LOCUS AF254067 2887 bp mRNA linear HUM 03-NOV-2000
DEFINITION Homo sapiens interleukin 21 receptor (IL21R) mRNA, complete cds.
ACCESSION AF254067
VERSION AF254067.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2887)
AUTHORS Parrish-Novak,J., Dillon,S.R., Nelson,A., Hammond,A., Sprecher,C.,
Gross,J.A., Johnston,J., Madden,K., Xu,W., West,J., Schrader,S.,
Burkhead,S., Heipel,M., Brandt,C., Kuijper,J.L., Kramer,J.,
Conklin,D., Presnell,S.R., Berry,J., Shiota,F., Bort,S., Hambly,K.,
Mudri,S., Clegg,C., Moore,M., Grant,F.J., Lofton-Day,C.,
Gilbert,T., Rayond,F., Ching,A., Yao,L., Smith,D., Webster,P.,
Whitmore,T., Maurer,M., Kaushansky,K., Holly,R.D. and Foster,D.
TITLE Interleukin 21 and its receptor are involved in NK cell expansion
and regulation of lymphocyte function
JOURNAL Nature 408 (6808), 57-63 (2000)
PUBMED 11081504
REFERENCE 2 (bases 1 to 2887)
AUTHORS Parrish-Novak,J.E., Presnell,S.R., Conklin,D.C. and Hammond,A.K.
TITLE Direct Submission
JOURNAL Submitted (10-APR-2000) Functional Cloning, ZymoGenetics, Inc.,
1201 Eastlake Ave. E., Seattle, WA 98102, USA
FEATURES Location/Qualifiers
source 1..2887
/db_xref="H-InvDB:HIT000075103"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="16"
/map="16p11"
gene 1..2887
/gene="IL21R"
CDS 69..1685
/gene="IL21R"
/note="class I cytokine receptor"
/codon_start=1
/product="interleukin 21 receptor"
/protein_id="AAG29346.1"
/translation="MPRGWAAPLLLLLLQGGWGCPDLVCYTDYLQTVICILEMWNLHP
STLTLTWQDQYEELKDEATSCSLHRSAHNATHATYTCHMDVFHFMADDIFSVNITDQS
GNYSQECGSFLLAESIKPAPPFNVTVTFSGQYNISWRSDYEDPAFYMLKGKLQYELQY
RNRGDPWAVSPRRKLISVDSRSVSLLPLEFRKDSSYELQVRAGPMPGSSYQGTWSEWS
DPVIFQTQSEELKEGWNPHLLLLLLLVIVFIPAFWSLKTHPLWRLWKKIWAVPSPERF
FMPLYKGCSGDFKKWVGAPFTGSSLELGPWSPEVPSTLEVYSCHPPRSPAKRLQLTEL
QEPAELVESDGVPKPSFWPTAQNSGGSAYSEERDRPYGLVSIDTVTVLDAEGPCTWPC
SCEDDGYPALDLDAGLEPSPGLEDPLLDAGTTVLSCGCVSAGSPGLGGPLGSLLDRLK
PPLADGEDWAGGLPWGGRSPGGVSESEAGSPLAGLDMDTFDSGFVGSDCSSPVECDFT
SPGDEGPPRSYLRQWVVIPPPLSSPGPQAS"
BASE COUNT 571 a 860 c 840 g 616 t
ORIGIN
1 gaagcagcag gtaccccctc cacatcccta gggctctgtg atgtaggcag aggcccgtgg
61 gagtcagcat gccgcgtggc tgggccgccc ccttgctcct gctgctgctc cagggaggct
121 ggggctgccc cgacctcgtc tgctacaccg attacctcca gacggtcatc tgcatcctgg
181 aaatgtggaa cctccacccc agcacgctca cccttacctg gcaagaccag tatgaagagc
241 tgaaggacga ggccacctcc tgcagcctcc acaggtcggc ccacaatgcc acgcatgcca
301 cctacacctg ccacatggat gtattccact tcatggccga cgacattttc agtgtcaaca
361 tcacagacca gtctggcaac tactcccagg agtgtggcag ctttctcctg gctgagagca
421 tcaagccggc tccccctttc aacgtgactg tgaccttctc aggacagtat aatatctcct
481 ggcgctcaga ttacgaagac cctgccttct acatgctgaa gggcaagctt cagtatgagc
541 tgcagtacag gaaccgggga gacccctggg ctgtgagtcc gaggagaaag ctgatctcag
