LOCUS AF279890 2730 bp mRNA linear HUM 20-SEP-2000
DEFINITION Homo sapiens 2P domain potassium channel TREK2 (KCNK10) mRNA,
complete cds.
ACCESSION AF279890
VERSION AF279890.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2730)
AUTHORS Lesage,F., Terrenoire,C., Romey,G. and Lazdunski,M.
TITLE Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple
regulations by polyunsaturated fatty acids, lysophospholipids, and
Gs, Gi, and Gq protein-coupled receptors
JOURNAL J. Biol. Chem. 275 (37), 28398-28405 (2000)
PUBMED 10880510
REFERENCE 2 (bases 1 to 2730)
AUTHORS Lesage,F.
TITLE Direct Submission
JOURNAL Submitted (20-JUN-2000) IPMC, CNRS, 660 Route des Lucioles,
Valbonne 06560, France
FEATURES Location/Qualifiers
source 1..2730
/db_xref="H-InvDB:HIT000076068"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="14"
/map="14q31"
gene 1..2730
/gene="KCNK10"
CDS 473..2089
/gene="KCNK10"
/codon_start=1
/product="2P domain potassium channel TREK2"
/protein_id="AAG15191.1"
/translation="MFFLYTDFFLSLVAVPAAAPVCQPKSATNGQPPAPAPTPTPRLS
ISSRATVVARMEGTSQGGLQTVMKWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQK
NTIALEKAEFLRDHVCVSPQELETLIQHALDADNAGVSPIGNSSNNSSHWDLGSAFFF
AGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVE
KVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTT
VGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVG
EIKAHAAEWKANVTAEFRETRRRLSVEIHDKLQRAATIRSMERRRLGLDQRAHSLDML
SPEKRSVFAALDTGRFKASSQESINNRPNNLRLKGPEQLNKHGQGASEDNIINKFGST
SRLTKRKNKDLKKTLPEDVQKIYKTFRNYSLDEEKKEEETEKMCNSDNSSTAMLTDCI
QQHAELENGMIPTDTKDREPENNSLLEDRN"
BASE COUNT 658 a 680 c 772 g 620 t
ORIGIN
1 gactagtgat taagatgaca gcagggatcg tctcctccgg tctcacagct accccgggct
61 ggagcgtggg gagggggtaa gggagccagc caactcgggg aaacttcgtt gccagagatg
121 actggggttt tcgggctttc ccagccttcc catgccgggc cacacggcat tcattaaagt
181 ggtggggcaa ctattggtgc gctccagccg ggcaggtttt gagctgcaga gacccgtgcc
241 cggtagcagc gctttgccac cgagtgcacc caggacgcag tggccgccag cccgggtctc
301 ctgctggggg ccggcgagtg cagggagact ttgcgccacg atgttttgtt ttcctgccgc
361 aggaacgcta ggcagtctct ttccaccaga cttaacccgc ctgaagcaat agccatggaa
421 gttgcggcgg cacagaggga gacagaaccg cttggcgcgg catctttctt ggatgttttt
481 tctctacaca gacttctttc tttccttggt ggccgttccc gcagcagcac cggtgtgcca
541 gcccaagagc gccactaacg ggcaaccccc ggctccggct ccgactccaa ctccgcgcct
601 gtccatttcc tcccgagcca cagtggtagc caggatggaa ggcacctccc aagggggctt
661 gcagaccgtc atgaagtgga agacggtggt tgccatcttt gtggttgtgg tggtctacct
721 tgtcactggc ggtcttgtct tccgggcatt ggagcagccc tttgagagca gccagaagaa
781 taccatcgcc ttggagaagg cggaattcct gcgggatcat gtctgtgtga gcccccagga
841 gctggagacg ttgatccagc atgctcttga tgctgacaat gcgggagtca gtccaatagg
901 aaactcttcc aacaacagca gccactggga cctcggcagt gcctttttct ttgctggaac
961 tgtcattacg accatagggt atgggaatat tgctccgagc actgaaggag gcaaaatctt
1021 ttgtatttta tatgccatct ttggaattcc actctttggt ttcttattgg ctggaattgg
1081 agaccaactt ggaaccatct ttgggaaaag cattgcaaga gtggagaagg tctttcgaaa
1141 aaagcaagtg agtcagacca agatccgggt catctcaacc atcctgttca tcttggccgg
1201 ctgcattgtg tttgtgacga tccctgctgt catctttaag tacatcgagg gctggacggc
1261 cttggagtcc atttactttg tggtggtcac tctgaccacg gtgggctttg gtgattttgt
1321 ggcaggggga aacgctggca tcaattatcg ggagtggtat aagcccctag tgtggttttg
1381 gatccttgtt ggccttgcct actttgcagc tgtcctcagt atgatcggag attggctacg
1441 ggttctgtcc aaaaagacaa aagaagaggt gggtgaaatc aaggcccatg cggcagagtg
1501 gaaggccaat gtcacggctg agttccggga gacacggcga aggctcagcg tggagatcca
1561 cgataagctg cagcgggcgg ccaccatccg cagcatggag cgccggcggc tgggcctgga
1621 ccagcgggcc cactcactgg acatgctgtc ccccgagaag cgctctgtct ttgctgccct
1681 ggacaccggc cgcttcaagg cctcatccca ggagagcatc aacaaccggc ccaacaacct
1741 gcgcctgaag gggccggagc agctgaacaa gcatgggcag ggtgcgtccg aggacaacat
1801 catcaacaag ttcgggtcca cctccagact caccaagagg aaaaacaagg acctcaaaaa
1861 gaccttgccc gaggacgttc agaaaatcta caagaccttc cggaattact ccctggacga
1921 ggagaagaaa gaggaggaga cggaaaagat gtgtaactca gacaactcca gcacagccat
1981 gctgacggac tgtatccagc agcacgctga gttggagaac ggaatgatac ccacggacac
2041 caaagaccgg gagccggaga acaactcatt acttgaagac agaaactaaa tgtgaaggac
2101 attggtcttg gactgagcgt tgtgtgtgtg tgtgtgtgtg tgtttttaat attcacactg
2161 agacatgtgc cttaaacaga ctttttagtc caaaattaca tagcattgaa gaatatattt
2221 cactgtgcca taaacaactg aaagcttgct ctgccaaaag gaatcagaga acaagaactt
2281 catttcagat agcaaacgca ggacacacca agagtgtccg tgcacgtagc cggttctggc
2341 cgtacatgtt aagggcattt cagtggcagt gctgtacccc tgggcagtgc tacctgggca
2401 cacacgtaga caagggcagc tattccttag accagcctcc tgaaagaaac aggtgtgtct
2461 ttttagtgga gtcgtagtaa tatgtgcaca cacagaaggg gacctgattg ggtgggagct
2521 ggttatgtgt aactagcgtt ggagttgaca ttttggcatg tgctctgagc ttgaattttg
2581 ataccaacca ttcagtgcat catacctagt ctttctatgc tccaaatgaa tgtctgtggg
2641 gacctgagag cacctggaat ttgttggaag cagatcagag cacacgtacg aaaaggtgca
2701 attgcttttc tcatgacaaa agaaaaaaaa
//