LOCUS AF240467 5007 bp mRNA linear HUM 05-FEB-2001
DEFINITION Homo sapiens toll-like receptor 7 (TLR7) mRNA, complete cds.
ACCESSION AF240467
VERSION AF240467.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5007)
AUTHORS Du,X., Poltorak,A., Wei,Y. and Beutler,B.
TITLE Three novel mammalian toll-like receptors: gene structure,
expression, and evolution
JOURNAL Eur. Cytokine Netw. 11 (3), 362-371 (2000)
PUBMED 11022119
REFERENCE 2 (bases 1 to 5007)
AUTHORS Du,X., Wei,Y., Poltorak,A. and Beutler,B.
TITLE Direct Submission
JOURNAL Submitted (01-MAR-2000) Internal Medicine, UT Southwestern Medical
Center/HHMI, 5323 Harry Hines Boulevard, Dallas, TX 75235-9050, USA
FEATURES Location/Qualifiers
source 1..5007
/db_xref="H-InvDB:HIT000074810"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xp22.3"
/clone="Humtlr7"
/tissue_type="placenta"
/note="5' and 3' ends established by RACE"
gene 1..5007
/gene="TLR7"
CDS 136..3285
/gene="TLR7"
/codon_start=1
/product="toll-like receptor 7"
/protein_id="AAF60188.1"
/translation="MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPK
NHVIVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVP
IPLGSKNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNI
FSIRKENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTA
VPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNN
SPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAK
FLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSP
LHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNART
SVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFFV
KSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELH
KLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESESLRTL
EFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSL
AKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTK
YFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWV
NHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSLSISVSLFLMVM
MTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTKDPAVTEWVLAELVA
KLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFKIAFY
LSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQAHPYFWQCLK
NALATDNHVAYSQVFKETV"
BASE COUNT 1527 a 1076 c 968 g 1436 t
ORIGIN
1 actccagata taggatcact ccatgccatc aagaaagttg atgctattgg gcccatctca
61 agctgatctt ggcacctctc atgctctgct ctcttcaacc agacctctac attccatttt
121 ggaagaagac taaaaatggt gtttccaatg tggacactga agagacaaat tcttatcctt
181 tttaacataa tcctaatttc caaactcctt ggggctagat ggtttcctaa aactctgccc
241 tgtgatgtca ctctggatgt tccaaagaac catgtgatcg tggactgcac agacaagcat
301 ttgacagaaa ttcctggagg tattcccacg aacaccacga acctcaccct caccattaac
361 cacataccag acatctcccc agcgtccttt cacagactgg accatctggt agagatcgat
421 ttcagatgca actgtgtacc tattccactg gggtcaaaaa acaacatgtg catcaagagg
481 ctgcagatta aacccagaag ctttagtgga ctcacttatt taaaatccct ttacctggat
541 ggaaaccagc tactagagat accgcagggc ctcccgccta gcttacagct tctcagcctt
601 gaggccaaca acatcttttc catcagaaaa gagaatctaa cagaactggc caacatagaa
661 atactctacc tgggccaaaa ctgttattat cgaaatcctt gttatgtttc atattcaata
721 gagaaagatg ccttcctaaa cttgacaaag ttaaaagtgc tctccctgaa agataacaat
781 gtcacagccg tccctactgt tttgccatct actttaacag aactatatct ctacaacaac
841 atgattgcaa aaatccaaga agatgatttt aataacctca accaattaca aattcttgac
901 ctaagtggaa attgccctcg ttgttataat gccccatttc cttgtgcgcc gtgtaaaaat
961 aattctcccc tacagatccc tgtaaatgct tttgatgcgc tgacagaatt aaaagtttta
1021 cgtctacaca gtaactctct tcagcatgtg cccccaagat ggtttaagaa catcaacaaa
1081 ctccaggaac tggatctgtc ccaaaacttc ttggccaaag aaattgggga tgctaaattt
1141 ctgcattttc tccccagcct catccaattg gatctgtctt tcaattttga acttcaggtc
1201 tatcgtgcat ctatgaatct atcacaagca ttttcttcac tgaaaagcct gaaaattctg
1261 cggatcagag gatatgtctt taaagagttg aaaagcttta acctctcgcc attacataat
1321 cttcaaaatc ttgaagttct tgatcttggc actaacttta taaaaattgc taacctcagc
1381 atgtttaaac aatttaaaag actgaaagtc atagatcttt cagtgaataa aatatcacct
1441 tcaggagatt caagtgaagt tggcttctgc tcaaatgcca gaacttctgt agaaagttat
1501 gaaccccagg tcctggaaca attacattat ttcagatatg ataagtatgc aaggagttgc
