LOCUS AF245447 2380 bp mRNA linear HUM 27-JUN-2000
DEFINITION Homo sapiens sphingosine kinase type 2 isoform mRNA, complete cds.
ACCESSION AF245447
VERSION AF245447.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2380)
AUTHORS Liu,H., Sugiura,M., Nava,V.E., Edsall,L.C., Kono,K., Poulton,S.,
Milstien,S., Kohama,T. and Spiegel,S.
TITLE Molecular cloning and functional characterization of a novel
mammalian sphingosine kinase type 2 isoform
JOURNAL J. Biol. Chem. 275 (26), 19513-19520 (2000)
PUBMED 10751414
REFERENCE 2 (bases 1 to 2380)
AUTHORS Liu,H., Sugiura,M., Nava,V.E., Edsall,L.C., Kono,K., Poulton,S.,
Milstien,S., Kohama,T. and Spiegel,S.
TITLE Direct Submission
JOURNAL Submitted (14-MAR-2000) Biochemistry, Georgetown University Medical
Center, 3900 Reservoir Rd. NW, Washington, DC 20007, USA
FEATURES Location/Qualifiers
source 1..2380
/db_xref="H-InvDB:HIT000074914"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 7..1863
/note="SPHK2"
/codon_start=1
/product="sphingosine kinase type 2 isoform"
/protein_id="AAF74124.1"
/translation="MAPPPPPLAASTPLLHGEFGSYPARGPRFALTLTSQALHIQRLR
PKPEARPRGGLVPLAEVSGCCTLRSRSPSDSAAYFCIYTYPRGRRGARRRATRTFRAD
GAATYEENRAEAQRWATALTCLLRGLPLPGDGEITPDLLPRPPRLLLLVNPFGGRGLA
WQWCKNHVLPMISEAGLSFNLIQTERQNHARELVQGLSLSEWDGIVTVSGDGLLHEVL
NGLLDRPDWEEAVKMPVGILPCGSGNALAGAVNQHGGFEPALGLDLLLNCSLLLCRGG
GHPLDLLSVTLASGSRCFSFLSVAWGFVSDVDIQSERFRALGSARFTLGTVLGLATLH
TYRGRLSYLPATVEPASPTPAHSLPRAKSELTLTPDPAPPMAHSPLHRSVSDLPLPLP
QPALASPGSPEPLPILSLNGGGPELAGDWGGAGDAPLSPDPLLSSPPGSPKAALHSPV
SEGAPVIPPSSGLPLPTPDARVGASTCGPPDHLLPPLGTPLPPDWVTLEGDFVLMLAI
SPSHLGADLVAAPHARFDDGLVHLCWVRSGISRAALLRLFLAMERGSHFSLGCPQLGY
AAARAFRLEPLTPRGVLTVDGEQVEYGPLQAQMHPGIGTLLTGPPGCPGREP"
BASE COUNT 338 a 854 c 742 g 446 t
ORIGIN
1 gccaccatgg ccccgccccc accgccactg gctgccagca ccccgctcct ccatggcgag
61 tttggctcct acccagcccg aggcccacgc tttgccctca cccttacatc gcaggccctg
121 cacatacagc ggctgcgccc caaacctgaa gccaggcccc ggggtggcct ggtcccgttg
181 gccgaggtct caggctgctg caccctgcga agccgcagcc cctcagactc agcggcctac
241 ttctgcatct acacctaccc tcggggccgg cgcggggccc ggcgcagagc cactcgcacc
301 ttccgggcag atggggccgc cacctacgaa gagaaccgtg ccgaggccca gcgctgggcc
361 actgccctca cctgtctgct ccgaggactg ccactgcccg gggatgggga gatcacccct
421 gacctgctac ctcggccgcc ccggttgctt ctattggtca atccctttgg gggtcggggc
481 ctggcctggc agtggtgtaa gaaccacgtg cttcccatga tctctgaagc tgggctgtcc
541 ttcaacctca tccagacaga acgacagaac cacgcccggg agctggtcca ggggctgagc
601 ctgagtgagt gggatggcat cgtcacggtc tcgggagacg ggctgctcca tgaggtgctg
661 aacgggctcc tagatcgccc tgactgggag gaagctgtga agatgcctgt gggcatcctc
721 ccctgcggct cgggcaacgc gctggccgga gcagtgaacc agcacggggg atttgagcca
781 gccctgggcc tcgacctgtt gctcaactgc tcactgttgc tgtgccgggg tggtggccac
841 ccactggacc tgctctccgt gacgctggcc tcgggctccc gctgtttctc cttcctgtct
901 gtggcctggg gcttcgtgtc agatgtggat atccagagcg agcgcttcag ggccttgggc
961 agtgcccgct tcacactggg cacggtgctg ggcctcgcca cactgcacac ctaccgcgga
1021 cgcctctcct acctccccgc cactgtggaa cctgcctcgc ccacccctgc ccatagcctg
1081 cctcgtgcca agtcggagct gaccctaacc ccagacccag ccccgcccat ggcccactca
1141 cccctgcatc gttctgtgtc tgacctgcct cttcccctgc cccagcctgc cctggcctct
1201 cctggctcgc cagaacccct gcccatcctg tccctcaacg gtgggggccc agagctggct
1261 ggggactggg gtggggctgg ggatgctccg ctgtccccgg acccactgct gtcttcacct
1321 cctggctctc ccaaggcagc tctacactca cccgtctccg aaggggcccc cgtaattccc
1381 ccatcctctg ggctcccact tcccacccct gatgcccggg taggggcctc cacctgcggc
1441 ccgcccgacc acctgctgcc tccgctgggc accccgctgc ccccagactg ggtgacgctg
1501 gagggggact ttgtgctcat gttggccatc tcgcccagcc acctaggcgc tgacctggtg
1561 gcagctccgc atgcgcgctt cgacgacggc ctggtgcacc tgtgctgggt gcgtagcggc
1621 atctcgcggg ctgcgctgct gcgccttttc ttggccatgg agcgtggtag ccacttcagc
1681 ctgggctgtc cgcagctggg ctacgccgcg gcccgtgcct tccgcctaga gccgctcaca
1741 ccacgcggcg tgctcacagt ggacggggag caggtggagt atgggccgct acaggcacag
1801 atgcaccctg gcatcggtac actgctcact gggcctcctg gctgcccggg gcgggagccc
1861 tgaaactaaa caagcttggt acccgccggg ggcggggcct acattccaat ggggcggagc
1921 ttgagctagg gggtgtggcc tggctgctag agttgtggtg gcaggggccc tggccccgtc
1981 tcaggattgc gctcgctttc atgggaccag acgtgatgct ggaaggtggg cgtcgtcacg
2041 gttaaagaga aatgggctcg tcccgagggt agtgcctgat caatgagggc ggggcctggc
2101 gtctgatctg gggccgccct tacggggcag ggctcagtcc tgacgcttgc cacctgctcc
2161 tacccggcca ggatggctga gggcggagtc tattttacgc gtcgcccaat gacaggacct
2221 ggaatgtact ggctggggta ggcctcagtg agtcggccgg tcagggcccg cagcctcgcc
2281 ccatccactc cggtgcctcc atttagctgg ccaatcagcc caggaggggc aggttccccg
2341 gggccggcgc taggatttgc actaatgttc ctctccccgc
//