LOCUS AF247457 7718 bp mRNA linear HUM 10-SEP-2001
DEFINITION Homo sapiens myosin X (MYO10) mRNA, complete cds.
ACCESSION AF247457
VERSION AF247457.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7718)
AUTHORS Berg,J.S., Derfler,B.H., Pennisi,C.M., Corey,D.P. and Cheney,R.E.
TITLE Myosin-X, a novel myosin with pleckstrin homology domains,
associates with regions of dynamic actin
JOURNAL J. Cell. Sci. 113 (Pt 19), 3439-3451 (2000)
PUBMED 10984435
REFERENCE 2 (bases 1 to 7718)
AUTHORS Corey,D.P.
TITLE Direct Submission
JOURNAL Submitted (20-MAR-2000) Neurobiology, Massachusetts General
Hospital, WEL414, Boston, MA 02114, USA
REFERENCE 3 (bases 1 to 7718)
AUTHORS Corey,D.P.
TITLE Direct Submission
JOURNAL Submitted (25-AUG-2000) Neurobiology, Massachusetts General
Hospital, WEL414, Boston, MA 02114, USA
REMARK Sequence update by submitter
COMMENT On Aug 25, 2000 this sequence version replaced AF247457.1.
FEATURES Location/Qualifiers
source 1..7718
/db_xref="H-InvDB:HIT000074952_02"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..7718
/gene="MYO10"
CDS 154..6330
/gene="MYO10"
/codon_start=1
/product="myosin X"
/protein_id="AAF68025.2"
/translation="MDNFFTEGTRVWLRENGQHFPSTVNSCAEGIVVFRTDYGQVFTY
KQSTITHQKVTAMHPTNEEGVDDMASLTELHGGSIMYNLFQRYKRNQIYTYIGSILAS
VNPYQPIAGLYEPATMEQYSRRHLGELPPHIFAIANECYRCLWKRHDNQCILISGESG
AGKTESTKLILKFLSVISQQSLELSLKEKTSCVERAILESSPIMEAFGNAKTVYNNNS
SRFGKFVQLNICQKGNIQGGRIVDYLLEKNRVVRQNPWERNYHIFYALLAGLEHEERE
EFYLSTPENYHYLNQSGCVEDKTISDQESFREVITAMDVMQFSKEEVWEVSRLLAGIL
HLGNIEFITAGGAQVSFKTALGRSAELLGLDPTQLTDALTQRSMFLRGEEILTPLNVQ
QAVDSRDSLAMALYACCFEWVIKKINSRIKGNEDFKSIGILDIFGFENFEVNHFEQFN
INYANEKLQEYFNKHIFSLEQLEYSREGLVWEDIDWIDNGECLDLIEKKLGLLALINE
ESHFPQATDSTLLEKLHSQHANNHFYVKPRVAVNNFGVKHYAGEVQYDVRGILEKNRD
TFRDDLLNLLRESRFDFIYDLFEHVSSRNNQDTLKCGSKHRRPTVSSQFKDSLHSLMA
TLSSSNPFFVRCIKPNMQKMPDQFDQAVVLNQLRYSGMLETVRIRKAGYAVRRPFQDF
YKRYKVLMRNLALPEDVRGKCTSLLQLYDASNSEWQLGKTKVFLRESLEQKLEKRREE
EVSHAAMVIRAHVLGFLARKQYRKVLYCVVIIQKNYRAFLLRRRFLHLKKAAIVFQKQ
LRGQIARRVYRQLLAEKREQEEKKKQEEEEKKKREEEERERERERREAELRAQQEEET
RKQQELEALQKSQKEAELTRELEKQKENKQVEEILRLEKEIEDLQRMKEQQELSLTEA
SLQKLQERRDQELRRLEEEACRAAQEFLESLNFDEIDECVRNIERSLSVGSEFSSELA
ESACEEKPNFNFSQPYPEEEVDEGFEADDDAFKDSPNPSEHGHSDQRTSGIRTSDDSS
EEDPYMNDTVVPTSPSADSTVLLAPSVQDSGSLHNSSSGESTYCMPQNAGDLPSPDGD
YDYDQDDYEDGAITSGSSVTFSNSYGSQWSPDYRCSVGTYNSSGAYRFSSEGAQSSFE
DSEEDFDSRFDTDDELSYRRDSVYSCVTLPYFHSFLYMKGGLMNSWKRRWCVLKDETF
LWFRSKQEALKQGWLHKKGGGSSTLSRRNWKKRWFVLRQSKLMYFENDSEEKLKGTVE
VRTAKEIIDNTTKENGIDIIMADRTFHLIAESPEDASQWFSVLSQVHASTDQEIQEMH
DEQANPQNAVGTLDVGLIDSVCASDSPDRPNSFVIITANRVLHCNADTPEEMHHWITL
LQRSKGDTRVEGQEFIVRGWLHKEVKNSPKMSSLKLKKRWFVLTHNSLDYYKSSEKNA
