LOCUS AF246971 3367 bp mRNA linear HUM 05-FEB-2001
DEFINITION Homo sapiens Toll-like receptor 8 (TLR8) mRNA, complete cds.
ACCESSION AF246971
VERSION AF246971.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3367)
AUTHORS Du,X., Poltorak,A., Wei,Y. and Beutler,B.
TITLE Three novel mammalian toll-like receptors: gene structure,
expression, and evolution
JOURNAL Eur. Cytokine Netw. 11 (3), 362-371 (2000)
PUBMED 11022119
REFERENCE 2 (bases 1 to 3367)
AUTHORS Du,X., Wei,Y., Poltorak,A. and Beutler,B.
TITLE Direct Submission
JOURNAL Submitted (20-MAR-2000) Internal Medicine, UT Southwestern Medical
Center, 5323 Harry Hines Blvd., Dallas, TX 75235-9050, USA
FEATURES Location/Qualifiers
source 1..3367
/db_xref="H-InvDB:HIT000074942"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xp22"
/tissue_type="placenta"
gene 1..3367
/gene="TLR8"
CDS 152..3331
/gene="TLR8"
/codon_start=1
/product="Toll-like receptor 8"
/protein_id="AAF64061.1"
/translation="MKESSLQNSSCSLGKETKKENMFLQSSMLTCIFLLISGSCELCA
EENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQ
GLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPS
GLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETL
TNLELLSLSFNSLSHVSPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCP
RCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVL
DLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKPLSLRALHL
RGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISP
LVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSL
NSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNAS
ALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLE
SKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPA
SLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHN
RISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDI
GDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFI
TTMVMLAALAHHLFYWDVWFIYNVCLAKIKGYRSLSTSQTFYDAYISYDTKDASVTDW
VINELRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSW
NFKTAFYLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEG
LFWQTLRNVVLTENDSRYNNMYVDSIKQY"
BASE COUNT 1042 a 712 c 629 g 984 t
ORIGIN
1 ctcctgcata gagggtacca ttctgcgctg ctgcaagtta cggaatgaaa aattagaaca
61 acagaaacgt ggttctcttg acacttcagt gttagggaac atcagcaaga cccatcccag
121 gagaccttga aggaagcctt tgaaagggag aatgaaggag tcatctttgc aaaatagctc
181 ctgcagcctg ggaaaggaga ctaaaaagga aaacatgttc cttcagtcgt caatgctgac
241 ctgcattttc ctgctaatat ctggttcctg tgagttatgc gccgaagaaa atttttctag
301 aagctatcct tgtgatgaga aaaagcaaaa tgactcagtt attgcagagt gcagcaatcg
361 tcgactacag gaagttcccc aaacggtggg caaatatgtg acagaactag acctgtctga
421 taatttcatc acacacataa cgaatgaatc atttcaaggg ctgcaaaatc tcactaaaat
481 aaatctaaac cacaacccca atgtacagca ccagaacgga aatcccggta tacaatcaaa
541 tggcttgaat atcacagacg gggcattcct caacctaaaa aacctaaggg agttactgct
601 tgaagacaac cagttacccc aaataccctc tggtttgcca gagtctttga cagaacttag
661 tctaattcaa aacaatatat acaacataac taaagagggc atttcaagac ttataaactt
721 gaaaaatctc tatttggcct ggaactgcta ttttaacaaa gtttgcgaga aaactaacat
