LOCUS AF279145 5540 bp mRNA linear HUM 09-MAY-2001
DEFINITION Homo sapiens tumor endothelial marker 8 precursor (TEM8) mRNA,
complete cds.
ACCESSION AF279145
VERSION AF279145.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5540)
AUTHORS St. Croix,B., Rago,C., Velculescu,V., Traverso,G., Romans,K.E.,
Montgomery,E., Lal,A., Riggins,G.J., Lengauer,C., Vogelstein,B. and
Kinzler,K.W.
TITLE Genes expressed in human tumor endothelium
JOURNAL Science 289 (5482), 1197-1202 (2000)
PUBMED 10947988
REFERENCE 2 (bases 1 to 5540)
AUTHORS St. Croix,B., Vogelstein,B. and Kinzler,K.W.
TITLE Direct Submission
JOURNAL Submitted (16-JUN-2000) Johns Hopkins Oncology Center, Johns
Hopkins University, 1650 Orleans Street, Baltimore, MD 21231, USA
REFERENCE 3 (bases 1 to 5540)
AUTHORS St. Croix,B., Vogelstein,B. and Kinzler,K.W.
TITLE Direct Submission
JOURNAL Submitted (09-MAY-2001) Johns Hopkins Oncology Center, Johns
Hopkins University, 1650 Orleans Street, Baltimore, MD 21231, USA
REMARK Sequence update by submitter
COMMENT On May 9, 2001 this sequence version replaced AF279145.1.
FEATURES Location/Qualifiers
source 1..5540
/db_xref="H-InvDB:HIT000076038"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="4"
gene 1..5540
/gene="TEM8"
CDS 144..1838
/gene="TEM8"
/codon_start=1
/product="tumor endothelial marker 8 precursor"
/protein_id="AAK52094.1"
/translation="MATAERRALGIGFQWLSLATLVLICAGQGGRREDGGPACYGGFD
LYFILDKSGSVLHHWNEIYYFVEQLAHKFISPQLRMSFIVFSTRGTTLMKLTEDREQI
RQGLEELQKVLPGGDTYMHEGFERASEQIYYENRQGYRTASVIIALTDGELHEDLFFY
SEREANRSRDLGAIVYCVGVKDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKK
SCIEILAAEPSTICAGESFQVVVRGNGFRHARNVDRVLCSFKINDSVTLNEKPFSVED
TYLLCPAPILKEVGMKAALQVSMNDGLSFISSSVIITTTHCSDGSILAIALLILFLLL
ALALLWWFWPLCCTVIIKEVPPPPAEESEEEDDDGLPKKKWPTVDASYYGGRGVGGIK
RMEVRWGEKGSTEEGAKLEKAKNARVKMPEQEYEFPEPRNLNNNMRRPSSPRKWYSPI
KGKLDALWVLLRKGYDRVSVMRPQPGDTGRCINFTRVKNNQPAKYPLNNAYHTSSPPP
APIYTPPPPAPHCPPPPPSAPTPPIPSPPSTLPPPPQAPPPNRAPPPSRPPPRPSV"
sig_peptide 144..224
/gene="TEM8"
mat_peptide 225..1835
/gene="TEM8"
/product="tumor endothelial marker 8"
misc_feature 1104..1172
/gene="TEM8"
/note="Region: predicted transmembrane domain"
BASE COUNT 1601 a 1306 c 1187 g 1446 t
ORIGIN
1 aattgcttcc ggggagttgc gagggagcga gggggaataa aggacccgcg aggaagggcc
61 cgcggatggc gcgtccctga gggtcgtggc gagttcgcgg agcgtgggaa ggagcggacc
121 ctgctctccc cgggctgcgg gccatggcca cggcggagcg gagagccctc ggcatcggct
181 tccagtggct ctctttggcc actctggtgc tcatctgcgc cgggcaaggg ggacgcaggg
241 aggatggggg tccagcctgc tacggcggat ttgacctgta cttcattttg gacaaatcag
301 gaagtgtgct gcaccactgg aatgaaatct attactttgt ggaacagttg gctcacaaat
361 tcatcagccc acagttgaga atgtccttta ttgttttctc cacccgagga acaaccttaa
421 tgaaactgac agaagacaga gaacaaatcc gtcaaggcct agaagaactc cagaaagttc
481 tgccaggagg agacacttac atgcatgaag gatttgaaag ggccagtgag cagatttatt
541 atgaaaacag acaagggtac aggacagcca gcgtcatcat tgctttgact gatggagaac
