LOCUS AF263523 2843 bp mRNA linear HUM 31-OCT-2000
DEFINITION Homo sapiens vanilloid receptor-related osmotically activated
channel (VROAC) mRNA, complete cds.
ACCESSION AF263523
VERSION AF263523.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2843)
AUTHORS Liedtke,W., Choe,Y., Marti-Renom,M.A., Bell,A.M., Denis,C.S.,
Sali,A., Hudspeth,A.J., Friedman,J.M. and Heller,S.
TITLE Vanilloid receptor-related osmotically activated channel (VR-OAC),
a candidate vertebrate osmoreceptor
JOURNAL Cell 103 (3), 525-535 (2000)
PUBMED 11081638
REFERENCE 2 (bases 1 to 2843)
AUTHORS Liedtke,W.B. and Friedman,J.M.
TITLE Direct Submission
JOURNAL Submitted (05-MAY-2000) Molecular Genetics, The Rockefeller
University, 1230 York Avenue, New York, NY 10021, USA
FEATURES Location/Qualifiers
source 1..2843
/db_xref="H-InvDB:HIT000075494"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q24.1"
/cell_line="HEK 293"
/note="between STS markers D12S1339 and D12S2291"
gene 1..2843
/gene="VROAC"
CDS 1..2616
/gene="VROAC"
/note="VR-OAC; non-selective cation channel; responsive to
osmotic stimuli"
/codon_start=1
/product="vanilloid receptor-related osmotically activated
channel"
/protein_id="AAG28029.1"
/translation="MADSSEGPRAGPGEVAELPGDESGTPGGEAFPLSSLANLFEGED
GSLSPSPADASRPAGPGDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKA
PMDSLFDYGTYRHHSSDNKRWRKKIIEKQPQSPKAPAPQPPPILKVFNRPILFDIVSR
GSTADLDGLLPFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAE
RTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPK
DEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADN
TRENTKFVTKMYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGVFQHIIRR
EVTDEDTRHLSRKFKDWAYGPVYSSLYDLSSLDTCGEEASVLEILVYNSKIENRHEML
AVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTVDY
LRLAGEVITLFTGVLFFFTNIKDLFMKKCPGVNSLFIDGSFQLLYFIYSVLVIVSAAL
YLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLF
MIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPSCRDSETFSTFLLDLFKLTIGMGD
LEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATT
ILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVNEVNWSHWNQNLGIINED
PGKNETYQYYGFSHTVGRLRRDRWSSVVPRVVELNKNSNPDEVVVPLDSMGNPRCDGH
QQGYPRKWRTDDAPL"
BASE COUNT 553 a 921 c 788 g 581 t
ORIGIN
1 atggcggatt ccagcgaagg cccccgcgcg gggcccgggg aggtggctga gctccccggg
61 gatgagagtg gcaccccagg tggggaggct tttcctctct cctccctggc caatctgttt
121 gagggggagg atggctccct ttcgccctca ccggctgatg ccagtcgccc tgctggccca
181 ggcgatgggc gaccaaatct gcgcatgaag ttccagggcg ccttccgcaa gggggtgccc
241 aaccccatcg atctgctgga gtccacccta tatgagtcct cggtggtgcc tgggcccaag
301 aaagcaccca tggactcact gtttgactac ggcacctatc gtcaccactc cagtgacaac
361 aagaggtgga ggaagaagat catagagaag cagccgcaga gccccaaagc tcccgcccct
421 cagccgcccc ccatcctcaa agtcttcaac cggcccatcc tctttgacat cgtgtcccgg
