LOCUS       AF233396                1638 bp    mRNA    linear   HUM 14-JUL-2000
DEFINITION  Homo sapiens sir2-related protein type 6 (SIRT6) mRNA, complete
            cds.
ACCESSION   AF233396
VERSION     AF233396.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1638)
  AUTHORS   Frye,R.A.
  TITLE     Phylogenetic classification of prokaryotic and eukaryotic Sir2-like
            proteins
  JOURNAL   Biochem. Biophys. Res. Commun. 273 (2), 793-798 (2000)
   PUBMED   10873683
REFERENCE   2  (bases 1 to 1638)
  AUTHORS   Frye,R.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-FEB-2000) Pathology, VA Med. Center, University of
            Pittsburgh, University Drive C, Pittsburgh, PA 15240, USA
FEATURES             Location/Qualifiers
     source          1..1638
                     /db_xref="H-InvDB:HIT000074679"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3; between CDC34 and D19S325"
                     /tissue_type="spleen"
     gene            1..1638
                     /gene="SIRT6"
     CDS             61..1128
                     /gene="SIRT6"
                     /function="putatively binds and cleaves N-acetyl bonds"
                     /function="metabolizes NAD"
                     /function="ADP-ribosyltransferase activity"
                     /note="sirtuin6; similar to yeast silent information
                     regulator 2 protein, sir2p"
                     /codon_start=1
                     /product="sir2-related protein type 6"
                     /protein_id="AAF43432.1"
                     /translation="MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQS
                     SSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLE
                     RVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLK
                     ATGRLCTVAKARGLRACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQ
                     IRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMEHLGLEIPAW
                     DGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRE
                     RPTSPAPHRPPKRVKAKAVPS"
BASE COUNT          298 a          545 c          516 g          279 t
ORIGIN      
        1 gcttccggcg gaagcggcct caacaaggga aactttattg ttcccgtggg gcagtcgagg
       61 atgtcggtga attacgcggc ggggctgtcg ccgtacgcgg acaagggcaa gtgcggcctc
      121 ccggagatct tcgacccccc ggaggagctg gagcggaagg tgtgggaact ggcgaggctg
      181 gtctggcagt cttccagtgt ggtgttccac acgggtgccg gcatcagcac tgcctctggc
      241 atccccgact tcaggggtcc ccacggagtc tggaccatgg aggagcgagg tctggccccc
      301 aagttcgaca ccacctttga gagcgcgcgg cccacgcaga cccacatggc gctggtgcag
      361 ctggagcgcg tgggcctcct ccgcttcctg gtcagccaga acgtggacgg gctccatgtg
      421 cgctcaggct tccccaggga caaactggca gagctccacg ggaacatgtt tgtggaagaa
      481 tgtgccaagt gtaagacgca gtacgtccga gacacagtcg tgggcaccat gggcctgaag
      541 gccacgggcc ggctctgcac cgtggctaag gcaagggggc tgcgagcctg caggggagag
      601 ctgagggaca ccatcctaga ctgggaggac tccctgcccg accgggacct ggcactcgcc
      661 gatgaggcca gcaggaacgc cgacctgtcc atcacgctgg gtacatcgct gcagatccgg
      721 cccagcggga acctgccgct ggctaccaag cgccggggag gccgcctggt catcgtcaac
      781 ctgcagccca ccaagcacga ccgccatgct gacctccgca tccatggcta cgttgacgag
      841 gtcatgaccc ggctcatgga gcacctgggg ctggagatcc ccgcctggga cggcccccgt
      901 gtgctggaga gggcgctgcc acccctgccc cgcccgccca cccccaagct ggagcccaag
      961 gaggaatctc ccacccggat caacggctct atccccgccg gccccaagca ggagccctgc
     1021 gcccagcaca acggctcaga gcccgccagc cccaaacggg agcggcccac cagccctgcc
     1081 ccccacagac cccccaaaag ggtgaaggcc aaggcggtcc ccagctgacc agggtgcttg
     1141 gggagggtgg ggctttttgt agaaactgtg gattcttttt ctctcgtggt ctcactttgt
     1201 tacttgtttc tgtccccggg agcctcaggg ctctgagagc tgtgctccag gccaggggtt
     1261 acacctgccc tccgtggtcc ctccctgggc tccaggggcc tctggtgcgg ttccgggaag
     1321 aagccacacc ccagaggtga cagctgagcc cctgccacac cccagcctct gacttgctgt
     1381 gttgtccaga ggtgaggctg ggccctccct ggtctccagc ttaaacagga gtgaactccc
     1441 tctgtcccca gggcctccct tctgggcccc ctacagccca ccctacccct cctccatggg
     1501 ccctgcagga ggggagaccc accttgaagt gggggatcag tagaggcttg cactgccttt
     1561 ggggctggag ggagacgtgg gtccaccagg cttctggaaa agtcctcaat gcaataaaaa
     1621 caatttcttt cttgcaaa
//