LOCUS AF261655 2912 bp mRNA linear HUM 10-OCT-2000
DEFINITION Homo sapiens 1,2-alpha-mannosidase IC mRNA, complete cds.
ACCESSION AF261655
VERSION AF261655.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2912)
AUTHORS Tremblay,L.O. and Herscovics,A.
TITLE Characterization of a cDNA encoding a novel human Golgi alpha 1,
2-mannosidase (IC) involved in N-glycan biosynthesis
JOURNAL J. Biol. Chem. 275 (41), 31655-31660 (2000)
PUBMED 10915796
REFERENCE 2 (bases 1 to 2912)
AUTHORS Tremblay,L.O. and Herscovics,A.
TITLE Direct Submission
JOURNAL Submitted (27-APR-2000) McGill Cancer Centre, McGill University,
3655 Sir William Osler, Montreal, Quebec H3G 1Y6, Canada
FEATURES Location/Qualifiers
source 1..2912
/db_xref="H-InvDB:HIT000075300"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p35"
/tissue_type="brain; eye"
/dev_stage="fetus"
CDS 331..2223
/function="trims Man9GlcNAc2 to Man5GlcNAc2"
/note="HMIC"
/codon_start=1
/product="1,2-alpha-mannosidase IC"
/protein_id="AAF97058.1"
/translation="MLMRKVPGFVPASPWGLRLPQKFLFLLFLSGLVTLCFGALFLLP
HSSRLKRLFLAPRTQQPGLEVVAEIAGHAPAREQEPPPNPAPAAPAPGEDDPSSWASP
RRRKGGLRRTRPTGPREEATAARGNSIPASRPGDEGVPFRFDFNAFRSRLRHPVLGTR
ADESQEPQSQVRAQREKIKEMMQFAWQSYKRYAMGKNELRPLTKDGYEGNMFGGLSGA
TVIDSLDTLYLMELKEEFQEAKAWVGESFHLNVSGEASLFEVNIRYIGGLLSAFYLTG
EEVFRIKAIRLGEKLLPAFNTPTGIPKGVVSFKSGNWGWATAGSSSILAEFGSLHLEF
LHLTELSGNQVFAEKVRNIRKVLRKIEKPFGLYPNFLSPVSGNWVQHHVSVGGLGDSF
YEYLIKSWLMSGKTDMEAKNMYYEALEAIETYLLNVSPGGLTYIAEWRGGILDHKMGH
LACFSGGMIALGAEDAKEEKRAHYRELAAQITKTCHESYARSDTKLGPEAFWFNSGRE
AVATQLSESYYILRPEVVESYMYLWRQTHNPIYREWGWEVVLALEKYCRTEAGFSGIQ
DVYSSTPNHDNKQQSFFLAETLKYLYLLFSEDDLLSLEDWVFNTEAHPLPVNHSDSSG
RAWGRH"
BASE COUNT 639 a 872 c 816 g 585 t
ORIGIN
1 aaggcgcggg ccccggcgcg gcggggaggg ctcggccgga ggggaggctg cggcgcgcgg
61 ccggtcgctg cgggcccggg ccccaagccg tgccgctccg ctcgcccggg cccagccgag
121 gccgctgcgc ccccgcctcc tcgcgggagg actcgctcca aactccctga acttcgggga
181 cagtcccccg aagcggcgaa actctcaggg ttggcaaccc tgcccaggga cccccatccc
241 gggcggcgct ccggacgccc tcccctcacc gcgcccccgc agacacgtgc ctggactccg
301 agggcttctg gagccaccgg ccgggccacg atgctcatga ggaaagtgcc cggcttcgtc
361 ccggcctccc cgtgggggct gcggctgccg cagaagttcc tcttcctcct cttcctctcg
421 ggcctggtca ccctgtgctt cggggccctc ttcctgctgc cccactcctc tcgcctcaag
481 cgcctcttcc tggccccccg gacccagcag cctggtctgg aagtggtggc tgaaatcgcc
541 ggccatgccc cggcccgcga gcaggagccg cctcccaacc cggcccccgc cgcgccggcc
601 ccgggcgagg atgaccccag cagctgggcc agtccccgcc gcaggaaagg ggggctgcgg
661 cgcacccgcc ccactggacc ccgcgaggag gccacggcgg cccggggcaa tagcatcccg
721 gcctccaggc ccggggacga gggcgtccct ttccgctttg acttcaacgc attccggagc
