LOCUS AF240775 3520 bp mRNA linear HUM 04-JUL-2000
DEFINITION Homo sapiens eIF4E-transporter mRNA, complete cds.
ACCESSION AF240775
VERSION AF240775.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3520)
AUTHORS Dostie,J., Ferraiuolo,M., Pause,A., Adam,S.A. and Sonenberg,N.
TITLE A novel shuttling protein, 4E-T, mediates the nuclear import of the
mRNA 5' cap-binding protein, eIF4E
JOURNAL EMBO J. 19 (12), 3142-3156 (2000)
PUBMED 10856257
REFERENCE 2 (bases 1 to 3520)
AUTHORS Dostie,J., Ferraiuolo,M., Pause,A., Adam,S.A. and Sonenberg,N.
TITLE Direct Submission
JOURNAL Submitted (01-MAR-2000) Biochemistry, McGill University, 3655
Sir-William-Osler, Montreal, Qc H3G 1Y6, Canada
FEATURES Location/Qualifiers
source 1..3520
/db_xref="H-InvDB:HIT000074818"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="22"
/map="22q11.2"
CDS 53..3010
/function="mediates the nuclear import of eIF4E"
/note="nucleocytoplasmic shuttling protein"
/codon_start=1
/product="eIF4E-transporter"
/protein_id="AAF81693.1"
/translation="MDRRSMGETESGDAFLDLKKPPASKCPHRYTKEELLDIKELPHS
KQRPSCLSEKYDSDGVWDPEKWHASLYPASGRSSPVESLKKELDTDRPSLVRRIVDPR
ERVKEDDLDVVFSPQRRSFGGGCHVTAAVSSRRSGSPLEKDSDGLRLLGGRRIGSGRI
ISARTFEKDHRLSDKDLRDLRDRDRERDFKDKRFRREFGDSKRVFGERRRNDSYTEEE
PEWFSAGPTSQSETIELTGFDDKILEEDHKGRKRTRRRTASVKEGIVECNGGVAEEDE
VEVILAQEPAADQEVPRDAVLPEQSPGDFDFNEFFNLDKVPCLASMIEDVLGEGSVSA
SRFSRWFSNPSRSGSRSSSLGSTPHEELERLAGLEQAILSPGQNSGNYFAPIPLEDHA
ENKVDILEMLQKAKVDLKPLLSSLSANKEKLKESSHSGVVLSVEEVEAGLKGLKVDQQ
VKNSTPFMAEHLEETLSAVTNNRQLKKDGDMTAFNKLVSTMKASGTLPSQPKVSRNLE
SHLMSPAEIPGQPVPKNILQELLGQPVQRPASSNLLSGLMGSLEPTTSLLGQRAPSPP
LSQVFQTRAASADYLRPRIPSPIGFTPGPQQLLGDPFQGMRKPMSPITAQMSQLELQQ
AALEGLALPHDLAVQAANFYQPGFGKPQVDRTRDGFRNRQQRVTKSPAPVHRGNSSSP
APAASITSMLSPSFTPTSVIRKMYESKEKSKEEPASGKAALGDSKEDTQKASEENLLS
SSSVPSADRDSSPTTNSKLSALQRSSCSTPLSQANRYTKEQDYRPKATGRKTPTLASP
VPTTPFLRPVHQVPLVPHVPMVRPAHQLHPGLVQRMLAQGVHPQHLPSLLQTGVLPPG
MDLSHLQGISGPILGQPFYPLPAASHPLLNPRPGTPLHLAMVQQQLQRSVLHPPGSGS
HAAAVSVQTTPQNVPSRSGLPHMHSQLEHRPSQRSSSPVGLAKWFGSDVLQQPLPSMP
AKVISVDELEYRQ"
BASE COUNT 935 a 877 c 890 g 818 t
ORIGIN
1 ggccgccgag cggcggaggc accgagtgca gagcattgta gaccaaggag ccatggatag
61 gagaagtatg ggtgaaacag aaagtggaga tgctttcctt gacctgaaga agcctcctgc
121 ctccaaatgc ccccatcgct atacaaaaga agaactcttg gatataaaag aactccccca
181 ttccaaacag aggccttcat gcctttctga aaaatatgac agtgatggtg tctgggaccc
241 tgagaagtgg catgcctctc tctacccagc ttcagggcgg agctcaccag tggaaagtct
301 gaagaaagag ttggatacag accggccttc cctggtgcgc aggatagtag atccacgaga
361 gcgtgtgaaa gaagatgact tagatgttgt tttcagccct cagagacgga gctttggagg
421 gggctgccac gtgacagccg ctgttagctc ccggcgctca ggaagtccat tagagaaaga
481 tagtgatggg cttcgtctgc ttggtggacg taggattggc agtgggagga taatctctgc
541 ccggaccttt gagaaggatc accgtcttag cgataaggac ctgcgggact tgagagacag
601 agaccgagag agggacttca aggacaagcg tttcaggaga gagtttggag atagtaagcg
661 tgtctttggt gagcgtagaa gaaatgattc ttacacagaa gaagaaccag agtggttctc
721 tgctggaccc acaagtcagt ctgaaaccat cgaactgact ggctttgatg ataagatact
781 agaagaagat cacaaaggga gaaaaagaac aaggcgacgg acagcctctg tgaaggaagg
841 tatagtagag tgcaatggag gagtggccga agaggatgaa gtggaggtca tccttgcaca
