LOCUS AF259262 3868 bp mRNA linear HUM 05-FEB-2001
DEFINITION Homo sapiens toll-like receptor 9 form A (TLR9) mRNA, complete cds;
alternatively spliced.
ACCESSION AF259262
VERSION AF259262.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3868)
AUTHORS Du,X., Poltorak,A., Wei,Y. and Beutler,B.
TITLE Three novel mammalian toll-like receptors: gene structure,
expression, and evolution
JOURNAL Eur. Cytokine Netw. 11 (3), 362-371 (2000)
PUBMED 11022119
REFERENCE 2 (bases 1 to 3868)
AUTHORS Du,X., Poltorak,A., Wei,Y. and Beutler,B.
TITLE Direct Submission
JOURNAL Submitted (21-APR-2000) Internal Medicine, UT Southwestern Medical
Center, 5323 Harry Hines Boulevard, Dallas, TX 75235-9050, USA
FEATURES Location/Qualifiers
source 1..3868
/db_xref="H-InvDB:HIT000075247"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="3p21.3"
/cell_line="THP-1"
gene 1..3868
/gene="TLR9"
5'UTR 1..634
/gene="TLR9"
/experiment="experimental evidence, no additional details
recorded"
CDS 635..3733
/gene="TLR9"
/note="orphan receptor; member of the toll-like receptor
family; alternatively spliced"
/codon_start=1
/product="toll-like receptor 9 form A"
/protein_id="AAF72189.1"
/translation="MGFCRSALHPLSLLVQAIMLAMTLALGTLPAFLPCELQPHGLVN
CNWLFLKSVPHFSMAAPRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVG
LSPMHFPCHMTIEPSTFLAVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDS
ASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNL
PSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLH
PDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLT
QLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLPM
LQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEADGGEKVWLQP
GDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCI
SQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGMQGVGH
NFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEGDLYLHFF
QGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVL
DLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTV
DHSWFGPLASALQILDVSANPLHCACGAAFMDFLLEVQAAVPGLPSRVKCGSPGQLQG
LSIFAQDLRLCLDEALSWDCFALSLLAVALGLGVPMLHHLCGWDLWYCFHLCLAWLPW
RGRQSGRDEDALPYDAFVVFDKTQSAVADWVYNELRGQLEECRGRWALRLCLEERDWL
PGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRASFLLAQQRLLEDRKDVVVLVILS
PDGRRSRYVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMALTRDNHHFYNRNFCQGPT
AE"
3'UTR 3734..3868
/gene="TLR9"
regulatory 3850..3855
/regulatory_class="polyA_signal_sequence"
/gene="TLR9"
/experiment="experimental evidence, no additional details
recorded"
polyA_site 3868
/gene="TLR9"
BASE COUNT 694 a 1325 c 1061 g 788 t
ORIGIN
1 ggaggtcttg tttccggaag atgttgcaag gctgtggtga aggcaggtgc agcctagcct
61 cctgctcaag ctacaccctg gccctccacg catgaggccc tgcagaactc tggagatggt
121 gcctacaagg gcagaaaagg acaagtcggc agccgctgtc ctgagggcac cagctgtggt
181 gcaggagcca agacctgagg gtggaagtgt cctcttagaa tggggagtgc ccagcaaggt
241 gtacccgcta ctggtgctat ccagaattcc catctctccc tgctctctgc ctgagctctg
301 ggccttagct cctccctggg cttggtagag gacaggtgtg aggccctcat gggatgtagg
361 ctgtctgaga ggggagtgga aagaggaagg ggtgaaggag ctgtctgcca tttgactatg
421 caaatggcct ttgactcatg ggaccctgtc ctcctcactg ggggcagggt ggagtggagg
481 gggagctact aggctggtat aaaaatctta cttcctctat tctctgagcc gctgctgccc
541 ctgtgggaag ggacctcgag tgtgaagcat ccttccctgt agctgctgtc cagtctgccc
601 gccagaccct ctggagaagc ccctgccccc cagcatgggt ttctgccgca gcgccctgca
661 cccgctgtct ctcctggtgc aggccatcat gctggccatg accctggccc tgggtacctt
721 gcctgccttc ctaccctgtg agctccagcc ccacggcctg gtgaactgca actggctgtt
781 cctgaagtct gtgccccact tctccatggc agcaccccgt ggcaatgtca ccagcctttc
