LOCUS AF233395 1718 bp mRNA linear HUM 14-JUL-2000
DEFINITION Homo sapiens sir2-related protein type 7 (SIRT7) mRNA, complete
cds.
ACCESSION AF233395
VERSION AF233395.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1718)
AUTHORS Frye,R.A.
TITLE Phylogenetic classification of prokaryotic and eukaryotic Sir2-like
proteins
JOURNAL Biochem. Biophys. Res. Commun. 273 (2), 793-798 (2000)
PUBMED 10873683
REFERENCE 2 (bases 1 to 1718)
AUTHORS Frye,R.A.
TITLE Direct Submission
JOURNAL Submitted (10-FEB-2000) Pathology, VA Med. Center, University of
Pittsburgh, University Drive C, Pittsburgh, PA 15240, USA
FEATURES Location/Qualifiers
source 1..1718
/db_xref="H-InvDB:HIT000074678"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="spleen"
gene 1..1718
/gene="SIRT7"
CDS 34..1236
/gene="SIRT7"
/function="putatively binds and cleaves N-acetyl bonds"
/function="metabolizes NAD"
/function="ADP-ribosyltransferase activity"
/note="sirtuin7; similar to yeast silent information
regulator 2 protein, sir2p"
/codon_start=1
/product="sir2-related protein type 7"
/protein_id="AAF43431.1"
/translation="MAAGGLSRSERKAAERVRRLREEQQRERLRQVSRILRKAAAERS
AEEGRLLAESADLVTELQGRSRRREGLKRRQEEVCDDPEELRGKVRELASAVRNAKYL
VVYTGAGISTAASIPDYRGPNGVWTLLQKGRSVSAADLSEAEPTLTHMSITRLHEQKL
VQHVVSQNCDGLHLRSGLPRTAISELHGNMYIEVCTSCVPNREYVRVFDVTERTALHR
HQTGRTCHKCGTQLRDTIVHFGERGTLGQPLNWEAATEAASRADTILCLGSSLKVLKK
YPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGKCDDVMRLLMAELGLEIPAYS
RWQDPIFSLATPLRAGEEGSHSRKSLCRSREEAPPGDRGAPLSSAPILGGWFGRGCTK
RTKRKKVT"
BASE COUNT 355 a 483 c 575 g 305 t
ORIGIN
1 gcggaagcgg aagagcaggt ctccagggga gcgatggcag ccgggggtct gagccgctcc
61 gagcgcaaag cggcggagcg ggtccggagg ttgcgggagg agcagcagag ggagcgcctc
121 cgccaggtgt cgcgcatcct gaggaaggcg gcggcggagc gcagcgccga ggagggccgg
181 ctgctggccg agagcgcgga cctggtaacg gagctgcagg gccggagccg gcggcgcgag
241 ggcctgaagc ggcggcagga ggaggtgtgc gacgacccgg aggagctgcg ggggaaggtc
301 cgggagctgg ccagcgccgt ccggaacgcc aaatacttgg tcgtctacac aggcgcggga
361 atcagcacgg cagcgtctat cccagactac cggggcccta atggagtgtg gacactgctt
421 cagaaaggga gaagcgttag tgctgccgac ctgagcgagg ccgagccaac cctcacccac
481 atgagcatca cccgtctgca tgagcagaag ctggtgcagc atgtggtgtc tcagaactgt
541 gacgggctcc acctgaggag tgggctgccg cgcacggcca tctccgagct ccacgggaac
601 atgtacattg aagtctgtac ctcctgcgtt cccaacaggg agtacgtgcg ggtgttcgat
661 gtgacggagc gcactgccct ccacagacac cagacaggcc ggacctgcca caagtgtggg
721 acccagctgc gggacaccat tgtgcacttt ggggagaggg ggacgttggg gcagcctctg
781 aactgggaag cggcgaccga ggctgccagc agagcagaca ccatcctgtg tctagggtcc
841 agcctgaagg ttctaaagaa gtacccacgc ctctggtgca tgaccaagcc ccctagccgg
901 cggccgaagc tttacatcgt gaacctgcag tggaccccga aggatgactg ggctgccctg
961 aagctacatg ggaagtgtga tgacgtcatg cggctcctca tggccgagct gggcttggag
1021 atccccgcct atagcaggtg gcaggatccc attttctcac tggcgactcc cctgcgtgct
1081 ggtgaagaag gcagccacag tcggaagtcg ctgtgcagaa gcagagagga ggccccgcct
1141 ggggaccggg gtgcaccgct tagctcggcc cccatcctag ggggctggtt tggcaggggc
1201 tgcacaaaac gcacaaaaag gaagaaagtg acgtaatcac gtgctcgatg aagaacagtt
1261 ggcactttgc agatggccag tgtcacggtg aaggctgggt tgcccccacg ggtctaggga
1321 gaacgaactc tttggggatg acattttcac cgtgacattt ttagccattt gtccttgagg
1381 aagccccttg cactgctgcg gttgtaccct gatacggcct ggccatcgag gacacctgcc
1441 catccggcct ctgtgtcaag aggtggcagc cgcacctttc tgtgagaacg gaactcgggt
1501 tatttcagcc ccggcctgca gagtggaagc gcccagcggc ctttcctcgc tcaccaggcc
1561 agtctcaggg cctcaccgta tttctactac tacttaatga aaaagtgtga actttataga
1621 atcctctctg tactggatgt gcggcagagg ggtggctccg agcctcggct ctatgcagac
1681 ctttttattt ctattaaacg tttctgcact ggcaaaaa
//