LKLGTLVLNSLCSVVPPDEKIFKETGYWNVTVYGRKHCYRLYTKLLNEATRWSSAIQN
VTDTKAPIDTPTQQLIQDIKENCLNSDVVEQIYKRNPILRYTHHPLHSPLLPLPYGDI
NLNLLKDKGYTTLQDEAIKIFNSLQQLESMSDPIPIIQGILQTGHDLRPLRDELYCQL
IKQTNKVPHPGSVGNLYSWQILTCLSCTFLPSRGILKYLKFHLKRIREQFPGTEMEKY
ALFTYESLKKTKCREFVPSRDEIEALIHRQEMTSTVYCHGGGSCKITINSHTTAGEVV
EKLIRGLAMEDSRNMFALFEYNGHVDKAIESRTVVADVLAKFEKLAATSEVGDLPWKF
YFKLYCFLDTDNVPKDSVEFAFMFEQAHEAVIHGHHPAPEENLQVLAALRLQYLQGDY
TLHAAIPPLEEVYSLQRLKARISQSTKTFTPCERLEKRRTSFLEGTLRRSFRTGSVVR
QKVEEEQMLDMWIKEEVSSARASIIDKWRKFQGMNQEQAMAKYMALIKEWPGYGSTLF
DVECKEGGFPQELWLGVSADAVSVYKRGEGRPLEVFQYEHILSFGAPLANTYKIVVDE
RELLFETSEVVDVAKLMKAYISMIVKKRYSTTRSASSQGSSR"
misc_feature 154..2379
/gene="MYO10"
/note="Region: head domain"
misc_feature 2398..2433
/gene="MYO10"
/note="Region: IQ domain"
misc_feature 2467..2502
/gene="MYO10"
/note="Region: IQ domain"
misc_feature 2536..2571
/gene="MYO10"
/note="Region: IQ domain"
misc_feature 3091..3162
/gene="MYO10"
/note="Region: PEST domain"
misc_feature 3211..3324
/gene="MYO10"
/note="Region: PEST domain"
misc_feature 3346..3471
/gene="MYO10"
/note="Region: PEST domain"
misc_feature 3673..3783
/gene="MYO10"
/note="Region: PH domain 1a"
misc_feature 3787..4083
/gene="MYO10"
/note="Region: PH domain 2"
misc_feature 4147..4305
/gene="MYO10"
/note="Region: PH domain 1b"
misc_feature 4327..4644
/gene="MYO10"
/note="Region: PH domain 3"
misc_feature 4795..5238
/gene="MYO10"
/note="Region: MyTH4 domain"
misc_feature 5452..6312
/gene="MYO10"
/note="Region: FERM domain"
BASE COUNT 2120 a 1889 c 2034 g 1675 t
ORIGIN
1 caagaaggga ccgggcgatg gcagcagggg agccccgcgg gcgcgcgtcc tcgggagtgg
61 cgccgtgaca cgcatggttt ccccggaccc gcggcggcgc tgacttccgc gagtcggagc
121 ggcactcggc gagtccggga ctgcgctgga acaatggata acttcttcac cgagggaaca
181 cgggtctggc tgagagaaaa tggccagcat tttccaagta ctgtaaattc ctgtgcagaa
241 ggcatcgtcg tcttccggac agactatggt caggtattca cttacaagca gagcacaatt
301 acccaccaga aggtgactgc tatgcacccc acgaacgagg agggcgtgga tgacatggcg
361 tccttgacag agctccatgg cggctccatc atgtataact tattccagcg gtataagaga
421 aatcaaatat atacctacat cggctccatc ctggcctccg tgaaccccta ccagcccatc
481 gccgggctgt acgagcctgc caccatggag cagtacagcc ggcgccacct gggcgagctg
541 cccccgcaca tcttcgccat cgccaacgag tgctaccgct gcctgtggaa gcgccacgac
601 aaccagtgca tcctcatcag tggtgaaagt ggggcaggta aaaccgaaag cactaaattg
661 atcctcaagt ttctgtcagt catcagtcaa cagtctttgg aattgtcctt aaaggagaag
721 acatcctgtg ttgaacgagc tattcttgaa agcagcccca tcatggaagc tttcggcaat
781 gcgaagaccg tgtacaacaa caactctagt cgctttggga agtttgttca gctgaacatc
841 tgtcagaaag gaaatattca gggcgggaga attgtagatt atttattaga aaaaaaccga
901 gtagtaaggc aaaatccctg ggaaaggaat tatcacatat tttatgcact gctggcaggg
