LOCUS AF245703 3311 bp mRNA linear HUM 21-MAR-2001
DEFINITION Homo sapiens toll-like receptor 8 (TLR8) mRNA, complete cds.
ACCESSION AF245703
VERSION AF245703.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3311)
AUTHORS Chuang,T.H. and Ulevitch,R.J.
TITLE Cloning and characterization of a sub-family of human toll-like
receptors: hTLR7, hTLR8 and hTLR9
JOURNAL Eur. Cytokine Netw. 11 (3), 372-378 (2000)
PUBMED 11022120
REFERENCE 2 (bases 1 to 3311)
AUTHORS Chuang,T.-H.H. and Ulevitch,R.J.
TITLE Direct Submission
JOURNAL Submitted (15-MAR-2000) Immunology, The Scripps Research Institute,
10550 North Torrey Pines Road, La Jolla, CA 92037, USA
FEATURES Location/Qualifiers
source 1..3311
/db_xref="H-InvDB:HIT000074926"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xp22"
/tissue_type="placenta"
gene 1..3311
/gene="TLR8"
CDS 49..3174
/gene="TLR8"
/codon_start=1
/product="toll-like receptor 8"
/protein_id="AAF78036.1"
/translation="MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDS
VIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQH
QNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYN
ITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPP
KLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASI
NIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLT
MLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQ
LPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRH
IRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIA
CLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSH
YFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILW
NDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWT
LLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKH
LDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKIPRL
VDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITTMVMLAALAHHLFYWDV
WFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESRDKNVL
LCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYLALQRLMDENM
DVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRNVVLTENDSRY
NNMYVDSIKQY"
BASE COUNT 1024 a 697 c 604 g 986 t
ORIGIN
1 ttctgcgctg ctgcaagtta cggaatgaaa aattagaaca acagaaacat ggaaaacatg
61 ttccttcagt cgtcaatgct gacctgcatt ttcctgctaa tatctggttc ctgtgagtta
121 tgcgccgaag aaaatttttc tagaagctat ccttgtgatg agaaaaagca aaatgactca
181 gttattgcag agtgcagcaa tcgtcgacta caggaagttc cccaaacggt gggcaaatat
241 gtgacagaac tagacctgtc tgataatttc atcacacaca taacgaatga atcatttcaa
301 gggctgcaaa atctcactaa aataaatcta aaccacaacc ccaatgtaca gcaccagaac
361 ggaaatcccg gtatacaatc aaatggcttg aatatcacag acggggcatt cctcaaccta
421 aaaaacctaa gggagttact gcttgaagac aaccagttac cccaaatacc ctctggtttg
481 ccagagtctt tgacagaact tagtctaatt caaaacaata tatacaacat aactaaagag
541 ggcatttcaa gacttataaa cttgaaaaat ctctatttgg cctggaactg ctattttaac
601 aaagtttgcg agaaaactaa catagaagat ggagtatttg aaacgctgac aaatttggag
661 ttgctatcac tatctttcaa ttctctttca cacgtgccac ccaaactgcc aagctcccta
721 cgcaaacttt ttctgagcaa cacccagatc aaatacatta gtgaagaaga tttcaaggga
