LOCUS AF282732 5139 bp mRNA linear HUM 17-JUL-2000
DEFINITION Homo sapiens tolloid-like protein mRNA, complete cds.
ACCESSION AF282732
VERSION AF282732.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5139)
AUTHORS Arleth,A.J., Elshourbagy,N.A., Li,X. and Willette,R.N.
TITLE Human cardiac/brain tolloid-like protein
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 5139)
AUTHORS Arleth,A.J., Elshourbagy,N.A., Li,X. and Willette,R.N.
TITLE Direct Submission
JOURNAL Submitted (26-JUN-2000) Cardiovascular Pharmacology, SmithKline
Beecham Pharmaceuticals, PO Box 1539 UW2323, King of Prussia, PA
19406, USA
FEATURES Location/Qualifiers
source 1..5139
/db_xref="H-InvDB:HIT000076150"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="cardiac; brain"
CDS 252..3293
/note="metalloprotease"
/codon_start=1
/product="tolloid-like protein"
/protein_id="AAF86287.1"
/translation="MGLGTLSPRMLVWLVASGIVFYGELWVCAGLDYDYTFDGNEEDK
TETIDYKDPCKAAVFWGDIALDDEDLNIFQIDRTIDLTQNPFGNLGHTTGGLGDHAMS
KKRGALYQLIDRIRRIGFGLEQNNTVKGKVPLQFSGQNEKNRVPRAATSRTERVWPGG
VIPYVIGGNFTGSQRAMFKQAMRHWEKHTCVTFIERSDEESYIVFTYRPCGCCSYVGR
RGSGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQEYNF
LKMEPGEANSLGERYDFDSIMHYARNTFSRGMFLDTILPSRDDNGIRPAIGQRTRLSK
GDIAQARKLYRCPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFT
TMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWV
GKGFAAVYEAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFE
IERHDNCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAG
FAANFFKEEDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTK
LNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGL
SSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGG
CQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRK
ECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDP
LVATGNKMFVRFVSDASVQRKGFQATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQ
VDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPE
EIYSIGDSVLIHFHTDDTINKKGFHIRYKSIRYPDTTHTKK"
BASE COUNT 1535 a 990 c 1177 g 1437 t
ORIGIN
1 cttacctgcc ctccgcccac ccgtgggccc ctagccaact tctccctgcg actgggggta
61 acaggcagtg cttgccctct ctactgtccc ggcggcatcc acatgtttcc ggacacctga
121 gcaccccggt cccgccgagg agcctccggg tggggagaag agcaccggtg cccctagccc
181 cgcacatcag cgcggaccgc ggctgcctaa cttctgggtc ccgtcccttc cttttcctcc
241 gggggaggag gatggggttg ggaacgcttt ccccgaggat gctcgtgtgg ctggtggcct
301 cggggattgt tttctacggg gagctatggg tctgcgctgg cctcgattat gattacactt
361 ttgatgggaa cgaagaggat aaaacagaga ctatagatta caaggacccg tgtaaagccg
421 ctgtattttg gggcgatatt gccttagatg atgaagactt aaatatcttt caaatagata
481 ggacaattga ccttacgcag aacccctttg gaaaccttgg acataccaca ggtggacttg
541 gagaccatgc tatgtcaaag aagcgagggg ccctctacca acttatagac aggataagaa
