LOCUS AF243495 6722 bp mRNA linear HUM 17-JUL-2002
DEFINITION Homo sapiens hepatocellular carcinoma-associated antigen 67 (HCA67)
mRNA, complete cds.
ACCESSION AF243495
VERSION AF243495.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6722)
AUTHORS Wang,Y., Han,K.J., Pang,X.W., Vaughan,H.A., Qu,W., Dong,X.Y.,
Peng,J.R., Zhao,H.T., Rui,J.A., Leng,X.S., Cebon,J., Burgess,A.W.
and Chen,W.F.
TITLE Large scale identification of human hepatocellular
carcinoma-associated antigens by autoantibodies
JOURNAL J. Immunol. 169 (2), 1102-1109 (2002)
PUBMED 12097419
REFERENCE 2 (bases 1 to 6722)
AUTHORS Han,K., Wang,Y., Qu,W., Pang,X., Zhang,H. and Chen,W.
TITLE Cloning and characterization of novel genes related to
hepatocellular carcinoma
JOURNAL Unpublished
REFERENCE 3 (bases 1 to 6722)
AUTHORS Han,K., Wang,Y., Qu,W., Pang,X., Zhang,H. and Chen,W.
TITLE Direct Submission
JOURNAL Submitted (09-MAR-2000) Department of Immunology, Beijing Medical
University, 38 XueYuan Road, Beijing 100083, P.R China
REFERENCE 4 (bases 1 to 6722)
AUTHORS Han,K., Wang,Y., Qu,W., Pang,X., Zhang,H. and Chen,W.
TITLE Direct Submission
JOURNAL Submitted (25-APR-2000) Department of Immunology, Beijing Medical
University, 38 XueYuan Road, Beijing 100083, P.R China
REMARK Sequence update by submitter
COMMENT On Apr 25, 2000 this sequence version replaced AF243495.1.
FEATURES Location/Qualifiers
source 1..6722
/db_xref="H-InvDB:HIT000074867"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="hepatocellular carcinoma"
gene 1..6722
/gene="HCA67"
CDS 53..1657
/gene="HCA67"
/note="overexpressed in hepatocellular carcinoma; can
induce humoral immunoresponse"
/codon_start=1
/product="hepatocellular carcinoma-associated antigen 67"
/protein_id="AAF61269.2"
/translation="MGYSSGVTNGLNDASDSIYTKGTPEIAFWGSNAGVKTTRLEAHS
EMGSTEILEKETPENLSNGTSSNVEAAKRLAKRLYQLDRFKRSDVAKHLGKNNEFSKL
VAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIHFSNRYFYCNPDTIASQ
DGVHCLTCAIMLLNTDLHGHVNIGKKMTCQEFIANLQGVNEGVDFSKDLLKALYNSIK
NEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRIGSTTNPFLDIPHDPNAAVYKSG
FLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEEDLKNAVSV
HHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFSAPPFP
AAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKKVKAKDV
DEYKLKDHYLEFEKTRYEMYVSILKEGGKELLSNDESEAAGLKKSHSSPSLNPDTSPI
TAKVKRNVSERKDHRPETPSIKQKVT"
BASE COUNT 1949 a 1321 c 1423 g 2029 t
ORIGIN
1 ggcacgggga catcaggata tcctgagtgt gtctgcagat ggtggcatcg tgatgggcta
61 ttctagtggc gtcaccaatg ggctgaatga tgccagcgac tccatctaca cgaaaggcac
121 cccggagatt gctttctggg gaagcaatgc tggggtgaaa acaacacggc tagaagctca