961 ctggaacatg aagaaagaga agaattttat ttatctacgc cagaaaacta ccactacttg
1021 aatcagtctg gatgtgtaga agacaagaca atcagtgacc aggaatcctt tagggaagtt
1081 attacggcaa tggacgtgat gcagttcagc aaggaggaag tttgggaagt gtcgaggctg
1141 cttgctggta tactgcatct tgggaacata gaatttatca ctgctggtgg ggcacaggtt
1201 tccttcaaaa cagctttggg cagatctgcg gagttacttg ggctggaccc aacacagctc
1261 acagatgctt tgacccagag atcaatgttc ctcaggggag aagagatcct cacgcctctc
1321 aatgttcaac aggcagtaga cagcagggac tccctggcca tggctctgta tgcgtgctgc
1381 tttgagtggg taatcaagaa gatcaacagc aggatcaaag gcaatgagga cttcaagtct
1441 attggcatcc tcgacatctt tggatttgaa aactttgagg ttaatcactt tgaacagttc
1501 aatataaact atgcaaacga gaaacttcag gagtacttca acaagcatat tttttcttta
1561 gaacaactag aatatagccg ggaaggatta gtgtgggaag atattgactg gatagacaat
1621 ggagaatgcc tggacttgat tgagaagaaa cttggcctcc tagcccttat caatgaagaa
1681 agccattttc ctcaagccac agacagcacc ttattggaga agctacacag tcagcatgcg
1741 aataaccact tttatgtgaa gcccagagtt gcagttaaca attttggagt gaagcactat
1801 gctggagagg tgcaatatga tgtccgaggt atcttggaga agaacagaga tacatttcga
1861 gatgaccttc tcaatttgct aagagaaagc cgatttgact ttatctacga tctttttgaa
1921 catgtttcaa gccgcaacaa ccaggatacc ttgaaatgtg gaagcaaaca tcggcggcct
1981 acagtcagct cacagttcaa ggactcactg cattccttaa tggcaacgct aagctcctct
2041 aatcctttct ttgttcgctg tatcaagcca aacatgcaga agatgccaga ccagtttgac
2101 caggcggttg tgctgaacca gctgcggtac tcagggatgc tggagactgt gagaatccgc
2161 aaagctgggt atgcggtccg aagacccttt caggactttt acaaaaggta taaagtgctg
2221 atgaggaatc tggctctgcc tgaggacgtc cgagggaagt gcacgagcct gctgcagctc
2281 tatgatgcct ccaacagcga gtggcagctg gggaagacca aggtctttct tcgagaatcc
2341 ttggaacaga aactggagaa gcggagggaa gaggaagtga gccacgcggc catggtgatt
2401 cgggcccatg tcttgggctt cttagcacga aaacaataca gaaaggtcct ttattgtgtg
2461 gtgataatac agaagaatta cagagcattc cttctgagga ggagattttt gcacctgaaa
2521 aaggcagcca tagttttcca gaagcaactc agaggtcaga ttgctcggag agtttacaga
2581 caattgctgg cagagaaaag ggagcaagaa gaaaagaaga aacaggaaga ggaagaaaag
2641 aagaaacggg aggaagaaga aagagaaaga gagagagagc gaagagaagc cgagctccgc
2701 gcccagcagg aagaagaaac gaggaagcag caagaactcg aagccttgca gaagagccag
2761 aaggaagctg aactgacccg tgaactggag aaacagaagg aaaataagca ggtggaagag
2821 atcctccgtc tggagaaaga aatcgaggac ctgcagcgca tgaaggagca gcaggagctg
2881 tcgctgaccg aggcttccct gcagaagctg caggagcggc gggaccagga gctccgcagg
2941 ctggaggagg aagcgtgcag ggcggcccag gagttcctcg agtccctcaa tttcgacgag
3001 atcgacgagt gtgtccggaa tatcgagcgg tccctgtcgg tgggaagcga attttccagc
3061 gagctggctg agagcgcatg cgaggagaag cccaacttca acttcagcca gccctaccca
3121 gaggaggagg tcgatgaggg cttcgaagcc gacgacgacg ccttcaagga ctcccccaac
3181 cccagcgagc acggccactc agaccagcga acaagtggca tccggaccag cgatgactct
