LOCUS AF249744 3561 bp mRNA linear HUM 29-JUN-2000
DEFINITION Homo sapiens chromosome 3p13-p21 RhoGEF mRNA, complete cds.
ACCESSION AF249744
VERSION AF249744.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3561)
AUTHORS Thiesen,S., Kubart,S., Ropers,H.H. and Nothwang,H.G.
TITLE Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in
3p13-21 and 2q22
JOURNAL Biochem. Biophys. Res. Commun. 273 (1), 364-369 (2000)
PUBMED 10873612
REFERENCE 2 (bases 1 to 3561)
AUTHORS Thiesen,S., Kuebart,S., Ropers,H.H. and Nothwang,H.G.
TITLE Direct Submission
JOURNAL Submitted (26-MAR-2000) MPI fuer Molekulare Genetik, Ihnestr. 73,
14195 Berlin, Germany
FEATURES Location/Qualifiers
source 1..3561
/db_xref="H-InvDB:HIT000075001"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3p13-p21"
CDS 128..1708
/codon_start=1
/product="RhoGEF"
/protein_id="AAF79954.1"
/translation="MVAKDYPFYLTVKRANCSLELPPASGPAKDAEEPSNKRVKPLSR
VTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDILAPRPWSRNAAPSSTKRRDSK
LWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTE
QELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQ
VAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRH
TPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRV
LCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDG
EVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKET
VLCAAGQAGVLDSEGSFLNPTTGSRELQGETKLEQMDQSDSESDCSMDTSEVSLDCER
MEQTDSSCGNSRHGESNV"
BASE COUNT 1029 a 790 c 821 g 921 t
ORIGIN
1 ccggctgtcg gtctccgtgt cgccgccgcc gcccggcatc gtggagctgg ggcccccttt
61 tgcctgggag ttttgtagtc gcctagggtc agcggtgaca tcccaaaggg caggcccggc
121 agccgccatg gtggccaagg attacccctt ctacctcacg gtcaagagag cgaactgcag
181 cctggagcta cctccggcca gcggtccggc caaggacgct gaggagccta gtaataaacg
241 ggtcaaaccc ctttcccgag tcacgtcgct agcaaacctc atcccgcccg tgaaggccac
301 gccattaaag cgcttcagtc aaaccctgca gcgctccatt agcttccgca gtgagagccg
361 ccctgacatc ctcgcccccc gaccctggtc cagaaatgcc gccccctcga gcacgaaacg
421 gagagatagc aagctgtgga gtgagacctt cgatgtgtgc gtcaatcaga tgcttacatc
481 caaggaaatc aaacgtcagg aggcgatctt tgagctttcc caaggagaag aagacttgat
541 agaagacttg aaattagcaa aaaaggccta tcatgacccc atgctgaaac tctccataat
601 gacagaacaa gagttgaatc aaatttttgg aacactggac tctctaattc ctctacatga
661 agagctcctt agtcagcttc gagatgttag gaagcctgat ggctcgactg aacatgttgg
721 tcccatcctc gtgggctggc tcccttgcct cagctcctat gatagctact gcagcaatca
781 agtagccgcc aaagctctgc tggaccacaa aaagcaagat caccgagtcc aggatttcct
841 acagcgatgt ttagaatccc cctttagccg caaactagat ctctggaatt tcctcgatat
901 tccaagaagc cgcctggtaa aataccctct gcttctccga gaaatcttga ggcacacacc
961 aaatgataat ccagatcagc agcacttgga agaagctata aatatcattc agggaattgt
1021 ggcagaaatc aacaccaaga ctggtgaatc tgaatgccgc tattataaag agcggcttct
1081 ttacttggaa gaaggccaga aagactccct gatcgacagc tctcgagtct tgtgttgtca
1141 tggtgaactg aagaacaatc ggggcgtgaa actgcatgtt ttcctgttcc aagaagtgct