181 ttctgaaatg gggagcactg aaattttgga aaaggagacc ccagaaaatc tcagtaatgg
241 taccagcagc aatgtggaag cagccaaaag gttggccaaa cgcctttatc agctggacag
301 attcaaaaga tcagatgttg caaaacacct tggcaagaac aacgaattta gcaaactagt
361 tgcagaagaa tatctgaagt tttttgattt tacaggaatg acgctggatc agtcactcag
421 gtatttcttt aaagcattct ctcttgtggg agaaactcaa gaacgagaga gagttttaat
481 acacttctcc aatagatatt tttattgtaa cccagatacc attgcttcac aagatggagt
541 ccattgcctt acctgtgcaa taatgcttct taataccgat ctacatggcc acgtgaatat
601 tggaaagaag atgacctgtc aggagttcat tgcaaatctg caaggggtaa atgagggtgt
661 tgatttctcc aaggatctgc tgaaagctct gtacaactca atcaagaatg agaagcttga
721 atgggcagta gatgatgaag agaaaaaaaa gtctccctca gaaagtactg aggagaaagc
781 taacggaaca catccaaaga ccatcagtcg tattggaagt actactaacc catttttgga
841 cattcctcat gatccaaatg ctgctgtgta caaaagtgga ttcttggctc ggaaaattca
901 tgcagatatg gatggaaaga agactccaag aggaaaacga ggatggaaaa ccttttatgc
961 tgtactgaag ggaacagttc tttacttgca aaaggatgaa tacaagccag aaaaggcctt
1021 gtctgaagag gacttgaaaa acgctgtgag tgtgcaccac gcattggcat ccaaggccac
1081 ggactatgag aagaaaccaa acgtgtttaa acttaaaact gccgactgga gggtcttgct
1141 ttttcaaact cagagcccag aggaaatgca agggtggata aacaaaatca attgtgtggc
1201 agctgtattt tctgcaccac catttccagc agcaatcggc tctcagaaga agtttagccg
1261 cccacttctg cctgccacta caacaaaact gtctcaggag gagcaactga agtcacatga
1321 aagtaagctg aagcagatca ccaccgagct ggccgagcac cgctcatatc cccccgacaa
1381 gaaggtcaaa gccaaggacg tcgatgagta caaactgaaa gaccactatc tggagtttga
1441 gaaaacccgc tatgaaatgt atgtcagcat tctcaaggaa ggaggcaaag agctactgag
1501 taacgatgaa agcgaggctg caggactgaa gaagtcgcac tcgagtcctt cgctgaaccc
1561 ggatacttct ccaatcactg ccaaagtcaa gcgtaacgtg tcagagagga aggatcaccg
1621 acctgaaaca ccaagcatta agcaaaaagt tacttagagt ccatctgcgg ccaggaagtg
1681 ctggtcatgg agcaaaatag ggtttttcaa gatctttctg gtaatccgtg aatatattta
1741 aaaaaaaaaa agtctgtgac aaaacggtgc attagtaatt ttttctattg tatatttttg
1801 ttagtttctg tacagattgt ctttgctctt gatttctttt gctttgatga tttttgcaac
1861 ttgatagcta atgcaccttt tctgtgagga ggaggggatc gtgatttcag aatgaattat
1921 gtatcccttc tcttttggtt ttctcttgtt tgcagtctgc tcagttgttt tatgtattct
1981 catatcaact gttaaacttt tttttaaggt taaagaattt aatccattgt gaaacactta
2041 actggacaaa ctgtagtttt agtaaattct agctggagtt aatatacgcc tttatatgtg
2101 aaatcttgcc cagtcacaga ggtagaattg agcactcaca gatgctccag taagaatcac
2161 agtgctggga atctagttgc tccaatatga ggcagcttca tgtgcagctt agcacttgtt
2221 gttgagatcg gaccctgctg gaagcaggga aaagaagcgt gaagatcgta ggattgagaa
2281 cttagggaag cacattagct tgcttgaagt gctgattcca tttcagccaa gcaagggaaa