781 agaagatgga gtatttgaaa cgctgacaaa tttggagttg ctatcactat ctttcaattc
841 tctttcacac gtgtcaccca aactgccaag ctccctacgc aaactttttc tgagcaacac
901 ccagatcaaa tacattagtg aagaagattt caagggattg ataaatttaa cattactaga
961 tttaagcggg aactgtccga ggtgcttcaa tgccccattt ccatgcgtgc cttgtgatgg
1021 tggtgcttca attaatatag atcgttttgc ttttcaaaac ttgacccaac ttcgatacct
1081 aaacctctct agcacttccc tcaggaagat taatgctgcc tggtttaaaa atatgcctca
1141 tctgaaggtg ctggatcttg aattcaacta tttagtggga gaaatagcct ctggggcatt
1201 tttaacgatg ctgccccgct tagaaatact tgacttgtct tttaactata taaaggggag
1261 ttatccacag catattaata tttccagaaa cttctctaaa cctttgtctc tacgggcatt
1321 gcatttaaga ggttatgtgt tccaggaact cagagaagat gatttccagc ccctgatgca
1381 gcttccaaac ttatcgacta tcaacttggg tattaatttt attaagcaaa tcgatttcaa
1441 acttttccaa aatttctcca atctggaaat tatttacttg tcagaaaaca gaatatcacc
1501 gttggtaaaa gatacccggc agagttatgc aaatagttcc tcttttcaac gtcatatccg
1561 gaaacgacgc tcaacagatt ttgagtttga cccacattcg aacttttatc atttcacccg
1621 tcctttaata aagccacaat gtgctgctta tggaaaagcc ttagatttaa gcctcaacag
1681 tattttcttc attgggccaa accaatttga aaatcttcct gacattgcct gtttaaatct
1741 gtctgcaaat agcaatgctc aagtgttaag tggaactgaa ttttcagcca ttcctcatgt
1801 caaatatttg gatttgacaa acaatagact agactttgat aatgctagtg ctcttactga
1861 attgtccgac ttggaagttc tagatctcag ctataattca cactatttca gaatagcagg
1921 cgtaacacat catctagaat ttattcaaaa tttcacaaat ctaaaagttt taaacttgag
1981 ccacaacaac atttatactt taacagataa gtataacctg gaaagcaagt ccctggtaga
2041 attagttttc agtggcaatc gccttgacat tttgtggaat gatgatgaca acaggtatat
2101 ctccattttc aaaggtctca agaatctgac acgtctggat ttatccctta ataggctgaa
2161 gcacatccca aatgaagcat tccttaattt gccagcgagt ctcactgaac tacatataaa
2221 tgataatatg ttaaagtttt ttaactggac attactccag cagtttcctc gtctcgagtt
2281 gcttgactta cgtggaaaca aactactctt tttaactgat agcctatctg actttacatc
2341 ttcccttcgg acactgctgc tgagtcataa caggatttcc cacctaccct ctggctttct
2401 ttctgaagtc agtagtctga agcacctcga tttaagttcc aatctgctaa aaacaatcaa
2461 caaatccgca cttgaaacta agaccaccac caaattatct atgttggaac tacacggaaa
2521 cccctttgaa tgcacctgtg acattggaga tttccgaaga tggatggatg aacatctgaa
2581 tgtcaaaatt cccagactgg tagatgtcat ttgtgccagt cctggggatc aaagagggaa
2641 gagtattgtg agtctggagc taacaacttg tgtttcagat gtcactgcag tgatattatt
2701 tttcttcacg ttctttatca ccaccatggt tatgttggct gccctggctc accatttgtt
2761 ttactgggat gtttggttta tatataatgt gtgtttagct aagataaaag gctacaggtc
2821 tctttccaca tcccaaactt tctatgatgc ttacatttct tatgacacca aagatgcctc
2881 tgttactgac tgggtgataa atgagctgcg ctaccacctt gaagagagcc gagacaaaaa
2941 cgttctcctt tgtctagagg agagggattg ggacccggga ttggccatca tcgacaacct
3001 catgcagagc atcaaccaaa gcaagaaaac agtatttgtt ttaaccaaaa aatatgcaaa
3061 aagctggaac tttaaaacag ctttttactt ggctttgcag aggctaatgg atgagaacat
3121 ggatgtgatt atatttatcc tgctggagcc agtgttacag cattctcagt atttgaggct
3181 acggcagcgg atctgtaaga gctccatcct ccagtggcct gacaacccga aggcagaagg
3241 cttgttttgg caaactctga gaaatgtggt cttgactgaa aatgattcac ggtataacaa
3301 tatgtatgtc gattccatta agcaatacta actgacgtta agtcatgatt tcgcgccata
3361 ataaaga
//