3241 tcagaggagg acccatacat gaacgacacg gtggtgccca ccagccccag tgcggacagc
3301 acggtgctgc tcgccccatc agtgcaggac tccgggagcc tacacaactc ctccagcggc
3361 gagtccacct actgcatgcc ccagaacgct ggggacttgc cctccccaga cggcgactac
3421 gactacgacc aggatgacta tgaggacggt gccatcactt ccggcagcag cgtgaccttc
3481 tccaactcct acggcagcca gtggtccccc gactaccgct gctctgtggg gacctacaac
3541 agctcgggtg cctaccggtt cagctctgag ggggcgcagt cctcgtttga agatagtgaa
3601 gaggactttg attccaggtt tgatacagat gatgagcttt cataccggcg tgactctgtg
3661 tacagctgtg tcactctgcc gtatttccac agctttctgt acatgaaagg tggcctgatg
3721 aactcttgga aacgccgctg gtgcgtcctc aaggatgaaa ccttcttgtg gttccgctcc
3781 aagcaggagg ccctcaagca aggctggctc cacaaaaaag gggggggctc ctccacgctg
3841 tccaggagaa attggaagaa gcgctggttt gtcctccgcc agtccaagct gatgtacttt
3901 gaaaacgaca gcgaggagaa gctcaagggc accgtagaag tgcgaacggc aaaagagatc
3961 atagataaca ccaccaagga gaatgggatc gacatcatta tggccgatag gactttccac
4021 ctgattgcag agtccccaga agatgccagc cagtggttca gcgtgctgag tcaggtccac
4081 gcgtccacgg accaggagat ccaggagatg catgatgagc aggcaaaccc acagaatgct
4141 gtgggcacct tggatgtggg gctgattgat tctgtgtgtg cctctgacag ccctgataga
4201 cccaactcgt ttgtgatcat cacggccaac cgggtgctgc actgcaacgc cgacacgccg
4261 gaggagatgc accactggat aaccctgctg cagaggtcca aaggggacac cagagtggag
4321 ggccaggaat tcatcgtgag aggatggttg cacaaagagg tgaagaacag tccaaagatg
4381 tcttcactga aactgaagaa acggtggttt gtactcaccc acaattccct ggattactac
4441 aagagttcag agaagaacgc gctcaaactg gggaccctgg tcctcaacag cctctgctct
4501 gtcgtccccc cagatgagaa gatattcaaa gagacaggct actggaacgt caccgtgtac
4561 gggcgcaagc actgttaccg gctctacacc aagctgctca acgaggccac ccggtggtcc
4621 agtgccattc aaaacgtgac tgacaccaag gccccgatcg acacccccac ccagcagctg
4681 attcaagata tcaaggagaa ctgcctgaac tcggatgtgg tggaacagat ttacaagcgg
4741 aacccgatcc ttcgatacac ccatcacccc ttgcactccc cgctcctgcc ccttccgtat
4801 ggggacataa atctcaactt gctcaaagac aaaggctata ccacccttca ggatgaggcc
4861 atcaagatat tcaattccct gcagcaactg gagtccatgt ctgacccaat tccaataatc
4921 cagggcatcc tacagacagg gcatgacctg cgacctctgc gggacgagct gtactgccag
4981 cttatcaaac agaccaacaa agtgccccac cccggcagtg tgggcaacct gtacagctgg
5041 cagatcctga catgcctgag ctgcaccttc ctgccgagtc gagggattct caagtatctc
5101 aagttccatc tgaaaaggat acgggaacag tttccaggaa ccgagatgga aaaatacgct
5161 ctcttcactt acgaatctct taagaaaacc aaatgccgag agtttgtgcc ttcccgagat
5221 gaaatagaag ctctgatcca caggcaggaa atgacatcca cggtctattg ccatggcggc
5281 ggctcctgca agatcaccat caactcccac accaccgctg gggaggtggt ggagaagctg
5341 atccgaggcc tggccatgga ggacagcagg aacatgtttg ctttgtttga atacaacggc
5401 cacgtcgaca aagccattga aagtcgaacc gtcgtagctg atgtcttagc caagtttgaa
