LOCUS AF257238 4288 bp mRNA linear HUM 22-OCT-2000
DEFINITION Homo sapiens membrane-associated guanylate kinase MAGI3 mRNA,
complete cds.
ACCESSION AF257238
VERSION AF257238.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4288)
AUTHORS Wu,Y., Dowbenko,D., Spencer,S., Laura,R., Lee,J., Gu,Q. and
Lasky,L.A.
TITLE Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of
MAGI3, a novel membrane-associated guanylate kinase
JOURNAL J. Biol. Chem. 275 (28), 21477-21485 (2000)
PUBMED 10748157
REFERENCE 2 (bases 1 to 4288)
AUTHORS Wu,Y.Y. and Lasky,L.L.
TITLE Direct Submission
JOURNAL Submitted (17-APR-2000) Mol. Oncology, Genentech Inc., 1 DNA Way,
S. San Francisco, CA 94080, USA
FEATURES Location/Qualifiers
source 1..4288
/db_xref="H-InvDB:HIT000075166"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p21"
/tissue_type="breast"
CDS 711..4163
/codon_start=1
/product="membrane-associated guanylate kinase MAGI3"
/protein_id="AAG24545.1"
/translation="MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPY
LGRLREEPGGGTCCIVSGKAPNPSDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKT
VKPGKVINKDLRHYLSLQFQKGSIDHKLQQVIRDNLYLRTIPCTTRAPRDGEVPGVDY
NFISVEQFKALEESGALLESGTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDAES
QRKRTTSVSKMERMDSSLPEEEEDEDKGAINGSGNAENRERHSESSDWMKTVPSYNQT
NSSMDFRNYMMRDETLEPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAPE
DCEDGELPYGWEKIEDPQYGTYYVDFTLVAQAGVQWHDLGSLQPPPPGFNHLNQKTQF
ENPVEEAKRKKQLGQVEIGSSKPDMEKSHFTRDPSQLKGVLVRASLKKSTMGFGFTII
GGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVFGHTHADVVQMFQLVPVN
QYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQN
GKSGHTSTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIADSPTGQ
KVKMILDSQWCQGLQKEDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGP
PSTTKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLY
EDKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADEL
MCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNG
SPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGS
PADRCGKLKVGDHISAVNGQSIVELSHANIVQLIKDAGVTVTLTVIAEEEHHGPPSGT
NSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAV
ISVVGSRHNQNLGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIH
VGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLRPGTGLIPDHGLAPSGLCSYVK
PEQH"
BASE COUNT 1185 a 1038 c 1102 g 963 t
ORIGIN
1 cgaattcccc cctcccctcc ccataacatg cccactgccc caaataaaaa aaaaaccaac
61 tatgggagag cagccgagac agcaactagg ggcaggggaa agagacatgg aactcgaggg
121 cagcggtgaa gagaccatgc gtgtgctggg agggcccaga ggcagcggcg gcacaaacag
181 cgcaggtacg agtctctgtg tcttccccgg ggttatgtat aaatatagag agatgaggcc
241 ttctctcccc tgctctccct tccgctccgt gctgctcgcc gcggtcccag ctcctctttc
301 cacatgaggg cgaagggaag gggggatgaa caagtcatca ccgaattgca atcagaccca
361 catccatcag cttctggatc ttctgtgcta ttacaggatt ctttaagtgt tcgctgagtg
421 cctgctcctg gggacaattc ccttttcctt tcttcagcct aacccgcggt ggccctcgcg
481 gagtccggtc agccccgggg agcgcaaccc gggaggggcg tccaaggggc gtctcgcgtc
541 tgggaacggc cgggccccca gcgggctgtg gtcgcggggt gggggccgga gcggcgaggc
601 cccccttacc gggctgcgca ggccgcccag ggcccccggg ctgagacggg gccggagcgg
661 cgccccggcc gcccgcgcgg ggtctccccc atggtgcagc ggggttcggg atgtcgaaga
721 cgctgaagaa gaagaagcac tggctcagca aggtgcagga gtgcgccgtg tcctgggccg
781 ggcccccggg cgacttcggc gcggagatcc gcggtggcgc ggagcgtggc gaattcccct
841 acctggggcg gctccgcgaa gaacccggcg ggggcacctg ctgcatcgtc tcgggcaagg
901 cgcccaaccc aagcgatgtg ctgctggagg taaacgggac gcctgtcagc gggctcacca
961 accgggacac cctggctgtc atccgccact tccgcgagcc catccgtctc aagactgtga
1021 aaccaggcaa agtcattaat aaagatttgc ggcattacct aagtcttcag tttcaaaaag
1081 gatcaattga ccacaaactg cagcaagtga tcagagataa tctctacttg agaaccattc
1141 catgcactac aagggccccc agggatggag aagtaccagg agtggattat aatttcattt