601 tggactcaag aagtgtctcc ctcctccccc tggagttccg caaagactcg agctatgagc
661 tgcaggtgcg ggcagggccc atgcctggct cctcctacca ggggacctgg agtgaatgga
721 gtgacccggt catctttcag acccagtcag aggagttaaa ggaaggctgg aaccctcacc
781 tgctgcttct cctcctgctt gtcatagtct tcattcctgc cttctggagc ctgaagaccc
841 atccattgtg gaggctatgg aagaagatat gggccgtccc cagccctgag cggttcttca
901 tgcccctgta caagggctgc agcggagact tcaagaaatg ggtgggtgca cccttcactg
961 gctccagcct ggagctggga ccctggagcc cagaggtgcc ctccaccctg gaggtgtaca
1021 gctgccaccc accacggagc ccggccaaga ggctgcagct cacggagcta caagaaccag
1081 cagagctggt ggagtctgac ggtgtgccca agcccagctt ctggccgaca gcccagaact
1141 cggggggctc agcttacagt gaggagaggg atcggccata cggcctggtg tccattgaca
1201 cagtgactgt gctagatgca gaggggccat gcacctggcc ctgcagctgt gaggatgacg
1261 gctacccagc cctggacctg gatgctggcc tggagcccag cccaggccta gaggacccac
1321 tcttggatgc agggaccaca gtcctgtcct gtggctgtgt ctcagctggc agccctgggc
1381 taggagggcc cctgggaagc ctcctggaca gactaaagcc accccttgca gatggggagg
1441 actgggctgg gggactgccc tggggtggcc ggtcacctgg aggggtctca gagagtgagg
1501 cgggctcacc cctggccggc ctggatatgg acacgtttga cagtggcttt gtgggctctg
1561 actgcagcag ccctgtggag tgtgacttca ccagccccgg ggacgaagga cccccccgga
1621 gctacctccg ccagtgggtg gtcattcctc cgccactttc gagccctgga ccccaggcca
1681 gctaatgagg ctgactggat gtccagagct ggccaggcca ctgggccctg agccagagac
1741 aaggtcacct gggctgtgat gtgaagacac ctgcagcctt tggtctcctg gatgggcctt
1801 tgagcctgat gtttacagtg tctgtgtgtg tgtgtgcata tgtgtgtgtg tgcatatgca
1861 tgtgtgtgtg tgtgtgtgtc ttaggtgcgc agtggcatgt ccacgtgtgt gtgtgattgc
1921 acgtgcctgt gggcctggga taatgcccat ggtactccat gcattcacct gccctgtgca
1981 tgtctggact cacggagctc acccatgtgc acaagtgtgc acagtaaacg tgtttgtggt
2041 caacagatga caacagccgt cctccctcct agggtcttgt gttgcaagtt ggtccacagc
2101 atctccgggg ctttgtggga tcagggcatt gcctgtgact gaggcggagc ccagccctcc
2161 agcgtctgcc tccaggagct gcaagaagtc catattgttc cttatcacct gccaacagga
2221 agcgaaaggg gatggagtga gcccatggtg acctcgggaa tggcaatttt ttgggcggcc
2281 cctggacgaa ggtctgaatc ccgactctga taccttctgg ctgtgctacc tgagccaagt
2341 cgcctcccct ctctgggcta gagtttcctt atccagacag tggggaaggc atgacacacc
2401 tgggggaaat tggcgatgtc acccgtgtac ggtacgcagc ccagagcaga ccctcaataa
2461 acgtcagctt ccttccttct gcggccagag ccgaggcggg cgggggtgag aacatcaatc
2521 gtcagcgaca gcctgggcac ccgcggggcc gtcccgcctg cagagggcca ctcggggggg
2581 tttccaggct taaaatcagt ccgtttcgtc tcttggaaac agctccccac caaccaagat
2641 ttctttttct aacttctgct actaagtttt taaaaattcc ctttatgcac ccaagagata
2701 tttattaaac accaattacg tagcaggcca tggctcatgg gacccacccc ccgtggcact
2761 catggagggg gctgcaggtt ggaactatgc agtgtgctcc ggccacacat cctgctgggc
2821 cccctaccct gccccaattc aatcctgcca ataaatcctg tcttatttgt tcatcctgga
2881 gaattga
//