841 cttgtcctcc aaccgcatcc accacctcca tgattctgac tttgcccacc tgcccagcct
901 gcggcatctc aacctcaagt ggaactgccc gccggttggc ctcagcccca tgcacttccc
961 ctgccacatg accatcgagc ccagcacctt cttggctgtg cccaccctgg aagagctaaa
1021 cctgagctac aacaacatca tgactgtgcc tgcgctgccc aaatccctca tatccctgtc
1081 cctcagccat accaacatcc tgatgctaga ctctgccagc ctcgccggcc tgcatgccct
1141 gcgcttccta ttcatggacg gcaactgtta ttacaagaac ccctgcaggc aggcactgga
1201 ggtggccccg ggtgccctcc ttggcctggg caacctcacc cacctgtcac tcaagtacaa
1261 caacctcact gtggtgcccc gcaacctgcc ttccagcctg gagtatctgc tgttgtccta
1321 caaccgcatc gtcaaactgg cgcctgagga cctggccaat ctgaccgccc tgcgtgtgct
1381 cgatgtgggc ggaaattgcc gccgctgcga ccacgctccc aacccctgca tggagtgccc
1441 tcgtcacttc ccccagctac atcccgatac cttcagccac ctgagccgtc ttgaaggcct
1501 ggtgttgaag gacagttctc tctcctggct gaatgccagt tggttccgtg ggctgggaaa
1561 cctccgagtg ctggacctga gtgagaactt cctctacaaa tgcatcacta aaaccaaggc
1621 cttccagggc ctaacacagc tgcgcaagct taacctgtcc ttcaattacc aaaagagggt
1681 gtcctttgcc cacctgtctc tggccccttc cttcgggagc ctggtcgccc tgaaggagct
1741 ggacatgcac ggcatcttct tccgctcact cgatgagacc acgctccggc cactggcccg
1801 cctgcccatg ctccagactc tgcgtctgca gatgaacttc atcaaccagg cccagctcgg
1861 catcttcagg gccttccctg gcctgcgcta cgtggacctg tcggacaacc gcatcagcgg
1921 agcttcggag ctgacagcca ccatggggga ggcagatgga ggggagaagg tctggctgca
1981 gcctggggac cttgctccgg ccccagtgga cactcccagc tctgaagact tcaggcccaa
2041 ctgcagcacc ctcaacttca ccttggatct gtcacggaac aacctggtga ccgtgcagcc
2101 ggagatgttt gcccagctct cgcacctgca gtgcctgcgc ctgagccaca actgcatctc
2161 gcaggcagtc aatggctccc agttcctgcc gctgaccggt ctgcaggtgc tagacctgtc
2221 ccacaataag ctggacctct accacgagca ctcattcacg gagctaccac gactggaggc
2281 cctggacctc agctacaaca gccagccctt tggcatgcag ggcgtgggcc acaacttcag
2341 cttcgtggct cacctgcgca ccctgcgcca cctcagcctg gcccacaaca acatccacag
2401 ccaagtgtcc cagcagctct gcagtacgtc gctgcgggcc ctggacttca gcggcaatgc
2461 actgggccat atgtgggccg agggagacct ctatctgcac ttcttccaag gcctgagcgg
2521 tttgatctgg ctggacttgt cccagaaccg cctgcacacc ctcctgcccc aaaccctgcg
2581 caacctcccc aagagcctac aggtgctgcg tctccgtgac aattacctgg ccttctttaa
2641 gtggtggagc ctccacttcc tgcccaaact ggaagtcctc gacctggcag gaaaccagct
2701 gaaggccctg accaatggca gcctgcctgc tggcacccgg ctccggaggc tggatgtcag
2761 ctgcaacagc atcagcttcg tggcccccgg cttcttttcc aaggccaagg agctgcgaga
2821 gctcaacctt agcgccaacg ccctcaagac agtggaccac tcctggtttg ggcccctggc
2881 gagtgccctg caaatactag atgtaagcgc caaccctctg cactgcgcct gtggggcggc
2941 ctttatggac ttcctgctgg aggtgcaggc tgccgtgccc ggtctgccca gccgggtgaa
3001 gtgtggcagt ccgggccagc tccagggcct cagcatcttt gcacaggacc tgcgcctctg
3061 cctggatgag gccctctcct gggactgttt cgccctctcg ctgctggctg tggctctggg
3121 cctgggtgtg cccatgctgc atcacctctg tggctgggac ctctggtact gcttccacct
3181 gtgcctggcc tggcttccct ggcgggggcg gcaaagtggg cgagatgagg atgccctgcc
3241 ctacgatgcc ttcgtggtct tcgacaaaac gcagagcgca gtggcagact gggtgtacaa
3301 cgagcttcgg gggcagctgg aggagtgccg tgggcgctgg gcactccgcc tgtgcctgga
3361 ggaacgcgac tggctgcctg gcaaaaccct ctttgagaac ctgtgggcct cggtctatgg
3421 cagccgcaag acgctgtttg tgctggccca cacggaccgg gtcagtggtc tcttgcgcgc
3481 cagcttcctg ctggcccagc agcgcctgct ggaggaccgc aaggacgtcg tggtgctggt
3541 gatcctgagc cctgacggcc gccgctcccg ctacgtgcgg ctgcgccagc gcctctgccg
3601 ccagagtgtc ctcctctggc cccaccagcc cagtggtcag cgcagcttct gggcccagct
3661 gggcatggcc ctgaccaggg acaaccacca cttctataac cggaacttct gccagggacc
3721 cacggccgaa tagccgtgag ccggaatcct gcacggtgcc acctccacac tcacctcacc
3781 tctgcctgcc tggtctgacc ctcccctgct cgcctccctc accccacacc tgacacagag
3841 caggcactca ataaatgcta ccgaaggc
//