LOCUS AF242195 8735 bp DNA linear HUM 03-JAN-2001
DEFINITION Homo sapiens KLK15 (KLK15) gene, complete cds, alternatively
spliced.
ACCESSION AF242195
VERSION AF242195.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8735)
AUTHORS Yousef,G.M., Scorilas,A., Jung,K., Ashworth,L.K. and Diamandis,E.P.
TITLE Molecular cloning of the human kallikrein 15 gene (KLK15).
Up-regulation in prostate cancer
JOURNAL J. Biol. Chem. 276 (1), 53-61 (2001)
PUBMED 11010966
REFERENCE 2 (bases 1 to 8735)
AUTHORS Yousef,G.M., Diamandis,M.E. and Diamandis,E.P.
TITLE Direct Submission
JOURNAL Submitted (06-MAR-2000) Pathology and Laboratory Medicine, Mount
Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5,
Canada
FEATURES Location/Qualifiers
source 1..8735
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19q13.3-q13.4"
gene <1581..7786
/gene="KLK15"
mRNA join(<1581..1623,5259..5412,5913..6196,6317..6453,
7127..7786)
/gene="KLK15"
/product="KLK15"
mRNA join(<1581..1623,5259..5412,5913..6196,7127..7786)
/gene="KLK15"
/product="KLK15 splice variant 2"
mRNA join(<1581..1623,5259..5412,5913..6078,6317..6453,
7127..7786)
/gene="KLK15"
/product="KLK15 splice variant 1"
mRNA join(<1581..1623,5259..5412,5913..6078,7127..7786)
/gene="KLK15"
/product="KLK15 splice variant 3"
CDS join(1581..1623,5259..5412,5913..6196,6317..6453,
7127..7279)
/gene="KLK15"
/note="kallikrein-like serine protease; classical form"
/codon_start=1
/product="KLK15"
/protein_id="AAG09469.1"
/translation="MWLLLTLSFLLASTAAQDGDKLLEGDECAPHSQPWQVALYERGR
FNCGASLISPHWVLSAAHCQSRFMRVRLGEHNLRKRDGPEQLRTTSRVIPHPRYEARS
HRNDIMLLRLVQPARLNPQVRPAVLPTRCPHPGEACVVSGWGLVSHNEPGTAGSPRSQ
VSLPDTLHCANISIISDTSCDKSYPGRLTNTMVCAGAEGRGAESCEGDSGGPLVCGGI
LQGIVSWGDVPCDNTTKPGVYTKVCHYLEWIRETMKRN"
CDS join(1581..1623,5259..5412,5913..6078,7127..7279)
/gene="KLK15"
/codon_start=1
/product="KLK15 splice variant 3"
/protein_id="AAG09472.1"
/translation="MWLLLTLSFLLASTAAQDGDKLLEGDECAPHSQPWQVALYERGR
FNCGASLISPHWVLSAAHCQSRFMRVRLGEHNLRKRDGPEQLRTTSRVIPHPRYEARS
HRNDIMLLRLVQPARLNPQGDSGGPLVCGGILQGIVSWGDVPCDNTTKPGVYTKVCHY
LEWIRETMKRN"
CDS join(1581..1623,5259..5412,5913..6196,7127..7131)
/gene="KLK15"
/codon_start=1
/product="KLK15 splice variant 2"
/protein_id="AAG09471.1"
/translation="MWLLLTLSFLLASTAAQDGDKLLEGDECAPHSQPWQVALYERGR
FNCGASLISPHWVLSAAHCQSRFMRVRLGEHNLRKRDGPEQLRTTSRVIPHPRYEARS
HRNDIMLLRLVQPARLNPQVRPAVLPTRCPHPGEACVVSGWGLVSHNEPGTAGSPRSQ
G"
CDS join(1581..1623,5259..5412,5913..6078,6317..6319)
/gene="KLK15"
/codon_start=1
/product="KLK15 splice variant 1"
/protein_id="AAG09470.1"
/translation="MWLLLTLSFLLASTAAQDGDKLLEGDECAPHSQPWQVALYERGR
