LOCUS AF252297 4445 bp mRNA linear HUM 14-JUN-2000
DEFINITION Homo sapiens cytochrome P450 retinoid metabolizing protein
P450RAI-2 mRNA, complete cds.
ACCESSION AF252297
VERSION AF252297.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4445)
AUTHORS White,J.A., Ramshaw,H., Taimi,M., Stangle,W., Zhang,A.,
Everingham,S., Creighton,S., Tam,S.P., Jones,G. and Petkovich,M.
TITLE Identification of the human cytochrome P450, P450RAI-2, which is
predominantly expressed in the adult cerebellum and is responsible
for all-trans-retinoic acid metabolism
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 97 (12), 6403-6408 (2000)
PUBMED 10823918
REFERENCE 2 (bases 1 to 4445)
AUTHORS White,J.A., Ramshaw,H., Taimi,M., Stangle,W., Zhang,A.,
Everingham,S., Creighton,S., Tam,S.-P., Jones,G. and Petkovich,M.
TITLE Direct Submission
JOURNAL Submitted (04-APR-2000) Cytochroma Inc., 116 Barrie Street,
Bioscience Complex, Suite 2424, Kingston, ONT K7L 3N6, Canada
FEATURES Location/Qualifiers
source 1..4445
/db_xref="H-InvDB:HIT000075090"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 1..1539
/codon_start=1
/product="cytochrome P450 retinoid metabolizing protein
P450RAI-2"
/protein_id="AAF76003.1"
/translation="MLFEGLDLVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKS
CKLPIPKGSMGFPLIGETGHWLLQGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENV
RKILMGEHHLVSTEWPRSTRMLLGPNTVSNSIGDIHRNKRKVFSKIFSHEALESYLPK
IQLVIQDTLRAWSSHPEAINVYQEAQKLTFRMAIRVLLGFSIPEEDLGHLFEVYQQFV
DNVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYLDALDLLIESSKE
HGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHS
GGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQTFELDGFQIPKGWSV
MYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLF
LKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNEILPETEAML
SATV"
BASE COUNT 893 a 1265 c 1240 g 1047 t
ORIGIN
1 atgctctttg agggcttgga tctggtgtcg gcgctggcca ccctcgccgc gtgcctggtg
61 tccgtgacgc tgctgctggc cgtgtcgcag cagctgtggc agctgcgctg ggccgccact
121 cgcgacaaga gctgcaagct gcccatcccc aagggatcca tgggcttccc gctcatcgga
181 gagaccggcc actggctgct gcagggttct ggcttccagt cgtcgcggag ggagaagtat
241 ggcaacgtgt tcaagacgca tttgttgggg cggccgctga tacgcgtgac cggcgcggag
301 aacgtgcgca agatcctcat gggcgagcac cacctcgtga gcaccgagtg gcctcgcagc
361 acccgcatgt tgctgggccc caacacggtg tccaattcca ttggcgacat ccaccgcaac
421 aagcgcaagg tcttctccaa gatcttcagc cacgaggccc tggagagtta cctgcccaag
481 atccagctgg tgatccagga cacactgcgc gcctggagca gccaccccga ggccatcaac
541 gtgtaccagg aggcgcagaa gctgaccttc cgcatggcca tccgggtgct gctgggcttc
601 agcatccctg aggaggacct tgggcacctc tttgaggtct accagcagtt tgtggacaat
661 gtcttctccc tgcctgtcga cctgcccttc agtggctacc ggcggggcat tcaggctcgg
721 cagatcctgc agaaggggct ggagaaggcc atccgggaga agctgcagtg cacacagggc
781 aaggactact tggacgccct ggacctcctc attgagagca gcaaggagca cgggaaggag
841 atgaccatgc aggagctgaa ggacgggacc ctggagctga tctttgcggc ctatgccacc
901 acggccagcg ccagcacctc actcatcatg cagctgctga agcaccccac tgtgctggag
961 aagctgcggg atgagctgcg ggctcatggc atcctgcaca gtggcggctg cccctgcgag
1021 ggcacactgc gcctggacac gctcagtggg ctgcgctacc tggactgcgt catcaaggag
1081 gtcatgcgcc tgttcacgcc catttccggc ggctaccgca ctgtgctgca gaccttcgag
1141 cttgatggtt tccagatccc caaaggctgg agtgtcatgt atagcatccg ggacacccat
1201 gacacagcgc ccgtgttcaa agacgtgaac gtgttcgacc ccgatcgctt cagccaggcg
1261 cggagcgagg acaaggatgg ccgcttccat tacctcccgt tcggtggcgg tgtccggacc
1321 tgcctgggca agcacctggc caagctgttc ctgaaggtgc tggcggtgga gctggctagc
1381 accagccgct ttgagctggc tacacggacc ttcccccgca tcaccttggt ccccgtcctg
