LOCUS AF254956 3512 bp mRNA linear HUM 06-AUG-2000
DEFINITION Homo sapiens candidate tumor suppressor protein mRNA, complete cds.
ACCESSION AF254956
VERSION AF254956.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3512)
AUTHORS Guan,X.-Y.Y., Zhou,H., Sham,J.S.T., Zhang,H.-E. and Trent,J.M.
TITLE Characterization of a Complex Chromosome Rearrangement Involving 6q
in a Melanoma Cell Line: Isolation of a Candidate Tumor Suppressor
Gene Interrupted by the Breakpoint at 6q16
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 3512)
AUTHORS Guan,X.-Y.Y., Zhou,H., Sham,J.S.T., Zhang,H.-E. and Trent,J.M.
TITLE Direct Submission
JOURNAL Submitted (09-APR-2000) Clinical Oncology, The University of Hong
Kong, Pokfulam, Hong Kong, China
FEATURES Location/Qualifiers
source 1..3512
/db_xref="H-InvDB:HIT000075128"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="6"
/map="6q16"
CDS 262..1461
/codon_start=1
/product="candidate tumor suppressor protein"
/protein_id="AAF97788.1"
/translation="MNFRQLLLHLPRYLGASGSPRRLWWSPSLDTISSVGSWRGRSSK
SPAHWNQVXSEAEKIVGYPTSFMSLRCLLSDXLSNIAMQVRKLVGTQHPLLTTARGLV
HDSWNSLQLRGLVVLLISKAAGPSSVNTSCQNYDMVSGIYSCQRSLAEITELIHIALL
VHRGIVNLNELQSSDGPLKDMQFGNKIAILSGDFLLANACNGLALLQNTKVVELLASA
LMDLVQGVYHENSTSKESYITDDIGISTWKEQTFLSHGALLAKSCQAAMELAKHDAEV
QNMAFQYGKHMAMSHKINSDVQPFIKEKTSDSMTFNLNSAPVVLHQEFLGRDLWIKQI
GEAQEKGRLDYAKLRERIKAGKGVTSAIDLCRYHGNKALEALESFPPSEARSALENIV
FAVTRFS"
BASE COUNT 957 a 715 c 793 g 1040 t
ORIGIN
1 ctccacatag gcagtggctg tggtttctac cccgggtggc cgggsgcagt gctgagctgg
61 gactgttgtt tgcccagcct gggctgctag aaagcagcag ttaaagttcg tttctggtca
121 ctgctccagg aagccacctt actctgaggg tcaagaattg ccgcttcctt ttagttactg
181 taagttcctc ctctgcccct ggtttgtttc ccgcggcact tctggatacc cccaggtccc
241 agacccttcc agactcaaac catgaacttt cggcagctgc tgttgcactt gccacgttat
301 cttggagcct cgggttcccc gcgtcgcctg tggtggtccc cgtccctcga caccatctcc
361 tcggtgggct cttggcgtgg tcggtcctcc aagtccccgg cccactggaa tcaggtartg
421 tcagaggcgg agaaratcgt ggggtacccc acgtccttca tgagccttcg ctgcctgctg
481 agcgacragc tcagcaacat cgctatgcag gtgcggaagc tggtgggcac tcagcaccct
541 ctgcttacca cagccagggg gcttgtacat gacagctgga atagcctcca gttgaggggc
601 ttggtggtgc tccttatctc taaagcagct gggcccagca gcgtgaacac ttcatgtcag
661 aactatgaca tggtcagtgg gatctactca tgtcaaagaa gtttggcaga gatcacggag
721 ctaattcata ttgctctcct tgtacatcgt gggatagtaa atttaaatga gttgcaatca
781 tctgatggtc cactgaaaga catgcaattt ggaaataaaa ttgctatcct gagtggagac
841 tttcttctag caaatgcctg caatggacta gctctgctac agaacaccaa ggttgtggaa
901 cttttagcaa gtgctcttat ggacttggta caaggagtat atcatgaaaa ttctacttca
961 aaggaaagtt atatcacaga tgatattgga atatcgactt ggaaggagca gacttttctc
1021 tcccatggtg ccttactagc aaagagctgc caagctgcaa tggaattagc aaagcatgat
1081 gctgaggttc agaatatggc atttcagtat gggaagcaca tggccatgag tcataagata
1141 aattctgatg tccagccttt tattaaagaa aagaccagtg actccatgac ttttaatcta