FNCGASLISPHWVLSAAHCQSRFMRVRLGEHNLRKRDGPEQLRTTSRVIPHPRYEARS
HRNDIMLLRLVQPARLNPQ"
3'UTR 7280..7786
/gene="KLK15"
BASE COUNT 2038 a 2107 c 2532 g 2058 t
ORIGIN
1 agaatgggtg ctgtgggatt caggggagac acctgttagg tgttggggcc tcccagaaga
61 ggtgggggca gagtgtcaga ggacaaagat gaatttggaa gatatgggga agaaggattt
121 caattcaccc tcaaagcttc ctgaggcctc ccgtgggtcg ggccctgcag tactggagac
181 ccagagtgga gtcagaccag ctcctcgggg agctgccagt ctcgtagggg aggcagacac
241 cactgagggt caggggaggt cagagaaggc ctcaaggagg aagcggggct ggaagggaat
301 ggcgttggat atgcggtggg aggaatagcc taagcatgaa atggcaggag ggaaaatggc
361 agcactggct gcgtctagga caaggtcatg ggagacccag ggagaggggc tggaagggaa
421 gaagccactt ttgtccttga aagtgaggct ggagccaggc aactcatgcc tgtaatccca
481 gcactttggg aggctgaggc gggtggatca ctagaggtca ggagttcaag accagcctgg
541 ccaacatggt gaaactccgt ctctactaaa attacaaaaa ttagctgggc gtggtggcac
601 acacctgtaa tcccaattgc ttgggaggct gaggcaggag aatctcttga acccagaagg
661 cagaggttac agtgagcgga gatcacgcca ctccactcca acctgggcta cagagccaga
721 ctccgtctca aaaaaaaaaa aaaaaaagaa aaaaaaagaa agaaagtgaa tttgaagagc
781 tggactttat cctggtggtg ccaaggatcc atggagggtg gtgagcaggg gaggggcaca
841 gccagctcca gatgtagaaa gaccctttgg ggtcatggct ggagggcaag ctggtggagg
901 ggactggact ggagggggac ccaaaaggcc agataagagg gttgagatag accaggcgcg
961 gtggctcatg cctgtaatcc cagcactttg ggaggccgag gtgggtggat catgaagtca
1021 agagattgag gccatcctgg ctaacacggt gaaaccctgt ctctacttaa aaaaaaaaaa
1081 tttccaaaaa attagccggg cacggtggtg ggcgcctgta gtcccagcta ctcgggaggc
1141 tgaggcggga gaatggtgtg aacctgggag gtggagcttg cagtgagccg acattgtgcc
1201 actgcactcc agcctgggtg acagagtgag actccgtctc aaaaaaataa aaaaagttgg
1261 gacagggggt ccttgcgtga tgatggagag agatccaccc gctggtagca tggtgctgga
1321 ggctgacagg tggaggaggt ggggcagggt ctgtccgagt gcctagagga agagtaaacc
1381 ttccagagat gggggaccca gaaggaagcg cagagtgggg ttgggggaag gggataccgg
1441 tggtcagaag aaatttatta acagtggatg ggataagtct gtgtctggag ggatcctggt
1501 ggaggcagaa gggtcctgcc tcacctggat tctctcactc cctccccaga ctgcagccga
1561 accctggtcc ctcctccaca atgtggcttc tcctcactct ctccttcctg ctggcatcca
1621 caggtgaggt ggccccagga gggggccagg tctgtgggag caggtgcccc cttcccaagc
1681 atgtctgggc ccagtgatct gccagcccct acctcaccca gagaccacta aagatccttc
1741 cttcaccctc cacctgtgcc aatgtcccta agcccttacc gtcaggtgct ggtgctgctg
1801 ctctggagtc gctatgttgc ctggggcctc tcgctgccca cgacaaggaa cacggtcctg
1861 gggttacaca aacctgagct gagtcctggg gcaaccgctt ccttgctgtg tgtccttgag
1921 ggaactgctt cacctctctg ggcttcgaat gccttctcta taagacagca cccacttgag
1981 acaataacag tgaggtctca atagcataac agaggtaata tacatagcaa gcattagaca
2041 agtgctgaga ggccaacagc acagacagac tccagcttga gtcccacacc tgccactccc
