LOCUS AF247361 5791 bp DNA linear HUM 26-JUN-2002
DEFINITION Homo sapiens CC chemokine receptor 3 (CCR3) gene, complete cds.
ACCESSION AF247361
VERSION AF247361.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5791)
AUTHORS Vijh,S., Dayhoff,D.E., Wang,C.E., Imam,Z., Ehrenberg,P.K. and
Michael,N.L.
TITLE Transcription Regulation of Human Chemokine Receptor CCR3: Evidence
for a Rare TATA-less Promoter Structure Conserved between
Drosophila and Humans
JOURNAL Genomics 80 (1), 86-95 (2002)
PUBMED 12079287
REFERENCE 2 (bases 1 to 5791)
AUTHORS Vijh,S., Dayhoff,D.E., Wang,C.E., Ehrenberg,P.K. and Michael,N.L.
TITLE Direct Submission
JOURNAL Submitted (21-MAR-2000) Dept. of Mol. Diag. and Pathogenesis, U.S.
Military HIV Research Program, 1600 E. Gude Drive, Rockville, MD
20850, USA
FEATURES Location/Qualifiers
source 1..5791
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3p21; between CCR1 and CCR5"
/clone="11A5, frag B"
/cell_type="peripheral blood mononuclear cell"
gene <1..5562
/gene="CCR3"
mRNA <2249..5562
/gene="CCR3"
/product="CC chemokine receptor 3"
mRNA <4004..5562
/gene="CCR3"
/product="CC chemokine receptor 3"
CDS 4015..5082
/gene="CCR3"
/note="CCR3; G-protein coupled seven transmembrane
spanning receptor; principle cell-surface receptor for
eotaxin family of chemokines; expressed on eosinophils,
CD4/Th2 and CD8 lymphocytes, monocytes, microglia, and
dendritic cells"
/codon_start=1
/product="CC chemokine receptor 3"
/protein_id="AAL85154.1"
/translation="MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLV
FTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFG
HGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGL
AVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAIC
YTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERS
KHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSE
KLERTSSVSPSTAEPELSIVF"
regulatory 5542..5547
/regulatory_class="polyA_signal_sequence"
/gene="CCR3"
polyA_site 5562
/gene="CCR3"
BASE COUNT 1624 a 1285 c 1160 g 1722 t
ORIGIN
1 ttcttcctaa atttatttac aaatgtaaca caattccacc caaacttatg tttttataag
61 taattgagta gatgatccta aagtttaata aaacaaatgg ctctaatagg taagacattt
121 ggaaatgtat aatgaaaggg agttgcataa taagatcatc tatataaatc atctaataaa
181 tctacaataa aaagtgtctc tagcacagaa ataagatatc aatagaatat aaggtacaaa
241 atcagattca ggaacattaa agaatatacg acaaaggtga tatttcaagc ccaaagggga
301 gaagatggtt attcaacaca tagtgtttta aaatttgtca gataagaatg gagaggagga
361 ggctcctctc ctctgacccc agggaatgtg agaagagaca cagtggttat gaaaggaagc
421 agtcacacct gtggatccct accttcccca tcagagctag ggggcatgga gcgctctctg
481 ctaagatggg gacccccaag gaatgtctcc ctgtggggca cttccttacc agatgggatg
541 gccagtgcgg ttaagttggt ggtcaggcag aaaaaaaaga tctagtttgt actcttgaga
601 gttcctcggt ttgttcatgg catgggcagg gagtcaagga gcagcagcct tgcctcagtg
661 cctaccagtg caggaaaagg tgcatagcct gggccagggc cagggccctg gtggaggcgt
721 agtggtaaca gagagggctc tccattccag cccaaggaag actaagaatg aatacctcat
