LOCUS AF257077 1602 bp mRNA linear HUM 02-AUG-2000
DEFINITION Homo sapiens eukaryotic translation initiation factor EIF2B subunit
3 (EIF2B3) mRNA, complete cds.
ACCESSION AF257077
VERSION AF257077.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1602)
AUTHORS Kruger,M., Beger,C., Li,Q.X., Welch,P.J., Tritz,R., Leavitt,M.,
Barber,J.R. and Wong-Staal,F.
TITLE Identification of eIF2Bgamma and eIF2gamma as cofactors of
hepatitis C virus internal ribosome entry site-mediated translation
using a functional genomics approach
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 97 (15), 8566-8571 (2000)
PUBMED 10900014
REFERENCE 2 (bases 1 to 1602)
AUTHORS Krueger,M., Beger,C., Welch,P.J., Barber,J.R. and Wong-Staal,F.
TITLE Direct Submission
JOURNAL Submitted (16-APR-2000) Departments of Biology and Medicine, Center
for AIDS Research/AIDS Research Institute, University of
California, San Diego, 9500 Gilman Drive, 0665, La Jolla, CA 92093,
USA
FEATURES Location/Qualifiers
source 1..1602
/db_xref="H-InvDB:HIT000075153"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..1602
/gene="EIF2B3"
/note="EIF2Bgamma"
CDS 103..1461
/gene="EIF2B3"
/note="eukaryotic translation initiation factor
EIF2Bgamma; guanine nucleotide exchange factor"
/codon_start=1
/product="eukaryotic translation initiation factor EIF2B
subunit 3"
/protein_id="AAF91351.1"
/translation="MEFQAVVMAVGGGSRMTDLTSSIPKPLLPVGNKPLIWYPLNLLE
RVGFEEVIVVTTRDVQKALCAEFKMKMKPDIVCIPDDADMGTADSLRYIYPKLKTDVL
VLSCDLITDVALHEVVDLFRAYDASLAMLMRKGQDSIEPVPGQKGKKKAVEQRDFIGV
DSTGKRLLFMANEADLDEELVIKGSILQKHPRIRFHTGLVDAHLYCLKKYIVDFLMEN
GSITSIRSELIPYLVRKQFSSASSQQGQEEKEEDLKKKELKSLDIYSFIKEANTLNLA
PYDACWNACRGDRWEDLSRSQVRCYVHIMKEGLCSRVSTLGLYMEANRQVPKLLSALC
PEEPPVHSSAQIVSKHLVGVDSLIGPETQIGEKSSIKRSVIGSSCLIKDRVTITNCLL
MNSVTVEEGSNIQGSVICNNAVIEKGADIKDCLIGSGQRIEAKAKRVNEVIVGNDQLM
EI"
BASE COUNT 479 a 332 c 406 g 385 t
ORIGIN
1 ggagatcgct gggagcggtt gcgcgtgcgg ggagctgagt tatagctgtg acttctgccc
61 tgccaggccg cacacagcgg tctgacccgg tttggtttgt aaatggaatt tcaagcagta
121 gtgatggcag taggtggagg atctcggatg acagacctaa cttccagcat tcccaaacct
181 ctgcttccag ttgggaacaa acctttaatt tggtacccat tgaacctgct tgagcgtgtt
241 ggatttgaag aagtcattgt ggttacaacc agggatgttc aaaaggctct atgtgcagaa
301 ttcaagatga aaatgaagcc agatattgtg tgtattcctg atgacgctga catgggaact
361 gcagattctt tgcgctacat atatccaaaa cttaagacag atgtgctggt gctgagctgt
421 gatctgataa cagacgttgc cttacatgag gttgtggacc tgtttagagc ttatgatgca
481 tcacttgcta tgttgatgag aaaaggccaa gatagcatag aacctgttcc cggtcaaaag
541 gggaaaaaaa aagcagtgga gcagcgtgac ttcattggag tggacagcac aggaaagagg
601 ctgctcttca tggctaatga agcagacttg gatgaagagc tggtcattaa gggatccatc
661 ctacagaagc atcctagaat acgtttccac acgggtcttg tggatgccca cctctactgt
721 ttgaaaaaat acatcgtgga tttcctaatg gaaaatgggt caataacttc tatccggagt
781 gaactgattc catatttagt gagaaaacag ttttcctcag cttcctcaca acagggacaa
841 gaagaaaaag aggaggatct aaagaaaaag gagctgaagt ccttagatat ctacagtttt
901 ataaaagaag ccaatacact gaacctggct ccctatgatg cctgctggaa tgcctgtcga
961 ggagacaggt gggaagactt gtccagatca caggtgcgct gctatgtcca catcatgaaa
1021 gaggggctct gctctcgagt gagcacactg ggactctaca tggaagcaaa cagacaggtg
1081 cccaaattgc tgtctgctct ctgtccagaa gaaccaccag tccattcgtc agcccagatt
1141 gtcagcaaac acctggttgg agttgacagc ctcattgggc cagagacaca gattggagag
1201 aagtcatcca ttaagcgctc agtcattggc tcatcctgtc tcataaaaga tagagtgact
1261 attaccaatt gccttctcat gaactcagtc actgtggagg aaggaagcaa tatccaaggc
1321 agtgtcatct gcaacaatgc tgtgatcgag aagggtgcag acatcaagga ctgcttgatt
1381 ggaagtggcc agaggattga agccaaagct aaacgagtga atgaggtgat cgtggggaat
1441 gaccagctca tggagatctg agttctgagc aagtcagact ccttcctttt ggcctccaaa
1501 gccacagatg ttggccggcc cacctgttta actctgtatt tatttcccaa taaagaaggg
1561 cttccaaagg taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//