LOCUS AF241230 2787 bp mRNA linear HUM 02-MAY-2000
DEFINITION Homo sapiens TAK1-binding protein 2 mRNA, complete cds.
ACCESSION AF241230
VERSION AF241230.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2787)
AUTHORS Takaesu,G., Kishida,S., Hiyama,A., Yamaguchi,K., Shibuya,H.,
Irie,K., Ninomiya-Tsuji,J. and Matsumoto,K.
TITLE TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK
by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway
JOURNAL Mol. Cell 5 (4), 649-658 (2000)
PUBMED 10882101
REFERENCE 2 (bases 1 to 2787)
AUTHORS Takaesu,G., Kishida,S., Hiyama,A., Yamaguchi,K., Shibuya,H.,
Irie,K., Ninomiya-Tsuji,J. and Matsumoto,K.
TITLE Direct Submission
JOURNAL Submitted (02-MAR-2000) Molecular Biology, Nagoya University,
Chikusa-ku, Nagoya 464-8602, Japan
FEATURES Location/Qualifiers
source 1..2787
/db_xref="H-InvDB:HIT000074821"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 81..2162
/note="TAB2"
/codon_start=1
/product="TAK1-binding protein 2"
/protein_id="AAF67176.1"
/translation="MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCA
VLSQESTRYLYGEGDLNFSDDSGISGLRNHMTSLNLDLQSQNIYHHGREGSRMNGSRT
LTHSISDGQLQGGQSNSELFQQEPQTAPAQVPQGFNVFGMSSSSGASNSAPHLGFHLG
SKGTSSLSQQTPRFNPIMVTLAPNIQTGRNTPTSLHIHGVPPPVLNSPQGNSIYIRPY
ITTPGGTTRQTQQHSGWVSQFNPMNPQQVYQPSQPGPWTTCPASNPLSHTSSQQPNQQ
GHQTSHVYMPISSPTTSQPPTIHSSGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQ
RNNSSKLRSSGPRTSSTSSSVNSQTLNRNQPTVYIAASPPNTDELMSRSQPKVYISAN
AATGDEQVMRNQPTLFISTNSGASAASRNMSGQVSMGPAFIHHHPPKSRAIGNNSATS
PRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTFELTNLLNHPDHYVETENIQHLTD
PTLAHVDRISETRKLSMGSDDAAYTQALLVHQKARMERLQRELEIQKKKLDKLKSEVN
EMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNRQLQIDIDCLTKEIDLFQARGPHFN
PSAIHNFYDNIGFVGPVPPKPKDQRSIIKTPKTQDTEDDEGAQWNCTACTFLNHPALI
RCEQCEMPRHF"
BASE COUNT 862 a 673 c 517 g 735 t
ORIGIN
1 gaattcgtga gatgagtact atttccacta aggcctagaa ttgcctactg tacaaatagt
61 cctgatcagg caatatacga atggcccaag gaagccacca aattgatttt caggttttac
121 atgacctgcg acaaaaattc cctgaagtac ctgaagttgt tgtatccagg tgcatgttac
181 agaataataa taacctggat gcctgctgtg ctgttctctc tcaggagagt acaagatatc
241 tttatggtga aggagacttg aatttttcag atgattctgg aatttctggt ctacgcaatc
301 acatgacttc tctcaacttg gacttgcaat cacagaacat ttaccaccat ggaagagaag
361 gaagtagaat gaatggaagt aggactctaa cgcacagcat tagtgatgga caacttcaag
421 gtggccagtc caatagtgaa ctatttcagc aggagccaca gacagcacca gctcaagttc
481 ctcaaggctt taatgttttt ggaatgtcca gttcctctgg tgcttcaaat tcagcaccac
541 atcttggatt tcacttaggc agcaaaggaa catctagcct ttctcaacaa actcccagat
