LOCUS AF251442 3931 bp mRNA linear HUM 14-JUL-2016
DEFINITION Homo sapiens mixed lineage kinase MLK1 mRNA, partial cds.
ACCESSION AF251442
VERSION AF251442.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3931)
AUTHORS McNee,J.J., Dower,S.K. and Guesdon,F.
TITLE cDNA sequence and gene organisation of mixed lineage kinase 1
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 3931)
AUTHORS McNee,J.J. and Guesdon,F.
TITLE Direct Submission
JOURNAL Submitted (03-APR-2000) Molecular and Genetic Medicine, University
of Sheffield, Royal Hallamshire Hospital, Glossop Road, Sheffield
S10 2JF, United Kingdom
FEATURES Location/Qualifiers
source 1..3931
/db_xref="H-InvDB:HIT000075070"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS <1..3202
/note="protein kinase"
/codon_start=2
/product="mixed lineage kinase MLK1"
/protein_id="AAG44591.1"
/translation="PLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWT
GQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGG
FGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLK
EPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLK
SSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSK
GSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCW
NPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKEL
RTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRK
GKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLR
AIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQ
RREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMA
LLAASWVVPIDIEEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEE
PTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLL
PLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLS
LSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQ
SLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPS
RDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFV
SPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLL
DLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS"
BASE COUNT 875 a 1153 c 1134 g 769 t
ORIGIN
1 gccgctgccc tactggacgg ccgtgttcga gtacgaggcg gcgggcgagg acgagctgac
61 cctgcggctg ggcgacgtgg tggaggtgct gtccaaggac tcgcaggtgt ccggcgacga
121 gggctggtgg accgggcagc tgaaccagcg ggtgggcatc ttccccagca actacgtgac
181 cccgcgcagc gccttctcca gccgctgcca gcccggcggc gaggacccca gttgctaccc
241 gcccattcag ttgttagaaa ttgattttgc ggagctcacc ttggaagaga ttattggcat
301 cgggggcttt gggaaggtct atcgtgcttt ctggataggg gatgaggttg ctgtgaaagc
361 agctcgccac gaccctgatg aggacatcag ccagaccata gagaatgttc gccaagaggc
421 caagctcttc gccatgctga agcaccccaa catcattgcc ctaagagggg tatgtctgaa
481 ggagcccaac ctctgcttgg tcatggagtt tgctcgtgga ggacctttga atagagtgtt
541 atctgggaaa aggattcccc cagacatcct ggtgaattgg gctgtgcaga ttgccagagg
601 gatgaactac ttacatgatg aggcaattgt tcccatcatc caccgcgacc ttaagtccag
661 caacatattg atcctccaga aggtggagaa tggagacctg agcaacaaga ttctgaagat
721 cactgatttt ggcctggctc gggaatggca ccgaaccacc aagatgagtg cggcagggac
781 gtatgcttgg atggcacccg aagtcatccg ggcctccatg ttttccaaag gcagtgatgt
841 gtggagctat ggggtgctac tttgggagtt gctgactggt gaggtgccct ttcgaggcat
901 tgatggctta gcagtcgctt atggagtggc catgaacaaa ctcgcccttc ctattccttc
961 tacgtgccca gaaccttttg ccaaactcat ggaagactgc tggaatcctg atccccactc
1021 acgaccatct ttcacgaata tcctggacca gctaaccacc atagaggagt ctggtttctt
1081 tgaaatgccc aaggactcct tccactgcct gcaggacaac tggaaacacg agattcagga
