LOCUS AF251441 3767 bp mRNA linear HUM 26-APR-2000
DEFINITION Homo sapiens sterile-alpha motif and leucine zipper containing
kinase AZK mRNA, complete cds.
ACCESSION AF251441
VERSION AF251441.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3767)
AUTHORS McNee,J.J., Frima,N., Diamond,T.E., Dower,S.K. and Guesdon,F.
TITLE Cloning and characterisation of AZK, a mixed lineage kinase
containing a sterile-alpha motif
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 3767)
AUTHORS McNee,J.J. and Guesdon,F.
TITLE Direct Submission
JOURNAL Submitted (03-APR-2000) Molecular and Genetic Medicine, University
of Sheffield, Royal Hallamshire Hospital, Glossop Road, Sheffield
S10 2JF, United Kingdom
FEATURES Location/Qualifiers
source 1..3767
/db_xref="H-InvDB:HIT000075069"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q24.2"
CDS 79..2481
/note="protein kinase; catalytic domain related to the
mixed lineage kinases"
/codon_start=1
/product="sterile-alpha motif and leucine zipper
containing kinase AZK"
/protein_id="AAF65822.1"
/translation="MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAV
KKLLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEM
DMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNH
TTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLV
VEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSF
LHNKAEWRCEIEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNTPLLPSF
EIGAWTEDDVYCWVQQLVRKGDSSAEMSVYASLFKENNITGKRLLLLEEEDLKDMGIV
SKGHIIHFKSAIEKLTHDYINLFHFPPLIKDSGGEPEENEEKIVNLELVFGFHLKPGT
GPQDCKWKMYMEMDGDEIAITYIKDVTFNTNLPDAEILKMTKPPFVMEKWIVGIAKSQ
TVECTVTYESDVRTPKSTKHVHLIQWSRTKPQDEVKAVQLAIQTLFTNSDGNPGSRSD
SSADCQWLDTLRMRQIASNTSLQRSQSNPILGSPFFSHFDGQDSYAAAVRRPQVPIKY
QQITPVNQSRSSSPTQYGLTKNFSSLHLNSRDSGFSSGNTDTSSERGRYSDRSRNKYG
RGSISLNSSPRGRYSGKSQHSTPSRGRYPGKFYRVSQSALNPHQSPDFKRSPRDLHQP
NTIPGMPLHPETDSRASEEDSKVSEGGWTKVEYRKKPHRPSPAKTNKERARGDHRGWR
NF"
misc_feature 124..861
/note="Region: protein kinase domain"
misc_feature 958..1044
/note="Region: leucine zipper"
misc_feature 1087..1299
/note="Region: sterile-alpha motif"
misc_feature 2401..2454
/inference="non-experimental evidence, no additional
details recorded"
/note="Region: nuclear localization signal"
BASE COUNT 1176 a 756 c 828 g 1007 t
ORIGIN
1 cctccgcgcc cccggctgct gctcacgccc cgcccgggag ccagattttg tggaagtata
61 atactttgtc attatgagat gtcgtctctc ggtgcctcct ttgtgcaaat taaatttgat
121 gacttgcagt tttttgaaaa ctgcggtgga ggaagttttg ggagtgttta tcgagccaaa
181 tggatatcac aggacaagga ggtggctgta aagaagctcc tcaaaataga gaaagaggca
241 gaaatactca gtgtcctcag tcacagaaac atcatccagt tttatggagt aattcttgaa
301 cctcccaact atggcattgt cacagaatat gcttctctgg gatcactcta tgattacatt
361 aacagtaaca gaagtgagga gatggatatg gatcacatta tgacctgggc cactgatgta
421 gccaaaggaa tgcattattt acatatggag gctcctgtca aggtgattca cagagacctc
481 aagtcaagaa acgttgttat agctgctgat ggagtactga agatctgtga ctttggtgcc
541 tctcggttcc ataaccatac aacacacatg tccttggttg gaactttccc atggatggct
601 ccagaagtta tccagagtct ccctgtgtca gaaacttgtg acacatattc ctatggtgtg
661 gttctctggg agatgctaac aagggaggtc ccctttaaag gtttggaagg attacaagta
721 gcttggcttg tagtggaaaa aaacgagaga ttaaccattc caagcagttg ccccagaagt
781 tttgctgaac tgttacatca gtgttgggaa gctgatgcca agaaacggcc atcattcaag
841 caaatcattt caatcctgga gtccatgtca aatgacacga gccttcctga caagtgtaac
901 tcattcctac acaacaaggc ggagtggagg tgcgaaattg aggcaactct tgagaggcta