601 gaattggctt tggcttggag caaaacaaca cagttaaggg aaaagtacct ctacaattct
661 cagggcaaaa tgagaaaaat cgagttccca gagccgctac atcaagaacg gaaagagtat
721 ggcctggagg cgttattcct tatgttatag gaggaaactt cactggcagc cagagagcca
781 tgttcaagca ggccatgagg cactgggaaa agcacacatg tgtgactttc atagaaagaa
841 gtgatgaaga gagttacatt gtattcacct ataggccttg tggatgctgc tcctatgtag
901 gtcggcgagg aagtggacct caggcaatct ctatcggcaa gaactgtgat aaatttggga
961 ttgttgttca tgaattgggt catgtgatag gcttttggca tgaacacaca agaccagatc
1021 gagataacca cgtaactatc ataagagaaa acatccagcc aggtcaagag tacaattttc
1081 tgaagatgga gcctggagaa gcaaactcac ttggagaaag atatgatttc gacagtatca
1141 tgcactatgc caggaacacc ttctcaaggg ggatgtttct ggataccatt ctcccctccc
1201 gtgatgataa tggcatacgt cctgcaattg gtcagcgaac ccgtctaagc aaaggagata
1261 tcgcacaggc aagaaagctg tatagatgtc cagcatgtgg agaaactcta caagaatcca
1321 atggcaacct ttcctctcca ggatttccca atggctaccc ttcttacaca cactgcatct
1381 ggagagtttc tgtgacccca ggggagaaga ttgttttaaa ttttacaacg atggatctat
1441 acaagagtag tttgtgctgg tatgactata ttgaagtaag agacgggtac tggagaaaat
1501 cacctctcct tggtagattc tgtggggaca aattgcctga agttcttact tctacagaca
1561 gcagaatgtg gattgagttt cgtagcagca gtaattgggt aggaaaaggc tttgcagctg
1621 tctatgaagc gatctgtgga ggtgagatac gtaaaaatga aggacagatt cagtctccca
1681 attatcctga tgactatcgc ccgatgaagg aatgtgtgtg gaaaataaca gtgtctgaga
1741 gctaccacgt cgggctgacc tttcagtcct ttgagattga aagacatgac aattgtgctt
1801 atgactacct ggaagttaga gatggaacca gtgaaaatag ccctttgata gggcgtttct
1861 gtggttatga caaacctgaa gacataagat ctacctccaa tactttgtgg atgaagtttg
1921 tttctgacgg aactgtgaac aaagcagggt ttgctgctaa cttttttaaa gaggaagatg
1981 agtgtgccaa acctgaccgt ggaggctgtg agcagcgatg tctgaacact ctgggcagtt
2041 accagtgtgc ctgtgagcct ggctatgagc tgggcccaga cagaaggagc tgtgaagctg
2101 cttgtggtgg acttcttacc aaacttaacg gcaccataac cacccctggc tggcccaagg
2161 agtaccctcc taataagaac tgtgtgtggc aagtggttgc accaacccag tacagaattt
2221 ctgtgaagtt tgagtttttt gaattggaag gcaatgaggt ttgcaaatat gattatgtgg
2281 agatctggag tggtctttcc tctgagtcta aactgcatgg caaattctgt ggcgctgaag
2341 tgcctgaagt gatcacatcc cagttcaaca atatgagaat tgaattcaaa tctgacaata
2401 ctgtatccaa gaagggcttc aaagcacatt ttttctcaga caaagatgaa tgctctaagg
2461 ataatggtgg atgtcagcac gaatgtgtca acacgatggg gagctacatg tgtcaatgcc
2521 gtaatggatt tgtgctacat gacaataaac atgattgcaa ggaagctgag tgtgaacaga
2581 agatccacag tccaagtggc ctcatcacca gtcccaactg gccagacaag tacccaagca
2641 ggaaagaatg cacttgggaa atcagcgcca ctcctggcca ccgaatcaaa ttagccttta
2701 gtgaatttga gattgagcag catcaagaat gtgcttatga ccacttagaa gtatttgatg
2761 gagaaacaga aaagtcaccg attcttggac gactatgtgg caacaagata ccagatcccc
2821 ttgtggctac tggaaataaa atgtttgttc ggtttgtttc tgatgcatct gttcaaagaa