601 ttaatcccat tatggtaact ttagccccaa atatccagac tggtcgtaat actcctacat
661 ctttgcacat acatggtgta cctccacctg tacttaacag tccacaggga aattctatct
721 atattaggcc ttacattaca actcctggtg gtacaactcg acagacacaa cagcattctg
781 gctgggtatc tcagtttaat cccatgaacc ctcagcaagt ttatcagcct tcacagcctg
841 gtccctggac tacttgtcct gcatctaatc ctctgtcaca tacctcatct caacagccaa
901 atcagcaagg ccaccagacc tctcatgtct acatgccaat cagttcacct actacttcac
961 aaccaccaac cattcattca tctggtagct cacagtcttc tgcccatagc caatataaca
1021 ttcagaatat ttcaacagga cctcgaaaaa accagattga aatcaaactt gaacccccac
1081 aaagaaataa ttcttcaaaa ctgcgttctt ctggacctcg aacctccagc acttcctctt
1141 cagtcaatag ccagacctta aacagaaatc agcccactgt ttacatagct gccagccccc
1201 caaatacgga tgagctgatg tcccgtagtc aacctaaggt ctatatttca gcgaatgctg
1261 ccacaggaga tgaacaggtc atgcggaatc agcccacact cttcatatcc acaaactctg
1321 gagcatctgc tgcctccagg aacatgtctg ggcaagtgag catgggtcct gcctttattc
1381 atcaccatcc tcccaaaagt cgagcaatag gcaataactc tgcaacctct cctcgagtgg
1441 tagtcactca gcccaatacg aaatacactt tcaaaattac agtctctccc aataagcccc
1501 ctgcagtttc accaggggtg gtgtccccta cctttgaact tacaaatctt cttaatcatc
1561 ctgatcatta tgtagaaacc gagaatattc agcacctcac ggaccctaca ttagcacatg
1621 tggatagaat aagtgaaaca cggaaactga gtatgggatc tgatgatgct gcctacacac
1681 aagctctttt ggtacaccag aaggccagaa tggaacgact tcaaagagaa cttgagattc
1741 aaaagaaaaa gctggataaa ttaaaatctg aggttaatga aatggaaaat aatctaactc
1801 gaaggcgcct gaaaagatca aattctatat cccagatacc ttcccttgaa gaaatgcagc
1861 agctgagaag ttgtaataga caactccaga ttgacattga ctgcttaacc aaagaaattg
1921 atctttttca agcccgagga ccacatttta accccagcgc tattcataac ttttatgaca
1981 atattggatt tgtaggtcct gtgccaccaa aacccaaaga tcaaaggtcc atcatcaaaa
2041 caccaaagac tcaagacaca gaagatgatg agggagctca gtggaattgt accgcctgta
2101 cttttttgaa ccatccagcc ttaattcgct gtgaacagtg tgagatgcca aggcatttct
2161 gagccaaatg gccctgtatc ttctctaaaa ccacatctaa agttcaagaa actagtctgt
2221 catcgggaaa aagtttcact gctacatagg attttgtcaa attgaaggtg tgacaagatg
2281 gtgttctgct aatgttaaat gtcagcccac agagctaata atacctcagt ataatgtcat
2341 gagcagttga aattcatcac atgaaaagta atctgctgaa agacttggtt gcccactgcc
2401 taactgtgta cagtgttacc agtgtcccat tatggataat tctcaatatg ttaacaccta
2461 ggtgttccca ataccttttt cccctcatgt cactactgaa ttttgacagg aggaaggaat
2521 agaatgatag cttgttttat ttgtaaagct ttcagtgaaa cactacatac acgaagaaaa
2581 ggaacaaggt ttaactattt aagaaccatt tgctgccgca tagtgccatt ggatagggaa
2641 gaacttcaga aatctgtggt actcttggcc ttgtctttgt cttccctgaa cgtgtctcca
2701 ctctgtgaag ccagcatcta ggggctaaag atgcaaagga aagcagcatg cattgtctgt
2761 acaaatgtgc agcgaaatcc ggaattc
//