1561 agattcaaaa acaaagaggc ttctttcatg tctgttaatg aaagctgcta caagtatggg
1621 cagaccttgg atctaagtaa aaatagtata ttttttgtca agtcctctga ttttcagcat
1681 ctttctttcc tcaaatgcct gaatctgtca ggaaatctca ttagccaaac tcttaatggc
1741 agtgaattcc aacctttagc agagctgaga tatttggact tctccaacaa ccggcttgat
1801 ttactccatt caacagcatt tgaagagctt cacaaactgg aagttctgga tataagcagt
1861 aatagccatt attttcaatc agaaggaatt actcatatgc taaactttac caagaaccta
1921 aaggttctgc agaaactgat gatgaacgac aatgacatct cttcctccac cagcaggacc
1981 atggagagtg agtctcttag aactctggaa ttcagaggaa atcacttaga tgttttatgg
2041 agagaaggtg ataacagata cttacaatta ttcaagaatc tgctaaaatt agaggaatta
2101 gacatctcta aaaattccct aagtttcttg ccttctggag tttttgatgg tatgcctcca
2161 aatctaaaga atctctcttt ggccaaaaat gggctcaaat ctttcagttg gaagaaactc
2221 cagtgtctaa agaacctgga aactttggac ctcagccaca accaactgac cactgtccct
2281 gagagattat ccaactgttc cagaagcctc aagaatctga ttcttaagaa taatcaaatc
2341 aggagtctga cgaagtattt tctacaagat gccttccagt tgcgatatct ggatctcagc
2401 tcaaataaaa tccagatgat ccaaaagacc agcttcccag aaaatgtcct caacaatctg
2461 aagatgttgc ttttgcatca taatcggttt ctgtgcacct gtgatgctgt gtggtttgtc
2521 tggtgggtta accatacgga ggtgactatt ccttacctgg ccacagatgt gacttgtgtg
2581 gggccaggag cacacaaggg ccaaagtgtg atctccctgg atctgtacac ctgtgagtta
2641 gatctgacta acctgattct gttctcactt tccatatctg tatctctctt tctcatggtg
2701 atgatgacag caagtcacct ctatttctgg gatgtgtggt atatttacca tttctgtaag
2761 gccaagataa aggggtatca gcgtctaata tcaccagact gttgctatga tgcttttatt
2821 gtgtatgaca ctaaagaccc agctgtgacc gagtgggttt tggctgagct ggtggccaaa
2881 ctggaagacc caagagagaa acattttaat ttatgtctcg aggaaaggga ctggttacca
2941 gggcagccag ttctggaaaa cctttcccag agcatacagc ttagcaaaaa gacagtgttt
3001 gtgatgacag acaagtatgc aaagactgaa aattttaaga tagcatttta cttgtcccat
3061 cagaggctca tggatgaaaa agttgatgtg attatcttga tatttcttga gaagcccttt
3121 cagaagtcca agttcctcca gctccggaaa aggctctgtg ggagttctgt ccttgagtgg
3181 ccaacaaacc cgcaagctca cccatacttc tggcagtgtc taaagaacgc cctggccaca
3241 gacaatcatg tggcctatag tcaggtgttc aaggaaacgg tctagccctt ctttgcaaaa
3301 cacaactgcc tagtttacca aggagaggcc tggctgttta aattgttttc atatatatca
3361 caccaaaagc gtgttttgaa attcttcaag aaatgagatt gcccatattt caggggagcc
3421 accaacgtct gtcacaggag ttggaaagat ggggtttata taatgcatca agtcttcttt
3481 cttatctctc tgtgtctcta tttgcacttg agtctctcac ctcagctcct gtaaaagagt
3541 ggcaagtaaa aaacatgggg ctctgattct cctgtaattg tgataattaa atatacacac
3601 aatcatgaca ttgagaagaa ctgcatttct acccttaaaa agtactggta tatacagaaa
3661 tagggttaaa aaaaactcaa gctctctcta tatgagacca aaatgtacta gagttagttt
3721 agtgaaataa aaaaccagtc agctggccgg gcatggtggc tcatgcttgt aatcccagca
3781 ctttgggagg ccgaggcagg tggatcacga ggtcaggagt ttgagaccag tctggccaac
3841 atggtgaaac cccgtctgta ctaaaaatac aaaaattagc tgggcgtggt ggtgggtgcc
3901 tgtaatccca gctacttggg aggctgaggc aggagaatcg cttgaacccg ggaggtggag
3961 gtggcagtga gccgagatca cgccactgca atgcagcccg ggcaacagag ctagactgtc
4021 tcaaaagaac aaaaaaaaaa aaacacaaaa aaactcagtc agcttcttaa ccaattgctt
4081 ccgtgtcatc cagggcccca ttctgtgcag attgagtgtg ggcaccacac aggtggttgc
4141 tgcttcagtg cttcctgctc tttttccttg ggcctgcttc tgggttccat agggaaacag
4201 taagaaagaa agacacatcc ttaccataaa tgcatatggt ccacctacaa atagaaaaat
4261 atttaaatga tctgccttta tacaaagtga tattctctac ctttgataat ttacctgctt
4321 aaatgttttt atctgcactg caaagtactg tatccaaagt aaaatttcct catccaatat
4381 ctttcaaact gttttgttaa ctaatgccat atatttgtaa gtatctgcac acttgataca
4441 gcaacgttag atggttttga tggtaaaccc taaaggagga ctccaagagt gtgtatttat
4501 ttatagtttt atcagagatg acaattattt gaatgccaat tatatggatt cctttcattt
4561 tttgctggag gatgggagaa gaaaccaaag tttatagacc ttcacattga gaaagcttca
4621 gttttgaact tcagctatca gattcaaaaa caacagaaag aaccaagaca ttcttaagat
4681 gcctgtactt tcagctgggt ataaattcat gagttcaaag attgaaacct gaccaatttg
4741 ctttatttca tggaagaagt gatctacaaa ggtgtttgtg ccatttggaa aacagcgtgc
4801 atgtgttcaa gccttagatt ggcgatgtcg tattttcctc acgtgtggca atgccaaagg
4861 ctttacttta cctgtgagta cacactatat gaattatttc caacgtacat ttaatcaata
4921 agggtcacaa attcccaaat caatctctgg aataaataga gaggtaatta aattgctgga
4981 gccaactatt tcacaacttc tgtaagc
//