LOCUS AF288385 2926 bp mRNA linear HUM 22-FEB-2001
DEFINITION Homo sapiens carbonic anhydrase-related protein X mRNA, complete
cds.
ACCESSION AF288385
VERSION AF288385.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2926)
AUTHORS Hewett-Emmett,D. and Tashian,R.E.
TITLE Functional diversity, conservation, and convergence in the
evolution of the alpha-, beta-, and gamma-carbonic anhydrase gene
families
JOURNAL Mol. Phylogenet. Evol. 5 (1), 50-77 (1996)
PUBMED 8673298
REFERENCE 2 (bases 1 to 2926)
AUTHORS Hewett-Emmett,D., Shimmin,L.C., Wiebauer,K., Tashian,R.E. and
Porter,C.A.
TITLE Structure and expression of the human CA10 gene: Evolution of the
highly conserved alpha-carbonic anhydrase-related proteins, CA-RP X
and CA-RP XI
JOURNAL Unpublished
REFERENCE 3 (bases 1 to 2926)
AUTHORS Shimmin,L.C. and Hewett-Emmett,D.
TITLE Direct Submission
JOURNAL Submitted (19-JUL-2000) Human Genetics Center, School of Public
Health, University of Texas-Houston Health Science Center, P.O. Box
20334, Houston, TX 77225-0334, USA
FEATURES Location/Qualifiers
source 1..2926
/db_xref="H-InvDB:HIT000076340"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/clone="IMAGE 2517501"
/sex="male"
/tissue_type="frontal lobe"
/dev_stage="5 months post-conception"
/lab_host="DH10B"
/tissue_lib="Schneider fetal brain 00004"
exon 1..85
/note="span derived from the genomic sequence of GenBank
Accession Number AC026955; alternative exon 1b is present
in the cDNA sequences of GenBank Accession Numbers
AF064854 and AB036836"
/number=1a
exon 86..729
/note="span derived from the genomic sequence of GenBank
Accession Number AC026955"
/number=2
CDS 669..1655
/note="CA-RP X; CA10; member of the alpha-carbonic
anhydrase family"
/codon_start=1
/product="carbonic anhydrase-related protein X"
/protein_id="AAK11974.1"
/translation="MEIVWEVLFLLQANFIVCISAQQNSPKIHEGWWAYKEVVQGSFV
PVPSFWGLVNSAWNLCSVGKRQSPVNIETSHMIFDPFLTPLRINTGGRKVSGTMYNTG
RHVSLRLDKEHLVNISGGPMTYSHRLEEIRLHFGSEDSQGSEHLLNGQAFSGEVQLIH
YNHELYTNVTEAAKSPNGLVVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQ
GLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRLLSQNQPS
QIFLSMSDNFRPVQPLNNRCIRTNINFSLQGKDCPNNRAQKLQYRVNEWLLK"
exon 730..804
/note="span derived from the genomic sequence of GenBank
Accession Number AC006083"
/number=3
exon 805..947
/note="span derived from the genomic sequence of GenBank
Accession Number AC006083"
/number=4
exon 948..1133
/note="span derived from the genomic sequence of GenBank
Accession Number AC002090"
/number=5
misc_feature 1056..1058
/note="encodes active-site glutamic acid instead of
glutamine found in catalytically active alpha-carbonic
anhydrase family members"
misc_feature 1062..1064
/note="encodes active-site arginine instead of histidine
found in catalytically active alpha-carbonic anhydrase
family members"
exon 1134..1229
/note="span derived from the genomic sequence of GenBank
Accession Number AC002090"
/number=6
misc_feature 1137..1139
/note="encodes active-site glutamine instead of histidine
found in catalytically active alpha-carbonic anhydrase
family members"
exon 1230..1302
/note="span derived from the genomic sequence of GenBank
Accession Number AC002090"
/number=7
exon 1303..1457
/note="span derived from the genomic sequence of GenBank
Accession Number AC002090"
/number=8
variation 1373
/note="compared to the sequence of GenBank Accession
Number AC002090"
/replace="c"
exon 1458..1632
/note="span derived from the genomic sequence of GenBank
Accession Number AC005883"
/number=9
exon 1633..2926
/note="span derived from the genomic sequence of GenBank
Accession Number AC005883"
/number=10
variation 1912
/note="compared to the sequence of GenBank Accession
