LOCUS AF237982 2129 bp mRNA linear HUM 30-MAY-2000
DEFINITION Homo sapiens oxysterol 7alpha-hydroxylase (CYP39A1) mRNA, complete
cds.
ACCESSION AF237982
VERSION AF237982.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2129)
AUTHORS Li-Hawkins,J., Lund,E.G., Bronson,A.D. and Russell,D.W.
TITLE Expression cloning of an oxysterol 7alpha-hydroxylase selective for
24-hydroxycholesterol
JOURNAL J. Biol. Chem. 275 (22), 16543-16549 (2000)
PUBMED 10748047
REFERENCE 2 (bases 1 to 2129)
AUTHORS Li-Hawkins,J., Lund,E.G., Bronson,A.D. and Russell,D.W.
TITLE Direct Submission
JOURNAL Submitted (23-FEB-2000) Molecular Genetics, University of Texas
Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd.,
Dallas, TX 75235, USA
FEATURES Location/Qualifiers
source 1..2129
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="liver"
gene 1..2129
/gene="CYP39A1"
CDS 45..1454
/gene="CYP39A1"
/codon_start=1
/product="oxysterol 7alpha-hydroxylase"
/protein_id="AAF63329.1"
/translation="MELISPTVIIILGCLALFLLLQRKNLRRPPCIKGWIPWIGVGFE
FGKAPLEFIEKARIKYGPIFTVFAMGNRMTFVTEEEGINVFLKSKKVDFELAVQNIVY
RTASIPKNVFLALHEKLYIMLKGKMGTVNLHQFTGQLTEELHEQLENLGTHGTMDLNN
LVRHLLYPVTVNMLFNKSLFSTNKKKIKEFHQYFQVYDEDFEYGSQLPECLLRNWSKS
KKWFLELFEKNIPDIKACKSAKDNSMTLLQATLDIVETETSKENSPNYGLLLLWASLS
NAVPVAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLEKLLLIKWCVLE
TIRLKAPGVITRKVVKPVEILNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKK
ANLEKHSFLDCFMAFGSGKFQCPARWFALLEVQMCIILILYKYDCSLLDPLPKQSYLH
LVGVPQPEGQCRIEYKQRI"
BASE COUNT 680 a 374 c 415 g 660 t
ORIGIN
1 actgtttcac acttttctgc ttctggaagg tgctggacaa aaacatggaa ctaatttccc
61 caacagtgat tataatcctg ggttgccttg ctctgttctt actccttcag cggaagaatt
121 tgcgtagacc cccgtgcatc aagggctgga ttccttggat tggagttgga tttgagtttg
181 ggaaagcccc tctagaattt atagagaaag caagaatcaa gtatggacca atatttacag
241 tctttgctat gggaaaccga atgacctttg ttactgaaga agaaggaatt aatgtgtttc
301 taaaatccaa aaaagtagat tttgaactag cagtgcaaaa tatcgtttat cgtacagcat
361 caattccaaa gaatgtcttt ttagcactgc atgaaaaact ctatattatg ttgaaaggga
421 aaatggggac tgtcaatctc catcagttta ctgggcaact gactgaagaa ttacatgaac
481 aactggagaa tttaggcact catgggacaa tggacctgaa caacttagta agacatctcc
541 tttatccagt cacagtgaat atgctcttta ataaaagttt gttttccaca aacaagaaaa
601 aaatcaagga gttccatcag tattttcaag tttatgatga agattttgag tatgggtccc
661 agttgccaga gtgtcttcta agaaactggt caaaatccaa aaagtggttc ctggaactgt
721 ttgagaaaaa cattccagat ataaaagcat gtaaatctgc aaaagataat tccatgacat
781 tattgcaagc tacgctggat attgtagaga cggaaacaag taaggaaaac tcacccaatt
841 atgggctctt actgctttgg gcttctctgt ctaatgctgt tcctgttgca ttttggacac
901 ttgcatacgt cctttctcat cctgatatcc acaaggccat tatggaaggc atatcttctg
961 tgtttggcaa agcaggcaaa gataagatta aagtgtctga ggatgacctg gagaaactcc
1021 ttctaattaa atggtgtgtt ttggaaacca ttcgtttaaa agctcctggt gtcattacta
1081 gaaaagtggt gaagcctgtg gaaattttga attacatcat tccttctggt gacttgttga
1141 tgttgtctcc attttggctg catagaaatc caaagtattt tcctgagcct gaattgttca
1201 aacctgaacg ttggaaaaag gcaaatttag agaagcactc tttcttggac tgcttcatgg
1261 catttggaag cgggaagttc cagtgtcctg caaggtggtt tgctctgtta gaggttcaga
1321 tgtgtattat tttaatactt tataaatatg actgtagtct tctggaccca ttacccaaac
1381 agagttatct ccatttggtg ggtgtccccc agccggaagg gcaatgccga attgaatata
1441 aacaaagaat atgacatctg ttgggcctca caaggaccag ggccttctgg aggagtggca
1501 ctaccccacc tggcagcacc tagacctgag ctctacaaaa acacactgct tcactttgtt
1561 ttaggactta gttcaagaac acattcaaat ggtgcatgtg tttggtatct tcaacagtag
1621 accaagaatc taacatcact ctcagtaata tagagaccgg aatacatggt ttataggaaa
1681 tgatcaaatg atccaaaaaa actccacatt ttttaagaag ttggaatttg atttcatgca
1741 taactgtatt aaaacattaa atagaaataa tgtcatttga atgaaaatct tatcacatta
1801 aattcactgt gaaggcagca tacttaaagg aatttgattt catgcataac tgtattaaaa
1861 cattaaatag aaataatgtc atttgaatga aaatcttatc acattaaatt cactgtgaag
1921 gcagcatact taaattttta ttttgaaaag tctaaaaggc ttagattttt aaaatttaat
1981 aattatttct acaaattttc tatttttctt gaggtgattc tcaactagca attggaactc
2041 ctaggctcta ttaacataat tctttattgt aaacgtatct aatgctaaaa gtaataaaat
2101 ggtagttttc tgagacctgt gaggacagg
//