaag atcagaactc
7921 atagcacatg ttgaggggaa tggatataag tgttgggctc agcaaagaag ctcgtttatt
7981 ttattttatt ttaatttttc agatggagtc tcactctatt gcccagactg gagtgcagtg
8041 gcacgacctt ggctcactgc aacctccacc tcctgggttc aagcgattcc ctgcctcagc
8101 ctcctgagta gctggggtta caggcgcaca ccaccatgtc cggctaattt tgtagtttta
8161 gcagagacgg ggttttgccc tgttggccag gctggtctcg aactcttggc ctcaagtgat
8221 ccacccacct cggcctccca aagtgctgga attacaggct gagctaccac gcctggacaa
8281 tttcttaaaa aattttttta aagtaggatt gatagcagat gagttttctc ggtgggccag
8341 gtcctctgct agggatttca atggaatgat cccatttaaa cccactacaa cctcatgggg
8401 ctcttattgt cctcgtcttg tgggggcaga gaggaaaagt ccccagcatg cagagtgttg
8461 gaatctggat ttgtacacaa agccacgact ctgaattgtt caaatcccaa gactctcttc
8521 cccatctctg actctgtccc ccaactcttc actctctctg gatctctgtc taatcccact
8581 ccagtgtcct gaccctcctc gagctcaacc tttcctcctc ctgctaggac cctgccccct
8641 catccctgtg cccttctgtc tgggtctctg tccccttgtc tgggtgtctg tcaccctccg
8701 ctctctggtt cctcgccttc ccgtctctaa tctcacaggg ctgatgtgga cgctgctgta
8761 tggggggaac acctgccctg ctcacagggc tctgccactt ttcccttcca ggagggcatc
8821 ctggctgttt cacccgtgga cttgaacttg ccattggact gagctctttc tcagaagctg
8881 ctacaagatg acacctcatg tccctgccct cttcgtgtgc ttttccaagt cttcctattc
8941 cactcagggc tgtggggtgg tggttgccct acctgttttt gccaaaaata aattgtttaa
9001 aacttttctt attaaaaacg ttacaaagta ttcaattgtc tgttcttaca cttgggaact
9061 aaagttttaa ggagaggaga tttggttcag agatttctgt ggcttacgca aattgaggaa
9121 agaaccagtt cattcattct agaaatattt atttgcagca cctacaagag cctgtctcct
9181 ggacatgtaa catatttgag agaatacctg taaatattcc agcaacttgc attttttttt
9241 cctattgcac gatctggtta ttctagctaa tgctgtatga tggtcatgga gtctttccag
9301 tgaattccac agaaaggtac agtctaactt cacctgtgtc taggacacca ccctcttctt
9361 gtttttctcc tcccattgct cctttcaagt ctctcttgct ggtttctcat ctacctacag
9421 accagtggtt tgtctcacac acacccccca ctctcccttt ttttttggag atagggtctt
9481 gctctgttgc ctatacttgc actgttatat agatacagtg gcactatcat ggctcactgc
9541 agcctcaacc tcctgggctc aagtgatcct cccacttcag cctctctagt agctggaact
9601 aaaggcatgc gacacgacgc ctagctaatt tttaaaaaag aatttttatg ggaggccaag
9661 gcaggtggat cacttgaggt caggagttca agaccagcca
//