LOCUS AF233396 1638 bp mRNA linear HUM 14-JUL-2000 DEFINITION Homo sapiens sir2-related protein type 6 (SIRT6) mRNA, complete cds. ACCESSION AF233396 VERSION AF233396.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1638) AUTHORS Frye,R.A. TITLE Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins JOURNAL Biochem. Biophys. Res. Commun. 273 (2), 793-798 (2000) PUBMED 10873683 REFERENCE 2 (bases 1 to 1638) AUTHORS Frye,R.A. TITLE Direct Submission JOURNAL Submitted (10-FEB-2000) Pathology, VA Med. Center, University of Pittsburgh, University Drive C, Pittsburgh, PA 15240, USA FEATURES Location/Qualifiers source 1..1638 /db_xref="H-InvDB:HIT000074679" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="19" /map="19p13.3; between CDC34 and D19S325" /tissue_type="spleen" gene 1..1638 /gene="SIRT6" CDS 61..1128 /gene="SIRT6" /function="putatively binds and cleaves N-acetyl bonds" /function="metabolizes NAD" /function="ADP-ribosyltransferase activity" /note="sirtuin6; similar to yeast silent information regulator 2 protein, sir2p" /codon_start=1 /product="sir2-related protein type 6" /protein_id="AAF43432.1" /translation="MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQS SSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLE RVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLK ATGRLCTVAKARGLRACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQ IRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMEHLGLEIPAW DGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRE RPTSPAPHRPPKRVKAKAVPS" BASE COUNT 298 a 545 c 516 g 279 t ORIGIN 1 gcttccggcg gaagcggcct caacaaggga aactttattg ttcccgtggg gcagtcgagg 61 atgtcggtga attacgcggc ggggctgtcg ccgtacgcgg acaagggcaa gtgcggcctc 121 ccggagatct tcgacccccc ggaggagctg gagcggaagg tgtgggaact ggcgaggctg 181 gtctggcagt cttccagtgt ggtgttccac acgggtgccg gcatcagcac tgcctctggc 241 atccccgact tcaggggtcc ccacggagtc tggaccatgg aggagcgagg tctggccccc 301 aagttcgaca ccacctttga gagcgcgcgg cccacgcaga cccacatggc gctggtgcag 361 ctggagcgcg tgggcctcct ccgcttcctg gtcagccaga acgtggacgg gctccatgtg 421 cgctcaggct tccccaggga caaactggca gagctccacg ggaacatgtt tgtggaagaa 481 tgtgccaagt gtaagacgca gtacgtccga gacacagtcg tgggcaccat gggcctgaag 541 gccacgggcc ggctctgcac cgtggctaag gcaagggggc tgcgagcctg caggggagag 601 ctgagggaca ccatcctaga ctgggaggac tccctgcccg accgggacct ggcactcgcc 661 gatgaggcca gcaggaacgc cgacctgtcc atcacgctgg gtacatcgct gcagatccgg 721 cccagcggga acctgccgct ggctaccaag cgccggggag gccgcctggt catcgtcaac 781 ctgcagccca ccaagcacga ccgccatgct gacctccgca tccatggcta cgttgacgag 841 gtcatgaccc ggctcatgga gcacctgggg ctggagatcc ccgcctggga cggcccccgt 901 gtgctggaga gggcgctgcc acccctgccc cgcccgccca cccccaagct ggagcccaag 961 gaggaatctc ccacccggat caacggctct atccccgccg gccccaagca ggagccctgc 1021 gcccagcaca acggctcaga gcccgccagc cccaaacggg agcggcccac cagccctgcc 1081 ccccacagac cccccaaaag ggtgaaggcc aaggcggtcc ccagctgacc agggtgcttg 1141 gggagggtgg ggctttttgt agaaactgtg gattcttttt ctctcgtggt ctcactttgt 1201 tacttgtttc tgtccccggg agcctcaggg ctctgagagc tgtgctccag gccaggggtt 1261 acacctgccc tccgtggtcc ctccctgggc tccaggggcc tctggtgcgg ttccgggaag 1321 aagccacacc ccagaggtga cagctgagcc cctgccacac cccagcctct gacttgctgt 1381 gttgtccaga ggtgaggctg ggccctccct ggtctccagc ttaaacagga gtgaactccc 1441 tctgtcccca gggcctccct tctgggcccc ctacagccca ccctacccct cctccatggg 1501 ccctgcagga ggggagaccc accttgaagt gggggatcag tagaggcttg cactgccttt 1561 ggggctggag ggagacgtgg gtccaccagg cttctggaaa agtcctcaat gcaataaaaa 1621 caatttcttt cttgcaaa //