781 gagtatatta gctacaaacc accacagcag gttccagaaa aaggctcagc gttggaacca
841 ggtcaccccc actcagcaga caccagtcat ataaatcaag gaccaacagg agacaggaac
901 acccccttcc cactctgccc catgtctcaa gttgtagtgg cccttcctcc agatctctgc
961 caccatctta gaaaggaaca ctgaaagaag aaactgaaat tataagctga cagcataaag
1021 aggatgagta aaacctaaaa tcattgttca aatgaatgaa tcaagagaag tttaaaccac
1081 tttggactaa aatgtgtgaa tcctttttcc tgctatccag cagatgagaa gctggtaaca
1141 gagaccaaaa tagtttggag actaaagaat cattgcacat ttcactgctg agttgtattg
1201 tgagtaattt tagttgacct cacttttgta aatcttgcac acgggcatcc atatctgcac
1261 agagatatgt taacagtggt aaatgctgca tgaggagatt gggtgatttt tactttcgtt
1321 tttgtgctct tctttcttat tgttcttact tatttacgat taccctatcg ttttccaaaa
1381 tgtaaaaggc cattttgaaa gcctaattca aacctcttca ctattttgta tctaagtatt
1441 caccttgatt gagactgggt agacaggtga aaaccatatc aggtttttaa ttttttaatt
1501 tttaattatt tatttattta tttatttttt gagatggagt ctggctgtcg cccaggctgg
1561 agtgcagcgg cgtgatcaca gttcactgca gcctcaacct tctaggctca agggattctc
1621 ccacctcagc cccccaagta gttgggacca cacgtatgcg ccaccatgcc tggctaattt
1681 cttatttttt tgtagagata ggatctcact atattgtcca ggctggtctt gaattcctgg
1741 gctcaggtga gcctcccacc tgggcctccc aaagtactgg gattacaggc atgagccaag
1801 gtcccctgcc catatgagat tttctgtctc tgatcccatg cagctagtaa tcaaggactt
1861 ggctgctgac tctggaggac ctgcatgctt tcttgagctg tgaacttcag tgctaaaagc
1921 tcataggcag ccctgaaacc caaaccaaaa ggttctatgg tttatcatcc cgatcatgtt
1981 gattttatag aaataacaca tgaattaaag acactaccct caaactgagc aaaacttaag
2041 taattttttt aaagtttgac ctgtttttaa atcactcttg gagaaaaagg aaaataaata
2101 caaataatta acggtgaata caggctacta tacctttgtt ctccagaatt agcagttctg
2161 ttcttttctt gctttagatg ctgaagtgca gaaggacact ctgtgattgt acgtgtgtaa
2221 ctgacaaaat gtgtattttt tttctcagct gctatggatt ggattatgct attatgaata
2281 agaatgctga tgggagcaca cacaaaccat ttgttcctca gtccattttc ctcctcaaaa
2341 gcctggaatg tgccattgat cagtgggaga tgtacctgga cagacccatg aaaagagatc
2401 aacaagttcc acccaaggga ccctattttt cctaatttca tttgaaatgg cttctaattg
2461 tccttctttc attcctgctt cctaccagtt ttacagcttt ttctggtttc aaatgtgaac
2521 tcacatacac tctcattttt cctcatcaca accccaagtg acccaatggt cctcactttc
2581 gatataagta aaggaggctc tgcattaagg gcttgtccaa ggcacgcagc tgagaggcgc
2641 taggactggc tccatttcca tctctattct cactgacttt gactacccag aaccccaaca
2701 tgtggggcct cagtattcga tcaattattc tattaagaag caaaaacaat tccccgcatt
2761 ggccccagtt attaagcatt tctcagattt accttgagaa atgcccatcg gcctgtatat
2821 tcacatcttc acccttgtcc cttcctccta gaaaggagaa agtcagttgg atgccctctg
2881 aggaactagt gcatggctta actgtccttc catgactcct gccttatctg ttttctattt
2941 tcctcctttt ccaccgaagt ctataatctc aagaaaagca ggcactggcc ttagggctcc
3001 tggcctaaga aatatcaagt ccagtgagaa atcccattga ctgacccctc ctgcttaccc
3061 ctttgtgatg gagaagctcc caggggtttg ctttttgcat gttaccaggc ctaactcagc
3121 atcaccaggg gcaagaaaag gaaagtaacc taaactaatg ctgcttataa ttgtaattat
3181 tgtaatagtt aattactgtg attgtacatg tgtaacagac aaaatgtgta tttttttcac
3241 agctgctgtg gattggatta tgccatttgg aataagaatg ctgttaagag cacacaagcc
