LOCUS AF249745 3665 bp mRNA linear HUM 29-JUN-2000
DEFINITION Homo sapiens chromosome 2q22 RhoGEF mRNA, complete cds.
ACCESSION AF249745
VERSION AF249745.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3665)
AUTHORS Thiesen,S., Kubart,S., Ropers,H.H. and Nothwang,H.G.
TITLE Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in
3p13-21 and 2q22
JOURNAL Biochem. Biophys. Res. Commun. 273 (1), 364-369 (2000)
PUBMED 10873612
REFERENCE 2 (bases 1 to 3665)
AUTHORS Thiesen,S., Kuebart,S., Ropers,H.H. and Nothwang,H.G.
TITLE Direct Submission
JOURNAL Submitted (26-MAR-2000) MPI fuer Molekulare Genetik, Ihnestr. 73,
14195 Berlin, Germany
FEATURES Location/Qualifiers
source 1..3665
/db_xref="H-InvDB:HIT000075002"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q22"
CDS 620..2782
/codon_start=1
/product="RhoGEF"
/protein_id="AAF79955.1"
/translation="MVTWALLCISAETVRGEAPSQPRGIPHRSPVSVDDLWLEKTQRK
KLQKQAHVERRLHIGAVHKDGVKCWRKTIITSPESLNLPRRSHPLSQSAPTGLNHMGW
PEHTPGTAMPDGALDTAVCADEVGSEEDLYDDLHSSSHHYSHPGGGGEQLAINELISD
GSVVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRLR
VNQDEPADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEG
YVRQCRKRADMFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLE
HQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQ
KICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQS
SIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKKDLLRRDVL
YYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWLK
AFAREREQVQLDQETGFSITELQRKQAMLNASKQQVTGKPKAVGRPCYLTRQKHPALP
SNRPQQQVLVLAEPGASIYLLAQHQPAGTLPQVNWSLPDSTCWAFLPVAPSFSSPRPT
RPGLPLPASEQGWAGELLVPPRRARSVLLLSFSLLLVP"
BASE COUNT 834 a 1082 c 1085 g 664 t
ORIGIN
1 cagaaaaaac tcagggcaag gttggccttg gctcataaga ccttttcaaa ctttattgag
61 tcaatggttc tagagaaaga gaacacccat gaacgttccc caagttctcc caagggcgag
121 aaggggaaga gcaggctgcg ccagggttcc tggcgggcgt ttctgaaaag caaagatgcc
181 ggaagcccca aaaagcccac cctagtgagt ctgcctctag gacccgaagt tctctcccca
241 gcagagactg acagccactg tgaggaacgg gcggaggaca aagagggcta tgtttttagc
301 gatcactggg caccgccact tgcctccaca cctttgtcct ccagtttagt ttctccagaa
361 cacaggagga aaagtgaacc gaccatcaag tgcacagcca cccaggaagg cgacgctaaa
421 ccaagatgag cagaaggaag agagcaggga aggaggccag ggtccgcgcg gcttgggcac
481 agtgccctgg ctcagggacc ttcctgggag tgagaaccac atgccctggg aagaaccagc
541 aggtgagaag cccagttgct ctcacagtca gaaggcgttc cacatggagc ctgcccagaa
601 gccctgcttc accactgaca tggtgacatg ggccctcctc tgcatctctg cagagactgt
661 gcgtggggag gctccttcac agcctagggg catccctcac cgctcgcccg tcagtgtgga
721 tgacctgtgg ctggagaaga cacagagaaa gaagttgcag aagcaggccc acgtcgaaag
781 gaggctgcac ataggggcag tgcacaaaga tggagtcaag tgctggagaa agacgatcat
841 tacctctcca gagtctttga atctccctag aagaagccat ccactctccc agagtgctcc
901 aacgggactg aaccacatgg gctggccaga gcacacacca ggcactgcca tgcctgatgg
961 agctctggac acagctgtct gcgctgacga agtggggagc gaggaggacc tgtatgatga
1021 cctgcacagc tccagccacc actacagcca ccctggaggg ggtggggagc agctggctat
1081 caatgagctc atcagcgatg gcagtgtggt ctgcgctgaa gcactctggg accatgtcac