781 cgtctccgcc acccggtcct gggaacgagg gccgatgaga gtcaggagcc ccagagccaa
841 gtgcgagccc agcgggagaa aatcaaggag atgatgcagt ttgcttggca gagctataag
901 cgttatgcaa tggggaaaaa cgaactccgt ccactaacaa aagatggcta cgagggtaac
961 atgttcggag gcctcagcgg ggcaacagtc attgactccc tcgataccct ctacctcatg
1021 gagctgaagg aggagttcca ggaggccaag gcctgggtgg gagagagctt ccacctgaac
1081 gtgagcggag aagcatcctt gtttgaggtg aacatccgct acatcggggg actcctctca
1141 gccttctacc tgacaggaga agaggtgttc cgaataaagg ccatcaggct gggagagaag
1201 ctcctgccgg cgttcaacac ccccacggga atcccaaagg gcgtggtgag cttcaaaagt
1261 gggaactggg gctgggccac agccggcagc agcagcatct tggcggagtt tggatccctg
1321 cacttggaat tcttacacct cactgaactc tctggcaacc aggtcttcgc tgaaaaggtc
1381 aggaacatcc gcaaggtcct caggaagatc gaaaagccct ttggcctcta ccccaacttc
1441 ctcagcccag tgagtgggaa ctgggtgcaa caccatgtct cagttggagg actcggggac
1501 agtttttatg aatatttgat caaatcctgg ttgatgtcgg gcaagacaga tatggaggct
1561 aaaaatatgt actacgaagc cttggaggcg atagagacct acttgctgaa tgtctctccc
1621 ggggggctga cctacattgc cgagtggcga ggggggattc tggaccacaa gatggggcac
1681 ctggcctgtt tctccggggg catgatcgcc cttggcgccg aggatgccaa ggaagaaaag
1741 agggcccact accgagagct cgcagcccag atcaccaaga cgtgtcacga gtcatacgcc
1801 cgctcagaca ccaaacttgg gcctgaggcc ttctggttta actccggcag agaggccgtg
1861 gccacccagc tgagcgagag ctactacatc ctccggccag aggtggtgga gagctacatg
1921 tacctgtggc gacagaccca caaccccatc tacagggagt ggggctggga ggtggtgctg
1981 gccttggaga aatactgtcg gacagaagcc ggtttctctg ggatccaaga cgtgtacagt
2041 agcaccccca accacgacaa caagcagcag agcttctttc tagcggagac actaaagtat
2101 ctctatcttc tgttctctga agatgacttg ctctccctgg aagactgggt gttcaacacc
2161 gaggcccacc cactcccggt gaaccactca gacagctccg gcagagcctg gggcagacac
2221 tgaccccatc tcctgccgcc gccctggggc cgccgcaggg atgccttgcc ttttcaggat
2281 ttgagactgt tctcaaaggg attgggaacg aaggccccat ctcgggcaga cccccagcag
2341 atgtgtcgga caagcaactt cttttcctct gtgaggagac aagacttgga gactcagcga
2401 tgtcaggcca gggccatggc cacactggcc cacacattcc tttctacaga gaatttctat
2461 gaagcccact cacttgccat tccagggcca aaggaccgga ggtttgcata tccgcccctt
2521 gtatttgatt tgcttccttt tggtttcttg gtttttgttt ttgcttgatt ttgtcttttc
2581 tctacagttt agttttgtca caattacaca tatagttttc aaaatcatgc actttctaaa
2641 atggtgtcat cctgaaaaac aaaacccagt gtttgcacac acacaaaatc ttgaccccgt
2701 tatctatatt ttaaatgctt tttgcccaac actgacccta tgttcaactt tgtgtcattt
2761 accttataat ttgaggaggg gtttcccttt gggcctcagt gttacaaatt actagtgcta
2821 ttttcattat tattgtaatg gaaaaatctg tggactagaa taaaagagtt tattgaataa
2881 gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
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