2101 tgtctcttac agggtctttg aggggattaa atgtggttgt gtgtgaggca gaagcataag
2161 cctggcccag gtagtgcccc ttcaggtgtg caagccaggc acggtgctta gagcttacat
2221 acaacgtcta tgtgtggtgg gcaccaccga cctcatttga caagggaagg ggctgtggct
2281 cagagggacg gccacaacat caaggtcacc ttgggtgtca ggcaaactcc agattgaact
2341 cagctgccac acaccaagaa attaattgta acctgatgcc tctcttctgg agaaattggg
2401 gggtggactt tcattaacgt tctgccacaa atgaccctca ctcctggggg cccctgagac
2461 ccccacgcct ccagcctccc ctccggctct ctctgtgcac tcacctacct gcctcgcgcc
2521 tgcctgctgc gcccagctgg ggcctccacc ttcctctggc ttggactggc caggtgcagc
2581 ctcggtgccc agctgttcag cccgtaccct ccgcccttcg gaggacgacc tcacccttcc
2641 tttgttaagc cccttgtcca ccacatccgc attcccctgg tctcacgggg gcctttggcc
2701 cagttcctga ctgtgatggg gagagtgtgg gcatttggtc tggctgtgca aatcctgccc
2761 ctgtgtgggt gggagtgtgc atggcttcaa ccttcagggg atgcatccac attgcccagt
2821 ggagaggggt cctggtcctg tgaccttgaa tgtctctaat catgtcctta agcataatgc
2881 cattctgtgt gtgtgtgtgt gtgtgtgtgt gtacatgcac gtgtgcagtg ggtatacaag
2941 gccctgtatg ttcacatcct ctccacatgc atgagccaga tccccatatg tgaaacccaa
3001 tcagtgactc cacagatctg gcttgggggc tgatctagag atggataaat atgtcctgcc
3061 ctggctgcct ctggcttcag ctgcatgtct ttgaccttga atgcccagcc ccgtgtctgg
3121 gtgctgcccc agacagcaag tccacatctg agtgttggcc ttctgggttg gtgtctgcag
3181 ctctaactct acaaaatgtc ttgtgggtga atcacggttt taaccttgac ttttttttgt
3241 ttgtttggtt ttttttgaga cggagtctcg ctctgccgcc caagctggag ttcagtggtg
3301 caacctcagc tcactgcaac ctccgcctcc caggttcaag caattctgtc tctgcctccc
3361 gagtagctag aattacaggc acgcaccacc acgcccagct gatttttgta tttttattta
3421 tttatttatt tattttttag tagagacggg atttcacgat gttggccagg ctggtctcaa
3481 actcctgacc tcaggtgatc cacccacctc ggccttggcc tcccaaagtg ctgggattac
3541 aggcgtgagc caccacacct ggccaacctt gactatttat tataggtaat tctgtgcaga
3601 tgtctgactt atgttggcca tctccaggat ggacctgaac tttcacacgt atgtccctgt
3661 gactaaatcc aggtgtcatt tgcaaaaaac aactaatatt attaagtagc taccagggct
3721 aggtatcact caccatacat acacacatgc acacacacac atacacattc ctacctcatc
3781 cttacaacaa tcttcatttt acagatgagg aaacagaggc acagacaggt cgaataactt
3841 actcaaagtt tcacagctag tacattcgaa cccaggctta aggacccatc tttgtccaga
3901 ccctgtatgc aagtgtctgt gacactggat gccaagactc acactagaga tgttgaattt
3961 aggtctgaac aatatccaat tctgtgtgtg tgtttgtgtg tgcatgtgtg tgtgtgtatg
4021 tattcatgtc ttaaccatcc atattcatat acacatatga acatctgtgc tgtgattctt
4081 tttttttttt tttttttttt tttgagatgg agtttcactc ttgtcaccca ggctggagtg
4141 caatggagca acctccgctc actgcaatct ccgcctcccg ggttcaagcg attttcctgc
4201 ctcagcctcc agagtagctg ggattacagg cacccgccac catgcccagc taattttttg
4261 tatttttgtt agagacaggg tttccccata ttggccaggc tggtctcgaa ctcctgacct