5461 aagctggctg ccacatccga ggttggggac ctgccatgga aattctactt caaactttac
5521 tgcttcctgg acacagacaa cgtgccaaaa gacagtgtgg agtttgcatt tatgtttgaa
5581 caggcccacg aagcggttat ccatggccac catccagccc cggaagaaaa cctccaggtt
5641 cttgctgccc tgcgactcca gtatctgcag ggggattata ctctgcacgc tgccatccca
5701 cctctcgaag aggtttattc cctgcagaga ctcaaggccc gcatcagcca gtcaaccaaa
5761 accttcaccc cttgtgaacg gctggagaag aggcggacga gcttcctaga ggggaccctg
5821 aggcggagct tccggacagg atccgtggtc cggcagaagg tcgaggagga gcagatgctg
5881 gacatgtgga ttaaggaaga agtctcctct gctcgagcca gtatcattga caagtggagg
5941 aaatttcagg gaatgaacca ggaacaggcc atggccaagt acatggcctt gatcaaggag
6001 tggcctggct atggctcgac gctgtttgat gtggagtgca aggaaggtgg cttccctcag
6061 gaactctggt tgggtgtcag cgcggacgcc gtctccgtct acaagcgtgg agagggaaga
6121 ccactggaag tcttccagta tgaacacatc ctctcttttg gggcacccct ggcgaatacg
6181 tataagatcg tggtcgatga gagggagctg ctctttgaaa ccagtgaggt ggtggatgtg
6241 gccaagctca tgaaagccta catcagcatg atcgtgaaga agcgctacag cacgacacgc
6301 tccgccagca gccagggcag ctccaggtga aggcgggaca gagcccacct gtctttgcta
6361 cctgaacgca ccaccctctg gcctaggctg gctccagtgt gccatgccca gccaaaacaa
6421 acacagagct gcccaggctt tctggaagct tctggtctga gggaggtgtc tccgaggatc
6481 cttttgcctg ccgccttcat tgatcctgta ttaagctgtc aactttaaca gtctgcacag
6541 tttccaaagc tttactactc ttagaggaca catgccttaa aaaaggaggg gaggaaccac
6601 gctgccacca aagcagccgg aagtgcctta acttgtggaa ccaacactaa tcgaccgtaa
6661 ctgtgctact gaagggaact gcctttcccc cttctggggg agacttaaca gagcgtggaa
6721 ggggggcatt ctctgtcaat gatgcactaa cctcccaacc tgatttcccc gaatctgagg
6781 gaaggtgagg gagtgggaag ggggatggag agctcgaggg gacagtgtgt ttgagctgga
6841 gtgctgcggg cagcctttct catggaatga catgaatcaa cttttttctt tgtttcatct
6901 tttaagtgta cgtgcttgcc tgttcgtgca tgtgttcata aactcaacac cttaatcatg
6961 gtttcatgag cattaaaaag caaagggaaa aaggatgtgt aatggtgtac acagtctgta
7021 tattttaata atgcagagct atagtctcaa ttgttacttt ataaggtggt tttattaaca
7081 aacccaaatc ctggattttc ctgtctttgc tgtattttga aaaacacgtg ttgactccat
7141 tgttttacat gtagcaaagt ctgccatctg tgtctgctgt attataaaca gataagcagc
7201 ctacaagata actgtattta taaaccactc ttcaacagct ggctccagtg ctggttttag
7261 aacaagaatg aagtcatttt ggagtctttc atgtctaaaa gatttaagtt aaaaacaaag
7321 tgttacttgg aaggttagct tctatcattc tggatagatt acagatataa taaccatgtt
7381 gactatgggg gagagacgct gcattccaga aacgtcttaa cacttgagtg aatcttcaaa
7441 ggaccctgac attaaatgct gaggctttaa tacacacata ttttatccca agtttataat
7501 ggtggtctga acaaggcacc tgtaaataaa tcagcattta tgaccagaag aaaaataatc
7561 tggtcttgga ctttttattt ttatatggaa aagttttaag gacttgggcc aactaagtct
7621 acccacacga aaaaagaaat ttgccttgtc cctttgtgta caaccatgca aaactgtttg
7681 ttggctcaca gaagttctga caataaaaga tactagct
//