3301 aggttcctca agtccgtagc aaatttttca aaagttaaat ttaaaaatca ctacatttga
3361 atctagtgac aggagaaatg gacatggata gagactaaag atctagccca aattttatat
3421 ttacttgtta gaggattttg aacaaattac taaatttctt caaggttcaa tttccccatt
3481 aactataatg aatggctcat cattatgggg ccctggagaa gcataattac ttgtaattgt
3541 aataatcatt gttattatta ttatacatat tttgctttta aatggataag gatttttaag
3601 gtatatgtaa actgtaaaac ataaaatgca aaatgccgta agagacagta gtaataataa
3661 tgattattat attgttatca ttatctagcc tgttttttcc tgttttgtat ttcttccttt
3721 aaatgctttc agaaatctgt atccccattc ttcaccacca ccccacaaca tttctgcttc
3781 ttttcccatg ccgggtcatg ctaactttga aagcttcagc tctttccttc ctcaatcctt
3841 ttcctggcac ctctgatatg ccttttgaaa ttcatgttaa agaatcccta ggctgctatc
3901 acatgtggca tctttgttga gtacatgaat aaatcaactg gtgtgtttta cgaaggatga
3961 ttatgcttca ttgtgggatt gtatttttct tcttctatca cagggagaag tgaaatgaca
4021 acctcactag atacagttga gacctttggt accacatcct actatgatga cgtgggcctg
4081 ctctgtgaaa aagctgatac cagagcactg atggcccagt ttgtgccccc gctgtactcc
4141 ctggtgttca ctgtgggcct cttgggcaat gtggtggtgg tgatgatcct cataaaatac
4201 aggaggctcc gaattatgac caacatctac ctgctcaacc tggccatttc ggacctgctc
4261 ttcctcgtca cccttccatt ctggatccac tatgtcaggg ggcataactg ggtttttggc
4321 catggcatgt gtaagctcct ctcagggttt tatcacacag gcttgtacag cgagatcttt
4381 ttcataatcc tgctgacaat cgacaggtac ctggccattg tccatgctgt gtttgccctt
4441 cgagcccgga ctgtcacttt tggtgtcatc accagcatcg tcacctgggg cctggcagtg
4501 ctagcagctc ttcctgaatt tatcttctat gagactgaag agttgtttga agagactctt
4561 tgcagtgctc tttacccaga ggatacagta tatagctgga ggcatttcca cactctgaga
4621 atgaccatct tctgtctcgt tctccctctg ctcgttatgg ccatctgcta cacaggaatc
4681 atcaaaacgc tgctgaggtg ccccagtaaa aaaaagtaca aggccatccg gctcattttt
4741 gtcatcatgg cggtgttttt cattttctgg acaccctaca atgtggctat ccttctctct
4801 tcctatcaat ccatcttatt tggaaatgac tgtgagcgga gcaagcatct ggacctggtc
4861 atgctggtga cagaggtgat cgcctactcc cactgctgca tgaacccggt gatctacgcc
4921 tttgttggag agaggttccg gaagtacctg cgccacttct tccacaggca cttgctcatg
4981 cacctgggca gatacatccc attccttcct agtgagaagc tggaaagaac cagctctgtc
5041 tctccatcca cagcagagcc ggaactctct attgtgtttt aggtcagatg cagaaaattg
5101 cctaaagagg aaggaccaag gagatgaagc aaacacatta agccttccac actcacctct
5161 aaaacagtcc ttcaaacttc cagtgcaaca ctgaagctct tgaagacact gaaatataca
5221 cacagcagta gcagtagatg catgtaccct aaggtcatta ccacaggcca ggggctgggc
5281 agcgtactca tcatcaaccc taaaaagcag agctttgctt ctctctctaa aatgagttac
5341 ctacatttta atgcacctga atgttagata gttactatat gccgctacaa aaaggtaaaa
5401 ctttttatat tttatacatt aacttcagcc agctattgat ataaataaaa cattttcaca
5461 caatacaata agttaactat tttattttct aatgtgccta gttctttccc tgcttaatga
5521 aaagcttgtt ttttcagtgt gaataaataa tcgtaagcaa cataatggca tgccattcct
5581 gttctaaata ttcttcatag tttgttgatt tcctgttcac actgaatgac aaaatttccc
5641 atgggtgact cacagagccc tgagaagtgt gcactgtcct cttaatgcca atctgacatt
5701 gcagaggagg ccagggcctc ctgtacatat gaagtagccc gggtatggag cggggaggtg
5761 ttgggcttgc agggactctc ggcacctgta g
//