481 ggctccactg ctgacctgga cgggctgctc ccattcttgc tgacccacaa gaaacgccta
541 actgatgagg agtttcggga accatctacg gggaagacct gcctgcccaa ggccttgctg
601 aacctgagca atggccgcaa cgacaccatc cctgtgctgc tggacatcgc ggagcgcacc
661 ggcaacatga gggagttcat taactcgccc ttccgtgaca tctactatcg agggcagaca
721 gccctgcaca tcgccattga gcgtcgctgc aaacactacg tggaacttct cgtggcccag
781 ggagctgatg tccacgccca ggcccgtggg cgcttcttcc agcccaagga tgaggggggc
841 tacttctact ttggggagct gcccctgtcg ctggctgcct gcaccaacca gccccacatt
901 gtcaactacc tgacggagaa cccccacaag aaggcggaca tgcggcgcca ggactcgcga
961 ggcaacacag tgctgcatgc gctggtggcc attgctgaca acacccgtga gaacaccaag
1021 tttgttacca agatgtacga cctgctgctg ctcaagtgtg cccgcctctt ccccgacagc
1081 aacctggagg ccgtgctcaa caacgacggc ctctcgcccc tcatgatggc tgccaagacg
1141 ggcaagattg gggtctttca gcacatcatc cggcgggagg tgacggatga ggacacacgg
1201 cacctgtccc gcaagttcaa ggactgggcc tatgggccag tgtattcctc gctttatgac
1261 ctctcctccc tggacacgtg tggggaagag gcctccgtgc tggagatcct ggtgtacaac
1321 agcaagattg agaaccgcca cgagatgctg gctgtggagc ccatcaatga actgctgcgg
1381 gacaagtggc gcaagttcgg ggccgtctcc ttctacatca acgtggtctc ctacctgtgt
1441 gccatggtca tcttcactct caccgcctac taccagccgc tggagggcac accgccgtac
1501 ccttaccgca ccacggtgga ctacctgcgg ctggctggcg aggtcattac gctcttcact
1561 ggggtcctgt tcttcttcac caacatcaaa gacttgttca tgaagaaatg ccctggagtg
1621 aattctctct tcattgatgg ctccttccag ctgctctact tcatctactc tgtcctggtg
1681 atcgtctcag cagccctcta cctggcaggg atcgaggcct acctggccgt gatggtcttt
1741 gccctggtcc tgggctggat gaatgccctt tacttcaccc gtgggctgaa gctgacgggg
1801 acctatagca tcatgatcca gaagattctc ttcaaggacc ttttccgatt cctgctcgtc
1861 tacttgctct tcatgatcgg ctacgcctca gccctggtct ccctcctgaa cccgtgtgcc
1921 aacatgaagg tgtgcaatga ggaccagacc aactgcacag tgcccactta cccctcgtgc
1981 cgtgacagcg agaccttcag caccttcctc ctggacctgt ttaagctgac catcggcatg
2041 ggcgacctgg agatgctgag cagcaccaag taccccgtgg tcttcatcat cctgctggtg
2101 acctacatca tcctcacctt tgtgctgctc ctcaacatgc tcattgccct catgggcgag
2161 acagtgggcc aggtctccaa ggagagcaag cacatctgga agctgcagtg ggccaccacc
2221 atcctggaca ttgagcgctc cttccccgta ttcctgagga aggccttccg ctctggggag
2281 atggtcaccg tgggcaagag ctcggacggc actcctgacc gcaggtggtg cttcagggtg
2341 aatgaggtga actggtctca ctggaaccag aacttgggca tcatcaacga ggacccgggc
2401 aagaatgaga cctaccagta ttatggcttc tcgcataccg tgggccgcct ccgcagggat
2461 cgctggtcct cggtggtacc ccgcgtggtg gaactgaaca agaactcgaa cccggacgag
2521 gtggtggtgc ctctggacag catggggaac ccccgctgcg atggccacca gcagggttac
2581 ccccgcaagt ggaggactga tgacgccccg ctctagggac tgcagcccag ccccagcttc
2641 tctgcccact catttctagt ccagccgcat ttcagcagtg ccttctgggg tgtcccccca
2701 caccctgctt tggccccaga ggcgagggac cagtggaggt gccagggagg ccccaggacc
2761 ctgtggtccc ctggctctgc ctccccaccc tggggtgggg gctcccggcc acctgtcttg
2821 ctcctatgga gtcacataag cca
//