601 tccatgaaga tctctttttc tattcagaga gggaggctaa taggtctcga gatcttggtg
661 caattgttta ctgtgttggt gtgaaagatt tcaatgagac acagctggcc cggattgcgg
721 acagtaagga tcatgtgttt cccgtgaatg acggctttca ggctctgcaa ggcatcatcc
781 actcaatttt gaagaagtcc tgcatcgaaa ttctagcagc tgaaccatcc accatatgtg
841 caggagagtc atttcaagtt gtcgtgagag gaaacggctt ccgacatgcc cgcaacgtgg
901 acagggtcct ctgcagcttc aagatcaatg actcggtcac actcaatgag aagccctttt
961 ctgtggaaga tacttattta ctgtgtccag cgcctatctt aaaagaagtt ggcatgaaag
1021 ctgcactcca ggtcagcatg aacgatggcc tctcttttat ctccagttct gtcatcatca
1081 ccaccacaca ctgttctgac ggttccatcc tggccatcgc cctgctgatc ctgttcctgc
1141 tcctagccct ggctctcctc tggtggttct ggcccctctg ctgcactgtg attatcaagg
1201 aggtccctcc accccctgcc gaggagagtg aggaagaaga tgatgatggt ctgcctaaga
1261 aaaagtggcc aacggtagac gcctcttatt atggtgggag aggcgttgga ggcattaaaa
1321 gaatggaggt tcgttgggga gaaaagggct ccacagaaga aggtgctaag ttggaaaagg
1381 caaagaatgc aagagtcaag atgccggagc aggaatatga attccctgag ccgcgaaatc
1441 tcaacaacaa tatgcgtcgg ccttcttccc cccggaagtg gtactctcca atcaagggaa
1501 aactcgatgc cttgtgggtc ctactgagga aaggatatga tcgtgtgtct gtgatgcgtc
1561 cacagccagg agacacgggg cgctgcatca acttcaccag ggtcaagaac aaccagccag
1621 ccaagtaccc actcaacaac gcctaccaca cctcctcgcc gcctcctgcc cccatctaca
1681 ctcccccacc tcctgcgccc cactgccctc ccccgccccc cagcgcccct acccctccca
1741 tcccgtcccc accttccacc cttccccctc ctccccaggc tccacctccc aacagggcac
1801 ctcctccctc ccgccctcct ccaaggcctt ctgtctagag cccaaagttc ctgctctggg
1861 ctctctcaga aacttcagga gatgttagaa caagtctttc cagttagaga agaggagtgg
1921 tgataaagcc cactgacctt cacacattct aaaaattggt tggcaatgcc agtataccaa
1981 caatcatgat cagctgaaag aaacagatat tttaaattgc cagaaaacaa atgatgaggc
2041 aactacagtc agatttatag ccagccatct atcacctcta gaaggttcca gagacagtga
2101 aactgcaaga tgctctcaac aggattatgt ctcatggaga ccagtaagaa aatcatttat
2161 ctgaaggtga aatgcagagt tggataagaa atacattgct gggtttctaa aatgctgcct
2221 tcctgcctct actccacctc catccctgga ctttggaccc ttggcctagg agcctaagga
2281 ccttcacccc tgtgcaccac ccaagaaaga ggaaaacttt gcctacaact ttggaaatgc
2341 tggggtccct ggtgtggtaa gaaactcaac atcagacggg tatgcagaag gatgttcttc
2401 tgggatttgc aggtacataa aaaatgtatg gcatcttttc cttgcaaatt cttccagttt
2461 ccaagtgaga aggggagcag gtgtttactg atggaaaagg tatgttgcta tgttgatgtg
2521 taagtgaaat cagttgtgtg caatagacag gggcgtattc atgggagcat cagccagttt
2581 ctaaaaccca caggccatca gcagctagag gtggctggct ttggccagac atggacccta
2641 aatcaacaga caatggcatt gtcgaagagc aacctgttaa tgaatcatgt taaaaatcaa
2701 ggtttggctt cagtttaaat cacttgaggt atgaagttta tcctgttttc cagagataaa
2761 cataagttga tcttcccaaa ataccatcat taggacctat cacacaatat cactagtttt
2821 ttttgtttgt ttgttttttg ttttttttct tggtaaagcc atgcaccaca gacttctggg
2881 cagagctgag agacaatggt cctgacataa taaggatctt tgattaaccc ccataaggca
2941 tgtgtgtgta tacaaatata cttctctttg gcttttcgac atagaacctc agctgttaac
3001 caaggggaaa tacatcagat ctgcaacaca gaaatgctct gcctgaaatt tccaccatgc
