LOCUS AF270513 4009 bp mRNA linear HUM 18-APR-2001
DEFINITION Homo sapiens extracellular glycoprotein EMILIN-2 precursor, mRNA,
complete cds.
ACCESSION AF270513
VERSION AF270513.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4009)
AUTHORS Doliana,R., Bot,S., Mungiguerra,G., Canton,A., Cilli,S.P. and
Colombatti,A.
TITLE Isolation and characterization of EMILIN-2, a new component of the
growing EMILINs family and a member of the EMI domain-containing
superfamily
JOURNAL J. Biol. Chem. 276 (15), 12003-12011 (2001)
PUBMED 11278945
REFERENCE 2 (bases 1 to 4009)
AUTHORS Doliana,R., Bot,S. and Bucciotti,F.
TITLE Direct Submission
JOURNAL Submitted (19-MAY-2000) Oncologia Sperimentale, Centro di
Riferimento Oncologico di Aviano- IRCCS-, Pedemontana Occidentale,
Aviano, PN 33081, Italy
FEATURES Location/Qualifiers
source 1..4009
/db_xref="H-InvDB:HIT000075770"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="18"
/map="18p11.3"
/tissue_type="kidney"
/note="3' region isolated using EMILIN C1q domain as bait
in a yeast two-hybrid experiment"
CDS 160..3321
/codon_start=1
/product="extracellular glycoprotein EMILIN-2 precursor"
/protein_id="AAK37963.1"
/translation="MWQPRRPWPRVPWRWALALLALVGAGLCHAGPQPGYPARPSARN
KNWCAYIVNKNVSCSVLEGSESFIQAQYNCAWNQMPCPSALVYRVNFRPRYVTRYKTV
TQLEWRCCPGFRGGDCQEGPKDPVKTLRPTPARPRNSLKKATDNEPSQFSEPRKTLSP
TGTAQPSWGVDPKEGPQELQEKKIQVLEEKVLRLTRTVLDLQSSLAGVSENLKHATQD
DASRTRAPGLSSQHPKPDTTVSGDTETGQSPGVFNTKESGMKDIKSELAEVKDTLKNK
SDKLEELDGKVKGYEGQLRQLQEAAQGPTVTMTTNELYQAYVDSKIDALREELMEGMD
RKLADLKNSCEYKLTGLQQQCDDYGSSYLGVIELIGEKETSLRKEINNLRARLQEPSA
QANCCDSEKNGDIGQQIKTLDQKIERVAEATRMLNGRLDNEFDRLIVPEPDVDFDAKW
NELDARINVTEKNAEEHCFYIEETLRGAINGEVGDLKQLVDQKIQSLEDRLGSVLLQM
TNNTGAELSPPGAAALPGVSGSGDERVMMELNHLKDGVQVVEDICLLNIQGKPHGMEG
ALPNREDRAVRDSLHLLKSLNDTMHRKFQETEQTIQKLQQDFSFLYSQLNHTENDVTH
LQKEMSNCRAGENAGMGRFTKVGEQERTVDTLPSPQHPVAHCCSQLEERWQRLQSQVI
SELDACKECTQGVQREVSMVEGRVSHMEKTCSKLDSISGNLQRIKEGLNKHVSSLWNC
VRQMNGTLRSHSRDISGLKNSVQQFYSHVFQISTDLQDLVKFQPSAKAPSPPPPAEAP
KEPLQPEPAPPRPSGPATAEDPGRRPVLPQRPPEERPPQPPGSTGVIAETGQAGPPAG
AGVSGRGLPRGVDGQTGSGTVPGAEGFAGAPGYPKSPPVASPGAPVSSLVSFSAGLTQ
KPFPSDGGVVLFNKVLVNDGDVYNPSTGVFTAPYDGRYLITATLTPERDAYVEAVLSV
SNASVAQLHTAGYRREFLEYHRPPGALHTCGGPGAFHLIVHLKAGDAVNVVVTGGKLA
HTDFDEMYSTFSGVFLYPFLSHL"
sig_peptide 160..249
mat_peptide 250..3318
/product="extracellular glycoprotein EMILIN-2"
misc_feature 292..513
/note="Region: cysteine-rich EMI domain"
misc_feature 637..2559
/note="Region: coiled-coil domain"
