LOCUS       AF265565                1246 bp    mRNA    linear   HUM 12-JUN-2000
DEFINITION  Homo sapiens PAR6 (PAR6) mRNA, complete cds.
ACCESSION   AF265565
VERSION     AF265565.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1246)
  AUTHORS   Qiu,R.G., Abo,A. and Steven Martin,G.
  TITLE     A human homolog of the C. elegans polarity determinant Par-6 links
            Rac and Cdc42 to PKCzeta signaling and cell transformation
  JOURNAL   Curr. Biol. 10 (12), 697-707 (2000)
   PUBMED   10873802
REFERENCE   2  (bases 1 to 1246)
  AUTHORS   Qiu,R.-G. and Martin,G.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-MAY-2000) Molecular and Cell Biology, University of
            California, Berkeley, 401 Barker Hall #3204, Berkeley, CA
            94720-3204, USA
FEATURES             Location/Qualifiers
     source          1..1246
                     /db_xref="H-InvDB:HIT000075550"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     gene            1..1246
                     /gene="PAR6"
     CDS             66..1103
                     /gene="PAR6"
                     /function="mediates cell transformation by Rac/Cdc42"
                     /note="effector of Rac and Cdc42; binds atypical PKCs;
                     similar to Caenorhabditis elegans polarity protein Par-6;
                     contains PDZ and CRIB domains"
                     /codon_start=1
                     /product="PAR6"
                     /protein_id="AAF75548.1"
                     /translation="MARPQRTPARSPDSIVEVKSKFDAEFRRFALPRASVSGFQEFSR
                     LLRAVHQIPGLDVLLGYTDAHGDLLPLTNDDSLHRALASGPPPLRLLVQKREADSSGL
                     AFASNSLQRRKKGLLLRPVAPLRTRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRLH
                     KHGSDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVN
                     GIEVAGKTLDQVTDMMVANSHNLIVTVKPANQRNNVVRGASGRLTGPPSAGPGPAEPD
                     SDDDSSDLVIENRQPPSSNGLSQGPPCWDLHPGCRHPGTRSSLPSLDDQEQASSGWGS
                     RIRGDGSGFSL"
BASE COUNT          230 a          400 c          384 g          232 t
ORIGIN      
        1 ggcacgaggc acctgcgcct cggcgggccg cctggggcac cgtccccggc ccgcccggcc
       61 ccgccatggc ccggccgcag aggactccgg cgcgcagtcc cgatagcatc gtcgaggtga
      121 agagcaaatt tgacgccgag ttccgacgct tcgcgctgcc tcgcgcttcg gtgagcggct
      181 tccaggagtt ctcgcggttg ctgcgggcgg tgcaccagat cccgggcctg gacgtgctac
      241 ttggctatac ggatgctcat ggcgacctgc tgcccctcac caacgacgac agcctgcacc
      301 gggccctggc cagcgggccc ccgccactgc gcctactggt gcagaagcgg gaagctgact
      361 ccagcggcct ggcttttgcc tccaactctc tgcagcggcg caagaaaggg ctcttgctgc
      421 ggccagtggc acccctgcgc acccggccac ccttgctaat cagcctgccc caagatttcc
      481 gccaggtttc ctcagtcata gacgtggacc tactgcctga gacccaccga cgggtgcggc
      541 tgcacaagca tggttcagac cgccccctgg gcttctacat ccgagatggc atgagcgtgc
      601 gtgtggctcc ccagggcctg gagcgggttc caggaatctt catctcccgc ctggtacgtg
      661 ggggtctggc tgagagtaca gggctgctgg cggtcagtga tgagatcctc gaggtcaatg
      721 gcattgaagt agccgggaag accttggacc aagtgacgga catgatggtt gccaacagcc
      781 ataacctcat tgtcactgtc aagcccgcca accagcgcaa taacgtggtg cgaggggcat
      841 ctgggcgttt gacaggtcct ccctctgcag ggcctgggcc tgctgagcct gatagtgacg
      901 atgacagcag tgacctggtc attgagaacc gccagcctcc cagttccaat gggctgtctc
      961 aggggccccc gtgctgggac ctgcaccctg gctgccgaca tcctggtacc cgcagctctc
     1021 tgccctccct ggatgaccag gagcaggcca gttctggctg ggggagtcgc attcgaggag
     1081 atggtagtgg cttcagcctc tgacagtcag gatgaagccc catgccactc cacactgctg
     1141 ggacatggca gggacttcac agtgggggtt tttagctggc tcacagggct ccctcagcct
     1201 ggggaacatt aaaggttttc tacaaaaaaa aaaaaaaaaa agcatt
//