961 aagaaactag agcgtgatct cagctttaag gagcaggagc ttaaagaacg agaaagacgt
1021 ttaaagatgt gggagcaaaa gctgacagag cagtccaaca ccccgctgct gccttccttt
1081 gagattggtg catggacgga agacgatgtg tattgttggg ttcagcagct cgtcagaaaa
1141 ggtgactctt cagcagagat gagtgtatat gcaagcttgt ttaaagaaaa caacattaca
1201 gggaagcggc tgctgctgct ggaggaagaa gacctgaaag acatgggcat tgtctccaag
1261 gggcatatca ttcacttcaa gtcagccatt gagaaattaa cccatgatta cataaatttg
1321 tttcacttcc caccactaat taaggactca ggaggtgaac ctgaagaaaa tgaggaaaaa
1381 atagtgaacc tggaactggt ttttggtttt cacttgaaac caggaactgg cccacaggat
1441 tgtaagtgga aaatgtatat ggagatggat ggggatgaaa ttgcaataac ctacataaaa
1501 gatgtgacat tcaacactaa cctacctgat gcggagattt taaagatgac aaagccacca
1561 tttgtaatgg agaagtggat tgtaggaata gcaaaaagtc agactgtgga gtgcactgtc
1621 acatatgaga gtgatgttag aactccaaaa agcactaaac atgtccattt gattcagtgg
1681 agtagaacaa aacctcagga tgaagtgaaa gcagtccaac ttgccattca gacattattc
1741 accaattcag atggcaaccc tggaagcagg tccgactcaa gtgctgattg ccagtggtta
1801 gatactctga ggatgcggca gattgcatcc aacacttctt tacagcgttc ccagagcaat
1861 cctattctgg ggtcaccgtt cttctcacac tttgatggcc aggattccta cgctgctgct
1921 gtgagacggc cccaggtgcc cattaagtat caacagatta cacctgtgaa ccagtccaga
1981 agctcgtctc ctactcagta tggactgacc aaaaacttct cttccctaca tctcaactct
2041 agggacagtg gcttttccag tggcaatact gacacctctt cagagagggg tcgatactca
2101 gacagaagca ggaacaaata tggacgtggt agtatatcac tcaattcttc tcctagagga
2161 agatacagtg gaaagagtca gcattccact ccttcaagag gaagataccc tggaaagttc
2221 tacagggttt ctcagtcagc actcaatcct caccagtcgc ctgacttcaa gagaagcccc
2281 agggacctcc accaacccaa caccatacca gggatgcctt tgcaccctga gactgactca
2341 agagccagtg aagaggacag caaagtcagc gaagggggct ggacaaaagt ggaataccgg
2401 aaaaagcccc acaggccatc tcccgccaaa accaataaag agagagccag aggggaccac
2461 cgtggatgga gaaacttttg atgaattgaa ctacatagct tttctaagca ggttaaaaaa
2521 aaaaaaaaaa aaagaaatgt aatggttttt gataatatga tcccttcaga ttgaattaac
2581 gaaaagacaa cacttccagt ttttggattg ggaaatacct tctaattgag actatagcca
2641 aaccagggcc aaaattatgg atattggtca cccagtgatc ataactaggc ttgaaaatca
2701 ctacacatat tttctgcctt gagtgaacat ttttagagga aaggttatgc catcttttta
2761 ccctaaccac tgatattctg gttagcaggg ccaggacaag gggaaggaaa atgaggtcaa
2821 caaaaaaatc aaatttttag gaaaagataa gatgaatgtt actgattttt ccttttggct
2881 gaggctgcaa tatggcctgg caaggcactg ttactgatct tgtctttaac attttgatat
2941 tttgttcatc ataatttttg catttatttt tttaaatatt gcattaaaat atcatttagc
3001 ttgattatcg agttttttgg tttgaggttt tttgttgctt cttttttctt ttctttcttt
3061 ccccctcttt tttttggatg tccccttaaa ttttgtgccc aaggcaggta cctcactcat
3121 ctcatccttg gctcagccct gctggttagt atttagtatt tattttagta agatatttgt
3181 gtctgtatga tggtcagagt tgaactgatc tggcttgtca tttttcagta ataaaaaaag
3241 ttactgaatt taattgttga atatgatgca tatctcattc attacgattt atcagaaacc
3301 aaagatttaa attgcctaga tttgtggttc tttctcttcc taagttccca gcgactgctt
3361 tcaaatacta ttttctaaat ttcaccaaag gagcaaagag gataaaacaa cgctccataa
3421 aggcctcttg ggatgtcaga aatctaaaat ctaaaagaaa acagacacag agcaagacaa
3481 taacatcaca agctaaaagc cagagaaatt taaaattacc aacatccttg ttggagtaag
3541 acagtaaata tcagccttgc agcaagacag ctctgagcag ctgtgggcaa agaggtaaac
3601 cagtgggggt gcaaggagac tgtctgcagc ttagggcaga aatgggggga tccaacttgt
3661 gaaatgcttc atgttttaca aaccaaaaag tcgggtagca acaaacttat tgtatgtcaa
3721 atcaataaat gttactttca atatccaaaa aaaaaaaaaa aaaaaaa
//