misc_feature 2509..2676
/note="Region: proline-rich domain"
misc_feature 2677..2823
/note="Region: collagen domain"
misc_feature 2848..3318
/note="Region: C1q-like domain"
BASE COUNT 977 a 1075 c 1197 g 760 t
ORIGIN
1 ccggaggggg cggccgcgga gcactggttg gagcgccgcg ccgcgcccga gcctcttgcc
61 ttcgcgggcg gcgccctggc cgccggcagc cttgtggccg gtgccccgat ccgccgcgct
121 ccggacccgg gcaggcgggg cgcgcccgct gcgcgcggga tgtggcagcc cagacggccc
181 tggccccgcg tgccctggcg ctgggcgctg gcgctgctgg ccctggttgg cgcggggctg
241 tgccacgccg gcccgcagcc cgggtatccc gcgcggccca gcgccaggaa caagaactgg
301 tgcgcctaca tcgtgaacaa gaatgtgagc tgctccgtgc tggagggaag tgagagtttt
361 attcaggctc agtacaactg tgcctggaac cagatgccct gtccgtcggc gctggtgtat
421 cgagtgaact tcagacctag atatgtcact aggtataaga cagtgacaca gttggaatgg
481 aggtgctgtc ctggctttag agggggagat tgccaagaag gtcccaaaga ccccgtgaag
541 accctccgcc ccacgccggc tcggcctcga aatagcttga agaaagccac agataatgaa
601 cccagccaat tctcagagcc caggaagact ttgtccccaa ctggtacagc acaaccaagc
661 tggggggtag atccaaaaga ggggcctcag gaacttcagg aaaagaagat acaggtgcta
721 gaggagaagg ttcttcgact cacaaggacg gttcttgacc tccagtcttc ccttgctgga
781 gtgagtgaaa atctcaaaca tgccactcag gatgatgcca gtagaacacg ggcaccaggg
841 ctcagcagcc agcaccccaa gcctgacacc actgttagtg gagacacaga aacgggccag
901 agtcctggtg tcttcaacac taaggaatct ggcatgaagg acatcaagtc tgaattggct
961 gaagtcaaag atactctaaa gaacaaaagt gacaagctgg aagagctgga tggaaaagtg
1021 aagggctacg aagggcagct cagacagctc caggaagcag ctcagggccc gacggtgacc
1081 atgacaacca acgaactcta ccaagcctat gtggacagta agatcgacgc cctgagagag
1141 gagctcatgg agggcatgga cagaaagctg gctgacctga aaaactcatg tgagtacaag
1201 ctcactggcc tccagcagca gtgtgatgac tatgggagca gctacctggg agtgatagag
1261 ctcatagggg agaaggaaac aagcctgaga aaagaaataa ataacctccg agcccggcta
1321 caggagcctt cagcccaggc aaattgctgc gacagtgaaa agaatggtga cattggtcaa
1381 cagatcaaga cattggacca gaaaatcgag agagttgctg aagccaccag aatgctgaat
1441 ggaagactgg acaatgagtt tgaccgcctt atagttccag agccagatgt ggattttgat
1501 gcaaaatgga atgaactcga tgcaaggatc aatgtgacgg agaagaacgc tgaagaacat
1561 tgcttttaca ttgaggaaac ccttcggggc gccattaatg gagaggtggg tgacttgaag
1621 cagcttgttg atcagaaaat acagtctctg gaagaccgtc tggggagcgt tctcctacag
1681 atgaccaata acactggtgc agagctcagt cccccagggg cagcagccct gccaggagtg
1741 tcagggtcag gagatgaacg ggtcatgatg gaattaaacc acctgaagga cggagttcaa
1801 gttgttgaag acatttgcct gctgaacatc cagggaaagc ctcatgggat ggaaggtgcc
1861 ttgccaaaca gggaagaccg cgcagtacgc gacagcctgc accttttgaa atctctcaac
