LOCUS AF261715 1992 bp mRNA linear HUM 02-NOV-2000
DEFINITION Homo sapiens prostate-specific membrane antigen-like protein
(PSMAL/GCP III) mRNA, complete cds.
ACCESSION AF261715
VERSION AF261715.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1992)
AUTHORS O'Keefe,D.S., Bacich,D.J. and Heston,W.D.W.
TITLE Cloning and Characterization of a novel glutamate-preferring
peptidase that maps to the SCZDII locus: a candidate gene for
Schizophrenia?
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 1992)
AUTHORS O'Keefe,D.S., Bacich,D.J. and Heston,W.D.W.
TITLE Expression Profile of Prostate-Specific Membrane Antigen (PSMA)
versus a Prostate-Specific Membrane Antigen-Like Gene in Normal
Tissues, Prostate Cancer and Tumor Associated-Vasculature
JOURNAL Unpublished
REFERENCE 3 (bases 1 to 1992)
AUTHORS O'Keefe,D.S., Bacich,D.J. and Heston,W.D.W.
TITLE Direct Submission
JOURNAL Submitted (27-APR-2000) Cancer Biology, Cleveland Clinic
Foundation, NB 40, 9500 Euclid Avenue, Cleveland, OH 44195, USA
FEATURES Location/Qualifiers
source 1..1992
/db_xref="H-InvDB:HIT000075301"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q14.3"
/tissue_type="liver"
/note="maps to Schizophrenia Disorder Type II locus"
gene 1..1992
/gene="PSMAL/GCP III"
CDS 527..1855
/gene="PSMAL/GCP III"
/function="N-acetylated-alpha-linked-acidic dipeptidase"
/note="glutamate carboxypeptidase III; similar to Homo
sapiens PSMA; folate hydrolase-like; member of the M28
peptidase family; formed by duplication of the PSMA gene"
/codon_start=1
/product="prostate-specific membrane antigen-like protein"
/protein_id="AAG29102.1"
/translation="MGGSAPPDSSWRGSLKVSYNVGPGFTGNFSTQKVKMHIHSTNEV
TRIYNVIGTLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHETVRSFGTLKKEGW
RPRRTILFASWDAEEFGLLGSTEWAEDNSRLLQERGVAYINADSSIEGNYTLRVDCTP
LMYSLVYNLTKELKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQ
RLGIASGRARYTKNWETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMV
FELANSIVLPFDCRDYAVVLRKYADKIYNISMKHPQEMKTYSLSFDSLFSAVKNFTEI
ASKFSERLQDFDKSNPILLRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKY
AGESFPGIYDALFDIESKVDPSKAWGDVKRQISVAAFTVQAAAETLSEVA"
BASE COUNT 638 a 352 c 451 g 551 t
ORIGIN
1 agcaaatact cactaccaca aataagaaca tttccaaatc tgatgttctg aggattttta
61 gagcttatag tagcaaaaag aaaagggaaa ttctctctga gatgtccttt tttgtaggcc
121 taatgacaaa aggttgaaga taaagttcta gtactcattt aagtgtaata ttgaaaattg
181 atattaccaa atctggaaca accaatttaa aataaggaaa gaaagacact gtgttttcta
241 ggttaaaaat gcccagctgg caggggccaa aggagtcatt ctctactcag accctgctga
301 ctactttgct cctggggtga agtcctatcc agacggttgg aatcttcctg gaggtggtgt
361 ccagcgtgga aatatcctaa atctgaatgg tgcaggagac cctctcacac caggttaccc
421 agcaaatgaa tacgcttata ggcatggaat tgcagaggct gttggtcttc caagtattcc
481 tgttcatcca gttggatact atgatgcaca gaagctccta gaaaaaatgg gtggctcagc
541 accaccagat agcagctgga gaggaagtct caaagtgtcc tacaatgttg gacctggctt
601 tactggaaac ttttctacac aaaaagtcaa gatgcacatc cactctacca atgaagtgac
661 gagaatttac aatgtgatag gtactctcag aggagcagtg gaaccagaca gatatgtcat
721 tctgggaggt caccgggact catgggtgtt tggtggtatt gaccctcaga gtggagcagc
781 tgttgttcat gaaactgtga ggagctttgg aacactgaaa aaggaagggt ggagacctag
841 aagaacaatt ttgtttgcaa gctgggatgc agaagaattt ggtcttcttg gttctactga
901 gtgggcagag gataattcaa gactccttca agagcgtggc gtggcttata ttaatgctga
961 ctcatctata gaaggaaact acactctgag agttgattgt acaccactga tgtacagctt
1021 ggtatacaac ctaacaaaag agctgaaaag ccctgatgaa ggctttgaag gcaaatctct
1081 ttatgaaagt tggactaaaa aaagtccttc cccagagttc agtggcatgc ccaggataag
1141 caaattggga tctggaaatg attttgaggt gttcttccaa cgacttggaa ttgcttcagg
1201 cagagcacgg tatactaaaa attgggaaac aaacaaattc agcggctatc cactgtatca
1261 cagtgtctat gaaacatatg agttggtgga aaagttttat gatccaatgt ttaaatatca
1321 cctcactgtg gcccaggttc gaggagggat ggtgtttgag ctagccaatt ccatagtgct
1381 cccttttgat tgtcgagatt atgctgtagt tttaagaaag tatgctgaca aaatctacaa
1441 tatttctatg aaacatccac aggaaatgaa gacatacagt ttatcatttg attcactttt
1501 ttctgcagta aaaaatttta cagaaattgc ttccaagttc agcgagagac tccaggactt
1561 tgacaaaagc aacccaatat tgttaagaat gatgaatgat caactcatgt ttctggaaag
1621 agcatttatt gatccattag ggttaccaga cagacctttt tataggcatg tcatctatgc
1681 tccaagcagc cacaacaagt atgcagggga gtcattccca ggaatttatg atgctctgtt
1741 tgatattgaa agcaaagtgg acccttccaa ggcctgggga gatgtgaaga gacagatttc
1801 tgttgcagcc ttcacagtgc aggcagctgc agagactttg agtgaagtag cctaagagga
1861 ttctttagag actctgtatt gaatttgtgt ggtatgtcac tcaaagaata ataatgggta
1921 tattgataaa ttttaaaatt ggtatatttg aaataaagtt gaatattata tataaaaaaa
1981 aaaaaaaaaa aa
//