4321 caggtgatcc acccgcctcg gcctcccaaa gtgctgggat tacaggcatg agccaccgtg
4381 cccagcctgt gctgtgattc ttgaagctgc aacccatgtg catgcaagtg aatttcagct
4441 tccagtcctg tccatagctg tacctaagtg tggaagctgg atgtgcatgt atgcatgtcc
4501 atgaccttgt atagccacat ctgggactca tactgcacac tgaatttggc tgacatgtcc
4561 agactctggg gccaaggctg ggtcacacat actgagtggc cacatgcgtt tgacgtctgt
4621 gacaatttgg tgaccgtgaa tgactggttt caagtgacca cctgtctgaa cctgtatcca
4681 gtgcccctgt ctccaccccc aaccacagag gacttcttgc cctctggtct gttccccttc
4741 ctctctctcc cagagtctta tagcaaatgg ggtgggggct agagttctgg agaaaacagg
4801 cagcggttgt aaataaacaa cagggcaggc ggagcatggt ggctcacacc tgtaatccca
4861 gcactttggg aggctgaggc gggcagagca tttgaagtca gaagtttgag actacctggc
4921 taacatggtg agacctcgtc tctactaaaa atacaaaaat tagccaggtg tggtggcggg
4981 cacctcagct actcgggagg ctgaggcagg aggatcactt gaacccagga ggcggaagtt
5041 gcagtgagct gagatcatgc cactgcactc cagcctgggc aaaagagtga gactccgtct
5101 caaaaacaac aacaacaaca aaacaaaaaa cagggcaggg tgtcttgaga agttagggga
5161 aaggcatagg catatagtag ttagggcagg gtgcaaggaa ggtgtaggag gcaatgtaaa
5221 cgtccctgtc ctcaggcatc ctctacccct tctcttagca gcccaggatg gtgacaagtt
5281 gctggaaggt gacgagtgtg caccccactc ccagccatgg caagtggctc tctacgagcg
5341 tggacgcttt aactgtggcg cttccctcat ctccccacac tgggtgctgt ctgcggccca
5401 ctgccaaagc cggtatgaag gcaggggctc agggtcctga gggagcctgg ttcgggggga
5461 agagctccta gatttggggg aagacggagg cagacgccag aactcctggg ttctgaaaga
5521 cgaggaggcc ggatgtcaag cccctgggtt aggaaggagt gtgtgtttca aagccttcga
5581 tctctgaagg aggaaggaga agactagttc cagcttttga gcctcagttc tagggatgtg
5641 agaatcctgg attcggggac agaccaggag ggggctggga gtagttggag gggatcgagt
5701 tctaggagtg tgcctgactt cagactcgtt ggtccttgag gagcaggggc tggaaccatt
5761 ggcttcaggg tcttgggaaa aggtaatggg atgtcgagat ttctaaaggg tcgggagacc
5821 tcgggttgcc cactctttga tctttctgtc ctctacttgc gggtaaccac tggcccgcac
5881 tccactggcg ggaaaaccac tcgcccgcac agcttcatga gagtgcgcct gggagagcac
5941 aacctgcgca agcgcgatgg cccagagcaa ctacggacca cgtctcgggt cattccacac
6001 ccgcgctacg aagcgcgcag ccaccgcaac gacatcatgt tgctgcgcct agtccagccc
6061 gcacgcctga acccccaggt gcgccccgcg gtgctaccca cgcgttgccc ccacccgggg
6121 gaggcctgtg tggtgtctgg ctggggcctg gtgtcccaca acgagcctgg gaccgctggg
6181 agcccccggt cacaaggtgc gtgaaaggat ggagctggat gcgaggcctc aaggaatcct
6241 atgctccagg gctcttgggc ggaggggaca agggccggaa tttatggatc tgctccaagt
6301 ccactgtctt ccccagtgag tctcccagat acgttgcatt gtgccaacat cagcattatc
6361 tcggacacat cttgtgacaa gagctaccca gggcgcctga caaacaccat ggtgtgtgca
6421 ggcgcggagg gcagaggcgc agaatcctgt gaggtcagag cctagagggg ccatcaggcg
6481 gaagaagagg gatggggaca ggtgtgggag tccggatggg gttggatttt ctttgctttg