1201 aactcagctc ctgtagtctt acatcaggaa tttcttggaa gagatttgtg gattaaacag
1261 atcggagagg ctcaagaaaa aggaagattg gactatgcta agttgcgaga aagaatcaaa
1321 gctggcaaag gtgtgacttc agctattgac ctgtgtcgtt accatggaaa caaggcactg
1381 gaggccctgg agagctttcc tccctcggag gccagatctg ctttagaaaa cattgtgttt
1441 gctgtgacca gattttcatg acatcaaatt aaaaagacac tattgttagt tagctgaaaa
1501 tcctagggaa tgaggttgat tgggagcgct ttcacgatgc gttaatgact tttaaaacat
1561 atgcattttt ccttcctttt atcacattgc taaatgagtt ctgctttctt tttggaactg
1621 ctacaaacaa aattagaaga aaaaaaggtc aagcagtttt cacttgtcac gccagaagca
1681 cacttgaggc tgcagtcgca gaaataatta atgagattcg ctcctgtgac ctcagcaaat
1741 ggacaggaaa taagtcctta ttgattggac cgagccaggg atggcgccag ggcggtggcc
1801 tgtggttttt cctgctagar aggacaaagc aagttggaag ctgcaggtgt caaragaaat
1861 gctctcaata ccaaccaggr aggattgtct aatcaaaaac tagtgaccaa tttgtcataa
1921 tggagagtag ttcaatggat tgagaaaaat atgttttatt tgttggcttg taattatgtc
1981 tctggattat tattattttt tttttagatg tagttttgct cttgttgccc aggctggagt
2041 gcaatggtgc agttttgact cactgcaacc tccgcctcct gggttcaagt gattctcctg
2101 cctcagcctc ccgagtagct ggaattacag gcacctgcca ccacgcctgg ctaattttgt
2161 atttttagta gagatggggt ttcactatgt tggtcaggct agtctcgaac tcctgacctc
2221 aggtgatccg cctgcctcgg cctcccaaag tgctgggatt agaggcttga gccactgcac
2281 ctggcctcat gtctctggat ttataatgca gtatgaatat actttgtgct ttatggtttt
2341 tataatgtct ttttggagaa attgccgaaa agttgccaaa tacttgaagt aggagattaa
2401 aatgttatca aatgttaaat tggttatatt aggaatagtc tgtttttctt tcctgaagat
2461 cagttttttt attcaaacac atttcaaaga accaaatttt ttttttcttt aaggaaaaag
2521 gagctttttt tcaagtgaaa tgtattcatt tgtaatactt tggtttaagg catactttaa
2581 tttttacgag tttcagaaac agaatttttg tactagggaa ttcattggtg agagtgttct
2641 tttaacctca gaatgtcaaa ttttggtctt gaaccacaga catccaatta cagaaagaat
2701 ataagcaatc tcacaggcct gcaatcggac actgtctctg tgtggttcat aggagatgat
2761 ttttgaggtt tgcactcatg caatttgaga acaccgttga caagaaggct gagtttacat
2821 aaatgatcta gattgaaact cagctacctt tcttcctcat gtggtgtaat tacagcccta
2881 tctggagaca gcgaatacag caaacagatt ttattaccta gttcgctcaa acactacatg
2941 aagttatttt agttaaagcc ctcccccaaa agttataaaa ccatttttat cagggcccaa
3001 catgtggcat gcaatgaaga gaaaatgtaa agctacagag gttaatgtat tgtattataa
3061 aatattttaa gtgtactcaa aatatcataa ttgtacagtt tatgccacca taatttgagg
3121 cctatagatt tagcttaaga gaacactgtt ctgtttgaaa tgctttctgt cactgaaatt
3181 ggcttaatta gtaaccatgg ataagatgct ttagatcaga ctaggtttta atcattaact
3241 tccacaaaga agtcatactt tgcgttaggt gtgctggttg gatgtgcagg aacttcagca
3301 agcagtaggt tttactaagc agatggtcgg gcactgcagg gcaccaggca ggatcctagg
3361 gcgcctctta ttctgcgtta gcatctggtt tgctgtatga ccttgcacaa gtcacttcct
3421 tctgagcctc aattttctca tctgtacaat gagattcaaa agttgacctg aaagtcaagt
3481 gtgaaaaaaa aaaagagatt aaacaagata at
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