1141 catggacgac caggagctgg gcttcaaagc tggggacgtc atcgaagtga tggatgccac
1201 caacagagag tggtggtggg gccgggtcgc cgatggcgag ggctggtttc cagccagctt
1261 cgttcggctg agggtgaatc aggacgagcc cgcggatgac gacgcccctc tggccgggaa
1321 cagcggagcg gaggacggcg gggcggaggc gcagagcagc aaggaccaga tgcggaccaa
1381 cgtcatcaac gagatcctca gcactgagcg ggactacatc aagcacctgc gcgacatctg
1441 cgagggctac gtccggcagt gccgcaagcg cgcagacatg ttcagcgagg agcagctgcg
1501 taccatcttc gggaacatcg aggacatcta ccgctgccag aaggccttcg tgaaggccct
1561 ggagcagagg ttcaaccgcg agcgcccaca cctgagcgag ctgggtgcct gcttcctgga
1621 gcatcaagcc gacttccaga tctactcgga gtactgcaat aaccacccca acgcctgcgt
1681 ggagctctcc cggctcacca agctcagcaa gtacgtgtac ttcttcgagg cctgccggct
1741 gctgcagaag atgattgaca tctccctgga tggcttcctg ctgactccgg tgcagaagat
1801 ctgcaagtac cctctgcagc tggccgagct gctcaaatac acgcaccccc agcacaggga
1861 cttcaaggat gttgaagccg ccttgcatgc catgaagaac gtggcccagc tcatcaacga
1921 gcggaagcgg agacttgaga acatcgacaa gattgctcag tggcagagct ccatagagga
1981 ctgggaggga gaagatctct tggtcaggag ctcagaactc atctactcgg gggagctgac
2041 tcgagttaca cagcctcaag ccaaaagcca gcagcgaatg ttctttctct ttgaccacca
2101 gctcatctac tgtaagaagg acctgctccg ccgcgacgtg ttgtactaca agggccggct
2161 ggacatggac ggcctggagg tggtggacct ggaggacggg aaggacagag acctccatgt
2221 gagcatcaag aacgccttcc ggctgcaccg tggcgccaca ggggacagcc acctgctgtg
2281 caccaggaag cctgagcaga agcagcgctg gctcaaggcc tttgccaggg agagggagca
2341 ggtgcagctg gaccaggaga caggcttctc catcactgaa ctgcagagga agcaggccat
2401 gctgaatgcc agcaagcagc aggtcacagg gaagcccaaa gctgttggcc ggccctgcta
2461 cctgacgcgc cagaagcacc cagccctgcc cagcaaccgg ccccagcagc aggtcctggt
2521 gctggcggag ccaggcgcaa gcatctacct tctggcacag catcagccgg ctggcaccct
2581 tccgcaagtg aactggtccc tgcctgacag cacctgctgg gccttcctgc cagtggcccc
2641 cagtttttct tccccgaggc ccactcggcc tggccttcct ctgcctgcaa gtgagcaggg
2701 atgggctggg gagttgcttg tgccaccaag acgtgccagg tctgtactcc tgttgtcttt
2761 ttccctgctc ctggtgccct gaagagacca gcaagggggc agaccccgca ctcgccacac
2821 cgccgctgca gcttgggccc catccgccct ctggacctgt gtagggcctc actgctggag
2881 cggggaaacc gcagctcagc ccaggcccag ctggggagaa ggcgctacct gcgtgggacc
2941 ctcttctctg gaaacctaat cctcctttca tttcctctgg gcaggactct ctggccttct
3001 gtggcctgca atgccaggcc atgtgcccct ctgccctcta gttctccaag tccccagccc
3061 ggccagtggt gccaggcagc ttgccacttg ggagggcaga agccaggaat tccacaccct
3121 tgtgttgcgc ccggagcccg cccttcgcct cccagcccct caagacaccg ctggctgctg
3181 gacaccctct tcacttgtgt gtgtgtgtgt agcggaaaag gacaagacgg tgcagtcggc
3241 tgcatactcc cagtcgggag tgtggtcagt ctgcctgctg ctgtgcggta gctccagaac
3301 cacctcgttc ctggttttgt ttggattttg gcatcttgtt tttctaacaa caaacaatgg
3361 agaaaaagaa ttgattctta gtgacacaga agattgcctt acgctcgtga gcgtgagaag
3421 ccataagaga gagaccgaat tctgtggctc agcacacagg actgacccac agcccaggca
3481 gcgggtgtgt ggagatggcg ccctgtcctg ccaaggggcg ccaggagcag agccagggcc
3541 tggcgagctg gcgtggagcc cacaggattc agcagcatgg acagtcactc ttgcactatt
3601 ccttctccaa gccagaaacc acatttaatt tcataaataa atttatgaaa agtaacctgg
3661 ctgct
//