1201 ccgttgaaca gttcaaagca ctggaggaga gtggagcatt gttagaaagt gggacatatg
1261 atggaaactt ctatggaact cccaagcctc cagcagaacc cagccctttt cagccagatc
1321 cagttgatca agtcctcttt gataatgagt ttgatgcaga atctcaaaga aaacgaacga
1381 catctgtcag caagatggaa agaatggata gctctcttcc tgaagaggaa gaagatgagg
1441 acaagggagc tattaatggc agtggaaacg cagaaaacag agagaggcat tctgagtcat
1501 ctgactggat gaagactgtt ccaagttaca accaaacaaa tagctccatg gactttagaa
1561 attatatgat gagagatgag actctggaac cactgcccaa aaactgggaa atggcctaca
1621 ctgacacagg gatgatctac ttcattgacc acaataccaa gacaaccact tggttggatc
1681 ctcgtctttg taagaaagcc aaagcccctg aagactgtga agatggagag cttccttatg
1741 gctgggagaa aatagaggac cctcagtatg ggacatacta tgttgatttc actcttgtcg
1801 cccaagctgg agtgcaatgg catgatctcg gctcactgca acctccgcct cctgggttca
1861 atcaccttaa ccagaaaacc cagtttgaaa atccagtgga ggaagccaaa aggaaaaagc
1921 agttaggaca ggttgaaatt gggtcttcaa aaccagatat ggaaaaatca cacttcacaa
1981 gagatccatc ccagcttaaa ggtgtccttg ttcgagcatc actgaaaaaa agcacaatgg
2041 gatttggttt tactattatt ggtggagata gacctgatga gttcctacaa gtgaaaaatg
2101 tgctgaaaga tggtcccgca gctcaggatg ggaaaattgc accaggcgat gttattgtag
2161 acatcaatgg caactgtgtc ttcggtcaca ctcatgcaga tgttgtccag atgtttcaat
2221 tggtacctgt caatcagtat gtaaacctca ctttatgtcg tggttatcca cttcctgatg
2281 acagtgaaga tcctgttgtg gacattgttg ctgctacccc tgtcatcaat ggacagtcat
2341 taaccaaggg agagacttgc atgaatcctc aggattttaa gccaggagca atggttctgg
2401 agcagaatgg aaaatcggga cacacttcga ctggtgatgg tctcaatgga ccatcagatg
2461 caagtgagca gagagtatcc atggcatcgt caggcagctc ccagcctgaa ctagtgacta
2521 tccctttgat taagggccct aaagggtttg ggtttgcaat tgctgacagc cctactggac
2581 agaaggtgaa aatgatactg gatagtcagt ggtgtcaagg ccttcagaaa gaagatataa
2641 ttaaggaaat ataccatcaa aatgtgcaga atttaacaca tctccaagtg gtagaggtgc
2701 taaagcagtt tccagtaggt gctgatgtac cattgcttat cttaagagga ggtcctcctt
2761 caacaaccaa aactgccaaa atgaaaacag ataaaaagga aaatgcagga agtttggagg
2821 ccataaatga gcctattcct cagcctatgc cttttccacc gagcattatc aggtcaggat
2881 ccccaaaatt ggatccttct gaggtctacc tgaaatctaa gactttatat gaagataaac
2941 caccaaacac caaagatttg gatgtttttc ttcgaaaaca agagtcaggg tttggcttca
3001 gggtgctagg aggagatgga cctgaccagt ctatatatat tggggctatt attcccctgg
3061 gagcagctga gaaagatggt cggctccgcg cagctgatga actaatgtgc attgatggaa
3121 ttcctgttaa agggaaatca cacaaacaag tcttggacct catgacaact gctgctcgaa
3181 atggccatgt gttactaact gtcagacgga agatcttcta tggagaaaaa caacccgagg
3241 acgacagctc tcaggccttc atttcaacac agaatggatc tccccgcctg aaccgggcag
3301 aggtcccagc caggcctgca ccccaggagc cctatgatgt tgtcttgcaa cgaaaagaaa
3361 atgaaggatt tggctttgtc atcctcacct ccaaaaacaa accacctcca ggagttattc
3421 ctcataaaat tggccgagtc atagaaggaa gtccggctga ccgctgtgga aaactgaaag
3481 ttggagatca tatctctgca gtgaatgggc agtccattgt tgaactgtct catgctaaca
3541 ttgttcagct gatcaaagat gctggtgtca ccgtcacact aacggtcatt gctgaagaag
3601 agcatcatgg tccaccatca ggaacaaact cagccaggca aagcccagcc ctgcagcaca
3661 ggcccatggg acagtcacag gccaaccaca tacctgggga cagaagtgcc ctagaaggtg
3721 aaattggaaa agatgtctcc acttcttaca gacattcttg gtcagaccac aagcaccttg
3781 cacagcctga caccgcagta atttcagttg taggcagtcg gcacaatcag aaccttggtt
3841 gttatccagt agagctggag agaggccccc ggggctttgg attcagcctc cgagggggga
3901 aggagtacaa catggggctg ttcatccttc gtcttgctga agatggtcct gccatcaaag
3961 atggcagaat tcatgttggt gaccaaattg ttgaaatcaa tggggaacct acacaaggaa
4021 tcacacatac tcgagcaatt gagctcattc aggctggtgg aaataaagtt cttcttcttt
4081 tgaggccagg aactggcttg atacctgacc atggtttggc tccttccggt ctgtgctcct
4141 acgtgaaacc cgagcaacat taaggctttc agggcttttc ttggtctttc cttaaaaaga
4201 cttggtaaat ttgcatgtct tgtaaatcac tttcttcttt tgttttcttt taaattaaaa
4261 atgatgctat taaataaaaa aaaaaaaa
//