Number AC005883"
/replace="t"
regulatory 2444..2449
/regulatory_class="polyA_signal_sequence"
/note="alternative"
regulatory 2898..2903
/regulatory_class="polyA_signal_sequence"
BASE COUNT 774 a 723 c 671 g 758 t
ORIGIN
1 aatcgggaca agcgcgccga gaaatcctgg atcttcccag ggattccctc tacgctccct
61 cctcttcttc aataacccca aagaggagaa gaactgcccc ggagcgcagc agccaccctc
121 cgaccatgcc ccggtgaggg gggcggactt cgagggcaac ttgccgcgga ctgcctgggc
181 ttagccagcg agctacgcgc tcccgggagc ccggaattgc acggcgcagc ccggcggggg
241 gctatcgtct atgtcttctt ggggcgccag acgaatcggg gtctcgtttt tgctggaaga
301 gcccagtgtt ggtggcttca ggtggctgct gccgccgccg ccgccgccgc cgctgctagt
361 gcggtttccg ccgctggtgc gaagagaaga gacacgcgag cggggagacc tccaaggcag
421 cgaggcatcg gacatgtgtc agcacatctg gggcgcacat ccgtcgagcc cgaggggaga
481 tttgccggaa caattcaaac tgcgatattg atcttggggg tgactgtccc tggccggctg
541 tcgggtggga gtgcgagtgt gcactcgctc ggaagtgtgt gcgagtgtgt atgtgtgtgt
601 gccgtgtcgg gctcccccct tccccccgtt ttcccgtcga gtgatgcact tggaatgaga
661 atcagaggat ggaaatagtc tgggaggtgc tttttcttct tcaagccaat ttcatcgtct
721 gcatatcagc tcaacagaat tcaccaaaaa tccatgaagg ctggtgggca tacaaggagg
781 tggtccaggg aagctttgtt ccagttcctt ctttctgggg attggtgaac tcagcttgga
841 atctttgctc tgtggggaaa cggcagtcgc cagtcaacat agagaccagt cacatgatct
901 tcgacccctt tctgacacct cttcgcatca acacgggggg caggaaggtc agtgggacca
961 tgtacaacac tggaagacac gtatcccttc gcctggacaa ggagcacttg gtcaacatat
1021 ctggagggcc catgacatac agccaccggc tggaggagat ccgactacac tttgggagtg
1081 aggacagcca agggtcggag cacctcctca atggacaggc cttctctggg gaggtgcagc
1141 tcatccacta taaccatgag ctatatacga atgtcacaga agctgcaaag agtccaaatg
1201 gattggtggt agtttctata tttataaaag tttctgattc atcaaaccca tttcttaatc
1261 gaatgctcaa cagagatact atcacaagaa taacatataa aaatgatgca tatttactac
1321 aggggcttaa tatagaggaa ctatatccag agacctctag tttcatcact tatgatgggt
1381 cgatgactat cccaccctgc tatgagacag caagttggat cataatgaac aaacctgtct
1441 atataaccag gatgcagatg cattccttgc gcctgctcag ccagaaccag ccatctcaga
1501 tctttctgag catgagtgac aacttcaggc ctgtccagcc actcaacaac cgctgcatcc
1561 gcaccaatat caacttcagt ttacagggga aggactgtcc aaacaaccga gcccagaagc
1621 ttcagtatag agtaaatgaa tggctcctca agtagggaac aaagccaaga agaatcccac
1681 ctcagtgaaa tgctacaact gtgaattgac gtaacctaga atgtccccct tcttgcttct
1741 ctctccttct ttcccccaag cctcattcat tcttgggatt ggccctttct tcatgaaaag
1801 tgtctgcaaa accatggcag aggaatacat ctctcacaca tactcacaaa cacacacaca
1861 agcacttgca catacataca aacacatgca aacataccta cacacacaca cactcttaca
1921 acctccatca tgggaagtca agtttcagaa acaaaagtct cattcataag aggtcttaga
1981 agaaaataac cagttaacct gatttcaatt ttgataccgt tttcctgaac taataaatct
2041 acccaatgag acttttcagc ctttgtacat acaaaattct tccaaaagag agaggagaaa
2101 atacagctct gatggcatca aacggacttt gcatcaagta atttcagata gtgtcctagg
2161 atcctttgag ggtgctggta gcaggtgagc aggacaaagt tgaccaagga cacttatttc
2221 tagattatga ttcttctgtt tactcaacaa tttacaaaga aaaaaaggac agacattgaa
2281 gagctacaca ttgtatatat atcaccacag actataagga aatggaatta tttccctctt
2341 tgtcacatat ctgtagtagg atttgccaag atcagaaatg atccatttgc tgtttcttgt
2401 tttccaaagg tcatacattg tgtttggtta ttgttaccag ctcaataaat gtgtttaacg
2461 agttaatttc atttttctgg ctttggtctg ttctccttcc ttacaggcta agccctggct
2521 ccatgcaact gcattctttg atttcacttg ttccttcatc tacatgtttt gttcatttgc
2581 agccagtttt tactgagttt gtggcaatca ggaatgcatt tgctaagcaa gtatgacttt
2641 aattccactc catggctcaa tcattcacat gaggtgagct tcagcctgag atagcaggcg
2701 acagacttct tgcgtttcaa aactgccatg cccccctgtg atgctcccgt gaaggaatgc
2761 actttgcctt gtaagttcct gggaaagggg tatgttttct ctccaggtgc agccagatct
2821 cacaaagtac aaaacgaatg cctttctttt cttgtttata atggtcactc actgtgtttg
2881 gttactgtca agaaatcaat aaatgtgttt aacaagttac ccagta
//