2341 gaggaagtgg agtcattttg cctttgaagg ctgaggaaag attgataccc agttaatttt
2401 gtttgctaaa ggatgggggc aataatcggc ccttgaggag ctgcagcagt aggcatgtgc
2461 tcagtctgca ggaattgtta cctcactccc acagggtcta gactagaaat ccatcatctc
2521 tatcgttgat atccttccat ccaggaatag atttttctta ctctacatat gtgtgtgtgc
2581 gtgcgtgtgt gtgcgtgtgt gggcatgggg ttgtgtcctg gttgtgatat tgaggtcttc
2641 cttcctaaca aattaatact aaaatgaaac agcttttctt gtgtccttaa gacaaaataa
2701 ggaaggaaaa cgtagctgca gttgtccacg atggatattg gttctttaaa atatatctga
2761 aagtagtagt cagaatgaat tatggttgga aaactgagga atcttctggt tgcaggtgca
2821 aagtgacttt gtttattctt gtctcagtct ccttgatagc cacttcactc tgctactact
2881 caactttctc ctaaaaatac ttcatctatt ttcagtcctt tctttctgtc tactcaaaat
2941 ggttctatta actttgcagt catgagcttg ttccagttac agtccctttg aagttcaggg
3001 tgataaacag aatattcttc tgtagaggaa gagaaaggag tgaaagttta gcccactgag
3061 acctagagct ttgtgatttc ctaaccttga aactctgtaa tccctaaagt taaaatctcc
3121 gcaagtggca caacttcaga actaatagta tcactttgat ttttcttttt cctcccttag
3181 aaagtttctc tagttctata gtttatttgt tgaaggtact atgaccaaag aatcagctgc
3241 tctacaggaa tagcatggtt ccagtgaatt agagaaaacc tgctgtaaag ccatggtagt
3301 gtctaagtgg tatgttatta tgatgtacta gcatttattt acagaattat ttattaacgt
3361 ttacttcctt cccctctgta aatgtccatg actattgccc agagaaggct tacccctctc
3421 tagggttgca gttgctttct ttgtaataag tattttgcca cacctgtaaa aaaaaaaaac
3481 ctcactttta actctctgcc ttgtttgggt aaaggcagta actaagttta tgtttcagaa
3541 ctgcaaaaca aacaggatag ttaccaatat ggcccatgtg tcagattgat ttttgtagcc
3601 tctcactgaa tccaacatat ccacaagcaa gttatctgtc tttctacctg ataatctaaa
3661 ttatcaggat atttgttttc tgcctaaatg tttatactaa gccgagggga gagaggtacc
3721 tagaccatgt catctacgag cttcagtaac taaagaaaaa ggaacttccc tgagtggctt
3781 gaatgtgttt gcccacagtc tatatctatg tatatagaat gtctgtatgt attttactta
3841 tttaatatac attgaatggt accttgctac agtatttctg acatttagag tagtgttgaa
3901 atactcggct agcatcagca ccactatagc actgtccgtg tcatatgagt cactaatatt
3961 aactccaggg acttctggat aggctaatag atcattggat acgaagggct cttttgaagc
4021 ttcagtatac catgtttgca tagtttatct ttaaaaacaa ctttaaaggt tcttttgtga
4081 gccaggatct cagactgccg tagcatgatg ctgtccatct ttagcgcatg ggctgagaac
4141 acctcttccc tgaggcttct gaaggttgct gtctgtcatg agtgcatgaa ggaggccaag
4201 agtttatgct atgggaggaa ccagtcactg atttgcctag attctgagag tctggcccat
4261 agccaaccac attttccttt gggataattt atttcctgtg gcatctagcc agaagaaatt
4321 gaggatgttt cctttcacag ctgctccaag cctgttgccc aattcacggt acaagggagc
4381 accccttccc tttcctctga aggtacgcca cccacctccg tcgcccacct cagcgcccag
4441 gagccttggg acttccttcc atatgataaa tcattcttct tcacgtcaat acacttcata
4501 ttaatttcta gtacagaaaa tcttgacagc tatcagaatg ccttggtcat agtgttgttg