1201 tgtgatcact cgagccgtca cccacaatga gcagctttgc taccagctgt accgtcagcc
1261 aatccccgtg aaagacctcc tgctggaaga cctccaggat ggagaagtga ggctgggtgg
1321 ctccctgcga ggggcattca gcaacaatga gagaattaaa aacttcttca gagtcagttt
1381 caaaaatgga tcccaaagtc agacccactc gctacaagcc aatgacactt tcaacaaaca
1441 gcagtggctt aactgtattc gtcaagccaa agaaacagtt ttgtgtgctg ccgggcaagc
1501 tggggtgctt gactccgagg gatcgttcct aaatcccacc accgggagca gagagctaca
1561 gggagaaaca aaacttgagc agatggacca atcggacagt gagtcagact gtagtatgga
1621 cacgagtgag gtcagcctcg actgtgagcg catggaacag acagactctt cctgtggaaa
1681 cagcaggcac ggtgaaagta acgtctgaca gaagcatgtg cacttcggga agcaggcctg
1741 catcttacct gtacagtatt tgcattccac agatggaacg gtttggagaa gcactttttc
1801 atacttttgt gaaagtatac atgttggccc agtctctcgt atctgtacct ttgtccctag
1861 tactgtaact gccaatctgt ctgtgtaagc tggaatctgt ggcaactatt accctgtgtt
1921 gtatttccca agtgtctgga tggatggaga ggtactcaaa caagttactt tcagttgtcc
1981 tgctggattt taaaaaaata gaaaaagaat ctcaaaacta ctgttttaca tagattgttt
2041 gaagagtcct tcctcttgtg cttctgtacc actttcccag ctcttagatg tggtagctaa
2101 aggcacggaa tttagacggc cttgtaaata gggcatgagg aactcatctg tgtattggga
2161 tggtattaga gagagaatca ggaaagacca actcatgaag tgaacttggt ttgatcttac
2221 tcaactagaa agcttgaaaa catccctggg gattctgaag gcttaatttt gcaaaggagg
2281 atgcattgtc tgaactttgc aacttcatcc agtgcaagtt tgatgcaaga atgtattagg
2341 acataaaata gaggctgacc ttaaaagggc caggacagaa gcggctgcca gctctgaatc
2401 tttaactgaa atgcacatgg caccaggagg tgtctctcat agttggttgc tagcctaaaa
2461 catcagaata gaacccaaag ggcttaggaa ggcctgccag gataacaaga aggccctgta
2521 ttcattgtgt ttcatctgcc taggcctact cattatttta gagaatgaat gaagcaacaa
2581 ggaagagaga acatgactct atcgatgaca ctgtttatag aaacacagga gaggaagaat
2641 ttggaatgaa aagcacttcg tcagaacctt ctgtgggagc cattgagaga aaagcatggt
2701 ccagtgcctt ctgagaaagg ccagagcttt gggctttcct gctctgcttt tgggtcgtca
2761 atttgccatc tctggttctg tgctataatc agaattgtaa ttatgttctc cagaggccaa
2821 tttcattaac tctgattaat tagaatcagc tagccagatt agtaacctct ttgtccagcc
2881 ttgatttaca gtgcagggta aagtgcagac cttaaaaaca gctaagtacc tagaagagct
2941 ccctgcaagt gtaaatatta aggatgacct gtgcaaaatt atacccacac cagcactagt
3001 ggtaattatt ctaaattatt gccaaaaagt tttttttaat ctgtctttca agtttacaga
3061 aaagaaagca gtaaatgcat tgatgtcatt ttattatgta catatatcat gtgcattcaa
3121 gctgtgtgac aagatatatc aatataaaaa caaggtatat actttattat tttttgaaaa
3181 caaggatatt gtgatcaatt ttaccctgta aaacatattt ctgtatttat aggtcttaaa
3241 catgatgaat tttttctatt acaagtttat ttaaaactgc tttctcaagt cgttattgat
3301 acagcaagtg aacctgctgc agacagaagc agaggaaagc caagaacagc ctttattggt
3361 gaagaaaaga atgaatgatt ctttgtaggc gccatcagcc acttttagaa gccatcagcc
3421 agtgtgttgg gaaaagaggt ttgtcaagtg ttggcctatg ggaaggtggt caatgaatgt
3481 tttgatgaaa tgaatgtttt tgtataatgg ccttaaactt ttctggaagt atttcaaata
3541 aattacatta ttaagtcatc a
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