2881 aaggctttca agccacacat tctacagagt gtggcggacg attgaaagca gaatcaaaac
2941 caagagatct gtactcacat gctcagtttg gtgataacaa ctacccagga caggttgact
3001 gtgaatggct attagtatca gaacggggct ctcgacttga attatccttc cagacatttg
3061 aagtggagga agaagcggac tgtggctatg actatgtgga gctctttgat ggtcttgatt
3121 caacagctgt ggggcttggt cgattctgtg gatccgggcc accagaagag atttattcaa
3181 ttggagattc agttttaatt catttccaca ctgatgacac aatcaacaag aagggatttc
3241 atataagata caaaagcata agatatccag ataccacaca taccaaaaaa taacaccaaa
3301 acctctgtca gaacacaaag gaatgtgcat aatggagaga agacatattt tttttaaaac
3361 tgaagatatt ggcacaaatg ttttatacaa agagtttgaa caaaaaatcc ctgtaagacc
3421 agaattatct ttgtactaaa agagaagttt ccagcaaaac cctcatcagc attacaagga
3481 tatttgaact ccatgcttga tggtattaat aaagctggtg aaagggcatc atatacttca
3541 aggaagactc tacaagcttt tgttcacagc ttgaaataga tgcctcacaa ttcagacagt
3601 ttaattcagg aactgtgacc ctgaagtgtt ctttttgaca atttgtcaag atttagggac
3661 ataaaatgat cttgcaggtc gtaaactgga aaacagtatt ttggttgtct taggataatt
3721 gctgactttg tatcttggat acagtgtaaa ccagatccat ataaggtgaa tgtgaaatgg
3781 gagtcttctg agggtgattt gtactttcca tgtgtatgtg tgtgtctggt gtttggaaac
3841 tgggatattt cagcttcatt atttccactt gcaggccagc ttaacctctg aaacacaaat
3901 gatcttgaga ccactttagt gtacttacat ttagatgagt ttgaaatctc aatggtgtct
3961 aattattgca gttaaattct agacatcagt tctttaagtc tcagaaaacg cccagtgaat
4021 tggtaaactt agttcttttt tttggaagtg ctgccttttc acaccaaatc caagaagcct
4081 gtgatgtctt atgaacctta tgagaaaact ccgaagaggt gtgagcagga ttcttctgaa
4141 tgactgtctg gatggttcat tactcaagtt actgctgctg ctattgtctt tcctttgttg
4201 tcgatctgtt attgttgtat tattattgtt gatgttgtca tggttaatct attttttaaa
4261 attgaaatga agcagaagta ggccttgtga gaactgaaag gtctctttca tttttctctt
4321 cctgggattc attttttcaa aacacaatgc tggaaaaaaa agatttgttt ctgaaagact
4381 tcttatggtg ctattccata aacttttttt caaacaagtt tttgaccttt gagccaaccc
4441 acccgtagac tacgaatgtc tccctatggc tggtagcatt tgaagactaa agacttgtca
4501 aatatatcaa gagtatatca ttgcaagggc agcacttgtc ctgtggaaca actacttata
4561 atgccttaga attcctgcac atgatcaaac agatcctcct aaaacacacc ttttgaaatg
4621 ttgaacataa tagtgtatgt taattaacag ctctatgaag aaaatccatt tccatgactg
4681 aagcattgga tataaatatg gtgtcctgct ttttttgtag aaaatgtaat ttgaggatga
4741 attttctgct ttaaaggcat gtgtgttttt aaaattaatg aatgtagatg tgtgattgtc
4801 tgagtgagtg aaactacaag aggtaaaaaa taatgggtgg ttgaaaagtt aaaatgtatg
4861 tgccaagttc tactagaatt ccatttgaaa tagcaccttc cttaggtttc atggacaaat
4921 aatgggaact tctaattttg atcaatccca ttaaaaaaag gctctttcct ttagagaaac
4981 tctattttga tgtcaatata gattactgta tgaagtagct ttgtgtctgt tacctgtcca
5041 tgagcataca acattgaata caattgggtg tattctttca gttttacaca attaaagtat
5101 acacacagat gtaaaaaaaa aaaaaaaaaa aaaaaaaaa
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