1921 gacacgatgc acaggaagtt tcaagaaacc gaacaaacca tccagaaact tcaacaggat
1981 tttagttttc tttattctca attaaaccac acagaaaatg atgtgactca tcttcaaaag
2041 gaaatgagca attgtagagc aggtgaaaac gctggcatgg gtaggttcac taaggtgggt
2101 gagcaagaaa ggacagtgga caccctgccg tccccccagc accccgtggc tcattgctgc
2161 agtcagctgg aggagaggtg gcagaggttg cagagccagg tcatctcgga gctggatgct
2221 tgtaaggaat gcacgcaggg ggtccagagg gaggtctcca tggtggaggg cagggtgtct
2281 catatggaga aaacttgcag caagctggac tctatctcag gaaatcttca gaggatcaag
2341 gaggggctca acaagcatgt cagcagcctg tggaactgtg tcaggcagat gaacggaacg
2401 ctcaggtcgc attccagaga catttctggc ctgaagaatt cagtccagca gttctacagc
2461 cacgtcttcc agatttctac tgatttgcaa gatctggtca aatttcagcc atcagcaaag
2521 gcgccctcgc ccccgccgcc cgcagaggcc ccgaaggagc cgctgcagcc cgagcccgcc
2581 ccgccgaggc ccagcggccc cgcaaccgca gaggaccctg ggcgacggcc cgtcctgccc
2641 cagcggcccc ccgaggagag gccgccccag ccgccaggct ccaccggggt catcgcggag
2701 acgggccagg ccgggccccc cgcaggcgca ggcgtgtctg ggcggggtct gccgcggggc
2761 gtggacggcc agaccgggag cggcaccgtc cccggcgcag aaggcttcgc gggcgcacca
2821 ggatacccga agtcacctcc tgtagcttcc ccaggagctc cggtgtcttc tctggtgtct
2881 ttttctgcgg ggctcaccca gaagcctttc cccagtgatg ggggcgttgt cctctttaac
2941 aaagtgctgg tgaacgacgg ggatgtttac aaccccagca ccggggtctt cacggctcct
3001 tatgatgggc gctacctgat cacggccacc ctcacccccg agagagacgc ctacgtggaa
3061 gcagtgctgt cggtctccaa cgccagcgtg gcccagctgc ataccgctgg gtacaggaga
3121 gagttcctgg aataccaccg ccctccagga gctttgcata cctgcggggg cccgggggca
3181 ttccacctca tcgtgcacct gaaggcggga gatgcagtca acgtcgtggt gactgggggc
3241 aagctggctc acacagactt tgatgaaatg tactccacat ttagtggggt tttcttatat
3301 cctttccttt cccacctcta aggtggctgg ggagatgtca ggggaaagat agatagttgt
3361 aaaaactcta aagctttaat atattcggtt tgtatgtaat ggaagcacgg ggctagagtt
3421 tccacatagg ccccaacata aaggccttcc ctcgctgttg aggccaccat gccttactgc
3481 atccagccag gctgcaggga gtgaggcaca cggtgaacat ggccactgac ttttctgcca
3541 ctctaactgg acaactggaa gacttggaaa ggcctccacc tgtatctaca ctctgagggc
3601 cctggactgg gcctgagctt gccacagagg ctccgtctga ctgtgggctg ggaggaggga
3661 ggcaggggag agccggtcac ggtggctggt ctttactgca gggcagcact gtggccagct
3721 gtctgtcttt acactgcatg cagaagttta aacactgaag tgccgaagtg gcccgtgccg
3781 ccgcacagag accccgactt tagtttgggc tgttccacgc ttggctcacc attgccgcct
3841 gggacttaac ctgctcaggc gggccttcgc ccagctgcaa atagggatgc gttagagact
3901 gttcccaaag cttgttgggc tccttaaatg gcatgtacaa tttaagtgca aagacaggga
3961 gtgtcaataa agatggaaag ccatttccag ttaacttttg ttaatttaa
//