1141 gatgtttgac caactcaggg ccaaagaaaa ggaacttcgc acctgggagg aggagctgac
1201 gcgggctgca ctgcagcaga agaaccagga ggaactgctg cggcgtcggg agcaggagct
1261 ggccgagcgg gagattgaca tcctggaacg ggagctcaac atcatcatcc accagctgtg
1321 ccaggagaag ccccgggtga agaaacgcaa gggcaagttc aggaagagcc ggctgaagct
1381 caaggatggc aaccgcatca gcctcccttc tgatttccag cacaagttca cggtgcaggc
1441 ctcccctacc atggataaaa ggaagagtct tatcaacagc cgctccagtc ctcctgcaag
1501 ccccaccatc attcctcgcc ttcgagccat ccagttgaca ccaggtgaaa gcagcaaaac
1561 ctggggcagg agctcagtcg tcccaaagga ggaaggggag gaggaggaga agagggcccc
1621 aaagaagaag ggacggacgt gggggccagg gacgcttggt cagaaagagc ttgcctcggg
1681 agatgaagga tcccctcaga gacgtgagaa agctaatggt ttaagtaccc catcagaatc
1741 tccacatttc cacttgggcc tcaagtccct ggtagatgga tataagcagt ggtcgtccag
1801 tgcccccaac ctggtgaagg gcccaaggag tagcccggcc ctgccagggt tcaccagcct
1861 tatggagatg gccttgctgg cagccagttg ggtggtgccc atcgacattg aagaggatga
1921 ggacagtgaa ggcccaggga gtggagagag tcgcctacag cattcaccca gccagtccta
1981 cctctgtatc ccattccctc gtggagagga tggcgatggc ccctccagtg atggaatcca
2041 tgaggagccc accccagtca actcggccac gagtacccct cagctgacgc caaccaacag
2101 cctcaagcgg ggcggtgccc accaccgccg ctgcgaggtg gctctgctcg gctgtggggc
2161 tgttctggca gccacaggcc tagggtttga cttgctggaa gctggcaagt gccagctgct
2221 tcccctggag gagcctgagc caccagcccg ggaggagaag aaaagacggg agggtctttt
2281 tcagaggtcc agccgtcctc gtcggagcac cagcccccca tcccgaaagc ttttcaagaa
2341 ggaggagccc atgctgttgc taggagaccc ctctgcctcc ctgacgctgc tctccctctc
2401 ctccatctcc gagtgcaact ccacacgctc cctgctgcgc tccgacagcg atgaaattgt
2461 cgtgtatgag atgccagtca gcccagtcga ggcccctccc ctgagtccat gtacccacaa
2521 ccccctggtc aatgtccgag tagagcgctt caaacgagat cctaaccaat ctctgactcc
2581 cacccatgtc accctcacca ccccctcgca gcccagcagt caccggcgga ctccttctga
2641 tggggccctt aagccagaga ctctcctagc cagcaggagc ccctccagca atgggttgag
2701 ccccagtcct ggagcaggaa tgttgaaaac ccccagtccc agccgagacc caggtgaatt
2761 cccccgtctc cctgacccca atgtggtctt ccccccaacc ccaaggcgct ggaacactca
2821 gcaggactct accttggaga gacccaagac tctggagttt ctgcctcggc cgcgtccttc
2881 tgccaaccgg caacggctgg acccttggtg gtttgtgtcc cccagccatg cccgcagcac
2941 ctccccagcc aacagctcca gcacagagac gcccagcaac ctggactcct gctttgctag
3001 cagtagcagc actgtagagg agcggcctgg acttccagcc ctgctcccgt tccaggcagg
3061 gccgctgccc ccgactgagc ggacgctcct ggacctggat gcagaggggc agagtcagga
3121 cagcaccgtg ccgctgtgca gagcggaact gaacacacac aggcctgccc cttatgagat
3181 ccagcaggag ttctggtctt agcacgaaaa ggattggggc gggcaagggg gacagccagc
3241 ggagatgagg ggagctggcg ggcacagccc tttctcaggg ttggaccccc tgagatccag
3301 ccctacttct tgcactgata atgcactttg aagatggaag ggatggaaac agggccactt
3361 cagagggtct cctgccctgc agggcctttc tacccgtgtc cactggaggg gctgtggcca
3421 tcagctctgg ctgtgtaggg gaggaagggg tgcatgcatg tcccccaccc tccacagtct
3481 tccttgcctt tagagtgacc ctgcagagtc actcagccaa atctgtctgc tgctccctct
3541 cctcagccag ttgggtgtgc gcagagctgt catagggtcc ctttgtcagc cccgagttca
3601 gcttcccaaa caccagtgtt ggatattctg tgattgattt tggtcctcct ccgctgtccc
3661 ccaacaccca ggaatgggaa tctggcttgg ttcgagatag gagcttttct gtgtcctaag
3721 ccctttcatg ctagcaggaa gactgaaagc aaggtggccc agtgtggggt catagggctt
3781 gatagacctg gcactgccta tctgcacttc caggtgcccc acctatttat ctgagcccac
3841 aggtggaaag gggaactgcc tcagtgagaa cggggggacg gggatgttag gaaaaataca
3901 gtaaagttgc aatgaagagg ttcatgaagt a
//