781 ttgataaatt taacattact agatttaagc gggaactgtc cgaggtgctt caatgcccca
841 tttccatgcg tgccttgtga tggtggtgct tcaattaata tagatcgttt tgcttttcaa
901 aacttgaccc aacttcgata cctaaacctc tctagcactt ccctcaggaa gattaatgct
961 gcctggttta aaaatatgcc tcatctgaag gtgctggatc ttgaattcaa ctatttagtg
1021 ggagaaatag cctctggggc atttttaacg atgctgcccc gcttagaaat acttgacttg
1081 tcttttaact atataaaggg gagttatcca cagcatatta atatttccag aaacttctct
1141 aaacttttgt ctctacgggc attgcattta agaggttatg tgttccagga actcagagaa
1201 gatgatttcc agcccctgat gcagcttcca aacttatcga ctatcaactt gggtattaat
1261 tttattaagc aaatcgattt caaacttttc caaaatttct ccaatctgga aattatttac
1321 ttgtcagaaa acagaatatc accgttggta aaagataccc ggcagagtta tgcaaatagt
1381 tcctcttttc aacgtcatat ccggaaacga cgctcaacag attttgagtt tgacccacat
1441 tcgaactttt atcatttcac ccgtccttta ataaagccac aatgtgctgc ttatggaaaa
1501 gccttagatt taagcctcaa cagtattttc ttcattgggc caaaccaatt tgaaaatctt
1561 cctgacattg cctgtttaaa tctgtctgca aatagcaatg ctcaagtgtt aagtggaact
1621 gaattttcag ccattcctca tgtcaaatat ttggatttga caaacaatag actagacttt
1681 gataatgcta gtgctcttac tgaattgtcc gacttggaag ttctagatct cagctataat
1741 tcacactatt tcagaatagc aggcgtaaca catcatctag aatttattca aaatttcaca
1801 aatctaaaag ttttaaactt gagccacaac aacatttata ctttaacaga taagtataac
1861 ctggaaagca agtccctggt agaattagtt ttcagtggca atcgccttga cattttgtgg
1921 aatgatgatg acaacaggta tatctccatt ttcaaaggtc tcaagaatct gacacgtctg
1981 gatttatccc ttaataggct gaagcacatc ccaaatgaag cattccttaa tttgccagcg
2041 agtctcactg aactacatat aaatgataat atgttaaagt tttttaactg gacattactc
2101 cagcagttcc ctcgtctcga gttgcttgac ttacgtggaa acaaactact ctttttaact
2161 gatagcctat ctgactttac atcttccctt cggacactgc tgctgagtca taacaggatt
2221 tcccacctac cctctggctt tctttctgaa gtcagtagtc tgaagcacct cgatttaagt
2281 tccaatctgc taaaaacaat caacaaatcc gcacttgaaa ctaagaccac caccaaatta
2341 tctatgttgg aactacacgg aaaccccttt gaatgcacct gtgacattgg agatttccga
2401 agatggatgg atgaacatct gaatgtcaaa attcccagac tggtagatgt catttgtgcc
2461 agtcctgggg atcaaagagg gaagagtatt gtgagtctgg agctgacaac ttgtgtttca
2521 gatgtcactg cagtgatatt atttttcttc acgttcttta tcaccaccat ggttatgttg
2581 gctgccctgg ctcaccattt gttttactgg gatgtttggt ttatatataa tgtgtgttta
2641 gctaaggtaa aaggctacag gtctctttcc acatcccaaa ctttctatga tgcttacatt
2701 tcttatgaca ccaaagatgc ctctgttact gactgggtga taaatgagct gcgctaccac
2761 cttgaagaga gccgagacaa aaacgttctc ctttgtctag aggagaggga ttgggacccg
2821 ggattggcca tcatcgacaa cctcatgcag agcatcaacc aaagcaagaa aacagtattt
2881 gttttaacca aaaaatatgc aaaaagctgg aactttaaaa cagcttttta cttggctttg
2941 cagaggctaa tggatgagaa catggatgtg attatattta tcctgctgga gccagtgtta
3001 cagcattctc agtatttgag gctacggcag cggatctgta agagctccat cctccagtgg
3061 cctgacaacc cgaaggcaga aggcttgttt tggcaaactc tgagaaatgt ggtcttgact
3121 gaaaatgatt cacggtataa caatatgtat gtcgattcca ttaagcaata ctaactgacg
3181 ttaagtcatg atttcgcgcc ataataaaga tgcaaaggaa tgacatttct gtattagtta
3241 tctattgcta tgtaacaaat tatcccaaaa cttagtggtt taaaacaaca catttgctgg
3301 cccacagttt t
//