1441 caccccgtgg atggcctcag cgtcaagttc tttggcctgg actccaacca gaacgagatc
1501 ctgccggaga cggaggccat gctgagcgcc acagtctaac ccaagaccca cccgcctcag
1561 cccagcccag gcagcggggt ggtggttgtg ggaggtagaa acctgtgtgt gggagggggc
1621 cggaacgggg agggcgagtg gcccccatac ttgccctccc ttgctccccc tccctggcaa
1681 accctaccca aagccagtgg gccccattcc tagggctggg ctccccttct ggctccagct
1741 tccctccagc cactccccat ttaccatcag ctcagcccct gggaagggcg tggcaggggc
1801 tctgcatgcc cgtgacagtg ttaggtgtca gcgcgtgcta cagtgttttt gtgatgttct
1861 gaactgctcc cttccctccg ttcctttcgg acccttttag ctggggttgg gggacgggaa
1921 gagccgtgcc cccttgggcg cactcttcag cgtctcctcc tcctgcgccc ccactgcgtc
1981 tgcccaggaa cagcatcctg ggtagcagaa caggagtcaa ccttggcggg gcgggggctg
2041 cgtccaacct ggagattgcc cttccctatg ccacggttcc caccctccct caccagtttg
2101 gacaatttga aattacctat tgctgctact tgttctgtcc tctgaccttg gggcaaagga
2161 gccccaggcc ctgtctcccc agcatcctcc ctggtggccc tgggcaggtg cactgacacc
2221 cccaccttcc catcccctgc tgaaccaggc cctgttacac acagccgcct aaggcccgcg
2281 gctcatgtgc tgcccgcccc catatttatt cactgataga gaatcttggg gatgctgggg
2341 tctggagtga acatctcctc cccttcatgc cctagcctgt gttctagctg tcctggcgag
2401 acttctgtga gtgaagagga aggggtctct ggtcaaaccc agcccccagg gcctagggtt
2461 gaaagccttc cccggctccg ggcattattt gggtttaatc tcggagcctc actcctggac
2521 tgaagtccgg tgcctctgcc ttatccctgg tggagatgga atgtggccca ttgcctcctc
2581 cctctcctgt caaaaaccct gatcaggtag atttggaggc ggccacgatt tcctgtttgg
2641 cccctgttca ccccagtgca ctggccctga ctccaggcgt gagtatgggg aaggatacgg
2701 gttcttctga cggggagcaa gggcctccgt cttcccttcc ttaactctcc ccctttgccc
2761 tccgccctga aaaaggtgtc cttgaagtcc cttccacctc tatgccactg tctgcttagc
2821 ccagctcagg ggtggggaag aggcgaaagc gtgggggagg tgagcgcagc ggcagttctg
2881 cctcggagct gattgcaggg ccctgtgtgg tctccggaca gctgcgggaa ggctgccgca
2941 gctgaagctg aagaggcggc tacgtgcggt ttgtcagggg gattgggttg aaaactggcc
3001 agtcgggatg actgggtgaa agaggagtag ctcctgccac tggcgttttg agtgttggca
3061 atttgggatg cctcctgggg aaggtttccg ggcgtttggt gagtctctag atttttcctt
3121 gctttctgtg tttattggtt tttgatgttg taaaagcaat gaatcccctt tacaagaaaa
3181 tcgaaaacac agaagaatga aggacatgcc agtccccgat cgctgctgtg agcacctcag
3241 tggctccctc agaccagatc ccgtaggcag ccccacagac cgaccctgac cccactcaca
3301 gccaccctga agatagacta taggaacggg cccataccac acagactgct ctccaatccc
3361 tgagtctcag atgtttcatt tatttcctac ttttccacta ctaaaaaaca gtgtggaata
3421 gacattattg gcaaaattgc tcatccctaa tcctgaaaaa caggccagaa tgggtaaaga
3481 cttgtcaaag cttgcaacat agctacatgg tgcacccgga cctgtacccc ctccccccaa
3541 cacaaaacca gtgtctggga ggttcatttt cctttaaact gatccagctg gccctgaacc
3601 aattgttttt gactgagtat ctaggagagc agtaagtgga acttcagaca agcccactgg
3661 gtctggtcca ggtgaggggc agggggcatg gggctgggag gtctcagggg ccttccctgg
3721 gggtggccag cctggtaggg ggcagagaag gaaaagctga ggggggtccc tgtgagggag
3781 gaaagaagga tcatttgccc cgctgggtct caaaggcagt gagaagagag ctgaagaaag
3841 ctctggctgg ctgacaggat ccctgtgttg taattggtcc ctcctttcag ctctctagtg
3901 agatgcccgt gtctgtgcgt gtgcgtgtgt gtttcataca gctagcatta gatgggtgat
3961 gtttcttact tatcatccct aactattgca acttgacctt aaaaagacaa aaccccacaa
4021 aactcttcct gccacgggct tgcagattga agcactttcg atgttgggcg ctggcgtttg
4081 tgttctgggc accaccgtga ccctgcccag atggctataa tattatttta tacacaaacc
4141 ttttttttca taaatgttat aattttgtgt ctgtctttat aaactattat aagtactatt
4201 tttgttataa ttcaaaatag atatttagta taaagttttt gctgttaaat atttgttatt
4261 tagtaaaata tgaattttgc tctattgtaa acatggttca aaatattaat atgtttttat
4321 cacagtcgtt ttaatattga aaaagcactt gtgtgttttg ttttgatatg aaactggtac
4381 cgtgtgagtg tttttgctgt cgtggtttta atctgtatat aatattccat gttgcatatt
4441 aaaaa
//