6541 ggccagagaa gatgctaggg ttaggcttgg agatggagta ggaagagaag ttagaatagg
6601 ggtgaggttg gagttggggt tataggtggg gattgcgttg tttgaggtgg ataactgtga
6661 tagttagttt gagatggcat gggttggggt tgagaatggg aatggtttgg tttgattctg
6721 ggtgggaaat acgtcagggt tgaattggga tgaggtagat tttgtttgga atgcagaaga
6781 catgaagatt gagattggat tttgagatgg gcatgggttt gatttgattt tgaatggtga
6841 ggatgtgggc tgagttggat ttaacttagt acagttgcac tggagttgca tgggggtgag
6901 attggatata ggttgggtga gttgtattga gctgtgttga attggggttg gggttggggt
6961 tgggttggct ctgtttggga taaactgggc tgtattgagt tgagttgggt tggggttccc
7021 tgggatgggg atggattggg tttggggtga gattgcaaat ggtgattagg atgaggatga
7081 atccaggagg tttcactcaa cctgagaccc cctcttttcc ccacagggtg actctggggg
7141 acccctggtc tgtgggggca tcctgcaggg cattgtgtcc tggggtgacg tcccttgtga
7201 caacaccacc aagcctggtg tctataccaa agtctgccac tacttggagt ggatcaggga
7261 aaccatgaag aggaactgac tattctagcc tatctcctgt gcccctgact gagcagaagc
7321 ccccacagct ggccagcagc cccgcctgac atggaacaga acggagccat cccccaagac
7381 cctgtccaag gcccagatgt tagccaagga cttgtcccac ctgaggacaa agctggcgct
7441 caaggtcacc tgtttaatgc caagataaca aagcgctgat ccaagttgct ctgtaggaat
7501 ttctgtgact tttttctggg gtcaaagaga aaccccgaga cactgtacac tgttcctttt
7561 cacccaccac cccgatccct aggtgaggag aagcggcttg aagcagggct ccattcattc
7621 aacacacatg accacccgtg tgatcttgaa caagaggccc aatctcactt cgccttggtt
7681 tccttatctg taaaatgaga ccatcttatt gctgacttca aagggctgtt gtgaggatta
7741 aatgagatga ttcgtctgaa ctgattaaaa tcgtgtctgg cactgagtaa ataccctcta
7801 tctctggatc ccagttaaag gacctaacag acactagatt accaagaatg gctttttctt
7861 taaggtttag ttctgggccg ggcatggtgg ctcacacctg taatcccagc actttgggag
7921 gccaaggcgg gcggctcact tgaggtcagg agtgcaagac cagcctggcc aacatggtga
7981 aaccccatct ctactaaaaa tactaaaaaa atttagccgg gcgtggtggc acacgactgt
8041 aatcctagct acttgggagg gtgatgtggg aggatcgctt gaacttagga ggcaggagtt
8101 gcagtgagcc gagatcgcgc cactgcactc cagcctggtg acagagcaag actccatctc
8161 agaaaaaaaa aaaaaaaaaa aaagatttag ttctgggctt cctggtagcc atggcaaaaa
8221 ggcaaatact gtcctttcct tagccaggtc cctgatatac agcagaggct ggaactctga
8281 gctgctttga ttttaccaaa aagccaagac aacctgttgg aagcctatgg gtttaccatt
8341 gaggctgcag gaatctagtt cctaattatc ttcagagacc acaaaatgtg atgttcaagg
8401 tcgctgaatg ttgaagtaca tgaacctggc tcgtgagacc taaatattgt actggtggtg
8461 ggggggaagg gtcattggaa tctgtggtta gcctgatctt gacctgcgag ggaaggttgt
8521 ccagatctct ggactttgga ggaccgacgt tgagcaccat aatgggagca gaagtgcgag
8581 gtctttgaga ccccgcttgt tggggcggcg ccggatttgg atgctaaaaa ttacctggga
8641 accctgaata catctgggtt gggcgcacaa tgtgtggctc cccacacatc tttaggaaca
8701 catttgggca acccggtggg agtgaacggc ctggc
//