3061 ctaggactca ccccatttat ccaggtcttt ctggatctgt ttaatcaata agccctataa
3121 tcacttgcta aacactgggc ttcatcaccc agggataaaa acagagatca ttgtcttgga
3181 cctcctgcat cagcctattc aaaattatct ctctctctag ctttccacaa atcctaaaat
3241 tcctgtccca agccacccaa attctcagat cttttctgga acaaggcaga atataaaata
3301 aatatacatt tagtggcttg ggctatggtc tccaaagatc cttcaaaaat acatcaagcc
3361 agcttcattc actcacttta cttagaacag agatataagg gcctgggatg catttatttt
3421 atcaatacca atttttgtgg ccatggcaga cattgctaat caatcacagc actatttcct
3481 attaagccca ctgatttctt cacaatcctt ctcaaattac aattccaaag agccgccact
3541 caacagtcag atgaacccaa cagtcagatg agagaaatga accctacttg ctatctctat
3601 cttagaaagc aaaaacaaac aggagtttcc agggagaatg ggaaagccag ggggcataaa
3661 aggtacagtc aggggaaaat agatctaggc agagtgcctt agtcagggac cacgggcgct
3721 gaatctgcag tgccaacacc aaactgacac atctccaggt gtacctccaa ccctagcctt
3781 ctcccacagc tgcctacaac agagtctccc agccttctca gagagctaaa accagaaatt
3841 tccagactca tgaaagcaac cccccagcct ctccccaacc ctgccgcatt gtctaatttt
3901 tagaacacta ggcttcttct ttcatgtagt tcctcataag caggggccag aatatctcag
3961 ccacctgcag tgacattgct ggacccctga aaaccattcc ataggagaat gggttcccca
4021 ggctcacagt gtagagacat tgagcccatc acaactgttt tgactgctgg cagtctaaaa
4081 cagtccaccc accccatggc actgccgcgt gattcccgcg gccattcaga agttcaagcc
4141 gagatgctga cgttgctgag caacgagatg gtgagcatca gtgcaaatgc accattcagc
4201 acatcagtca tatgcccagt gcagttacaa gatgttgttt cggcaaagca ttttgatgga
4261 atagggaact gcaaatgtat gatgattttg aaaaggctca gcaggatttg ttcttaaacc
4321 gactcagtgt gtcatccccg gttatttaga attacagtta agaaggagaa acttctataa
4381 gactgtatga acaaggtgat atcttcatag tgggctatta caggcaggaa aatgttttaa
4441 ctggtttaca aaatccatca atacttgtgt cattccctgt aaaaggcagg agacatgtga
4501 ttatgatcag gaaactgcac aaaattattg ttttcagccc ccgtgttatt gtccttttga
4561 actgtttttt ttttattaaa gccaaatttg tgttgtatat attcgtattc catgtgttag
4621 atggaagcat ttcctatcca gtgtgaataa aaagaacagt tgtagtaaat tattataaag
4681 ccgatgatat ttcatggcag gttattctac caagctgtgc ttgttggttt ttcccatgac
4741 tgtattgctt ttataaatgt acaaatagtt actgaaatga cgagaccctt gtttgcacag
4801 cattaataag aaccttgata agaaccatat tctgttgaca gccagctcac agtttcttgc
4861 ctgaagcttg gtgcaccctc cagtgagaca caagatctct cttttaccaa agttgagaac
4921 agagctggtg gattaattaa tagtcttcga tatctggcca tgggtaacct cattgtaact
4981 atcatcagaa tgggcagaga tgatcttgaa gtgtcacata cactaaagtc caaacactat
5041 gtcagatggg ggtaaaatcc attaaagaac aggaaaaaat aattataaga tgataagcaa
5101 atgtttcagc ccaatgtcaa cccagttaaa aaaaaaatta atgctgtgta aaatggttga
5161 attagtttgc aaactatata aagacatatg cagtaaaaag tctgttaatg cacatcctgt
5221 gggaatggag tgttctaacc aattgccttt tcttgttatc tgagctctcc tatattatca
5281 tactcagata accaaattaa aagaattaga atatgatttt taatacactt aacattaaac
5341 tcttctaact ttcttctttc tgtgataatt cagaagatag ttatggatct tcaatgcctc
5401 tgagtcattg ttataaaaaa tcagttatca ctataccatg ctataggaga ctgggcaaaa
5461 cctgtacaat gacaaccctg gaagttgctt tttttaaaaa aataataaat ttcttaaatc
5521 aaaaaaaaaa aaaaaaaaaa
//