901 ggagcctgcg gctgatcagg aagtgccaag ggatgctgtc ttgcctgagc agtccccagg
961 agactttgac tttaatgagt tctttaacct tgataaggtg ccatgcttgg cttcgatgat
1021 agaagatgtt ttgggagaag ggtcagtctc tgccagtcgg ttcagtaggt ggttctctaa
1081 cccgagcaga tcaggaagcc gatccagcag tcttgggtca acaccacatg aagagctaga
1141 gagacttgca ggtctggagc aagccatcct ctctcctgga cagaactcgg ggaattactt
1201 tgctcctata ccattggaag accatgctga aaataaagtg gatattttag aaatgctaca
1261 gaaagccaaa gtggatttga aacctcttct ttccagcctt tctgcaaata aagaaaaact
1321 taaagaaagc tcacattcag gggttgtgct ttcagtggag gaggtagaag caggtctgaa
1381 gggcttgaag gttgaccagc aagtgaagaa ttcaactccc ttcatggcag aacacctaga
1441 agagaccttg agtgccgtaa ccaacaatcg acaactgaag aaagacggag acatgactgc
1501 gttcaacaag ctagtgagca caatgaaggc aagtgggact ttgccttctc agcccaaagt
1561 cagccgaaac cttgaaagcc atttgatgtc ccctgctgag attccaggcc agcctgtccc
1621 taagaacatc ctgcaggaac ttctgggtca accagttcag agacctgctt cttccaatct
1681 tctgagtggc cttatgggga gcttggagcc tacaacatct ttactgggcc aaagagcacc
1741 ctctcctccc ttgtcacagg tgtttcaaac tcgagcagcc tcagctgact accttcgccc
1801 aagaatacca tcaccaattg gtttcacacc aggaccacag cagctactcg gagatccatt
1861 ccaaggcatg cgcaaaccca tgagccccat cacagcccag atgagccagc tggagttgca
1921 acaggcagct ttagaagggc tggccttgcc acatgacctt gctgtacagg cagcaaactt
1981 ctaccagcct ggttttggca aaccacaggt ggacagaacc agagatggat tcagaaacag
2041 gcaacagcga gtgaccaagt caccagcacc cgtgcatcga gggaattcct cttcccctgc
2101 ccctgctgcc tccatcacaa gcatgctttc tccttccttt acccctacct cagtgattcg
2161 taagatgtac gagagcaaag agaaaagcaa ggaggagcca gcatctggaa aagcagctct
2221 tggtgacagt aaagaggata ctcagaaggc cagtgaagaa aacctcctgt catccagctc
2281 tgtacccagt gccgatcgag actcttctcc cactacaaat tccaaactgt cagcattaca
2341 gaggtcttcg tgttccaccc cactgtccca ggccaaccgt tacaccaaag aacaagatta
2401 tcgacctaaa gcaactggga gaaaaacacc caccttggca tccccagttc ctacaacacc
2461 ttttctccgc cctgtccacc aagttcccct tgtcccccat gtccctatgg ttaggcctgc
2521 tcaccagctt cacccagggt tggtacagag gatgctggcc cagggagtac atccacagca
2581 tcttccaagt ttgctccaaa ctggtgtgct tcctcctggg atggacttga gtcatttaca
2641 gggaatatct ggccccatcc tgggtcagcc cttttaccct ttacctgctg ctagtcaccc
2701 tctcttaaac cctcgtcctg gaacacctct gcatctggca atggtgcaac agcagctaca
2761 gcgctcagtt ctgcatcctc caggctctgg ttcccatgca gcagctgtca gcgttcagac
2821 aacccctcag aacgtgccca gccggtcagg cctgccccac atgcactccc agctggagca
2881 tcgccccagc cagaggagca gctcccctgt gggccttgcc aaatggtttg gctcagatgt
2941 gctacagcaa cccctgccct ccatgcccgc caaagttatc agtgtagatg aattggaata
3001 ccgacagtga gcagggcagg cagactcaac taagcccgga cctgtggtgg cacactgggc
3061 ggaccctgct tcatctcggg ttggtttatg ggcttttact ttggagcact ctgtgtgaag
3121 ctgtttggtg gaacccatgc atctggtgtg gtccgcatta tgatggaagg atcttaacca
3181 gtcgagtgga gtgtacattg tctgaataca ggatgcacaa tgttgtcaat cctggaaatg
3241 gtctttcttt tttgtaagat atgtgaatga agtgttggtg tcctcaccaa gaggtggcac
3301 ctaagggttc tgaggaaata aatgtataga cccttatgta cagacctgtg tataaacaac
3361 ttttgtatat acatatagga tagctttttt gaactataca gctgtacata aaagtagctg
3421 atattagtta ggcctgtgtc aacagtttgg atttttttca cttgtacatt tgggattttc
3481 ttttggttga ttaaaattgc atatgctaag tgtgtgaatg
//