4561 caaaattgac catacaggtg gcccatgtat aaaatctgaa ttttaggggt ttgtccccac
4621 ctcgcatgct ggcttttaca gggaggtgtc tgggattcct cattagcaat caaaacttaa
4681 ttactgggat gcagagtcct tactttatcg ccagcccgta ggcatttctg aagtgcactt
4741 ttttgaaaca tcattttgct aactctcagc agtgtctaat taaactgagc aatacttttg
4801 tgaattttaa ttaatctcag caaaaccatg atgggagaga gtcctctgat ggaaatgtag
4861 tccctggatt atgtgtaacc tttttattgc tcttagatgc agaggataga aagcattttt
4921 tggtgcagtg gtcttgtggc aaacacaaga ccctctatgc gtctccaact gttatcctaa
4981 tctagaaaat gaggactggc ccctgggcaa aagtgacatg aggaatttac tctggaagag
5041 gaaaatctgg gtggctttcc aaggctaaga taggtttgta tttcaccctg tggccaagct
5101 acagaacttc tgagattgtg gaagaatttt tgcaaccagc agggaaagag gcctcttact
5161 gcctaaacac aaagttacac tgagcttttc tactgtcctt tgcctattgc tccctctatc
5221 atgtaaagat ctgggaagga tgagaggcag ggcctgcttg tcatgagctg cactcttttc
5281 tttttaacta atcattgaca attggaagaa aattgacgtt aaagaagttt ctccattgtc
5341 ttactaacaa aaccttttgg gtttcattaa ttgtccttga aattgagttc ctttggcatt
5401 tttccttgca gtcatcagtt aagcatgttg catcctgaat tcacagaagt ttagctttgc
5461 aggtttgaat ctctgtaatt taactcccgt ggacttggtc gagttttcag caggttggga
5521 gccacctctc ttcatttcag cagtgagtca tcccttgact tttcaaatga cagaattttt
5581 tccaattgta aaattagcac tgtaaaacaa agaaccaaag tggcatccta agagttgtta
5641 aacctgaagt ctagtttatg aggaattgtc caagttggag tttaaatagt atctgctttt
5701 gtctcaaagc atctaagtta ttctgacaga aaatggtaag tcagctttgc aggcagatgc
5761 gcctctgggc ctcctacctt gctccacagc tttctggcca tcttgtctcc caggccatgc
5821 cactgctctg ccacatgtca gcaaatttct ttccaccagt cttatagcat cttacatgat
5881 caaatcatca cagaataacc ccgtgataga ttattgatag caatagagag gggcggcttt
5941 gtcactgatt tttctctcag attccttttc catctctcat ccataaagga aggactgaaa
6001 tccaaaggca ttctcctttt gtacctacag tatccagaac ccacgtgggc agccttctgc
6061 ttatgacaat aattggccca ttgcatgcag agagaatgtc ttcatagaga gaatgtcatt
6121 aaatacttga atctgcatga cagtttgact tgaatgcaac agcaggaaaa ttttgcaagt
6181 tacataattg tatatacagt aggttttctt aagtctcttc ggttcatcct ttgtaatttg
6241 tgtgtgtatc tgtagtattg caggcttttg gagactattc ttacaggcag tatgtcagtc
6301 atcaaagaaa atgctgtcac ctgccattgt tgtatttgtg ggtatttata gttgtatgta
6361 tgtaaatgca tcagtgtgta gattgcatat cagtgtatgg tacatgtaca tcaaaattat
6421 ttttgtcctt aatcagtgtg atatgaaaag caagtacaac ctcataggac tgattatata
6481 atgaagttgt tgagagtata tatagtggta ttgttttatt aaacttaaac tcaaataata
6541 ttttgattaa aatttttaat aagactttat gctagaaaat tctttgagct ttgaatcacc
6601 agggcaaaaa tgactttcaa ctaaccttgt gaatcttttg cagtgtactg tgtgcaatac
6661 caagggcata gctccctgta atttgggaaa tacagaaaga aaagaaaaaa aaaaaaaaaa
6721 aa
//